hSMUG1 can functionally compensate for Ung1 in the yeast Saccharomyces cerevisiae

DNA Repair

Volumn 2, Issue 3, 2003, Pages 315-323

  Elateri, Imane ^a   Tinkelenberg, Beverly A ^a   Hansbury, Michael ^b   Caradonna, Sal ^a   Muller Weeks, Susan ^a   Ladner, Robert D ^a  

^a UMDNJ School of Osteopathic Medicine   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Antifolates; Base excision repair; Fluoropyrimidines; SMUG; Uracil misincorporation; Uracil DNA glycosylase

Indexed keywords

DNA GLYCOSYLTRANSFERASE; FOLIC ACID ANTAGONIST; FUNGAL ENZYME; HSMUG1 ENZYME; SINGLE STRANDED DNA; UNCLASSIFIED DRUG; UNG1 ENZYME; URACIL;

ARTICLE; CELL CYCLE S PHASE; CONTROLLED STUDY; CYTOTOXICITY; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; ENZYME ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; SACCHAROMYCES CEREVISIAE;

ANIMALS; DNA; DNA GLYCOSYLASES; DNA REPLICATION; FLOW CYTOMETRY; GENE TRANSFER TECHNIQUES; HUMANS; MICE; MICE, KNOCKOUT; N-GLYCOSYL HYDROLASES; ORGANISMS, GENETICALLY MODIFIED; SACCHAROMYCES CEREVISIAE; URACIL; URACIL-DNA GLYCOSIDASE;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0037355326     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1568-7864(02)00221-5     Document Type: Article

References (24)

1. Viswanathan A., You H.J., Doetsch P.W. Phenotypic change caused by transcriptional bypass of uracil in nondividing cells. Science. 284:1999;159-162.
2. Krokan H.E., Standal R., Slupphaug G. DNA glycosylases in the base excision repair of DNA. Biochem. J. 325:1997;1-16.
3. Pearl L.H. Structure and function in the uracil-DNA glycosylase superfamily. Mutat. Res. 460:2000;165-181.
4. Nagelhus T.A., Haug T., Singh K.K., Keshav K.F., Skorpen F., Otterlei M., Bharati S., Lindmo T., Benichou S., Benarous R., Krokan H.E. A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34 kDa subunit of replication protein A. J. Biol. Chem. 272:1997;6561-6566.
5. Otterlei M., Warbrick E., Slepphug G., Nagelhus T.A., Haug T., Akbari M., Aas P.A., Steinsbekk K., Bakke O., Krokan H.E. Postreplicative base excsion repair in replication foci. EMBO J. 18:1999;3834-3844.
6. Nilsen H.R., Robins P.I., Skjelbred C.F., Andersen S., Slupphaug G., Baly G., Krokan H.E., Barnes D.E. Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication. Mol. Cell. 5:2000;1059-1065.
7. Nilsen H., Haushalter K.A., Robins P., Barnes D.E., Verdine G.L., Lindahl T. Excision of deaminated ctosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylase. EMBO J. 20:2001;4278-4286.
8. Haushalter K.A., Stukenberg P.T., Kirschner M.W., Verdine G.L. Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors. Curr. Biol. 9:1999;174-185.
9. Boorstein R.J., Cummings A. Jr., Marenstein D.R., Chan M.K., Ma Y., Neubert T.A., Brown S.M., Teebor G.W. Definitive identification of mammalian 5-hydroxymethyluracil-DNA N-glycosylase activity as SMUG1. J. Biol. Chem. 276:2001;41991-41997.
10. Baudin A., Ozier-Kalogeropoulos O., Denouel A., Lacroute F., Cullin C. A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae. Nucleic Acids Res. 21:1993;3329-3330.
11. Tinkelenberg B.A., Hansbury M.J., Ladner R.D. dUTPase and uracil-DNA glycosylase are central modulators of antifolate toxicity in Saccharomyces cerevisiae. Cancer Res. 62:2002;4909-4915.
12. D. Burke, D. Dawson, T. Stearns, Methods in Yeast Genetics, Cold Spring Harbor Laboratory Press, Plainview, 2000.
13. Muller-Weeks S.J., Caradonna S. Specific association of cyclin-like uracil-DNA glycosylase with the proliferating cell nuclear antigen. Exp. Cell Res. 226:1996;346-355.
14. Caradonna S., Ladner R., Hansbury M., Kosciuk M., Lynch F., Muller S. Affinity purification and comparative analysis of two distinct human uracil-DNA glycosylases. Exp. Cell Res. 222:1996;345-359.
15. Goulian M., Bleile B., Tseng B.Y. Methotrexate-induced misincorporation of uracil into DNA. Proc. Natl. Acad. Sci. U.S.A. 77:1980;1956-1960.
16. Goulian M., Bleile B., Tseng B.Y. The effect of methotrexate on levels of dUTP in animal cells. J. Biol. Chem. 255:1980;10630-10637.
17. Kunz B.A., Barclay B.J., Game J.C., Little J.G., Haynes R.H. Induction of mitotic recombination in yeast by starvation for thymine nucleotides. Proc. Natl. Acad. Sci. U.S.A. 77:1980;6057-6061.
18. Barclay B.A., Kunz B.A., Little J.G., Haynes R.H. Genetic and biochemical consequences of thymidilate stress. Can. J. Biochem. 60:1982;172-184.
19. Hennessy K.M., Lee A., Chen E., Botstein D. A group of interacting yeast DNA replication genes. Genes Dev. 5:1991;958-969.
20. Desany B.A., Alcasabas A.A., Bachant J.B., Elledge S.J. Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway. Genes Dev. 12:1998;2956-2970.
21. Duncan B.K., Weiss B. Specific mutator effects of ung (uracil-DNA glycosylase) mutations in Eschericia coli. J. Bacteriol. 151:1982;750-755.
22. Impellizzeri K.J., Anderson B., Burgers P.M. The spectrum of spontaneous mutations in a Saccharomyces cerevisiae uracil-DNA glycosylase mutant limits the function of this enzyme to cytosine deamination repair. J. Bacteriol. 173:1991;6807-6810.
23. Glassner B.J., Rasmussen L.J., Najarian M.T., Posnick L.M., Samson L.D. Generation of a strong mutator phenotype in yeast by imbalanced base excision repair. Proc. Natl. Acad. Sci. U.S.A. 95:1998;9997-10002.
24. Chatterjee A., Singh K.K. Uracil-DNA glycosylase-deficient yeast exhibit a mitochondrial mutator phenotype. Nucleic Acids Res. 29:2001;4935-4940.