Enhanced expression of HLA-DR, Fcγ receptor 1 (CD64) and leukocyte common antigen (CD45) indicate activation of monocytes in regenerative training periods of endurance athletes

International Journal of Sports Medicine

Volumn 18, Issue 2, 1997, Pages 136-141

  Gabriel, H ^a   Rothe, G ^b   Korpys, M ^a   Schmitz, G ^b   Kindermann, W ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

Athletes; Endurance training; Exercise; Flow cytometry; Immunophenotyping; Monocytes; Surface antigens

Indexed keywords

CD45 ANTIGEN; CD64 ANTIGEN; CELL SURFACE RECEPTOR; HLA DR ANTIGEN; MEMBRANE ANTIGEN;

ANAEROBIC THRESHOLD; ANTIGEN EXPRESSION; ARTICLE; ATHLETE; CELL ACTIVATION; CELL COUNT; CONTROLLED STUDY; ENDURANCE; FLOW CYTOMETRY; HUMAN; HUMAN EXPERIMENT; IMMUNOFLUORESCENCE; MALE; MONOCYTE; NORMAL HUMAN; OXYGEN CONSUMPTION; TRAINING;

ADULT; ANAEROBIC THRESHOLD; ANALYSIS OF VARIANCE; ANTIGENS, CD14; ANTIGENS, CD45; ANTIGENS, CD56; BICYCLING; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; GENE EXPRESSION REGULATION; HLA-DR ANTIGENS; HUMANS; MALE; MONOCYTES; OXYGEN CONSUMPTION; PHYSICAL EDUCATION AND TRAINING; PHYSICAL ENDURANCE; RECEPTORS, IGG; REGENERATION; RUNNING; SPORTS; SWIMMING;

EID: 0031044073     PISSN: 01724622     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-972609     Document Type: Article

References (38)

1. Bach F. H.: The HLA Class II genes and products of the HLA-D region, Immunol Today 6: 89-94, 1985.
2. Boltz-Nitulescu G., Wilhelm M., Spittler A., Leutmezer F., Tempfer C., Winkler W.: Modulation of IgA, IgE, and IgG Fc receptor expression on human mononuclear phagocytes by 1 alpha, 25-dihydroxyvitamin D3 and cytokines. J Leukoc Biol 58: 256-262, 1995.
3. Denis M.: Human monocytes/macrophages: NO or no NO? J Leukoc Biol 55: 682-684, 1994.
4. Frank M. M., Lawley T. J., Hamburger M. I., Brown E. J.: NIH conference: Immunoglobulin G Fc receptor-mediated clearance in autoimmune disease. Ann Intern Med 982: 206-218, 1983.
5. + blood monocytes is expanded in sepsis patients. Blood 82: 3170-3176, 1993.
6. Gabriel H., Schwarz L, Steffens G., Kindermann W.: Immunoregulatory hormones, circulating leucocyte and lymphocyte subpopulations before and after endurance exercise of different intensities. Int J Sports Med 13: 359-366, 1992.
7. Gabriel H., Brechtel L, Urhausen A., Kindermann W.: Recruit-ment and recirculation of leukocytes after an ultramarathon run: Preferential homing of cell expressing high levels of the adhesion molecule LFA-1. Int J Sports Med 15: S148-S153, 1994.
8. Gabriel H., Urhausen A., Brechtel L., Müller H. J., Kindermann W.: Alterations of regular and mature monocytes are distinct, and dependent of intensity and duration of exercise. Eur J Appl Physiol 69: 179-181, 1994.
9. Gabriel H., Urhausen A., Valet G., Weiler B., Heidelbach U., Kindermann W.: Diagnostic approach towards recognizing overtraining by lymphocyte immunophenotyping in endurance trained athletes, Int J Sports Med 15: 358, 1994.
10. Comez F., Ruiz P., Schreiber A. D.: Impaired function of macrophage Feγ receptors and bacterial infection in alcoholic cirrhosis. N Engl J Med 331: 1122-1128, 1994.
11. Gosselin E. J., Wardwell K., Gosselin D. R., Alter N., Fisher J. L, Guyre P. M.: Enhanced antigen presentation using human Fc gamma receptor (monocyte/macrophge)-specific immunogens. J Immunol 149: 3477-3481, 1992.
12. Guyre P. M., Campbell A. S., Kniffin W. D., Fanger M. W.: Monocytes and polymorphonuclear neutrophils with streptococcal pharyngitis express increased numbers of type 1 IgG Fc receptors. J Clin Invest 86: 1892-1896, 1990.
13. Haahr P. M., Pedersen B. K., Tvede N., Diamant F. M., Halkjaer-Kristensen J., Bendtzen K.: Effect of physical exercise on in vitro production of interleukin 1, interleukin 6, tumor necrosis factor-α, interleukin 2 and interferon-γ. Int J Sports Med 12: 223-227, 1991.
14. Hoffman-Goetz L., Pedersen B. K.: Exercise and the immune system: a model of the stress response? Immunol Today 15: 382-387, 1994.
15. Hohorst H. J.: L-(+)-Lactat, Bestimmung mit Lactatdehydrogenase und DPN, in Bergmeyer H. U. (ed): Methoden der enzy-matischen Analyse, Weinheim, Verlag Chemie, 1962, pp 266-277.
16. Hughes D. A., Townsend P. J., Haslam P. L: Enhancement of the antigen-presenting function of monocytes by cholesterol: possible relevance to inflammatory mechanisms in extrinsic allergic alveolitis and atherosclerosis. Clin Exp Immunol 87: 279-186, 1992.
17. Janeway C. A., Bottomly K., Babich J.: Quantitative variation in la antigen expression plays a central role in immune regulation. Immunol Today 5: 99-104, 1984.
18. Kimberly R. P., Parris T. M., Inman R. D., McDouglas J. S.: Dynamics of mononuclear phagocyte system Fc receptor function in systemic lupus erythematodes: Relation to disease activity and circulating immune complexes. Clin Exp Immunol 52: 261-268, 1983.
19. Klein J. (ed): Immunology, Oxford, Blackwell Scientific Publ., 1990.
20. Michie C. A., McLean A., Alcock C, Beverley P. C. L.: Lifespan of human lymphocyte subsets defined by CD45 isoforms. Nature 360: 264-265, 1992.
21. Naito M.: Macrophage heterogeneity in development and differentiation. Arch Histol Cytol 56: 331-351, 1993.
22. Northoff H., Berg A.: Immunologic mediators as parameters of the reaction to strenuous exercise. Int J Sports Med 12: S9-S15, 1991.
23. Northoff H, Weinstock C., Berg A.: The cytokine response to strenuous exercise. Int J Sports Med 15: S167-S171, 1994.
24. Nieman D. C.: Exercise, upper respiratory tract infection, and the immune system. Med Sci Sports Exerc 26: 128-139, 1994.
25. Passlik B., Flieger D., Ziegler-Heitbrock H. W. L.: Identification and characterization of a novel monocyte subpopulation in human peripheral blood. Blood 74: 2527-2535, 1989.
26. Ruiz P., Gomez F., Schneider A. D.: Impaired functin of macrophage Fc gamma receptors in end-stage renal disease. N Engl J Med 322: 717-722, 1990.
27. Schmitz G., Kovacs E., Rothe G.: Influence of lipoproteins on monocyte differentiation and activation. Atherosclerosis 25: 267-276, 1993.
28. Schned E. S., Inman R. D., Parris T. M., Kimberly R. P., Redecha P. B., Christian C. L.: Serial circulating immune complexes and mononuclear phagocyte system function in infective endocarditis. J Lab Clin Med 102: 947-959, 1983.
29. Spittler A., Winkler S., Gotzinger P., Oehler R., Wilhelm M., Tempfer C., Weigel G., Fugger G., Boltz-Nitulescu G., Roth E.: Influence of glutamine on the phenotype and function of human monocytes. Blood 86: 1564-1569, 1995.
30. Steel D. M., Whitehead A. S.: The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein, Immunol Today 15: 81-88, 1994.
31. Stegmann H., Kindermann W., Schnabel H.: Lactate kinetics and individual anaerobic threshold, Int J Sports Med 2: 160-165, 1981.
32. Unanue E. R.: Antigen-presenting function of the macrophage. Ann Rev Immunol 2: 395-428, 1985.
33. Valet G., Valet M., Tschöpe D., Gabriel H., Rothe G., Kellermann W., Kahle H.: White cell and thrombocyte disorders - Stand-ardized, self learning flow cytometric list mode data classification with the CLASSIF1 program system. Ann NY Acad Sci 677: 233-251, 1993.
34. Volk H. D.: Decrease of the proportion of HLA-DR+ monocytes as prognostic parameter for the clinical outcome of septic disease, in Masihi K. N., Lange W. (eds) Immunotherapeutic Prospects of Infectious Diseases, Berlin, Heidelberg, New York, Springer-Verlag, 1990, pp 297-301.
35. Winkel van de J. G. J., Capel P. J. A.: Human IgG Fc receptor heterogeneity: Molecular aspects and clinical implications. Immunol Today 14: 215-221, 1993.
36. Wormersley J.: A comparison of skinfold method with extend of "overweight" and various weight - height relationships in the assessment of obesity. Br J Nutr 38: 271 -284, 1977.
37. Ziegler-Heitbrock H. W. L, Ströbel M., Kieper D., Fingerle G., Schlunck T., Petersmann I., Ellwart J., Blumenstein M., Haas L G.: Differential expression of cytokines in human blood monocytes. Blood 79: 503-511, 1992.
38. Ziegler-Heitbrock H. W. L, Ulevitch R. J.: CD14: Cell surface receptor and differentiation marker, Immunol Today 14:121-125, 1993.