Effects of the Ca++-permeable nonselective cation channel blocker LOE 908 on subarachnoid hemorrhage-induced vasospasm in the basilar artery in rabbits

Journal of Neurosurgery

Volumn 98, Issue 3, 2003, Pages 561-564

  Kawanabe, Yoshifumi ^a,b   Masaki, Tomoh ^a   Hashimoto, Nobuo ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Ca++ influx; Nonselective cation channel; Rabbit; Vasospasm

Indexed keywords

2 (3,4 DIHYDRO 6,7 DIMETHOXY 1 ISOQUINOLINYL) 2 PHENYL N,N BIS[2 (2,3,4 TRIMETHOXYPHENYL)ETHYL]ACETAMIDE; CALCIUM ION; CATION CHANNEL; ENDOTHELIN 1; SODIUM CHLORIDE; THROMBOXANE A2;

ARTICLE; BASILAR ARTERY; BRAIN VASOSPASM; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG MECHANISM; NONHUMAN; PRIORITY JOURNAL; RABBIT; SUBARACHNOID HEMORRHAGE; TREATMENT OUTCOME;

EID: 0037373317     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.2003.98.3.0561     Document Type: Article

References (21)

1. Bertsch T, Kuehl S, Muehlhauser F, et al: Source of endothelin-1 in subarachnoid hemorrhage. Clin Chem Lab Med 39:341-345, 2001
2. 2+ entry pathway in human endothelial cells by the isoquinoline derivative LOE 908. Br J Pharmacol 119:702-706, 1996
3. Jahr JS, Lurie F, Xi S, et al: A novel approach to measuring circulating blood volume: the use of a hemoglobin-based oxygen carrier in a rabbit model. Anesth Analg 92:609-614, 2001
4. Kasuya H, Onda H, Takeshita M, et al: Efficacy and safety of nicardipine prolonged-release implants for preventing vasospasm in humans. Stroke 33:1011-1015, 2002
5. 2+ channels involved in endothelin-1-induced contraction of rabbit basilar artery. J Cardiovasc Pharmacol 40:438-447, 2002
6. Krautwurst D, Degtiar VE, Schultz G, et al: The isoquinoline derivative LOE 908 selectively blocks vasopressin-activated nonselective cation currents in A7r5 aortic smooth muscle cells. Naun-Schmiedeberg Arch Pharmacol 349:301-307, 1994
7. Krautwurst D, Hescheler J, Arndts D, et al: A novel potent inhibitor of receptor-activated nonselective cation currents in HL-60 cells. Mol Pharmacol 43:655-659, 1993
8. Li F, Carano RAD, Irie K, et al: Neuroprotective effects of novel broad-spectrum cation channel blocker, LOE 908 MS, on experimental focal ischemia: a multispectral study. J Magn Reson Imaging 10:138-145, 1999
9. Mima T, Yanagisawa M, Shigeno T, et al: Endothelin acts in feline and canine cerebral arteries from the adventitial side. Stroke 20:1553-1556, 1989
10. Pasqualin A, Vollmer DG, Marron JA, et al: The effect of nicardipine on vasospasm in rabbit basilar artery after subarachnoid hemorrhage. Neurosurgery 29:183-188, 1991
11. Seifert V, Loffler BM, Zimmermann M, et al: Endothelin concentrations in patients with aneurysmal subarachnoid hemorrhage. Correlation with cerebral vasospasm, delayed ischemic neurological deficits, and volume of hematoma. J Neurosurg 82:55-62, 1995
12. Shaw MDM, Vermeulen M, Murray GD, et al: Efficacy and safety of the endothelin receptor antagonist TAK-044 in treating subarachnoid hemorrhage: a report by the Steering Committee on behalf of the UK/Netherlands/Eire TAK-044 Subarachnoid Haemorrhage Study Group. J Neurosurg 93:992-997, 2000
13. Tatlisumak T, Carano RAD, Takano K, et al: Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat. J Neurol Sci 178:107-113, 2000
14. 2 receptor-mediated contraction in rat aorta. J Pharmacol Exp Ther 284:921-928, 1998
15. Varsos VG, Liszczak TM, Han DH, et al: Delayed cerebral vasospasm is not reversible by aminophylline, nifedipine, or papaverine in a "two-hemorrhage" canine model. J Neurosurg 58:11-17, 1983
16. Vorkapic P, Bevan JA, Bevan RD: Clentiazem protects against chronic cerebral vasospasm in rabbit basilar artery. Stroke 22:1409-1413, 1991
17. Zhang Z, Nagata I, Kikuchi H, et al: Broad-spectrum and selective serine protease inhibitors prevent expression of platelet-derived growth factor-BB and cerebral vasospasm after subarachnoid hemorrhage: vasospasm caused by cisternal injection of recombinant platelet-derived growth factor-BB. Stroke 32:1665-1672, 2001
18. Zubkov AY, Rollins KS, Parent AD, et al: Mechanism of endothelin-1-induced contraction in rabbit basilar artery. Stroke 31:526-533, 2000
19. 2+ in subarachnoid hemorrhage-induced spasm of the rabbit basilar artery. Stroke 27:1896-1902, 1996
20. B receptors in subarachnoid hemorrhage-induced cerebral vasospasm. Eur J Pharmacol 259:R1-R2, 1994
21. Zygmunt SC, Delgado-Zygmunt TJ: The haemodynamic effect of transcranial Doppler-guided high-dose nimodipine treatment in established vasospasm after subarachnoid haemorrhage. Acta Neurochir 135:179-185, 1995