Role of Ca2+-independent PKC in α1-adrenoceptormediated inotropic responses of neonatal rat hearts

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 273, Issue 3 42-3, 1997, Pages

  Deng, Xing Fei ^a   Mulay, Shree ^a   Varma, Daya R ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Bisindolylmaleimide; Diacylglycerol; Diacylglycrol kinase inhibitor; Go 6976; Phorbol 12,13 dibutyrate; Phosphatidylinositide; Protein kinase C isoforms; Thymeleatoxin

Indexed keywords

3 [2 [4 (4,4' DIFLUOROBENZHYDRYLIDENE)PIPERIDINO]ETHYL] 2,3 DIHYDRO 2 THIOXO 4(1H) QUINAZOLINONE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; BISINDOLYLMALEIMIDE; DIACYLGLYCEROL KINASE; ISOPRENALINE; METHOXAMINE; PHENYLEPHRINE; PHORBOL DIBUTYRATE; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C INHIBITOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HEART CONTRACTION; INOTROPISM; NEWBORN; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

EID: 33751269675     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1997.273.3.h1113     Document Type: Article

References (19)

1. 1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated epididymal vas deferens. Br. J. Pharmacol. 117: 224-230, 1996.
2. Clerk, A., M. A. Bogoyevitch, M. B. Andersson, and P. H. Sugden. Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts. J. Biol. Chem. 269: 32848-32857, 1994.
3. De Chaffoy de Courcelles, D., P. Roevens, H. Van Belle, L. Kennis, Y. Somers, and F. De Clerck. The role of endogenously formed diacylglycerol in the propagation and termination of platelet activation. A biochemical and functional analysis using the novel diacylglycerol kinase inhibitor, R 59 949. J. Biol. Chem. 264: 3274-3285, 1989.
4. 1-adrenoceptor subtypes in rats. J. Pharmacol. Exp. Ther. 276: 1155-1161, 1996.
5. 1D-adrenoceptor subtype in rat myocardium, aorta and other tissues. Br. J. Pharmacol. 119: 269-276, 1996.
6. 1D-Adrenoceptors do not contribute to inotropic responses of neonatal rat myocardium. J. Cardiovasc. Pharmacol. 29: 57-60, 1997.
7. Divecha, N., and R. F. Irvine. Phospholipid signaling. Cell 80: 269-278, 1995.
8. 1-adrenoceptors. Jpn. J. Pharmacol. 63: 17-26, 1993.
9. 1-adrenoceptor-mediated positive inotropic effects. Am. J. Physiol. 260 (Heart Circ. Physiol. 29): H27-H36, 1991.
10. 1-Adrenergic receptor subtypes. Molecular structure, function, and signaling. Circ. Res. 78: 737-749, 1996.
11. 2+ signaling in quiescent neonatal cardiac myocytes. Biochim. Biophys. Acta 1224: 517-526, 1994.
12. House, C., and B. E. Kemp. Protein kinase C contains a pseudosubstrate prototype in its regulatory domain. Science 238: 1726-1728, 1987.
13. Inayatulla, A., D. Y. Li, S. Chemtob, and D. R. Varma. Ontogeny of positive inotropic responses to sympathomimetic agents and of myocardial adrenoceptors in rats. Can. J. Physiol. Pharmacol. 72: 361-367, 1994.
14. Johnson, J. A., and D. Mochly-Rosen. Inhibition of the spontaneous rate of contraction of neonatal cardiac myocytes by protein kinase C isozymes. A putative role for the ε isozymes. Circ. Res. 76: 654-663, 1995.
15. Kijima, Y., A. Saito, T. L. Jetton, M. A. Magnuson, and S. Fleischer. Different intracellular localization of inositol 1,4,5-trisphosphate and ryanodine receptors in cardiomyocytes. J. Biol. Chem. 268: 3499-3506, 1993.
16. Martiny-Baron, G., M. G. Kazanietz, H. Mischak, P. M. Blumberg, G. Kochs, H. Hug, D. Marme, and C. Schachtele. Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. J. Biol. Chem. 268: 9194-9197, 1993.
17. Nishizuka, Y. Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 9: 484-496, 1995.
18. 1-adrenoceptor stimulation and phorbol ester in rat isolated left ventricular papillary muscle. Br. J. Pharmacol. 107: 22-26, 1992.
19. Puceat, M., R. Hilal-Dandan, B. Strulovici, L. L. Brunton, and J. H. Brown. Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes. J. Biol. Chem. 269: 16938-16944, 1994.