Non-synonymous single nucleotide alterations in the microsomal epoxide hydrolase gene and their functional effects

Xenobiotica

Volumn 33, Issue 3, 2003, Pages 277-287

  Maekawa, K ^a   Itoda, M ^a   Hanioka, N ^a   Saito, Y ^a   Murayama, N ^a   Nakajima, O ^a   Soyama, A ^a   Ishida, S ^a   Ozawa, S ^a   Ando, M ^a   Sawada, J ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; EPOXIDE HYDROLASE; STILBENE OXIDE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL LINE; CELL STRAIN COS1; CONTROLLED STUDY; DNA EXTRACTION; ENZYME ACTIVITY; EXON; GENE FUNCTION; GENETIC TRANSFECTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; INTRON; JAPAN; NONHUMAN; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL LINE; CERCOPITHECUS AETHIOPS; COS CELLS; DNA; DNA PRIMERS; EPOXIDE HYDROLASES; EXONS; HYDROLYSIS; INTRONS; KINETICS; MICROSOMES, LIVER; PLASMIDS; POLYMORPHISM, SINGLE NUCLEOTIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STILBENES;

ANIMALIA;

EID: 0037357366     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/0049825021000061615     Document Type: Article

References (29)

1. ARAND, M., MULLER, F., MECKY, A., HINZ, W., URBAN, P., POMPON, D., KELLNER, R. and OESCH, F., 1999, Catalytic triad of microsomal epoxide hydrolase: replacement of Glu404 with Asp leads to a strongly increased turnover rate. Biochemical Journal, 337, 37-43.
2. BELL, P. A. and KASPER, C. B., 1993, Expression of rat microsomal epoxide hydrolase in Escherichia coli. Identification of a histidyl residue essential for catalysis. Journal of Biological Chemistry, 268, 14011-14017.
3. BENHAMOU, S., REINIKAINEN, M., BOUCHARDY, C., DAYER, P. and HIRVONEN, A., 1998, Association between lung cancer and microsomal epoxide hydrolase genotypes. Cancer Research, 58, 5291-5293.
4. BROWN, T. and MACKEY, K., 1997, Analysis of RNA by Northern and slot blot hybridization. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith and K. Struhl (eds), Current Protocols in Molecular Biology (New York: Wiley), suppl. 37, unit 4.9.
5. CHRISTOU, M., JOVANOVICH, M. C. and JEFCOATE, C. R., 1989, Epoxide hydratase: sex specific expression and rate-limiting role in DMBA metabolism. Carcinogenesis, 10, 1883-1890.
6. EKINS, S., MAENPAA, J. and WRIGHTON, S. A., 1999, In vitro metabolism: subcelluar fractions. In T. F. Woolf (ed.), Handbook of Drug Metabolism (New York: Marcel Dekker), pp. 363-399.
7. FRETLAND, A. J. and OMIECINSKI, C. J., 2000, Epoxide hydrolase: biochemistry and molecular biology. Chemico-Biological Interactions, 129, 41-59.
8. GAEDIGK, A., SPIELBERG, S. P. and GRANT, D M., 1994, Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions. Pharmacogenetics, 4, 142-153.
9. HARRISON, D. J., HUBBARD, A. L., MACMILLAN, J., WYLLIE, A. H. and SMITH, C. A., 1999, Microsomal epoxide hydrolase gene polymorphism and susceptibility to colon cancer. British Journal of Cancer, 79, 168-171.
10. HASSETT, C., AICHER, L., SIDHU, J. S. and OMIECINSKI, C. J., 1994, Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants. Human Molecular Genetics, 3, 421-428.
11. JERINA, D. M., 1983, Metabolism of Aromatic hydrocarbons by the cytochrome P-450 system and epoxide hydrolase. Drug Metabolism and Disposition, 11, 1-4.
12. KITTERINGHAM, N. R., DAVIS, C., HOWARD, N., PIRMOHAMED, M. and PARK, K., 1996, Interindividual and interspecies variation in hepatic microsomal epoxide hydrolase activity: studies with cis-stilbene oxide, carbamazepine 10,11-epoxide and naphthalene. Journal of Pharmacology and Experimental Therapeutics, 278, 1018-1027.
13. LAURENZANA, E. M., HASSETT, C. and OMIECINSKI, C. J., 1998, Post-transcriptional regulation of human microsomal epoxide hydrolase. Pharmacogenetics, 8, 157-167.
14. LEBAILLY, P, WILLETT, E. V., MOORMAN, A. V., ROMAN, E., CARTWRIGHT, R., MORGAN, G. J. and WILD, C. P., 2002, Genetic polymorphisms in microsomal epoxide hydrolase and susceptibility to adult acute myeloid leukaemia with defined cytogenetic abnormalities. British Journal of Haematology, 116, 587-594.
15. LIN, P., WANG, S. L., WANG, H. J., CHEN, K. W., LEE, H. S., TSAI, K. J., CHEN, C. Y. and LEE, H., 2000, Association of CYP1A1 and microsomal epoxide hydrolase polymorphisms with lung squamous cell carcinoma. British Journal of Cancer, 82, 852-857.
16. OESCH, F., GLATT, H. and SCHMASSMANN, H., 1977, The apparent ubiquity of epoxide hydrotase in rat organs. Biochemical Pharmacology, 26, 603-607.
17. OMIECINSKI, C. J., AICHER, L., HOLUBKOV, R. and CHECKOWAY, H., 1993, Human peripheral lymphocytes as indicators of microsomal epoxide hydrolase in liver and lung. Pharmacogenetics, 3, 150-158.
18. RAAKA, S., HASSETT, C. and OMIECINSKI, J., 1998, Human microsomal epoxide hydrolase: 5′-flanking region genetic polymorphisms. Carcinogenesis, 19, 387-393.
19. SAITO, S., IIDA, A., SEKINE, A., EGUCHI, C., MIURA, Y. and NAKAMURA, Y., 2001, Seventy genetic variations in human microsomal and soluble epoxide hydrolase genes (EPHX1 and EPHX2) in the Japanese population. Journal of Human Genetics, 46, 325-329.
20. SEIDEGARD, J. and DEPIERRE, J. W., 1983, Microsomal epoxide hydrolase. Properties, regulation and function. Biochimica et Biophysica Acta, 695, 251-270.
21. SEIDEGARD, J., DEPIERRE, J. W. and PERO, R. W., 1984, Measurement and characterization of membrane-bound and soluble epoxide hydrolase activities in resting mononuclear leukocytes from human blood. Cancer Research, 44, 3654-3660.
22. SIMS, P, GROVER, P. L., SWAISLAND, A., PAL, K. and HEWER, A., 1974, Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide. Nature, 252, 326-328.
23. SMITH, C. A. and HARRISON, D. J., 1997, Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema. Lancet, 350, 630-633.
24. TYBRING, G., VON BAHR, C., BERTILSSON, L., COLLSTE, H., GLAUMANN, H. and SOLBRAND, M., 1981, Metabolism of carbamazepine and its epoxide metabolite in human and rat liver in vitro. Drug Metabolism and Disposition, 9, 561-564.
25. TZENG, H. F., LAUGHLIN, L. T. and ARMSTRONG, R. N., 1998, Semifunctional site-specific mutants affecting the hydrolytic half-reaction of microsomal epoxide hydrolase. Biochemistry, 37, 2905-2911.
26. VOGEL-BINDEL, U., BENTLEY, P. and OESCH, F., 1982, Endogenous role of microsomal epoxide hydrolase. Ontogenesis, induction inhibition, tissue distribution, immunological behaviour and purification of microsomal epoxide hydrolase with 16 alpha, 17 alpha-epoxyandrostene-3-one as substrate. European Journal of Biochemistry, 126, 425-431.
27. WATABE, T., KANAI, M., ISOBE, M. and OZAWA, N., 1981, The hepatic microsomal biotransformation of delta 5-steroids to 5 alpha, 6 beta-glycols via alpha- and beta-epoxides. Journal of Biological Chemistry, 256, 2900-2907.
28. WONG, N. A., RAE, F., BATHGATE, A., SMITH, C. A. and HARRISON, D. J., 2000, Polymorphisms of the gene for microsomal epoxide hydrolase and susceptibility to alcoholic liver disease and hepatocellular carcinoma in a Caucasian population. Toxicology Letters, 115, 17-22.
29. YOSHIKAWA, M., HIYAMA, K., ISHIOKA, S., MAEDA, H., MAEDA, A. and YAMAKIDO, M., 2000, Microsomal epoxide hydrolase genotypes and chronic obstructive pulmonary disease in Japanese. International Journal of Molecular Medicine, 51, 49-53.