Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat

Journal of the Neurological Sciences

Volumn 178, Issue 2, 2000, Pages 107-113

  Tatlisumak, Turgut ^a,b   Carano, Richard A D ^c,d   Takano, Kentaro ^b   Meiler, Michael R ^c   Li, Fuhai ^b   Sotak, Christopher H ^c   Arndts, Dietrich ^e   Pschorn, Uwe ^f   Fisher, Marc ^b  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b University of Massachusetts   (United States)

^c Worcester Polytechnic Institute   (United States)

^d SYNARC INC   (United States)

^e BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^f Devmt Med Div Boehringer I ^*  (Germany)

Author keywords

Calcium; Cerebral infarction; Cerebral ischemia, focal; Magnetic resonance imaging; Neuroprotection; Perfusion; Rats

Indexed keywords

(3,4 DIHYDRO 6,7 DIMETHOXYISOQUINOLINE 1 YL)2 PHENYL N,N DI[2(2,3,4 TRIMETHOXYPHENYL)ETHYL]ACETAMIDE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; CALCIUM ION; CATION CHANNEL INHIBITOR; DIZOCILPINE; LOE 908 MS; NEUROPROTECTIVE AGENT; POTASSIUM ION; SODIUM ION; TRIPHENYLTETRAZOLIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN PERFUSION; CATION CHANNEL; CATION TRANSPORT; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; INHIBITION KINETICS; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROLOGICAL COMPLICATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT; SIDE EFFECT; TREATMENT OUTCOME;

ACETAMIDES; ANIMAL; BRAIN ISCHEMIA; CELLS, CULTURED; CEREBRAL CORTEX; CEREBRAL INFARCTION; ION CHANNELS; ISOQUINOLINES; MAGNETIC RESONANCE IMAGING; MALE; NEURONS; POSTMORTEM CHANGES; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T; VERATRIDINE;

EID: 0034665235     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(00)00380-4     Document Type: Article

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