Synthesis and pharmacological evaluation of substituted naphth[1,2,3-de]isoquinolines (dinapsoline analogues) as D1 and D2 dopamine receptor ligands

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 7, 2003, Pages 1451-1464

  Qandil, Amjad M ^a,c   Lewis, Mechelle M ^b   Jassen, Amy ^b   Leonard, Sarah K ^b   Mailman, Richard B ^b   Nichols, David E ^a  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c JORDAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Jordan)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; 8,9 DIHYDROXY 4 METHYL 2,3,7,11B TETRAHYDRO 1H NAPHTH[1,2,3 DE]ISOQUINOLINE HYDROBROMIDE; 8,9 DIHYDROXY 6 METHYL 2,3,7,11B TETRAHYDRO 1H NAPHTH[1,2,3 DE]ISOQUINOLINE HYDROBROMIDE; CHLORPROMAZINE; DIHYDREXIDINE; DINAPSOLINE; DOPAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR STIMULATING AGENT; ISOPROTEIN; ISOQUINOLINE DERIVATIVE; LIGAND; METHYL GROUP; N ALLYL 8,9 DIHYDROXY 2,3,7,11B TETRAHYDRO 1H NAPHTH[1,2,3 DE]ISOQUINOLINE HYDROBROMIDE; N ALLYL 8,9 DIHYDROXY 4 METHYL 2,3,7,11B TETRAHYDRO 1H NAPHTH[1,2,3 DE]ISOQUINOLINE HYDROBROMIDE; N PROPYL 8,9 DIHYDROXY 2,3,7,11B TETRAHYDRO 1H NAPHTH[1,2,3 DE]ISOQUINOLINE HYDROBROMIDE; N PROPYL 8,9 DIHYDROXY 4 METHYL 2,3,7,11B TETRAHYDRO 1H NAPHTH[1,2,3 DE]ISOQUINOLINE HYDROBROMIDE; SPIPERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; CELL LINE; CHO CELL; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BRAIN NEOPLASMS; CELL MEMBRANE; CLONING, MOLECULAR; CYCLIC AMP; CYCLIZATION; DOPAMINE AGONISTS; GLIOMA; INDICATORS AND REAGENTS; ISOQUINOLINES; NAPHTHOLS; NEOSTRIATUM; RADIOLIGAND ASSAY; RATS; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0037375450     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00561-8     Document Type: Article

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