Modulation of intracellular Ca2+ via L-type calcium channels in heart cells by the autoantibody directed against the second extracellular loop of the α1-adrenoceptors

Canadian Journal of Physiology and Pharmacology

Volumn 81, Issue 3, 2003, Pages 234-246

  Bkaily, Ghassan ^a   El Bizri, Nesrine ^a   Bui, Michel ^a   Sukarieh, Rami ^a   Jacques, Danielle ^a   Fu, Michael L X ^b  

^a UNIVERSITY OF SHERBROOKE   (Canada)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Autoantibody; Calcium; Confocal microscopy; Heart cells; Ion channels; 1 adrenoceptor

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR AUTOANTIBODY; ALPHA 1A ADRENERGIC RECEPTOR; AUTOANTIBODY; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL T TYPE; ION CHANNEL; METHOXAMINE; NIFEDIPINE; PRAZOSIN; TETRODOTOXIN; UNCLASSIFIED DRUG; ANILINE DERIVATIVE; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; FLUO 3; FLUORESCENT DYE; POTASSIUM CHANNEL; SODIUM CHANNEL; XANTHENE DERIVATIVE;

ANIMAL CELL; CALCIUM CELL LEVEL; CALCIUM CURRENT; CHICK EMBRYO; CONFERENCE PAPER; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DELAYED OUTWARD POTASSIUM CURRENT; DRUG ANTAGONISM; EMBRYO; FAST SODIUM CURRENT; FETUS; FLUOROMETRY; HEART CONTRACTION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; ION CURRENT; MUSCLE FIBER CONTRACTION; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; SODIUM CURRENT; STAINING; VOLTAGE CLAMP; ANIMAL; ARTICLE; CELL CULTURE; COMPARATIVE STUDY; DRUG EFFECT; DRUG POTENTIATION; IMMUNOLOGY; METABOLISM; PHYSIOLOGY;

ANILINE COMPOUNDS; ANIMALS; AUTOANTIBODIES; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CALCIUM CHANNELS, T-TYPE; CELLS, CULTURED; CHICK EMBRYO; FETUS; FLUORESCENT DYES; HUMANS; METHOXAMINE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; NIFEDIPINE; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; RECEPTORS, ADRENERGIC, ALPHA-1; SODIUM CHANNELS; XANTHENES;

EID: 0037366931     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y03-044     Document Type: Conference Paper

References (41)

1. Anderson, K.E., and Woodcock, E.A. 1995. Preconditioning of peffused rat heart inhibits reperfusion-induced release of inositol(1,4,5)trisphosphate. J. Mol. Cell. Cardiol. 27: 2421-2431.
2. Auffermann, W., Stefenelli, T., Wu, S.T., Parmley, W.W., Wikman-Coffelt, J., and Mason, D.T. 1989. Influence of positive inotropic agents on intracellular calcium transients. Am. Heart. J. 118: 1219-1227.
3. Benfey, B.G. 1982. Function of myocardial alpha-adrenoceptors. Life Sci. 31: 101-112.
4. Bkaily, G. 1992. Single heart cells as models for studying cardiac toxicology. In In vitro methods in toxicology. Edited by G. Jolles and A. Cordier. Academic Press, London. pp 289-334.
5. + current in fetal single ventricular cells. J. Mol. Cell. Cardiol. 25: 1305-1316.
6. Bkaily, G., Gros-Louis, N., Naik, R., Jaalouk, D., and Pothier, P. 1996. Implication of the nucleus in excitation contraction coupling of heart cells. Mol. Cell. Biochem. 154: 113-121.
7. Bkaily, G., Pothier, P., D'Orleans-Juste, P., Simaan, M., Jacques, D., Jaalouk, D., Belzile, F., Hassan, G., Boutin, C., Haddad, G., and Neugebauer, W. 1997a. The use of confocal microscopy in the investigation of cell structure and function in the heart, vascular endothelium and smooth muscle cells. Mol. Cell. Biochem. 172: 171-194.
8. 2+ current in heart cells of the cardiomyopathic hamster. Mol. Cell. Biochem. 176: 199-204.
9. Bkaily, G., D'Orléans-Juste, P., Pothier, P., Calixto, J.B., and Yunes, R. 1997c. Nuclear membrane receptors and channels: potential therapeutic targets for drug action. Drug Devel. Res. 42: 211-222.
10. Bkaily, G., Jacques, D., and Pothier, P. 1999. Use of confocal to investigate cell structure and function. Methods Enzymol. 307: 119-135.
11. Bkaily, G., Jacques, D., Hassan, G., Choufani, S., and D'Orléans-Juste, P. 2001. Using confocal imaging to measure changes in intracellular ions. In Receptors: structure and function. Edited by C. Stanford and R. Horton. Oxford University Press, New York. pp 209-231.
12. Bruckner, R., Mugge, A., and Scholz, H. 1985. Existence and functional role of alpha 1-adrenoceptors in the mammalian heart. J. Mol. Cell. Cardiol. 17: 639-645.
13. Das, T., Baek, K.J., Gray, C., and Im, M.J. 1993. Evidence that the Gh protein is a signal mediator from alpha 1-adrenoceptor to a phospholipase C. II. Purification and characterization of a Gh-coupled 69-kDa phospholipase C and reconstitution of alpha 1-adrenoceptor, Gh family, and phospholipase C. J. Biol. Chem. 268: 27 398 - 27 405.
14. 2+-independent PKC in alpha 1-adrenoceptor-mediated inotropic responses of neonatal rat hearts. Am. J. Physiol. 273: H1113-H1118.
15. 2+ mediated through alpha- and beta-adrenoceptors. Circul. Res. 62: 247-265.
16. Eng, H., Magnusson, Y., Matell, G., Lefvert, A.K., Saponja, R., and Hoebeke, J. 1992. Beta 2-adrenergic receptor antibodies in myasthenia gravis. J Autoimmunity, 5: 213-227.
17. Fedida, D., and Bouchard, R.A. 1992. Mechanisms for the positive inotropic effect of alpha 1-adrenoceptor stimulation in rat cardiac myocytes. Circul. Res. 71: 673-688.
18. Fedida, D., Braun, A.P., and Giles, W.R. 1993. Alpha 1-adrenoceptors in myocardium: functional aspects and transmembrane signaling mechanisms. Physiol. Rev. 73: 469-487.
19. Fu, M.L. 1996. Characterization of anti-heart M2 muscarinic receptor antibodies - a combined clinical and experimental study. Mol. Cell. Biochem. 163-164: 343-347.
20. Fu, M.L.X., Magnusson, Y., Bergh, C.H., Liljeqvist, J.A., Waagstein, F., Hjalmarson, A., and Hoebeke, J. 1993. Localization of a functional autoimmune epitope on the muscarinic acetylcholine receptor-2 in patients with idiopathic dilated cardiomyopathy. J. Clin. Invest. 91: 1964-1968.
21. Fu, M., Schulze, W., Wolf, W.P., Hjalmarson, A., and Hoebeke, J. 1994a. Immunocytochemical localization of M2 muscarinic receptors in rat ventricles with anti-peptide antibodies. J. Histochem. Cytochem. 42: 337-343.
22. Fu, M.L., Gerd, W., Ake, H., and Johan, H. 1994b. Agonist-like activity of anti-peptide antibodies directed against an autoimmune epitope on the heart muscarinic acetylcholine receptor. Receptors & Channels, 2: 121-130.
23. Fu, M.L., Wallukat, G., Hjalmarson, A., and Hoebeke, J. 1994c. Characterization of anti-peptide antibodies directed against an extracellular immunogenic epitope on the human alpha 1-adrenergic receptor. Clin. Exper. Immunol. 97: 146-151.
24. Fu, M.L.X., Herlitz, H., Wallukat, G., Hilme, E., Hedner, T., Hoebeke, J., and Hjalmarson, A. 1994d. Functional autoimmune epitope on alpha 1-adrenergic receptors in patients with malignant hypertension. Lancet, 344: 1660-1663.
25. Graham, R.M., Perez, D.M., Hwa, J., and Piascik, M.T. 1996. alpha 1-adrenergic receptor subtypes. Molecular structure, function, and signaling. Circul. Res. 78: 737-749.
26. Han, K.J., Park, H., Yoo, S.M., Baek, S.H., Uhm, D.Y., Lee, H.S., Yun, H.Y., Kwon, N.S., and Baek, K.J. 1998. Identification of a distinct molecular mass G alpha(h) (transglutaminase II) coupled to alpha 1-adrenoceptor in mouse heart. Life Sci. 62: 1809-1816.
27. Hattori, Y., and Kanno, M. 1998. Role of alpha 1-adrenoceptor subtypes in production of the positive inotropic effects in mammalian myocardium: implications for the alpha 1-adrenoceptor subtype distribution. Life Sci. 62: 1449-1453.
28. + current in heart cells of cardiomyopathic hamster. Mol. Cell. Biochem. 176: 249-256.
29. Jahnel, U., Nawrath, H., Shieh, R.C., Sharma, V.K., Williford, D.J., and Sheu, S.S. 1992. Modulation of cytosolic free calcium concentration by alpha 1-adrenoceptors in rat atrial cells. Naunyn-Schmiedebergs Arch. Pharmacol. 346: 88-93.
30. Kaku, T., Lakatta, E., and Filburn, C. 1999. Alpha-adrenergic regulation of phosphoinositide metabolism and protein kinase C in isolated cardiac myocytes. Am. J. Physiol. 260: C635-C642.
31. Li, K., He, H., Li, C., Sirois, P., and Rouleau, J.L. 1997. Myocardial alpha 1-adrenoceptor: inotropic effect and physiologic and pathologic implications. Life Sci. 60: 1305-1318.
32. Luther, H,P., Homuth, V., and Wallukat, G. 1997. Alpha 1-adrenergic receptor antibodies in patients with primary hypertension. Hypertension, 29: 678-682.
33. Magnusson, Y., Hoyer, S., Lengagne, R., Chapot, M.P., Guillet, J.G., Hjalmarson, A., Strosberg, A.D., and Hoebeke. J. 1989. Antigenic analysis of the second extra-cellular loop of the human beta-adrenergic receptors. Clin. Exper. Immunol. 78: 42-48
34. Magnusson, Y., Marullo, S., Hoyer, S., Waagstein, F., Andersson, B., Vahlne, A., Guillet, J.G., Strosberg, A.D., Hjalmarson, A., and Hoebeke, J. 1990. Mapping of a functional autoimmune epitope on the beta 1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy. J. Clin. Invest. 86: 1658-1663.
35. Magnusson, Y., Wallukat, G., Guillet, J.G., Hjalmarson, A., and Hoebeke, J. 1991. Functional analysis of rabbit anti-peptide anti-bodies which mimic autoantibodies against the beta 1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy. J. Autoimmunity, 4: 893-905.
36. Magnusson, Y., Wallukat, G., Waagstein, F., Hjalmarson, A., and Hoebeke, J. 1994. Autoimmunity in idiopathic dilated cardiomyopathy. Characterization of antibodies against the beta 1-adrenoceptor with positive chronotropic effect. Circulation, 89: 2760-2767.
37. Matsui, S., and Fu, M.L. 1998. Myocardial injury due to G-protein coupled receptor-autoimmunity. Jpn. Heart J. 39: 261-274.
38. 2+ transient and contraction in single rat cardiomyocytes. J. Mol. Cell. Cardiol. 24: 809-820.
39. Schulze, W., and Fu, L.X. 1996. Localization of α1-adrenoceptors in rat and human hearts by immunocytochemistry. Mol. Cell. Biochem. 163/164: 159-165.
40. Terzic, A., Puceat, M., Vassort, G., and Vogel, S.M. 1993. Cardiac alpha 1-adrenoceptors: an overview. Pharmacol. Rev. 45: 147-175.
41. Varma, D.R., and Deng, X.-F. 2000. Cardiovascular α-adrenoceptor subtypes: functions and signalling. Can. J. Physiol. Pharmacol. 78: 267-292.