MMP-8 is only a minor gene product of human adult articular chondrocytes of the knee

Clinical and Experimental Rheumatology

Volumn 21, Issue 2, 2003, Pages 205-209

  Stremme, Sebastian ^a   Duerr, Stefan ^a   Bau, Brigitte ^a   Schmid, Erik ^a   Aigner, Thomas ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Aggrecanase; Cartilage; Collagen; Collagenase; Metalloproteinases; Osteoarthritis

Indexed keywords

COLLAGEN FIBRIL; COLLAGENASE; COLLAGENASE 3; GENE PRODUCT; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; MESSENGER RNA; MONOCLONAL ANTIBODY; NEUTROPHIL COLLAGENASE;

ADULT; AGED; ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CARTILAGE MATRIX; CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME DEGRADATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; KNEE OSTEOARTHRITIS; MALE; ONLINE ANALYSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; SYNOVIUM; TISSUE DISTRIBUTION; UPREGULATION;

ADULT; AGED; AGED, 80 AND OVER; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; FEMALE; HUMANS; INTERLEUKIN-1; MALE; MATRIX METALLOPROTEINASE 8; MIDDLE AGED; OSTEOARTHRITIS, KNEE; SYNOVIAL MEMBRANE;

EID: 0037366862     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. NGUYEN Q, MORT JS, ROUGHLEY PJ: Preferential mRNA expression of prostromelysin relative to procollagenase and in situ localization in human articular cartilage. J Clin Invest 1992; 89:1189-97.
2. MITCHELL PG, MAGNA HA, REEVES LM et al.: Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic, cartilage. J Clin Invest 1996; 97:761-8.
3. REBOUL P, PELLETIER JP, TARDIF G, CLOUTIER J-M, MARTEL-PELLETIER J: The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. J Clin Invest 1996; 97:2011-9.
4. BAU B, GEBHARD PM, HAAG J, KNORR T, BARTNIK E, AIGNER T: Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro. Arthritis Rheum 2002; 46:2648-57.
5. AIGNER T, ZIEN A, GEHRSITZ A, GEBHARD PM, MCKENNA LA: Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology. Arthritis Rheum 2001; 44:2777-89.
6. CHUBINSKAYA S, HUCH K, MIKECZ K et al.: Chondrocyte matrix metalloproteinase-8: up-regulation of neutrophil collagenase by interleukin-1 in human cartilage from knee and ankle joints. Lab Invest 1996; 74: 232-40.
7. COLE AA, CHUBINSKAYA S, SCHUMACHER BL et al.: Chondrocyte matrix metalloproteinase-8. J Biol Chem 1996; 271:11023-6.
8. AIGNER T, NEUREITER D, MÜLLER S, KÜSPERT G, BELKE J, KIRCHNER T: Extracellular matrix composition and gene expression in collagenous colitis. Gastroenterology 1997; 113:136-43.
9. MCKENNA LA, GEHRSITZ A, SOEDER S, EGER W, KIRCHNER T, AIGNER T: Effective isolation of high quality total RNA from human adult articular cartilage. Anal Biochem 2000; 286:80-5.
10. GEHRSITZ A, MCKENNA LA, SOEDER S, KIRCHNER T, AIGNER T: Isolation of RNA from small human articular cartilage specimens allows quantification of mRNA expression levels in local articular cartilage defects. J Orthop Res 2001; 19:478-82.
11. KANDEL RA, PETELYCKY M, DINARELLO CA, MINDEN M, PRITZKER KPH, CRUZ TF: Comparison of the effect of interleukin 6 and interleukin 1 on collagenase and proteoglycan production by chondrocytes. J Rheumatol 1990; 17:953-7.
12. STEPHENSON ML, GOLDRING MB, BIRKHEAD JR, KRANE M, RAHMSDORF HJ, ANGEL P: Stimulation of procollagenase synthesis parallels increases in cellular procollagenase mRNA in human articular chondrocytes exposed to recombinant interleukin 1b or phorbol ester. Biochem Biophys Res Commun 1987; 144-2:583-90.
13. MENGSHOL JA, VINCENTI MP, COON CI, BARCHOWSKY A, BRINCKERHOFF CE: Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum 2000; 43:801-11.
14. COLE AA, KUETTNER KE: MMP-8 (neutrophil collagenase) mRNA and aggrecanase cleavage products are present in normal and osteoarthritic human articular cartilage. Acta Orthop Scand 1995; 66:98-102.
15. TETLOW LC, ADLAM DJ, WOOLLEY DE: Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes. Arthritis Rheum 2001; 44:585-94.
16. NEUHOLD LA, KILLAR L, ZHAO W et al.: Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice. J Clin Invest 2001; 107: 35-44.