Neural stem cells: A pharmacological tool for brain diseases?

Pharmacological Research

Volumn 47, Issue 4, 2003, Pages 289-297

  Conti, Luciano ^a   Cataudella, Tiziana ^a   Cattaneo, Elena ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Adult neurogenesis; Brain diseases; Neural stem cells; Pharmacological control

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; CORTICOSTEROID; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; FLUOXETINE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLUCOCORTICOID; LITHIUM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PROTEIN BCL 2; RILUZOLE; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN UPTAKE INHIBITOR; SOMATOMEDIN C;

ADOPTIVE IMMUNOTHERAPY; ADRENALECTOMY; AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN; BRAIN DEVELOPMENT; BRAIN DISEASE; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN REGION; CELL AGGREGATION; CELL FUNCTION; CELL ISOLATION; CELL LINE; CELL MATURATION; CELL MIGRATION; CELL PROLIFERATION; CELL REGENERATION; CELL STIMULATION; CELL SUBPOPULATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM; CEREBELLUM; ELECTROCONVULSIVE THERAPY; EXERCISE; FETUS DEVELOPMENT; HIPPOCAMPUS; HORMONE ACTION; HUMAN; HUNTINGTON CHOREA; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INHIBITION KINETICS; MAJOR DEPRESSION; NERVE CELL; NERVE CELL MEMBRANE POTENTIAL; NERVE CELL PLASTICITY; NERVE CELL STIMULATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; PYRAMIDAL NERVE CELL; SIGNAL TRANSDUCTION; SOCIAL BEHAVIOR; STEM CELL; STRESS; UPREGULATION;

EID: 0037376867     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-6618(03)00038-0     Document Type: Article

References (95)

1. Temple S. The development of neural stem cells. Nature. 414(6859):2001;112-117.
2. McKay R. Stem cells in the central nervous system. Science. 276(5309):1997;66-71.
3. Cai L., Hayes N.L., Nowakowski R.S. Synchrony of clonal cell proliferation and contiguity of clonally related cells: production of mosaicism in the ventricular zone of developing mouse neocortex. J. Neurosci. 17(6):1997;2088-2100.
4. Sommer L., Rao M. Neural stem cells and regulation of cell number. Prog. Neurobiol. 66(1):2002;1-18.
5. Li L., Liu F., Salmonsen R.A., Turner T.K., Litofsky N.S., Di Cristofano A.et al. PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation. Mol. Cell Neurosci. 20(1):2002;21-29.
6. Rao M.S. Multipotent and restricted precursors in the central nervous system. Anat. Rec. 257(4):1999;137-148.
7. Frisen J., Johansson C.B., Lothian C., Lendahl U. Central nervous system stem cells in the embryo and adult. Cell Mol. Life Sci. 54(9):1998;935-945.
8. Qian X., Shen Q., Goderie S.K., He W., Capela A., Davis A.A.et al. Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cells. Neuron. 28(1):2000;69-80.
9. Altman J., Das G.D. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J. Comp. Neurol. 124(3):1965;319-335.
10. Reynolds B.A., Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science. 255(5052):1992;1707-1710.
11. Gage F.H. Neurogenesis in the adult brain. J. Neurosci. 22(3):2002;612-613.
12. Geuna S., Borrione P., Fornaro M., Giacobini-Robecchi M.G. Adult stem cells and neurogenesis: historical roots and state of the art. Anat. Rec. 265(3):2001;132-141.
13. Bjornson C.R., Rietze R.L., Reynolds B.A., Magli M.C., Vescovi A.L. Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo. Science. 283(5401):1999;534-537.
14. Galli R., Borello U., Gritti A., Minasi M.G., Bjornson C., Coletta M.et al. Skeletal myogenic potential of human and mouse neural stem cells. Nat. Neurosci. 3(10):2000;986-991.
15. Clarke D.L., Johansson C.B., Wilbertz J., Veress B., Nilsson E., Karlstrom H.et al. Generalized potential of adult neural stem cells. Science. 288(5471):2000;1660-1663.
16. Jiang Y., Jahagirdar B.N., Reinhardt R.L., Schwartz R.E., Keene C.D., Ortiz-Gonzalez X.R.et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 418(6893):2002;41-49.
17. Ying Q.L., Nichols J., Evans E.P., Smith A.G. Changing potency by spontaneous fusion. Nature. 416(6680):2002;545-548.
18. Wurmser A.E., Gage F.H. Stem cells: cell fusion causes confusion. Nature. 416(6880):2002;485-487.
19. Morshead C.M., Benveniste P., Iscove N.N., van der Kooy D. Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations. Nat. Med. 8(3):2002;268-273.
20. Magrassi L, Castello S, Ciardelli L, Podesta' M, Gasparoni A, Conti L, et al. Freshly dissociated fetal neural stem/progenitor cells do not turn into blood. Mol Cell Neurosci, in press.
21. Wagers A.J., Sherwood R.I., Christensen J.L., Weissman I.L. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science. 297(5590):2002;2256-2259.
22. Weiss S., Dunne C., Hewson J., Wohl C., Wheatley M., Peterson A.C.et al. Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis. J. Neurosci. 16(23):1996;7599-7609.
23. Represa A., Shimazaki T., Simmonds M., Weiss S. EGF-responsive neural stem cells are a transient population in the developing mouse spinal cord. Eur. J. Neurosci. 14(3):2001;452-462.
24. Gritti A., Parati E.A., Cova L., Frolichsthal P., Galli R., Wanke E.et al. Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor. J. Neurosci. 16(3):1996;1091-1100.
25. Kalyani A., Hobson K., Rao M.S. Neuroepithelial stem cells from the embryonic spinal cord: isolation characterization and clonal analysis. Dev. Biol. 186(2):1997;202-223.
26. Ciccolini F., Svendsen C.N. Fibroblast growth factor 2 (FGF-2) promotes acquisition of epidermal growth factor (EGF) responsiveness in mouse striatal precursor cells: identification of neural precursors responding to both EGF and FGF-2. J. Neurosci. 18(19):1998;7869-7880.
27. Rossi F., Cattaneo E. Opinion: neural stem cell therapy for neurological diseases. Dreams and reality. Nat. Rev. Neurosci. 3(5):2002;401-409.
28. Sawamoto K., Yamamoto A., Kawaguchi A., Yamaguchi M., Mori K., Goldman S.A.et al. Direct isolation of committed neuronal progenitor cells from transgenic mice coexpressing spectrally distinct fluorescent proteins regulated by stage-specific neural promoters. J. Neurosci. Res. 65(3):2001;220-227.
29. Sawamoto K., Nakao N., Kakishita K., Ogawa Y., Toyama Y., Yamamoto A.et al. Generation of dopaminergic neurons in the adult brain from mesencephalic precursor cells labeled with a nestin-GFP transgene. J. Neurosci. 21(11):2001;3895-3903.
30. Keyoung H.M., Roy N.S., Benraiss A., Louissaint A., Suzuki A., Hashimoto M.et al. High-yield selection and extraction of two promoter-defined phenotypes of neural stem cells from the fetal human brain. Nat. Biotechnol. 19(9):2001;843-850.
31. Gage F.H. Mammalian neural stem cells. Science. 287(5457):2000;1433-1438.
32. Zimmerman L., Parr B., Lendahl U., Cunningham M., McKay R., Gavin B.et al. Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursors. Neuron. 12(1):1994;11-24.
33. Doetsch F., Caille I., Lim D.A., Garcia-Verdugo J.M., Alvarez-Buylla A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell. 97(6):1999;703-716.
34. Laywell E.D., Rakic P., Kukekov V.G., Holland E.C., Steindler D.A. Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain. Proc. Natl. Acad. Sci. U.S.A. 97(25):2000;13883-13888.
35. Rietze R.L., Valcanis H., Brooker G.F., Thomas T., Voss A.K., Bartlett P.F. Purification of a pluripotent neural stem cell from the adult mouse brain. Nature. 412(6848):2001;736-739.
36. Gage F.H., Ray J., Fisher L.J. Isolation, characterization, and use of stem cells from the CNS. Annu. Rev. Neurosci. 18:1995;159-192.
37. Taupin P., Gage F.H. Adult neurogenesis and neural stem cells of the central nervous system in mammals. J. Neurosci. Res. 69(6):2002;745-749.
38. Lois C., Alvarez-Buylla A. Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia. Proc. Natl. Acad. Sci. U.S.A. 90(5):1993;2074-2077.
39. Morshead C.M., Reynolds B.A., Craig C.G., McBurney M.W., Staines W.A., Morassutti D.et al. Neural stem cells in the adult mammalian forebrain: a relatively quiescent subpopulation of subependymal cells. Neuron. 13(5):1994;1071-1082.
40. Peterson D.A. Stem cells in brain plasticity and repair. Curr. Opin. Pharmacol. 2(1):2002;34-42.
41. Chiasson B.J., Tropepe V., Morshead C.M., van der Kooy D. Adult mammalian forebrain ependymal and subependymal cells demonstrate proliferative potential, but only subependymal cells have neural stem cell characteristics. J. Neurosci. 19(11):1999;4462-4471.
42. Johansson C.B., Momma S., Clarke D.L., Risling M., Lendahl U., Frisen J. Identification of a neural stem cell in the adult mammalian central nervous system. Cell. 96(1):1999;25-34.
43. Capela A., Temple S. LeX/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal. Neuron. 35(5):2002;865.
44. Alvarez-Buylla A., Garcia-Verdugo J.M., Tramontin A.D. A unified hypothesis on the lineage of neural stem cells. Nat. Rev. Neurosci. 2(4):2001;287-293.
45. Kempermann G., Kuhn H.G., Gage F.H. More hippocampal neurons in adult mice living in an enriched environment. Nature. 386(6624):1997;493-495.
46. van Praag H., Kempermann G., Gage F.H. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat. Neurosci. 2(3):1999;266-270.
47. Eriksson P.S., Perfilieva E., Bjork-Eriksson T., Alborn A.M., Nordborg C., Peterson D.A.et al. Neurogenesis in the adult human hippocampus. Nat. Med. 4(11):1998;1313-1317.
48. Seaberg R.M., van der Kooy D. Adult rodent neurogenic regions: the ventricular subependyma contains neural stem cells, but the dentate gyrus contains restricted progenitors. J. Neurosci. 22(5):2002;1784-1793.
49. van Praag H., Schinder A.F., Christie B.R., Toni N., Palmer T.D., Gage F.H. Functional neurogenesis in the adult hippocampus. Nature. 415(6875):2002;1030-1034.
50. Song H.J., Stevens C.F., Gage F.H. Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons. Nat. Neurosci. 5(5):2002;438-445.
51. Song H., Stevens C.F., Gage F.H. Astroglia induce neurogenesis from adult neural stem cells. Nature. 417(6884):2002;39-44.
52. Magavi S.S., Macklis J.D. Induction of neuronal type-specific neurogenesis in the cerebral cortex of adult mice: manipulation of neural precursors in situ. Brain Res. Dev. Brain Res. 134(1/2):2002;57-76.
53. Lie D.C., Dziewczapolski G., Willhoite A.R., Kaspar B.K., Shults C.W., Gage F.H. The adult substantia nigra contains progenitor cells with neurogenic potential. J. Neurosci. 22(15):2002;6639-6649.
54. Carlen M., Cassidy R.M., Brismar H., Smith G.A., Enquist L.W., Frisen J. Functional integration of adult-born neurons. Curr. Biol. 12(7):2002;606-608.
55. Shors T.J., Miesegaes G., Beylin A., Zhao M., Rydel T., Gould E. Neurogenesis in the adult is involved in the formation of trace memories. Nature. 410(6826):2001;372-376.
56. Nakatomi H., Kuriu T., Okabe S., Yamamoto S., Hatano O., Kawahara N.et al. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell. 110(4):2002;429-441.
57. Armstrong R.J., Barker R.A. Neurodegeneration: a failure of neuroregeneration? Lancet. 358(9288):2001;1174-1176.
58. van Praag H., Kempermann G., Gage F.H. Neural consequences of environmental enrichment. Nat. Rev. Neurosci. 1(3):2000;191-198.
59. Cameron H.A., Hazel T.G., McKay R.D. Regulation of neurogenesis by growth factors and neurotransmitters. J. Neurobiol. 36(2):1998;287-306.
60. Zigova T., Pencea V., Wiegand S.J., Luskin M.B. Intraventricular administration of BDNF increases the number of newly generated neurons in the adult olfactory bulb. Mol. Cell. Neurosci. 11(4):1998;234-245.
61. Goldman S.A. Adult neurogenesis: from canaries to the clinic. J. Neurobiol. 36(2):1998;267-286.
62. Wagner J.P., Black I.B., DiCicco-Bloom E. Stimulation of neonatal and adult brain neurogenesis by subcutaneous injection of basic fibroblast growth factor. J. Neurosci. 19(14):1999;6006-6016.
63. Aberg M.A., Aberg N.D., Hedbacker H., Oscarsson J., Eriksson P.S. Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus. J. Neurosci. 20(8):2000;2896-2903.
64. Yoshimura S., Takagi Y., Harada J., Teramoto T., Thomas S.S., Waeber C.et al. FGF-2 regulation of neurogenesis in adult hippocampus after brain injury. Proc. Natl. Acad. Sci. U.S.A. 98(10):2001;5874-5879.
65. Carro E., Nunez A., Busiguina S., Torres-Aleman I. Circulating insulin-like growth factor I mediates effects of exercise on the brain. J. Neurosci. 20(8):2000;2926-2933.
66. Arvidsson A., Collin T., Kirik D., Kokaia Z., Lindvall O. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat. Med. 8(9):2002;963-970.
67. Fallon J., Reid S., Kinyamu R., Opole I., Opole R., Baratta J.et al. In vivo induction of massive proliferation, directed migration, and differentiation of neural cells in the adult mammalian brain. Proc. Natl. Acad. Sci. U.S.A. 97(26):2000;14686-14691.
68. Johansson C.B., Svensson M., Wallstedt L., Janson A.M., Frisen J. Neural stem cells in the adult human brain. Exp. Cell. Res. 253(2):1999;733-736.
69. Yamamoto S., Yamamoto N., Kitamura T., Nakamura K., Nakafuku M. Proliferation of parenchymal neural progenitors in response to injury in the adult rat spinal cord. Exp. Neurol. 172(1):2001;115-127.
70. Miller R.G. New approaches to therapy of amyotrophic lateral sclerosis. West J. Med. 168(4):1998;262-263.
71. Hurko O., Walsh F.S. Novel drug development for amyotrophic lateral sclerosis. J. Neurol. Sci. 180(1/2):2000;21-28.
72. Rosas H.D., Koroshetz W.J., Jenkins B.G., Chen Y.I., Hayden D.L., Beal M.F.et al. Riluzole therapy in Huntington's disease (HD). Mov. Disord. 14(2):1999;326-330.
73. Seppi K., Mueller J., Bodner T., Brandauer E., Benke T., Weirich-Schwaiger H.et al. Riluzole in Huntington's disease (HD): an open label study with one year follow up. J. Neurol. 248(10):2001;866-869.
74. Bonelli R.M., Niederwieser G., Diez J., Koltringer P. Riluzole and olanzapine in Huntington's disease. Eur. J. Neurol. 9(2):2002;183-184.
75. Mizuta I., Ohta M., Ohta K., Nishimura M., Mizuta E., Kuno S. Riluzole stimulates nerve growth factor, brain-derived, neurotrophic factor and glial cell line-derived neurotrophic factor synthesis in cultured mouse astrocytes. Neurosci. Lett. 310(2/3):2001;117-120.
76. Katoh-Semba R., Asano T., Ueda H., Morishita R., Takeuchi I.K., Inaguma Y.et al. Riluzole enhances expression of brain-derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus. FASEB J. 16(10):2002;1328-1330.
77. Conti L., De Fraja C., Gulisano M., Migliaccio E., Govoni S., Cattaneo E. Expression and activation of SH2/PTB-containing ShcA adaptor protein reflects the pattern of neurogenesis in the mammalian brain. Proc. Natl. Acad. Sci. U.S.A. 94(15):1997;8185-8190.
78. Conti L., Sipione S., Magrassi L., Bonfanti L., Rigamonti D., Pettirossi V.et al. Shc signaling in differentiating neural progenitor cells. Nat. Neurosci. 4(6):2001;579-586.
79. Kempermann G. Regulation of adult hippocampal neurogenesis - implications for novel theories of major depression. Bipolar Disord. 4(1):2002;17-33.
80. Gage F.H. Structural plasticity: cause result or correlate of depression. Biol. Psychiatry. 48(8):2000;713-714.
81. Jacobs B.L., Praag H., Gage F.H. Adult brain neurogenesis and psychiatry: a novel theory of depression. Mol. Psychiatry. 5(3):2000;262-269.
82. Duman R.S., Malberg J., Thome J. Neural plasticity to stress and antidepressant treatment. Biol. Psychiatry. 46(9):1999;1181-1191.
83. Sheline Y.I. 3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity. Biol. Psychiatry. 48(8):2000;791-800.
84. Brown E.S., Rush A.J., McEwen B.S. Hippocampal remodeling and damage by corticosteroids: implications for mood disorders. Neuropsychopharmacology. 21(4):1999;474-484.
85. Gould E., Woolley C.S., McEwen B.S. Adrenal steroids regulate postnatal development of the rat dentate gyrus: I. Effects of glucocorticoids on cell death. J. Comp. Neurol. 313(3):1991;479-485.
86. Cameron H.A., McKay R.D. Restoring production of hippocampal neurons in old age. Nat. Neurosci. 2(10):1999;894-897.
87. Chao H.M., McEwen B.S. Glucocorticoids and the expression of mRNAs for neurotrophins. Brain Res. Mol. Brain Res. 26(1/2):1994;271-276.
88. Hansson A.C., Cintra A., Belluardo N., Sommer W., Bhatnagar M., Bader M.et al. Gluco- and mineralocorticoid receptor-mediated regulation of neurotrophic factor gene expression in the dorsal hippocampus and the neocortex of the rat. Eur. J. Neurosci. 12(8):2000;2918-2934.
89. Malberg J.E., Eisch A.J., Nestler E.J., Duman R.S. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J. Neurosci. 20(24):2000;9104-9110.
90. Duman R.S., Malberg J., Nakagawa S. Regulation of adult neurogenesis by psychotropic drugs and stress. J. Pharmacol. Exp. Ther. 299(2):2001;401-407.
91. Gould E. Serotonin and hippocampal neurogenesis. Neuropsychopharmacology. 21(Suppl 2):1999;46S-51S.
92. McEwen B.S. Effects of adverse experiences for brain structure and function. Biol. Psychiatry. 48(8):2000;721-731.
93. Cameron H.A., McEwen B.S., Gould E. Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus. J. Neurosci. 15(6):1995;4687-4692.
94. Brezun J.M., Daszuta A. Serotonergic reinnervation reverses lesion-induced decreases in PSA-NCAM labeling and proliferation of hippocampal cells in adult rats. Hippocampus. 10(1):2000;37-46.
95. Chen G., Rajkowska G., Du F., Seraji-Bozorgzad N., Manji H.K. Enhancement of hippocampal neurogenesis by lithium. J. Neurochem. 75(4):2000;1729-1734.