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Volumn 222, Issue 7, 2003, Pages 946-951

Role of nonsteroidal anti-inflammatory drugs in gastrointestinal tract injury and repair

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; DICLOFENAC; IBUPROFEN; INDOMETACIN; KETOPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT;

EID: 0037377824     PISSN: 00031488     EISSN: None     Source Type: Journal    
DOI: 10.2460/javma.2003.222.946     Document Type: Review
Times cited : (42)

References (70)
  • 1
    • 0032476563 scopus 로고    scopus 로고
    • Pathogenesis of nonsteroidal anti-inflammatory drug-related toxicity
    • Soll A. Pathogenesis of nonsteroidal anti-inflammatory drug-related toxicity. Am J Med 1998;105:10S-15S.
    • (1998) Am J Med , vol.105
    • Soll, A.1
  • 2
    • 0033863020 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drug gastropathy
    • Hawkey CJ. Nonsteroidal anti-inflammatory drug gastropathy. Gastroenterology 2000;119:521-535.
    • (2000) Gastroenterology , vol.119 , pp. 521-535
    • Hawkey, C.J.1
  • 3
    • 0033577982 scopus 로고    scopus 로고
    • Gastrointestinal toxicity of nonsteroidal anti-inflammatory drugs
    • Wolfe MM, Lichtenstein DR, Singh G. Gastrointestinal toxicity of nonsteroidal anti-inflammatory drugs. N Engl J Med 1999;340:1888-1899.
    • (1999) N Engl J Med , vol.340 , pp. 1888-1899
    • Wolfe, M.M.1    Lichtenstein, D.R.2    Singh, G.3
  • 4
    • 0029884608 scopus 로고    scopus 로고
    • Role of prostaglandins in intestinal epithelial restitution stimulated by growth factors
    • Zushi S, Shinomura Y, Tatsuya K, et al. Role of prostaglandins in intestinal epithelial restitution stimulated by growth factors. Am J Physiol 1996;270:G757-G762.
    • (1996) Am J Physiol , vol.270
    • Zushi, S.1    Shinomura, Y.2    Tatsuya, K.3
  • 5
    • 0025033747 scopus 로고
    • Inhibitory effect of nonsteroidal anti-inflammatory drugs on mucosal cell proliferation associated with gastric ulcer healing
    • Levi S, Goodlad RA, Lee CY, et al. Inhibitory effect of nonsteroidal anti-inflammatory drugs on mucosal cell proliferation associated with gastric ulcer healing. Lancet 1990;336:840-43.
    • (1990) Lancet , vol.336 , pp. 840-843
    • Levi, S.1    Goodlad, R.A.2    Lee, C.Y.3
  • 6
    • 0026727058 scopus 로고
    • Gastric adaptation to nonsteroidal anti-inflammatory drugs in man
    • Olivero JJ, Graham DY. Gastric adaptation to nonsteroidal anti-inflammatory drugs in man. Scand J Gastroenterol 1992;27:53-58.
    • (1992) Scand J Gastroenterol , vol.27 , pp. 53-58
    • Olivero, J.J.1    Graham, D.Y.2
  • 7
    • 0015237292 scopus 로고
    • Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
    • Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature 1971;231:232-235.
    • (1971) Nature , vol.231 , pp. 232-235
    • Vane, J.R.1
  • 8
    • 0032777567 scopus 로고    scopus 로고
    • Renal effects of selective cyclooxygenase-2 inhibition in normotensive salt-depleted subjects
    • Rossat J, Mailard M, Nussberger J, et al. Renal effects of selective cyclooxygenase-2 inhibition in normotensive salt-depleted subjects. Clin Pharmacol Ther 1999;66:76-84.
    • (1999) Clin Pharmacol Ther , vol.66 , pp. 76-84
    • Rossat, J.1    Mailard, M.2    Nussberger, J.3
  • 9
    • 0024591782 scopus 로고
    • Mechanisms of nonsteroidal anti-inflammatory drug-induced gastric damage
    • Schoen RT, Vender RJ. Mechanisms of nonsteroidal anti-inflammatory drug-induced gastric damage. Am J Med 1989;86:449-458.
    • (1989) Am J Med , vol.86 , pp. 449-458
    • Schoen, R.T.1    Vender, R.J.2
  • 10
    • 0000100769 scopus 로고
    • Gastric mucosal injury by fatty acid and acetylsalicylic acids
    • Davenport HW. Gastric mucosal injury by fatty acid and acetylsalicylic acids. Gastroenterology 1964;93:245-253.
    • (1964) Gastroenterology , vol.93 , pp. 245-253
    • Davenport, H.W.1
  • 11
    • 0017046477 scopus 로고
    • Salicylate and aspirin-induced uncoupling of oxidative phosphorylation in mitochondria isolated from the mucosal membrane of the stomach
    • Jorgensen TG, Weis-Fogh US, Nielsen HH, et al. Salicylate and aspirin-induced uncoupling of oxidative phosphorylation in mitochondria isolated from the mucosal membrane of the stomach. Scand J Clin Lab Invest 1976;36:649-654.
    • (1976) Scand J Clin Lab Invest , vol.36 , pp. 649-654
    • Jorgensen, T.G.1    Weis-Fogh, U.S.2    Nielsen, H.H.3
  • 12
    • 0028796715 scopus 로고
    • Selective inhibition of fatty acid oxidation in colonocytes by ibuprofen: A cause of colitis?
    • Roediger WEW, Mollard S. Selective inhibition of fatty acid oxidation in colonocytes by ibuprofen: a cause of colitis? Gut 1995;36:55-59.
    • (1995) Gut , vol.36 , pp. 55-59
    • Roediger, W.E.W.1    Mollard, S.2
  • 13
    • 0027377232 scopus 로고
    • Mechanisms of acute and chronic intestinal inflammation induced by indomethacin
    • Yamanda T, Deitch E, Specian RD, et al. Mechanisms of acute and chronic intestinal inflammation induced by indomethacin. Inflammation 1993;17:641-662.
    • (1993) Inflammation , vol.17 , pp. 641-662
    • Yamanda, T.1    Deitch, E.2    Specian, R.D.3
  • 14
    • 0025853360 scopus 로고
    • Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons
    • Griffin MR, Piper JM, Daugherty JR, et al. Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons. Ann Intern Med 1991;114:257-263.
    • (1991) Ann Intern Med , vol.114 , pp. 257-263
    • Griffin, M.R.1    Piper, J.M.2    Daugherty, J.R.3
  • 16
    • 0017741070 scopus 로고
    • Mechanisms underlying gastric mucosal damage induced by indomethacin and bile salts, and the actions of prostaglandins
    • Whittle BJR. Mechanisms underlying gastric mucosal damage induced by indomethacin and bile salts, and the actions of prostaglandins. Br J Pharmacol 1977;60:455-460.
    • (1977) Br J Pharmacol , vol.60 , pp. 455-460
    • Whittle, B.J.R.1
  • 17
    • 0024215628 scopus 로고
    • The physiology of gastric acid secretion
    • Wolfe MM, Soll AH. The physiology of gastric acid secretion. N Engl J Med 1988;319:1707-1715.
    • (1988) N Engl J Med , vol.319 , pp. 1707-1715
    • Wolfe, M.M.1    Soll, A.H.2
  • 18
    • 0024264503 scopus 로고
    • Induction of rat gastric damage by the endothelium-derived peptide, endothelin
    • Whittle BJR, Espulugues JV. Induction of rat gastric damage by the endothelium-derived peptide, endothelin. Br J Pharmacol 1988;95:1033-1101.
    • (1988) Br J Pharmacol , vol.95 , pp. 1033-1101
    • Whittle, B.J.R.1    Espulugues, J.V.2
  • 21
    • 0027497355 scopus 로고
    • Gastric and duodenal mucosal blood flow in patients receiving nonsteroidal anti-inflammatory drugs, influence of age, smoking, ulceration and Helicobacter pylori
    • Taha AS, Angerson W, Nakshabendi I, et al. Gastric and duodenal mucosal blood flow in patients receiving nonsteroidal anti-inflammatory drugs, influence of age, smoking, ulceration and Helicobacter pylori. Aliment Pharmacol Ther 1993;7:41-45.
    • (1993) Aliment Pharmacol Ther , vol.7 , pp. 41-45
    • Taha, A.S.1    Angerson, W.2    Nakshabendi, I.3
  • 22
    • 0032875331 scopus 로고    scopus 로고
    • Indomethacin-induced disturbances in villous microcirculation in the rat ileum
    • Ruh J, Schmidt E, Vogel F, et al. Indomethacin-induced disturbances in villous microcirculation in the rat ileum. Microvasc Res 1999;58:137-143.
    • (1999) Microvasc Res , vol.58 , pp. 137-143
    • Ruh, J.1    Schmidt, E.2    Vogel, F.3
  • 23
    • 0022407333 scopus 로고
    • The role of endogenous prostaglandins in the regulation of gastric secretion in rhesus monkeys
    • El-Bayer H, Steel L, Montcalm E, et al. The role of endogenous prostaglandins in the regulation of gastric secretion in rhesus monkeys. Prostaglandins 1985;30:401-417.
    • (1985) Prostaglandins , vol.30 , pp. 401-417
    • El-Bayer, H.1    Steel, L.2    Montcalm, E.3
  • 24
    • 0023005794 scopus 로고
    • Mechanisms of action of antisecretory drugs
    • Soll AH. Mechanisms of action of antisecretory drugs. Scand J Gastroenterol 1986;21(125):1-6.
    • (1986) Scand J Gastroenterol , vol.21 , Issue.125 , pp. 1-6
    • Soll, A.H.1
  • 25
    • 0030045189 scopus 로고    scopus 로고
    • Tumor necrosis factor mediation of NSAID-induced gastric damage: Role of leukocyte adherence
    • Appleyard CB, McCafferty DM, Tigley AW, et al. Tumor necrosis factor mediation of NSAID-induced gastric damage: role of leukocyte adherence. Am J Physiol 1996;270:G42-G48.
    • (1996) Am J Physiol , vol.270
    • Appleyard, C.B.1    McCafferty, D.M.2    Tigley, A.W.3
  • 26
    • 0027142331 scopus 로고
    • Role of endothelial adhesion molecules in NSAID-induced gastric mucosal injury
    • Wallace JL, McKnight W, Miyasaka M, et al. Role of endothelial adhesion molecules in NSAID-induced gastric mucosal injury. Am J Physiol 1993;265:G993-G998.
    • (1993) Am J Physiol , vol.265
    • Wallace, J.L.1    McKnight, W.2    Miyasaka, M.3
  • 27
    • 0035102390 scopus 로고    scopus 로고
    • Mechanisms involved in enteropathy induced by administration of nonsteroidal anti-inflammatory drugs (NSAIDS)
    • Yamagiwa S, Yoshida Y, Halder RC, et al. Mechanisms involved in enteropathy induced by administration of nonsteroidal anti-inflammatory drugs (NSAIDS). Dig Dis Sci 2001;1:192-199.
    • (2001) Dig Dis Sci , vol.1 , pp. 192-199
    • Yamagiwa, S.1    Yoshida, Y.2    Halder, R.C.3
  • 28
    • 0028107431 scopus 로고
    • Acute indomethacin-induced jejunal injury in the rat: Early morphological and biochemical changes
    • Nygard G, Anthony A, Piasecki C, et al. Acute indomethacin-induced jejunal injury in the rat: early morphological and biochemical changes. Gastroenterology 1994;106:567-575.
    • (1994) Gastroenterology , vol.106 , pp. 567-575
    • Nygard, G.1    Anthony, A.2    Piasecki, C.3
  • 29
    • 0025998476 scopus 로고
    • Role of oxygen-derived free radicals in indomethacin-induced gastric injury
    • Vaananen PM, Meddings JB, Wallace JL. Role of oxygen-derived free radicals in indomethacin-induced gastric injury. Am J Physiol 1991;261:G470-G475.
    • (1991) Am J Physiol , vol.261
    • Vaananen, P.M.1    Meddings, J.B.2    Wallace, J.L.3
  • 30
    • 0026544632 scopus 로고
    • Pathogenesis of NSAID gastropathy: Are neutrophils the culprits?
    • Wallace JL, Granger DN. Pathogenesis of NSAID gastropathy: are neutrophils the culprits? Trends Pharmacol Sci 1992;13:129-131.
    • (1992) Trends Pharmacol Sci , vol.13 , pp. 129-131
    • Wallace, J.L.1    Granger, D.N.2
  • 31
    • 0033862877 scopus 로고    scopus 로고
    • Mechanisms of NSAID-induced gastrointestinal injury defined using mutant mice
    • Beck PL, Xavier R, Lu N, et al. Mechanisms of NSAID-induced gastrointestinal injury defined using mutant mice. Gastroenterology 2000;119:699-705.
    • (2000) Gastroenterology , vol.119 , pp. 699-705
    • Beck, P.L.1    Xavier, R.2    Lu, N.3
  • 32
    • 0026742483 scopus 로고
    • Indomethacin-induced leukocyte adhesion in mesenteric venules: Role of lipoxygenase products
    • Asako H, Hubes P, Wallace J, et al. Indomethacin-induced leukocyte adhesion in mesenteric venules: role of lipoxygenase products. Am J Physiol 1992;262:G903-G908.
    • (1992) Am J Physiol , vol.262
    • Asako, H.1    Hubes, P.2    Wallace, J.3
  • 33
    • 0030070025 scopus 로고    scopus 로고
    • Reversible prolonged skin bleeding time in acute gastrointestinal bleeding presumed due to NSAIDs
    • Day JP, Lanas A, Rustagi P, et al. Reversible prolonged skin bleeding time in acute gastrointestinal bleeding presumed due to NSAIDs. J Clin Gastroenterol 1996;22:96-103.
    • (1996) J Clin Gastroenterol , vol.22 , pp. 96-103
    • Day, J.P.1    Lanas, A.2    Rustagi, P.3
  • 34
    • 0026077897 scopus 로고
    • Separation of aspirin's impairment of hemostasis from mucosal injury in the human stomach
    • Hawkey CJ, Hawthorne AB, Hudson N, et al. Separation of aspirin's impairment of hemostasis from mucosal injury in the human stomach. Clin Sci 1991;81:565-573.
    • (1991) Clin Sci , vol.81 , pp. 565-573
    • Hawkey, C.J.1    Hawthorne, A.B.2    Hudson, N.3
  • 35
    • 0026011676 scopus 로고
    • Do nonsteroidal anti-inflammatory drugs increase colonic permeability?
    • Jenkins AP, Trew DR, Crump BJ, et al. Do nonsteroidal anti-inflammatory drugs increase colonic permeability? Gut 1991;32:66-69.
    • (1991) Gut , vol.32 , pp. 66-69
    • Jenkins, A.P.1    Trew, D.R.2    Crump, B.J.3
  • 36
    • 0030913612 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs are associated with emergency admission to hospital for colitis due to inflammatory bowel disease
    • Evans JM, McMahon AD, Murray FE, et al. Non-steroidal anti-inflammatory drugs are associated with emergency admission to hospital for colitis due to inflammatory bowel disease. Gut 1997;40:619-622.
    • (1997) Gut , vol.40 , pp. 619-622
    • Evans, J.M.1    McMahon, A.D.2    Murray, F.E.3
  • 37
    • 0028126534 scopus 로고
    • Benign colonic ulcers associated with nonsteroidal anti-inflammatory drug ingestion
    • Stamm C, Burkhalter CE, Pearce W, et al. Benign colonic ulcers associated with nonsteroidal anti-inflammatory drug ingestion. Am J Gastroenterol 1994;89:2230-2233.
    • (1994) Am J Gastroenterol , vol.89 , pp. 2230-2233
    • Stamm, C.1    Burkhalter, C.E.2    Pearce, W.3
  • 38
    • 0036112480 scopus 로고    scopus 로고
    • Recovery of ischemic-injured porcine ileum: Evidence for a contributory role of COX-1 and COX-2
    • Blikslager AT, Zimmel DN, Young KM, et al. Recovery of ischemic-injured porcine ileum: evidence for a contributory role of COX-1 and COX-2. Gut 2002;50:615-623.
    • (2002) Gut , vol.50 , pp. 615-623
    • Blikslager, A.T.1    Zimmel, D.N.2    Young, K.M.3
  • 40
    • 0032875139 scopus 로고    scopus 로고
    • Mucosal immunity and inflammation V. Innate mechanisms of mucosal defense and repair: The best offense is a good defense
    • Podolsky DK. Mucosal immunity and inflammation V. Innate mechanisms of mucosal defense and repair: the best offense is a good defense. Am J Physiol 1999;227:G495-G499.
    • (1999) Am J Physiol , vol.227
    • Podolsky, D.K.1
  • 41
    • 0025340618 scopus 로고
    • 2 induces villous contraction in rats without affecting intestinal restitution
    • 2 induces villous contraction in rats without affecting intestinal restitution. Gastroenterology 1990;99:708-716.
    • (1990) Gastroenterology , vol.99 , pp. 708-716
    • Erickson, R.A.1    Tarnawski, G.D.2    Dines, G.3
  • 42
    • 0030611762 scopus 로고    scopus 로고
    • 2 have a synergistic role in rescuing epithelial barrier function in porcine ileum
    • 2 have a synergistic role in rescuing epithelial barrier function in porcine ileum. J Clin Invest 1997;100:1928-1933.
    • (1997) J Clin Invest , vol.100 , pp. 1928-1933
    • Blikslager, A.T.1    Roberts, M.C.2    Argenzio, R.A.3
  • 43
    • 0032880998 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-1 and 2 by human gastric endothelial cells
    • Hull MA, Brough JL, Hawkey CJ. Expression of cyclooxygenase-1 and 2 by human gastric endothelial cells. Gut 1999;45:529-536.
    • (1999) Gut , vol.45 , pp. 529-536
    • Hull, M.A.1    Brough, J.L.2    Hawkey, C.J.3
  • 44
    • 0034797314 scopus 로고    scopus 로고
    • NSAIDs induce both necrosis and apoptosis in guinea pig gastric mucosal cells in primary culture
    • Tomisato W, Tsutsumi S, Rokutan K, et al. NSAIDs induce both necrosis and apoptosis in guinea pig gastric mucosal cells in primary culture. Am J Physiol 2001;281:G1092-G1100.
    • (2001) Am J Physiol , vol.281
    • Tomisato, W.1    Tsutsumi, S.2    Rokutan, K.3
  • 45
    • 0026024439 scopus 로고
    • Ranitidine in the treatment of nonsteroidal anti-inflammatory drug associated gastric and duodenal ulcers
    • Lancaster-Smith MJ, Jaderberg ME, Jackson DA. Ranitidine in the treatment of nonsteroidal anti-inflammatory drug associated gastric and duodenal ulcers. Gut 1991;32:252-255.
    • (1991) Gut , vol.32 , pp. 252-255
    • Lancaster-Smith, M.J.1    Jaderberg, M.E.2    Jackson, D.A.3
  • 46
    • 0024552757 scopus 로고
    • Effect of omeprazole and ranitidine on ulcer healing and relapse rates in patients with benign gastric ulcer
    • Walan A, Bader JP, Classen M, et al. Effect of omeprazole and ranitidine on ulcer healing and relapse rates in patients with benign gastric ulcer. N Engl J Med 1989;320:69-75.
    • (1989) N Engl J Med , vol.320 , pp. 69-75
    • Walan, A.1    Bader, J.P.2    Classen, M.3
  • 47
    • 0023697639 scopus 로고
    • Prevention of NSAID induced gastric ulcer with misoprostol: Multicentre, double-blind, placebo-controlled trial
    • Graham DY, Agrawal NM, Roth SH. Prevention of NSAID induced gastric ulcer with misoprostol: multicentre, double-blind, placebo-controlled trial. Lancet 1988;2:1277-1280.
    • (1988) Lancet , vol.2 , pp. 1277-1280
    • Graham, D.Y.1    Agrawal, N.M.2    Roth, S.H.3
  • 48
    • 0023783466 scopus 로고
    • Double-blind, placebo-controlled endoscopic comparison of the protective effects of misoprostol versus cimetidine on tolmetin-induced mucosal injury to the stomach and duodenum
    • Lanza FL, Aspinall RL, Swabb EA, et al. Double-blind, placebo-controlled endoscopic comparison of the protective effects of misoprostol versus cimetidine on tolmetin-induced mucosal injury to the stomach and duodenum. Gastroenterology 1988;95:289-294.
    • (1988) Gastroenterology , vol.95 , pp. 289-294
    • Lanza, F.L.1    Aspinall, R.L.2    Swabb, E.A.3
  • 49
    • 0025005862 scopus 로고
    • The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes
    • Fu JY, Masferrer JL, Seibert K, et al. The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes. J Biol Chem 1990;265:16737-16740.
    • (1990) J Biol Chem , vol.265 , pp. 16737-16740
    • Fu, J.Y.1    Masferrer, J.L.2    Seibert, K.3
  • 50
    • 0028322893 scopus 로고
    • Selective inhibition of inducible cyclooxygenase-2 in vivo is anti-inflammatory and nonulcerogenic
    • Masferrer JL, Zweifel BS, Manning PT, et al. Selective inhibition of inducible cyclooxygenase-2 in vivo is anti-inflammatory and nonulcerogenic. Proc Natl Acad Sci U S A 1994;91:3228-3232.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 3228-3232
    • Masferrer, J.L.1    Zweifel, B.S.2    Manning, P.T.3
  • 51
    • 0033031331 scopus 로고    scopus 로고
    • COX-2 inhibitors
    • Hawkey CJ. COX-2 inhibitors. Lancet 1999;353:307-314.
    • (1999) Lancet , vol.353 , pp. 307-314
    • Hawkey, C.J.1
  • 52
    • 0030733305 scopus 로고    scopus 로고
    • Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal antiinflammatory drugs and selective COX-2 inhibitors, using sensitive microsomal and platelet assays
    • Riendeau D, Charleson S, Cromlish W, et al. Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal antiinflammatory drugs and selective COX-2 inhibitors, using sensitive microsomal and platelet assays. Can J Physiol Pharmacol 1997;75:1088-1095.
    • (1997) Can J Physiol Pharmacol , vol.75 , pp. 1088-1095
    • Riendeau, D.1    Charleson, S.2    Cromlish, W.3
  • 53
    • 0032476648 scopus 로고    scopus 로고
    • Future trends in the development of safer nonsteroidal anti-inflammatory drugs
    • Wolfe MM. Future trends in the development of safer nonsteroidal anti-inflammatory drugs. Am J Med 1998;105(suppl 5A):44S-52S.
    • (1998) Am J Med , vol.105 , Issue.SUPPL. 5A
    • Wolfe, M.M.1
  • 54
    • 0031414270 scopus 로고    scopus 로고
    • Expression of the cyclooxygenase-2 gene in gastric epithelium
    • Sawaoka H, Tsuji S, Tsuji M, et al. Expression of the cyclooxygenase-2 gene in gastric epithelium. J Clin Gastroenerol 1997;25(suppl 1):S105-S110.
    • (1997) J Clin Gastroenerol , vol.25 , Issue.SUPPL. 1
    • Sawaoka, H.1    Tsuji, S.2    Tsuji, M.3
  • 55
    • 0031052116 scopus 로고    scopus 로고
    • Induction of cyclooxygenase-2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice
    • Mizuno H, Sakamoto C, Matsunda K, et al. Induction of cyclooxygenase-2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology 1997;112:387-397.
    • (1997) Gastroenterology , vol.112 , pp. 387-397
    • Mizuno, H.1    Sakamoto, C.2    Matsunda, K.3
  • 56
    • 0029907525 scopus 로고    scopus 로고
    • Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2
    • Reuter BK, Asfaha S, Buret A, et al. Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2. J Clin Invest 1996;98:2076-2085.
    • (1996) J Clin Invest , vol.98 , pp. 2076-2085
    • Reuter, B.K.1    Asfaha, S.2    Buret, A.3
  • 57
  • 58
    • 0034119475 scopus 로고    scopus 로고
    • Cyclooxygenase-1 and an alternatively spliced mRNA in the rat stomach, effects of aging and ulcers
    • Vogiagis D, Glare EM, Misajon A, et al. Cyclooxygenase-1 and an alternatively spliced mRNA in the rat stomach, effects of aging and ulcers. Am J Physiol 2000;278:G820-G827.
    • (2000) Am J Physiol , vol.278
    • Vogiagis, D.1    Glare, E.M.2    Misajon, A.3
  • 59
    • 0033851568 scopus 로고    scopus 로고
    • NSAID-induced gastric damage in rats: Requirement for inhibition of both cyclooxygenase-1 and 2
    • Wallace JL, McKnight W, Reuter B, et al. NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase-1 and 2. Gastroenterology 2000;119:706-714.
    • (2000) Gastroenterology , vol.119 , pp. 706-714
    • Wallace, J.L.1    McKnight, W.2    Reuter, B.3
  • 60
    • 0031749806 scopus 로고    scopus 로고
    • Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: Implications for gastrointestinal toxicity
    • Wallace JL, Bak A, McKnight W, et al. Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: implications for gastrointestinal toxicity. Gastroenterology 1998;115:101-109.
    • (1998) Gastroenterology , vol.115 , pp. 101-109
    • Wallace, J.L.1    Bak, A.2    McKnight, W.3
  • 61
    • 0034114830 scopus 로고    scopus 로고
    • Wound collagen deposition in rats: Effects of an NO-NSAID and a selective COX-2 inhibitor
    • Muscara MN, McKnight W, Asfaha S, et al. Wound collagen deposition in rats: effects of an NO-NSAID and a selective COX-2 inhibitor. Br J Pharmacol 2000;129:681-686.
    • (2000) Br J Pharmacol , vol.129 , pp. 681-686
    • Muscara, M.N.1    McKnight, W.2    Asfaha, S.3
  • 62
    • 15644372002 scopus 로고    scopus 로고
    • Comparison of indomethacin and nimesulide, a selective cyclooxygenase-2 inhibitor, on key pathophysiologic steps in the pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in the rat
    • Sigthorsson G, Jacob M, Wrigglesworth S, et al. Comparison of indomethacin and nimesulide, a selective cyclooxygenase-2 inhibitor, on key pathophysiologic steps in the pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in the rat. Scand J Gastroenterol 1998;33:728-735.
    • (1998) Scand J Gastroenterol , vol.33 , pp. 728-735
    • Sigthorsson, G.1    Jacob, M.2    Wrigglesworth, S.3
  • 63
    • 0032536198 scopus 로고    scopus 로고
    • Compensatory prostaglandin E2 biosynthesis in cyclooxygenase 1 or 2 null cells
    • Kirtikara K, Morham SG, Raghow R, et al. Compensatory prostaglandin E2 biosynthesis in cyclooxygenase 1 or 2 null cells. J Exp Med 1998;187:517-523.
    • (1998) J Exp Med , vol.187 , pp. 517-523
    • Kirtikara, K.1    Morham, S.G.2    Raghow, R.3
  • 64
    • 0028843881 scopus 로고
    • Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin induced gastric ulceration
    • Langenbach R, Morham SG, Tiano HF, et al. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin induced gastric ulceration. Cell 1995;83:483-492.
    • (1995) Cell , vol.83 , pp. 483-492
    • Langenbach, R.1    Morham, S.G.2    Tiano, H.F.3
  • 65
    • 0028818913 scopus 로고
    • Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase 11
    • Dinchuk JE, Car BD, Focht RJ, et al. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase 11. Nature 1995;378:406-409.
    • (1995) Nature , vol.378 , pp. 406-409
    • Dinchuk, J.E.1    Car, B.D.2    Focht, R.J.3
  • 66
    • 0033868029 scopus 로고    scopus 로고
    • Nitric oxide in mucosal defense: A little goes a long way
    • Wallace JL, Miller MJS. Nitric oxide in mucosal defense: a little goes a long way. Gastroenterology 2000;119:512-520.
    • (2000) Gastroenterology , vol.119 , pp. 512-520
    • Wallace, J.L.1    Miller, M.J.S.2
  • 67
    • 0032919342 scopus 로고    scopus 로고
    • Expression of endothelial cell-derived nitric oxide synthase (eNOS) is increased during gastric adaptation to chronic aspirin intake in humans
    • Fischer H, Becker JC, Boknik P, et al. Expression of endothelial cell-derived nitric oxide synthase (eNOS) is increased during gastric adaptation to chronic aspirin intake in humans. Aliment Pharmacol Ther 1999;13:507-514.
    • (1999) Aliment Pharmacol Ther , vol.13 , pp. 507-514
    • Fischer, H.1    Becker, J.C.2    Boknik, P.3
  • 68
    • 0033864016 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase modulates gastric ulcer healing in rats
    • Ma L, Wallace JL. Endothelial nitric oxide synthase modulates gastric ulcer healing in rats. Am J Physiol 2000;279:G341-G346.
    • (2000) Am J Physiol , vol.279
    • Ma, L.1    Wallace, J.L.2
  • 69
    • 0029100370 scopus 로고
    • A nitric oxide releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats
    • Elliot SN, McKnight W, Cirino G, et al. A nitric oxide releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats. Gastroenterology 1995;109:524-530.
    • (1995) Gastroenterology , vol.109 , pp. 524-530
    • Elliot, S.N.1    McKnight, W.2    Cirino, G.3
  • 70
    • 0028939954 scopus 로고
    • Nonsteroidal anti-inflammatory drugs associate with zwitteronic phospholipids: Insight into the mechanism and reversal of NSAID-induced gastrointestinal injury
    • Lichtenberger LM, Wang ZM, Romero JJ, et al. Nonsteroidal anti-inflammatory drugs associate with zwitteronic phospholipids: insight into the mechanism and reversal of NSAID-induced gastrointestinal injury. Nat Med 1995;1:154-158.
    • (1995) Nat Med , vol.1 , pp. 154-158
    • Lichtenberger, L.M.1    Wang, Z.M.2    Romero, J.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.