Regions of PspA/EF3296 best able to elicit protection against Streptococcus pneumoniae in a murine infection model

Infection and Immunity

Volumn 71, Issue 3, 2003, Pages 1033-1041

  Roche, Hazeline ^a   Håkansson, Anders ^a   Hollingshead, Susan K ^a   Briles, David E ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; PNEUMOCOCCAL SURFACE PROTEIN A; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL STRAIN; CARBOXY TERMINAL SEQUENCE; GENE MAPPING; IMMUNOGENICITY; INFECTION PREVENTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEROLOGY; STREPTOCOCCUS PNEUMONIAE;

ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL PROTEINS; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; IMMUNIZATION; MICE; MICE, INBRED BALB C; MICE, INBRED CBA; PEPTIDE FRAGMENTS; PNEUMOCOCCAL INFECTIONS; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; STREPTOCOCCUS PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037369739     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.3.1033-1041.2003     Document Type: Article

References (43)

1. Aaberge, I. S., J. Eng, G. Lermark, and M. Løvik. 1995. Virulence of Streptococcus pneumoniae in mice: a standardized method for preparation and frozen storage of the experimental bacterial inoculum. Microb. Pathog. 18: 141-152.
2. Abeyta, M. 1999. Pneumococcal surface protein A and capsular polysaccharide in virulence of Streptococcus pneumoniae. Ph.D. thesis. University of Alabama at Birmingham.
3. Amsbaugh, D. F., C. T. Hansen, B. Prescott, P. W. Stashak, D. R. Barthold, and P. J. Baker. 1972. Genetic control of the antibody response to type III pneumococcal polysaccharide in mice. I. Evidence that an X-linked gene plays a decisive role in determining responsiveness. J. Exp. Med. 136:931-949.
4. Anonymous. 1997. Prevention of pneumococcal disease: recommendations of the Advisory Committee on Immunization Practices. Morb. Mortal. Wkly. Rep. 46:1-24.
5. Anonymous. 2001. The QIAexpressionist handbook, 5th ed. Qiagen, Valencia, Calif.
6. Berry, A. M., and J. C. Paton. 2000. Additive attenuation of virulence of Streptococcus pneumoniae by mutation of the genes encoding pneumolysin and other putative pneumococcal virulence proteins, Infect. Immun. 68:133-140.
7. Briles, D. E., E. Ades, J. C. Paton, J. S. Sampson, G. M. Carlone, R. C. Huebner, A. Virolainen, E. Swiatlo, and S. K. Hollingshead. 2000. Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae. Infect. Immun. 68:796-800.
8. Briles, D. E., C. Forman, and M. Crain. 1992. Mouse antibody to phosphocholine can protect mice from infection with mouse-virulent human isolates of Streptococcus pneumoniae. Infect. Immun. 60:1957-1962.
9. Briles, D. E., C. Forman, J. C. Horowitz, J. E. Volanakis, W. H. Benjamin, Jr., L. S. McDaniel, J. Eldridge, and J. Brooks. 1989. Anti-pneumococcal effects of C-reactive protein and monoclonal antibodies to pneumococcal cell wall and capsular antigens. Infect. Immun. 57:1457-1464.
10. Briles, D. E., S. K. Hollingshead, J. King, A. Swift, P. A. Braun, M. K. Park, L. M. Ferguson, M. H. Nahm, and G. S. Nabors. 2000. Immunization of humans with recombinant pneumococcal surface protein A (rPspA) elicits antibodies that passively protect mice from fatal infection with Streptococcus pneumoniae bearing heterologous PspA. J. Infect. Dis. 182:1694-1701.
11. Briles, D. E., S. K. Hollingshead, E. Swiatlo, A. Brooks-Walter, A. Szalai, A. Virolainen, L. S. McDaniel, K. A. Benton, P. C. Aerts, H. van Dijk, and M. J. Crain. 2000. Pneumococcal proteins PspA and PspC: their potential for use as vaccines, p. 253-260. In A. Tomasz and R. Austrian (ed.), Molecular biology of pneumococci and pneumococcal diseases. Mary Ann Liebert Inc., Larchmont, N.Y.
12. Briles, D. E., J. Horowitz, L. S. McDaniel, W. H. Benjamin, Jr., J. L. Claflin, C. L. Booker, G. Scott, and C. Forman. 1986. Genetic control of the susceptibility to pneumococcal infection. Curr. Top. Microbiol. Immunol. 124:103-120.
13. Briles, D. E., J. D. King, M. A. Gray, L. S. McDaniel, E. Swiatlo, and K. A. Benton. 1996. PspA, a protection-eliciting pneumococcal protein: immunogenicity of isolated native PspA in mice. Vaccine 14:858-867.
14. Briles, D. E., G. S. Nabors, A. Brooks-Walter, J. Paton, C., and S. Hollingshead. 2001. The potential for using protein vaccines to protect against otitis media caused by Streptococcus pneumoniae. Vaccine 19:S87-S95.
15. Briles, D. E., M. Nahm, K. Schroer, J. Davie, P. Baker, J. Kearney, and R. Barletta. 1981. Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 Streptococcus pneumoniae. J. Exp. Med. 153:694-705.
16. Briles, D. E., R. C. Tart, H.-Y. Wu, B. A. Ralph, M. W. Russell, and L. S. McDaniel. 1996. Systemic and mucosal protective immunity to pneumococcal surface protein. Ann. N. Y. Acad. Sci. 797:118-126.
17. Brooks-Walter, A., D. E. Briles, and S. K. Hollingshead. 1999. The pspC gene of Streptococcus pneumoniae encodes a polymorphic protein, pspC, which elicits cross-reactive antibodies to PspA and provides immunity to pneumococcal bacteremia. Infect. Immun. 67:6533-6542.
18. Brown, E. J., S. W. Hosea, and M. M. Frank. 1983. The role of antibody and complement in the reticuloendothelial clearance of pneumococci from the bloodstream. Rev. Infect. Dis. 5 Suppl. 4:S797-S805.
19. Coral, M. C. V., N. Fonseca, E. Castaneda, J. L. Di Fabio, S. K. Hollingshead, and D. E. Briles. 2001. Families of pneumococcal surface protein A (PspA) of Streptococcus pneumoniae invasive isolates recovered from Colombian children. Emerg. Infect. Dis. 7:832-836.
20. Crain, M. J., W. D. Waltman II, J. S. Turner, J. Yother, D. F. Talkington, L. S. McDaniel, B. M. Gray, and D. E. Briles. 1990. Pneumococcal surface protein A (PspA) is serologically highly variable and is expressed by all clinically important capsular serotypes of Streptococcus pneumoniae. Infect. Immun. 58:3293-3299.
21. Dagan, R. 2000. Treatment of acute otitis media - challenges in the era of antibiotic resistance. Vaccine 19(Suppl. 1):S9-S16.
22. Dagan, R., R. Melamed, M. Muallem, L. Piglansky, D. Greenberg, O. Abramson, P. M. Mendelman, N. Bohidar, and P. Yagupsky. 1996. Reduction of nasopharyngeal carriage of pneumococci during the second year of life by a heptavalent conjugate pneumococcal vaccine. J. Infect. Dis. 174: 1271-1278.
23. Håkansson, A., H. Roche, S. Mirza, L. S. McDaniel, A. Brooks-Walter, and D. E. Briles. 2001. Characterization of binding of human lactoferrin to pneumococcal surface protein A. Infect. Immun. 69:3372-3381.
24. Hammerschmidt, S., S. R. Talay, P. Brandtzaeg, and G. S. Chhatwal. 1997. SpsA, a novel pneumococcal surface protein with specific binding to secretory immunoglobulin A and secretory component. Mol. Microbiol. 25:1113-1124.
25. Hollingshead, S. K., R. Becker, and D. E. Briles. 2000. Diversity of PspA: mosaic genes and evidence for past recombination in Streptococcus pneumoniae. Infect. Immun. 68:5889-5900.
26. Jedrzejas, M. J., S. K. Hollingshead, J. Lebowitz, L. Chantalat, D. E. Briles, and E. Lamani. 2000. Production and characterization of the functional fragment of pneumococcal surface protein A. Arch. Biochem. Biophys. 373: 116-125.
27. Lock, R. A., J. C. Paton, and D. Hansman. 1988. Comparative efficacy of pneumococcal neuraminidase and pneumolysin as immunogens protective against Streptococcus pneumoniae. Microb. Pathog. 5:461-467.
28. Lopez, R., E. Garcia, P. Garcia, and J. L. Garcia. 1997. The pneumococcal cell wall degrading enzymes: a modular design to create new lysins? Microb. Drug Resist. 3:199-211.
29. McDaniel, L. S., B. A. Ralph, D. O. McDaniel, and D. E. Briles. 1994. Localization of protection-eliciting epitopes on PspA of Streptococcus pneumoniae between amino acid residues 192 and 260. Microb. Pathog. 17:323-337.
30. McDaniel, L. S., G. Scott, K. Widenhofer, J. Carroll, and D. E. Briles. 1986. Analysis of a surface protein of Streptococcus pneumoniae recognized by protective monoclonal antibodies. Microb. Pathog. 1:519-531.
31. Mosier, D. E., I. M. Zitron, J. Mond, A. Aftab, I. Scher, and W. E. Paul. 1977. Surface immunoglobulin D as a functional receptor for a subclass of B lymphocytes. Immunol. Rev. 37:89-104.
32. Mulholland, E. K. 1997. A report prepared for the scientific advisory group of experts, global programme for vaccines and immunization. World Health Organization, Geneva, Switzerland.
33. Nabors, G. S., P. A. Braun, D. J. Herrmann, M. L. Heise, D. J. Pyle, S. Gravenstein, M. Schilling, L. M. Ferguson, S. K. Hollingshead, D. E. Briles, and R. S. Becker. 2000. Immunization of healthy adults with a single recombinant pneumococcal surface protein A (PspA) variant stimulates broadly cross-reactive antibodies to heterologous PspA molecules. Vaccine 18:1743-1754.
34. Ogunniyi, A. D., R. L. Folland, D. B. Briles, S. K. Hollingshead, and J. C. Paton. 2000. Immunization of mice with combinations of pneumococcal virulence proteins elicits enhanced protection against challenge with Streptococcus pneumoniae. Infect. Immun. 68:3028-3033.
35. Ralph, B. A., D. E. Briles, and L. S. McDaniel. 1994. Cross-reactive protection-eliciting epitopes of pneumococcal surface protein A. Ann. N. Y. Acad. Sci. 730:361-363.
36. Rosenow, C., P. Ryan, J. N. Weiser, S. Johnson, P. Fontan, A. Ortqvist, and H. R. Masure. 1997. Contribution of novel choline-binding proteins to adherence, colonization and immunogenicity of Streptococcus pneumoniae. Mol. Microbiol. 25:819-829.
37. Shinefield, H. R., and S. Black. 2000. Efficacy of pneumococcal conjugate vaccines in large scale field trials. Pediatr. Infect. Dis. J. 19:394-397.
38. Tart, R. C., L. S. McDaniel, B. A. Ralph, and D. E. Briles. 1996. Truncated Streptococcus pneumoniae PspA molecules elicit cross-protective immunity against pneumococcal challenge in mice. J. Infect. Dis. 173:380-386.
39. Tomasz, A. 1997. Antibiotic resistance in Streptococcus pneumoniae. Clin. Infect. Dis. 24:S85-S88.
40. Tong, H. H., L. E. Blue, M. A. James, and T. F. DeMaria. 2000. Evaluation of the virulence of a Streptococcus pneumoniae neuraminidase-deficient mutant in nasopharyngeal colonization and development of otitis media in the chinchilla model. Infect. Immun. 68:921-924.
41. Tu, A. H., R. L. Fulgham, M. A. McCrory, D. E. Briles, and A. J. Szalai. 1999. Pneumococcal surface protein A inhibits complement activation by Streptococcus pneumoniae. Infect. Immun. 67:4720-4724.
42. Yother, J., and D. E. Briles. 1992. Structural properties and evolutionary relationships of PspA, a surface protein of Streptococcus pneumoniae, as revealed by sequence analysis. J. Bacteriol. 174:601-609.
43. Yother, J., and J. M. White. 1994. Novel surface attachment mechanism of the Streptococcus pneumoniae protein PspA. J. Bacteriol. 176:2976-2985.