3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1- (4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a novel calmodulin antagonist, reduces brain edema through the inhibition of enhanced blood-brain barrier permeability after transient focal ischemia

Journal of Pharmacology and Experimental Therapeutics

Volumn 304, Issue 3, 2003, Pages 1042-1047

  Sato, Toshiyuki ^a   Morishima, Yoshiyuki ^a   Shirasaki, Yasufumi ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 [4 (3 CHLORO 2 METHYLPHENYL) 1 PIPERAZINYL]ETHYL] 5,6 DIMETHOXY 1 (4 IMIDAZOLYLMETHYL) 1H INDAZOLE; CALMODULIN; CALMODULIN INHIBITOR; DY 9760E; EVANS BLUE; INULIN; TRIFLUOPERAZINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN EDEMA; BRAIN ISCHEMIA; BRAIN PERFUSION; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; EXTRAVASATION; HEMISPHERE; MALE; MEMBRANE PERMEABILITY; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; STROKE; WATER CONTENT;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN EDEMA; CALMODULIN; CELL MEMBRANE PERMEABILITY; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; INDAZOLES; ISCHEMIC ATTACK, TRANSIENT; MALE; RATS; RATS, WISTAR; TRIFLUOPERAZINE; WATER;

EID: 0037373239     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.045039     Document Type: Article

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