Characterization of anti-heart M2 muscarinic receptor antibodies - A combined clinical and experimental study

Molecular and Cellular Biochemistry

Volumn 163-164, Issue , 1996, Pages 343-347

  Fu, Michael L X ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Autoimmunity; Dilated cardiomyopathy; Muscarinic receptor

Indexed keywords

AUTOANTIBODY; MUSCARINIC M2 RECEPTOR;

ARTICLE; AUTOIMMUNITY; CONGESTIVE CARDIOMYOPATHY; ETIOLOGY; HEART DILATATION; HUMAN; MEDICAL RESEARCH; NONHUMAN; PATHOGENESIS;

EID: 0029769336     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00408675     Document Type: Article

References (33)

1. Das SK, Cassidy JT, Petty RE: Antibodies against heart muscle and nuclear constituents in cardiomyopathy. Am Heart J 1972, 83: 159-166
2. Caforio ALP, Bonifacio E, Stewart JT, Neglia D, Parodi O, Bottazzo GF, McKenna WJ: Novel organ-specific circulating cardiac autoantibodies in dilated cardiomyopathy. J Am Coll Cardiol 15: 1527-1534, 1990
3. Latif N, Baker CS, Dunn MJ, Rose ML, Brady P, Yacoub MH: Frequency and specificity of antiheart antibodies in patients with dilated cardiomyopathy detected using SDS-PAGE and western blotting. J Am Coll Cardiol 22: 1378-1384, 1993
4. Neumann DA, Burek CL, Baughman KL, Rose NR, Herskowitz A: Circulating heart-reactive antibodies in patients with myocarditis or cardiomyopathy. J Am Coll Cardiol 16: 839-846, 1990
5. Caforio ALP, Grazzini M, Mann JM, Keeling PJ, Bottazzo GF McKenna WJ, Schiffino S: Identification of alpha and β myosin heavy chain isoforms as major autoantigens in dilated cardiomyopathy. Circulation 85: 1734-172, 1992
6. Schultheiss HP, Schwimmbeck P, Bolte FIDs Klingenberg M: The antigenic characteristics and the significance of the adenine nucleotide translocator as a major autoantigen to antimitochondrial antibodies in dilated cardiomyopathy. Adv Myocardiol 6: 311-327, 1985
7. Schulze K, Becker BF, Schauer R, Schultheiss HP: Antibodies to ADP-ATP carrier-an autoantigen in myocarditis and dilated cardiomyopathy-impaired cardiac function. Circulation 81: 959-969, 1990
8. Ansari AA, Herskowitz A, Danner DJ: Identification of mitochondrial proteins that serve as targets for autoimmunity in human dilated cardiomyopathy. Circulation 1988, 78 suppl 457
9. Klein R, Maisch B, Kochsiek K, Berg PA: Demonstration of organ-specific antibodies against heart mitochondria (anti-M7) in sera from patients with some forms of heart diseases. Clin Exp Immunol 58: 283-292, 1984
10. Ansari AA, Neckemann N, Villinger F, Leung P, Danner DJ, Brar SS, Zhao S, Gravanis MB, Mayne A, Gershwin ME, Herskowitz A: Epitope mapping of the branched chain alpha-ketoacid dehydrogenase dihydrolipoyl transacylase (BCKD-E2) protein that reacts with sera from patients with idiopathic dilated cardiomyopathy. J Immunol 153: 4754-4765, 1994
11. Wolff PG, Kuhl U. Schultheiss HP: Laminin distribution and autoantibodies to laminin in dilated cardiomyopathy and myocarditis. Am Heart J 117: 1303-1309, 1989
12. Sterin-Borda LA, Cremaschi G, Pascual J, Genaro A, Borda E: Alloimmune IgG binds and modulates cardiac β-adrenergic receptors. Clin Exp Immunol 58: 223-228, 1984
13. Limas CJ, Goldenberg IF, Limas C: Autoantibodies against β-adrenoreceptors in human dilated cardiomyopathy. Circ Res 64: 97-103, 1989
14. Limas CJ, Limas C, Kubo SH, Olivari MT: Anti-β receptor antibodies in human dilated cardiomyopathy and correlation with HLA-DR antigens. Am J Cardiol 65: 483-487, 1990
15. Magnusson Y, Marullo S, Hoyer S, Waagstein F, Andersson B, Vahln A, Guillet JG, Strosberg AD. Hjalmarson Å. Hoebeke J: Mapping of a functional autoimmune epitope on the β1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy. J Clin Invest 86: 1658-1663, 1990
16. Wallukat G, Morwinski M, Kowal K, Forster A, Boewer V, Wollenberger A: Antibodies against the β-adrenergic receptor in myocarditis and cardiomyopathy: β-adrenergic agonism without desensitization. Eur Heart J 12 (suppl D): 178-181, 1991
17. Limas CJ, Limas C. HLA-DR antigen linkage of anti-β receptor antibodies in idiopathic dilated and ischemic cardiomyopathy. Br Heart J 67: 402-405, 1992
18. Fu LX, Magnusson Y, Bergh C-H, Liljeqvist J-A, Waagstein F, Hjalmarson Å, Hoebeke J: Localization of a functional autoimmune epitope of second extracellular loop of the human muscarinic receptor in patients with idiopathic dilated cardiomyopathy. J Clin Invest 91: 1964-1968, 1993
19. Fu LXM, Hoebeke J, Matsui S, Matoba M, Magnusson Y, Hedner T, Herlitz H , Hjalmarson Å: Autoantibodies against cardiac G-protein-coupled receptors define different populations with cardiomyopathies but not with hypertension. Clin Immunol Immunopathol 72: 15-20, 1994
20. Matsui S, Fu LXM, Shimizu M, Fukuoka T, Teraoka K, Takekoshi N, Murakami E, Hjalmarson Å: Dilated cardiomyopathy defines serum autoantibodies against G-protein coupled cardiovascular receptors. Autoimmunity 21: 85-88, 1995
21. Fleming JW, Strawbridge RA, Watanabe AM: Muscarinic receptor regulation of cardiac adenylate cyclase activity. J Mol Cell Cardiol 19: 47-61, 1987
22. Levine RR, Birdsall NJM (eds). Nomenclature for muscarinic receptor subtypes recommended by symposium. Trends Pharmacol Sci 10(suppl): VII, 1989
23. Sterin-Borda L, Gorelik G, Borda ES: Chagasic IgG binding with cardiac muscarinic cholinergic receptors modifies cholinergic-mediated cellular transmembrane signals. Clin Immunol Immunopathol 61: 387-391, 1991
24. Fu LXM, Herlitz H, Wallukat G, Hilme E, Hedner T, Hoebeke J, Hjalmarson Å: A functional autoimmune epitope on alpha 1 adrenoceptors in patients with malignant hypertension. Lancet 344: 1660-1663, 1994
25. Fu LXM, Schulze W, Wallukat G, Hjalmarson Å, Hoebeke J: Functional epitope analysis of the second extracellular loop of the human heart muscarinic acetylcholine receptor. J Mol Cell Cardiol. 27: 427-436, 1995
26. Fu LXM, Wallukat G, Hjalmarson Å, Hoebeke J: Agonist-like activity of anti-peptide antibodies directed against an autoimmune epitope of human heart muscarinic acetylcholine receptor. Receptor and Channel 2: 121-130, 1994
27. Wang WZ, Zhao R, Wu BW, Fu LXM, Jin XH, Lin Z: Effects of anti-peptide antibodies against human M2 muscarinic receptors on cardiac function in rats in vivo. Blood Pressure 1996 (in press)
28. Wang WZ, Zhao R, Fu LXM, Lin Z, Jin XH: Effects of anti-peptide antibodies against M2 muscarinic receptors on the cAMP generating system in guinea-pig ventricles. Blood Pressure 1996 (in press)
29. Zhao R, Wang WZ, Wu B, Hoebeke J, Hjalmarson Å, Fu LXM: Effects of anti-peptide antibodies against the second extracellular loop of human M2 muscarinic acetylcholine receptors on transmembrane potentials and currents in guinea pig ventricular myocytes. Mol Cell Biochem 1996 (in press)
30. Fu LXM, Schulze W, Wolf WP, Hjalmarson Å, Hoebeke J: Immunocytochemical localization of M2 muscarinic receptor in rat ventricles using anti-peptide antibodies. J Histochem Cytochem 42: 337343, 1994
31. Zhu L, Wang WZ, Jin XH, Zhao R, Fu LXM: Immunocytochemical studies of M2 muscarinic receptors in guinea-pig atria and ventricles using anti-peptide antibodies. Blood Pressure 1996 (in press)
32. Schulze W, Fu LXM, Hoebeke J, Hjalmarson Å: Localization of muscarinic receptors in heart biopsies from patients with heart disease using rabbit antibodies against an autoimmune epitope on human M2 muscarinic receptors. J Mol Cell Cardiol 27: 1757-1764, 1995
33. Fu LXM, Herlitz H, Schulze W, Wallukat G, Hoebeke J, Hjalmarson Å: Autoantibodies against an extracellular domain on human angiotensin II receptor subtype 1 in patients with malignant hypertension (abstract). Circulation 1337: (suppl), 1995