Neuroprotective effects of a novel broad-spectrum cation channel blocker, LOE 908 MS, on experimental focal ischemia: A multispectral study

Journal of Magnetic Resonance Imaging

Volumn 10, Issue 2, 1999, Pages 138-145

  Li, Fuhai ^a,f   Carano, Richard A D ^b,g   Irie, Katsumi ^a   Tatlisumak, Turgut ^a,e   Silva, Matthew D ^b   Pschorni, Uwe ^d   Sotak, Christopher H ^a,b,c   Fisher, Marc ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b Worcester Polytechnic Institute   (United States)

^c Worcester Polytechnic Institute   (United States)

^d BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^e HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^f Synarc Inc ^*  (United States)

^g SYNARC INC   (United States)

Author keywords

Cation channel blocker; Focal cerebral ischemia; Magnetic resonance imaging; Multispectral analysis; Neuroprotection; Rat

Indexed keywords

(3,4 DIHYDRO 6,7 DIMETHOXYISOQUINOLINE 1 GAMMA 1) 2 PHENYL N,N DI 2 (2,3,4 TRIMETHOXYPHENYL)ETHYLACETAMIDE; BLOCKING AGENT; CATION CHANNEL; GADOLINIUM PENTETATE MEGLUMINE; PLACEBO; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT;

ACETAMIDES; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ION CHANNELS; ISCHEMIC ATTACK, TRANSIENT; ISOQUINOLINES; LEAST-SQUARES ANALYSIS; MAGNETIC RESONANCE IMAGING; MALE; NEUROPROTECTIVE AGENTS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; STATISTICS, NONPARAMETRIC; TIME FACTORS;

EID: 0032780449     PISSN: 10531807     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1522-2586(199908)10:2<138::AID-JMRI5>3.0.CO;2-G     Document Type: Article

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