Antioxidants attenuate the plasma cytokine response to exercise in humans

Journal of Applied Physiology

Volumn 94, Issue 3, 2003, Pages 1025-1032

  Vassilakopoulos, Theodoros ^a,b   Karatza, Maria Helena ^a   Katsaounou, Paraskevi ^a   Kollintza, Androniki ^a   Zakynthinos, Spyros ^a   Roussos, Charis ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b EVANGELISMOS HOSPITAL   (Greece)

Author keywords

Ergometry; Flow cytometry; Interleukins; Oxidative stress; Vitamins

Indexed keywords

ACETYLCYSTEINE; ALLOPURINOL; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CREATINE KINASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; REACTIVE OXYGEN METABOLITE; RETINOL; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BICYCLE ERGOMETRY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXERCISE; FLOW CYTOMETRY; HUMAN; HUMAN EXPERIMENT; MALE; MONOCYTE; NORMAL HUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

EID: 0037370846     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00735.2002     Document Type: Article

References (53)

1. Ali MH, Schlidt SA, Chandel NS, Hynes KL, Schumacker PT, and Gewertz BL. Endothelial permeability and IL-6 production during hypoxia: role of ROS in signal transduction. Am J Physiol Lung Cell Mol Physiol 277: L1057-L1065, 1999.
2. Ashton T, Young IS, Peters JR, Jones E, Jackson SK, Davies B, and Rowlands CC. Electron spin resonance spectroscopy, exercise, and oxidative stress: an ascorbic acid intervention study. J Appl Physiol 87: 2032-2036, 1999.
3. Baum M, Klopping-Menke K, Muller-Steinhardt M, Liesen H, and Kirchner H. Increased concentrations of interleukin 1-beta in whole blood cultures supernatants after 12 wk of moderate endurance exercise. Eur J Appl Physiol 79: 500-503, 1999.
4. Baum M, Liesen H, and Enneper J. Leucocytes, lymphocytes, activation parameters and cell adhesion molecules in middle-distance runners under different training conditions. Int J Sports Med 15, Suppl 3: S122-S126, 1994.
5. Camus G, Nys M, Poortmans JR, Venneman I, Monfils T, Deby-Dupont G, Juchmes-Ferir A, Deby C, Lamy M, and Duchateau J. Endotoxaemia, production of tumour necrosis factor alpha and polymorphonuclear neutrophil activation following strenuous exercise in humans. Eur J Appl Physiol 79: 62-68, 1998.
6. Cannon JG, Fielding RA, Fiatarone MA, Orencole SF, Dinarello CA, and Evans WJ. Increased interleukin-1β in human skeletal muscle after exercise. Am J Physiol Regul Integr Comp Physiol 257: R451-R455, 1989.
7. Clarkson PM and Thompson HS. Antioxidants: what role do they play in physical activity and health? Am J Clin Nutr 72: 637S-646S, 2000.
8. Colbert LH, Davis JM, Essig DA, Ghaffar A, and Mayer EP. Tissue expression and plasma concentrations of TNFalpha, IL-lbeta, and IL-6 following treadmill exercise in mice. Int J Sports Med 22: 261-267, 2001.
9. Dinarello CA. Interleukin-1. In: Inflammation: Basic Principles and Clinical Correlates, edited by Gallin JI and Snyderman R. Philadelphia, PA: Lippincott Williams & Wilkins, 1999, p. 443-461.
10. Droge W. Free radicals in the physiological control of cell function. Physiol Rev 82: 47-95, 2002.
11. Gabriel H, Rothe G, Korpys M, Schmitz G, and Kindermann W. Enhanced expression of HLA-DR, Fc gamma receptor 1 (CD64) and leukocyte common antigen (CD45) indicate activation of monocytes in regenerative training periods of endurance athletes. Int J Sports Med 18: 136-141, 1997.
12. Haahr PM, Pedersen BK, Fomsgaard A, Tvede N, Diamant M, Klarlund K, Halkjaer-Kristensen J, and Bendtzen K. Effect of physical exercise on in vitro production of interleukin-1, interleukin-6, tumour necrosis factor-alpha, interleukin-2 and interferon-gamma. Int J Sports Med 12: 223-227, 1991.
13. Haddad JJ, Safieh-Garabedian B, Saade NE, and Land SC. Thiol regulation of pro-inflammatory cytokines reveals a novel immunopharmacological potential of glutathione in the alveolar epithelium. J Pharmacol Exp Ther 296: 996-1005, 2001.
14. Heunks LM, Vina J, van Herwaarden CL, Folgering HT, Gimeno A, and Dekhuijzen PN. Xanthine oxidase is involved in exercise-induced oxidative stress in chronic obstructive pulmonary disease. Am J Physiol Regul Integr Comp Physiol 277: R1697-R1704, 1999.
15. Hochberg Y and Benjamini Y. More powerful procedures for multiple significance testing. Stat Med 9: 811-818, 1990.
16. Horton JW, White DJ, Maass DL, Hybki DP, Haudek S, and Giroir B. Antioxidant vitamin therapy alters burn trauma-mediated cardiac NF-kappaB activation and cardiomyocyte cytokine secretion. J Trauma 50: 397-406, 2001.
17. Ji LL. Antioxidants and oxidative stress in exercise. Proc Soc Exp Biol Med 222: 283-292, 1999.
18. Keller C, Steensberg A, Pilegaard H, Osada T, Saltin B, Pedersen BK, and Neufer PD. Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content. FASEB J 15: 2748-2750, 2001.
19. Kosmidou I, Vassilakopoulos T, Xagorari A, Zakynthinos S, Papapetropoulos A, and Roussos C. Production of interleukin-6 by skeletal myotubes: role of reactive oxygen species. Am J Respir Cell Mol Biol 26: 587-593, 2002.
20. Langberg H, Olesen JL, Gemmer C, and Kjaer M. Substantial elevation of interleukin-6 concentration in peritendinous tissue, in contrast to muscle, following prolonged exercise in humans. J Physiol 542: 985-990, 2002.
21. Lyngso D, Simonsen L, and Bulow J. Interleukin-6 production in human subcutaneous abdominal adipose tissue: the effect of exercise. J Physiol 543: 373-378, 2002.
22. Miyazaki H, Oh-ishi S, Ookawara T, Kizaki T, Toshinai K, Ha S, Haga S, Ji LL, and Ohno H. Strenuous endurance training in humans reduces oxidative stress following exhausting exercise. Eur J Appl Physiol 84: 1-6, 2001.
23. Moldoveanu AI, Shephard RJ, and Shek PN. Exercise elevates plasma levels but not gene expression of IL-1β, IL-6, and TNF-α in blood mononuclear cells. J Appl Physiol 89: 1499-1504, 2000.
24. Nara M, Kanda T, Tsukui S, Inukai T, Shimomura Y, Inoue S, and Kobayashi I. Running exercise increases tumor necrosis factor-alpha secreting from mesenteric fat in insulin-resistant rats. Life Sci 65: 237-244, 1999.
25. Nehlsen-Cannarella SL, Fagoaga OR, Nieman DC, Henson DA, Butterworth DE, Schmitt RL, Bailey EM, Warren BJ, Utter A, and Davis JM. Carbohydrate and the cytokine response to 2.5 h of running. J Appl Physiol 82: 1662-1667, 1997.
26. Nemet D, Oh Y, Kim HS, Hill M, and Cooper DM. Effect of intense exercise on inflammatory cytokines and growth mediators in adolescent boys. Pediatrics 110: 681-689, 2002.
27. Nieman DC, Peters EM, Henson DA, Nevines EI, and Thompson MM. Influence of vitamin C supplementation on cytokine changes following an ultramarathon. J Interferon Cytokine Res 20: 1029-1035, 2000.
28. Nybo L, Nielsen B, Pedersen BK, Moller K, and Secher NH. Interleukin-6 release from the human brain during prolonged exercise. J Physiol 542: 991-995, 2002.
29. Ostrowski K, Rohde T, Zacho M, Asp S, and Pedersen BK. Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running. J Physiol 508: 949-953, 1998.
30. Papanicolaou DA, Petrides JS, Tsigos C, Bina S, Kalogeras KT, Wilder R, Gold PW, Deuster PA, and Chrousos GP. Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines. Am J Physiol Endocrinol Metab 271: E601-E605, 1996.
31. Pedersen BK and Hoffman-Goetz L. Exercise and the immune system: regulation, integration, and adaptation. Physiol Rev 80: 1055-1081, 2000.
32. Petersen EW, Ostrowski K, Ibfelt T, Richelle M, Offord E, Halkjaer-Kristensen J, and Pedersen BK. Effect of vitamin supplementation on cytokine response and on muscle damage after strenuous exercise. Am J Physiol Cell Physiol 280: C1570-C1575, 2001.
33. Pool EJ, Robson PJ, Smith C, Van Wyk JH, and Myburgh KH. In vitro interleukin-6 release in whole blood cultures in samples taken at rest from triathletes and professional rugby players. Eur J Appl Physiol 87: 233-237, 2002.
34. Powers SK, Ji LL, and Leeuwenburgh C. Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review. Med Sci Sports Exerc 31: 987-997, 1999.
35. Reid MB. Invited Review: redox modulation of skeletal muscle contraction: what we know and what we don't. J Appl Physiol 90: 724-731, 2001.
36. Reimund JM, Allison AC, Muller CD, Dumont S, Kenney JS, Baumann R, Duclos B, and Poindron P. Antioxidants inhibit the in vitro production of inflammatory cytokines in Crohn's disease and ulcerative colitis. Eur J Clin Invest 28: 145-150, 1998.
37. Rhind S, Gannon G, Shephard R, and Shek P. Indomethacin modulates circulating cytokine responses to strenuous exercise in humans. Cytokine 19: 153-158, 2002.
38. Rhind SG, Castellani JW, Brenner IK, Shephard RJ, Zamecnik J, Montain SJ, Young AJ, and Shek PN. Intracellular monocyte and serum cytokine expression is modulated by exhausting exercise and cold exposure. Am J Physiol Regul Integr Comp Physiol 281: R66-R75, 2001.
39. Saghizadeh M, Ong JM, Garvey WT, Henry RR, and Kern PA. The expression of TNF-alpha by human muscle. Relationship to insulin resistance. J Clin Invest 97: 1111-1116, 1996.
40. Schindler R, Clark BD, and Dinarello CA. Dissociation between interleukin-1 beta mRNA and protein synthesis in human peripheral blood mononuclear cells. J Biol Chem 265: 10232-10237, 1990.
41. Sen CK and Packer L. Thiol homeostasis and supplements in physical exercise. Am J Clin Nutr 72: 653S-669S, 2000.
42. Sen CK, Rankinen T, Vaisanen S, and Rauramaa R. Oxidative stress after human exercise: effect of N-acetylcysteine supplementation. J Appl Physiol 76: 2570-2577, 1994.
43. Starkie RL, Angus DJ, Rolland J, Hargreaves M, and Febbraio MA. Effect of prolonged, submaximal exercise and carbohydrate ingestion on monocyte intracellular cytokine production in humans. J Physiol 528: 647-655, 2000.
44. Starkie RL, Rolland J, Angus DJ, Anderson MJ, and Febbraio MA. Circulating monocytes are not the source of elevations in plasma IL-6 and TNF-α levels after prolonged running. Am J Physiol Cell Physiol 280: C769-C774, 2001.
45. Steensberg A, van Hall G, Osada T, Sacchetti M, Saltin B, and Klarlund PB. Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J Physiol 529: 237-242, 2000.
46. Sumida S, Tanaka K, Kitao H, and Nakadomo F. Exercise-induced lipid peroxidation and leakage of enzymes before and after vitamin E supplementation. Int J Biochem 21: 835-838, 1989.
47. Tamion F, Richard V, Bonmarchand G, Leroy J, Hiron M, Daveau M, Thuillez C, and Lebreton JP. Reduced synthesis of inflammatory cytokines by a free radical scavenger after hemorrhagic shock in rats. Crit Care Med 28: 2522-2527, 2000.
48. Tirakitsoontorn P, Nussbaum E, Moser C, Hill M, and Cooper DM. Fitness, acute exercise, and anabolic and catabolic mediators in cystic fibrosis. Am J Respir Crit Care Med 164: 1432-1437, 2001.
49. Toft AD, Jensen LB, Bruunsgaard H, Ibfelt T, Halkjaer-Kristensen J, Febbraio M, and Pedersen BK. Cytokine response to eccentric exercise in young and elderly humans. Am J Physiol Cell Physiol 283: C289-C295, 2002.
50. Ullum H, Haahr PM, Diamant M, Palmo J, Halkjaer-Kristensen J, and Pedersen BK. Bicycle exercise enhances plasma IL-6 but does not change IL-1α, IL-1β, IL-6, or TNF-α pre-mRNA in BMNC. J Appl Physiol 77: 93-97, 1994.
51. Vina J, Gimeno A, Sastre J, Desco C, Asensi M, Pallardo FV, Cuesta A, Ferrero JA, Terada LS, and Repine JE. Mechanism of free radical production in exhaustive exercise in humans and rats; role of xanthine oxidase and protection by allopurinol. IUBMB Life 49: 539-544, 2000.
52. Yamashita N, Hoshida S, Otsu K, Asahi M, Kuzuya T, and Hori M. Exercise provides direct biphasic cardioprotection via manganese superoxide dismutase activation. J Exp Med 189: 1699-1706, 1999.
53. Ziegler-Heitbrock HW. Definition of human blood monocytes. J Leukoc Biol 67: 603-606, 2000.