DNA replicative functions of highly-expressed, codon-optimized human papillomavirus proteins E1 and E2

Journal of Virological Methods

Volumn 108, Issue 1, 2003, Pages 83-90

  Wang, Xin Min ^a   Jansen, Kathrin U ^a   McClements, William L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

DNA replication; E1; E2; Papillomavirus; Real time PCR; Vaccine

Indexed keywords

GLYCOPROTEIN E1; PROTEIN E2; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS PROTEIN;

ARTICLE; CODON; CONTROLLED STUDY; DNA REPLICATION; DNA REPLICATION ORIGIN; DNA SYNTHESIS; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; WART VIRUS;

AMINO ACID SUBSTITUTION; BASE SEQUENCE; CELL LINE; CODON; DNA REPLICATION; DNA, VIRAL; DNA-BINDING PROTEINS; HUMANS; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRIDAE; PLASMIDS; POINT MUTATION; POLYMERASE CHAIN REACTION; VIRAL VACCINES; VIROLOGY;

HUMAN PAPILLOMAVIRUS; HUMAN PAPILLOMAVIRUS TYPE 16; PAPILLOMAVIRUS;

EID: 0037357497     PISSN: 01660934     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-0934(02)00262-8     Document Type: Article

References (49)

1. Bauer-Hofmann R., Borghouts C., Auvinen E., Bourda E., Rosl F., Alonso A. Genomic cloning and characterization of the nonoccupied allele corresponding to the integration site of human papillomavirus type 16 DNA in the cervical cancer cell line SiHa. Virology. 217:1996;33-41.
2. Bosch F.X., Manos M.M., Munoz N., Sherman M., Jansen A.M., Peto J., Schiffman M.H., Moreno V., Kurman R., Shah K.V. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) Study Group. J. Natl. Cancer Inst. 87:1995;796-802.
3. Breitburd F., Kirnbauer R., Hubbert N.L., Nonnenmacher B., Trin-Dinh-Desmarquet C., Orth G., Schiller J.T., Lowy D.R. Immunization with virus-like particles from cottontail rabbit papillomavirus (CRPV) can protect against experimental CRPV infection. J. Virol. 69:1995;3959-3963.
4. Brown D.R., Bryan J.T., Cramer H., Fife K.H. Analysis of human papillomavirus types in exophytic condylomata acuminata by hybrid capture and Southern blot techniques. J. Clin. Microbiol. 131:(10):1993;2667-2673.
5. Brown D.R., Bryan J.T., Schroeder J.M., Robinson T.S., Fife K.H., Wheeler C.M., Barr E., Smith P.R., Chiacchierini L., DiCello A., Jansen K.U. Neutralization of human papillomavirus type 11 (HPV-11) by serum from women vaccinated with yeast-derived HPV-11 L1 virus-like particles: correlation with competitive radioimmunoassay titer. J. Infect. Dis. 184:(9):2001;1183-1186.
6. Chow L.T., Broker T.R. Papillomavirus DNA replication. Intervirology. 37:1994;150-158.
7. Christensen N.D., Hopfl R., DiAngelo S.L., Cladel N.M., Patrick S.D., Welsh P.A., Budgeon L.R., Reed C.A., Kreider J.W. Assembled baculovirus-expressed human papillomavirus type 11 L1 capsid protein virus-like particles are recognized by neutralizing monoclonal antibodies and induce high titres of neutralizing antibodies. J. Gen. Virol. 75:1994;2271-2276.
8. Christensen N.D., Reed C.A., Cladel N.M., Han R., Kreider J.W. Immunization with virus-like particles induces long-term protection of rabbits against challenge with cottontail rabbit papillomavirus. J. Virol. 70:1996;960-965.
9. Collier B., Oberg D., Zhao X., Schwartz S. Specific inactivation of inhibitory sequences in the 5′ end of the human papillomavirus type 16 L1 open reading frame results in production of high levels of L1 protein in human epithelial cells. J. Virol. 76:2002;2739-2752.
10. Del Vecchio A.M., Romanczuk H., Howley P.M., Baker C.C. Transient replication of human papillomavirus DNAs. J. Virol. 66:1992;5949-5958.
11. Desaintes C., Demeret C. Control of papillomavirus DNA replication and transcription. Semin. Cancer Biol. 7:1996;339-347.
12. Dupuy C., Buzoni-Gatel D., Touze A., Le-Cann P., Bout D., Coursaget P. Cell mediated immunity induced in mice by HPV 16 L1 virus-like particles. Microb. Pathog. 22:1997;219-225.
13. Emeny R.T., Wheeler C.M., Jansen K.U., Hunt W.C., Fu T.-M., Smith J.F., MacMullen S., Esser M.T., Paliard X. Priming of human papillomavirus type 11-specific humoral and cellular immune responses in college-aged women with a virus-like particle vaccine. J. Virol. 76:2002;7832-7842.
14. Evans T.G., Bonnez W., Rose R.C., Koenig S., Demeter L., Suzich J.A., O'Brien D., Campbell M., White W.I., Balsley J., Reichman R.C. A Phase 1 study of a recombinant viruslike particle vaccine against human papillomavirus type 11 in healthy adult volunteers. J. Infect. Dis. 183:2001;1485-1493.
15. Ferguson M.K., Botchan M.R. Genetic analysis of the activation domain of bovine papillomavirus protein E2: its role in transcription and replication. J. Virol. 70:1996;4193-4199.
16. Gissmann L., Wolnik L., Ikenberg H., Koldovsky U., Schnurch H.G., zur Hausen H. Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers. Proc. Natl. Acad. Sci. USA. 80:1983;560-563.
17. Haas J., Park E.C., Seed B. Codon usage limitation in the expression of HIV-1 envelope glycoprotein. Curr. Biol. 6:1996;315-324.
18. Hagensee M.E., Yaegashi N., Galloway D.A. Self-assembly of human papillomavirus type 1 capsids by expression of the L1 protein alone or by coexpression of the L1 and L2 capsid proteins. J. Virol. 67:1993;315-322.
19. Han R., Reed C.A., Cladel N.M., Christensen N.D. Immunization of rabbits with cottontail rabbit papillomavirus E1 and E2 genes: protective immunity induced by gene gun mediated intracutaneous delivery but not by intramuscular injection. Vaccine. 18:2000;2937-2944.
20. Harro C.D., Pang Y.Y., Roden R.B., Hildesheim A., Wang Z., Reynolds M.J., Mast T.C., Robinson R., Murphy B.R., Karron R.A., Dillner J., Schiller J.T., Lowy D.R. Safety and immunogenicity trial in adult volunteers of a human papillomavirus 16 L1 virus-like particle vaccine. J. Natl. Cancer Inst. 93:2001;284-292.
21. Hirt B. Selective extraction of polyma DNA from infected mouse cell cultures. J. Mol. Biol. 26:1967;365-369.
22. Hofmann K.J., Cook J.C., Joyce J.G., Brown D.R., Schultz L.D., George H.A., Rosolowsky M., Fife K.H., Jansen K.U. Sequence determination of human papillomavirus type 6a and assembly of virus-like particles in Saccharomyces cerevisiae. Virology. 209:1995;506-518.
23. Howley P.M. Papillomavirinae: the virus and their replication. Fields B.N., Knipe D.M., Howley P.M., et al. Fields Virology. third ed: 1996;2045-2076 Lippincott-Raven, Philadelphia.
24. Imler J.L. Adenovirus vectors as recombinant viral vaccines. Vaccine. 13:1995;1143-1151.
25. Jansen K.U., Rosolowsky M., Schultz L.D., Markus H.Z., Cook J.C., Donnely J.J., Martinez D., Ellis R.W., Shaw A.R. Vaccination with yeast expressed cottontail rabbit papillomavirus (CRPV) virus-like particles protects rabbits from CRPV-induced papilloma formation. Vaccine. 13:1995;1509-1514.
26. Kasukawa H., Howley P.M., Benson J.D. A fifteen-amino-acid peptide inhibits human papillomavirus E1-E2 interaction and human papillomavirus DNA replication in vitro. J. Virol. 72:1998;8166-8173.
27. Kirnbauer R., Booy F., Cheng N., Lowy D.R., Schiller J.T. Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic. Proc. Natl. Acad. Sci. USA. 89:1992;12180-12184.
28. Kirnbauer R., Chandrachud L., O'Neil B., Wagner E., Grindlay G., Armstrong A., McGarvie G., Schiller J., Lowy D., Campo M. Virus-like particles of bovine papillomavirus type 4 in prophylactic and therapeutic immunization. Virology. 187:1996;612-619.
29. Leder C., Kleinschmidt J.A., Wiethe C., Muller M. Enhancement of capsid gene expression: preparing the human papillomavirus type 16 major structural gene L1 for DNA vaccination purposes. J. Virol. 75:2001;9201-9209.
30. Masterson P.J., Stanley M.A., Lewis A.P., Romanos M.A. A C-terminal helicase domain of the human papillomavirus E1 protein binds E2 and the DNA polymerase alpha-primase p68 subunit. J. Virol. 72:1998;7407-7419.
31. McBride A.A., Romanczuk H., Howley P.M. The papillomavirus E2 regulatory proteins. J. Biol. Chem. 266:1991;18411-18414.
32. Montgomery D.L., Shiver J.W., Leander K.R., Perry H.C., Friedman A., Martinez D., Ulmer J.B., Donnelly J.J., Liu M.A. Heterologous and homologous protection against influenza A by DNA vaccination: optimization of DNA vectors. DNA Cell. Biol. 12:1993;777-783.
33. Moscufo N., Sverdrup F., Breiding D.E., Androphy E.J. Two distinct regions of the BPV1 E1 replication protein interact with the activation domain of E2. Virus Res. 65:1999;141-154.
34. Neeper, M.P., McClements, W.L., Jansen, K.U., Schultz, L.D., Chen, L., Wang, X.-M., Inventors, Merck & Co., Inc, Assignee, 2001. Synthetic Human Papillomavirus Genes. Patent Cooperation Treaty (PCT) International Publication Number WO 01/14416 A2.
35. Palker T.J., Monteiro J.M., Martin M.M., Kakareka C., Smith J.F., Cook J.C., Joyce J.G., Jansen K.U. Antibody, cytokine and cytotoxic T lymphocyte responses in chimpanzees immunized with human papillomavirus virus-like particles. Vaccine. 19:2001;3733-3743.
36. Peng S., Frazer I.H., Fernando G.J., Zhou J. Papillomavirus virus-like particles can deliver defined CTL epitopes to the MHC class I pathway. Virology. 5:1998;147-157.
37. Pisani P., Parkin D.M., Ferlay J. Estimates of the worldwide mortality from eighteen major cancers in 1985. Implications for prevention and projections of future burden. Int. J. Cancer. 55:1993;891-903.
38. Rose R.C., Bonnez W., Reichman R.C., Garcea R.L. Expression of human papillomavirus type 11 L1 protein in insect cells: in vivo and in vitro assembly of viruslike particles. J. Virol. 67:1993;1936-1944.
39. Sakai H., Yasugi T., Benson J.D., Dowhanick J.J., Howley P.M. Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functions. J. Virol. 70:1996;1602-1611.
40. Schäfer K., Muller M., Faath S., Henn A., Osen W., Zentgraf H., Benner A., Gissmann L., Jochmus I. Immune response to human papillomavirus 16 L1E7 chimeric virus-like particles: induction of cytotoxic T cells and specific tumor protection. Int. J. Cancer. 81:1999;881-888.
41. Storey A., Piccini A., Massimi P., Bouvard V., Banks L. Mutations in the human papillomavirus type 16 E2 protein identify a region of the protein involved in binding to E1 protein. J. Gen. Virol. 76:1995;819-826.
42. Suzich J.A., Ghim S., Palmer-Hill F.J., White W.I., Tamura J.K., Bell J.A., Newsome J.A., Jenson A.B., Schlegel R. Systemic immunization with papillomavirus L1 proteins completely prevents the development of viral mucosal papillomas. Proc. Natl. Acad. Sci. USA. 92:1995;11553-11557.
43. Tobery T.W., Wang S., Wang X.-M., Neeper M.P., Jansen K.U., McClements W.L., Caulfield M.J. A simple and efficient method for the monitoring of antigen-specific T cell responses using peptide pool arrays in a modified ELISpot assay. J. Immunol. Methods. 254:2001;59-66.
44. Ulmer J.B., Donnelly J.J., Parker S.E., Rhodes G.H., Felgner P.L., Dwarki V.J., Gromkowski S.H., Deck R.R., DeWitt C.M., Friedman A., Hawe L.A., Leander K.R., Martinez D., Perry H.C., Shiver J.W., Montgomery D.L., Liu M.A. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science. 259:1993;1745-1749.
45. Yasugi T., Benson J.D., Sakai H., Vidal M., Howley P. Mapping and characterization of the interaction domains of human papillomavirus type 16 E1 and E2 proteins. J. Virol. 71:1997;891-899.
46. Yasugi T., Vidal M., Sakai H., Howley P.M., Benson J.D. Two classes of human papillomavirus type 16 E1 mutants suggest pleiotropic conformational constraints affecting E1 multimerization, E2 interaction, and interaction with cellular proteins. J. Virol. 71:1997;5942-5951.
47. Zhou J., Liu W.J., Peng S.W., Sun X.Y., Frazer I. Papillomavirus capsid protein expression level depends on the match between codon usage and tRNA availability. J. Virol. 73:1999;4972-4982.
48. Zhou J., Sun X.Y., Stenzel D.J., Frazer I.H. Expression of vaccinia recombinant HPV 16 L1 and L2 ORF proteins in epithelial cells is sufficient for assembly of HPV virion-like particles. Virology. 185:(1):1991;251-257.
49. Zou N., Liu J.S., Kuo S.R., Broker T.R., Chow L.T. The carboxyl-terminal region of the human papillomavirus type 16 E1 protein determines E2 protein specificity during DNA replication. J. Virol. 72:1998;3436-3441.