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Volumn 11, Issue 3, 2003, Pages 134-138

Helicobacter pylori virulence factors and the host immune response: Implications for therapeutic vaccination

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; BACTERIAL ANTIGEN; CAGA PROTEIN; UREASE; VIRULENCE FACTOR;

EID: 0037342772     PISSN: 0966842X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0966-842X(03)00024-6     Document Type: Review
Times cited : (61)

References (49)
  • 1
    • 0035856021 scopus 로고    scopus 로고
    • Helicobacter pylori infection and the development of gastric cancer
    • Uemura N., et al. Helicobacter pylori infection and the development of gastric cancer. N. Engl. J. Med. 345:2001;784-789.
    • (2001) N. Engl. J. Med. , vol.345 , pp. 784-789
    • Uemura, N.1
  • 2
    • 0031904918 scopus 로고    scopus 로고
    • Pathogenesis of the transformation from gastritis to malignancy
    • Sipponen P., et al. Pathogenesis of the transformation from gastritis to malignancy. Aliment. Pharmacol. Ther. 12:(Suppl. 1):1998;61-71.
    • (1998) Aliment. Pharmacol. Ther. , vol.12 , Issue.SUPPL. 1 , pp. 61-71
    • Sipponen, P.1
  • 3
    • 0037885299 scopus 로고    scopus 로고
    • Natural history and epidemiology of Helicobacter pylori infection
    • Go M. Natural history and epidemiology of Helicobacter pylori infection. Aliment. Pharmacol. Ther. 16:(Suppl. 1):2002;3-15.
    • (2002) Aliment. Pharmacol. Ther. , vol.16 , Issue.SUPPL. 1 , pp. 3-15
    • Go, M.1
  • 4
    • 0034511840 scopus 로고    scopus 로고
    • Helicobacter pylori: Epidemiology and routes of transmission
    • Brown L.M. Helicobacter pylori: epidemiology and routes of transmission. Epidemiol. Rev. 22:2000;283-297.
    • (2000) Epidemiol. Rev. , vol.22 , pp. 283-297
    • Brown, L.M.1
  • 5
    • 0029163026 scopus 로고
    • Molecular biology of microbial ureases
    • Mobley H.L., et al. Molecular biology of microbial ureases. Microbiol. Rev. 59:1995;451-480.
    • (1995) Microbiol. Rev. , vol.59 , pp. 451-480
    • Mobley, H.L.1
  • 6
    • 0025324062 scopus 로고
    • Helicobacter pylori urease activity is toxic to human gastric epithelial cells
    • Smoot D.T., et al. Helicobacter pylori urease activity is toxic to human gastric epithelial cells. Infect. Immun. 58:1990;1992-1994.
    • (1990) Infect. Immun. , vol.58 , pp. 1992-1994
    • Smoot, D.T.1
  • 7
    • 0029879233 scopus 로고    scopus 로고
    • The role of Helicobacter pylori urease in the pathogenesis of gastritis and peptic ulceration
    • Mobley H.L. The role of Helicobacter pylori urease in the pathogenesis of gastritis and peptic ulceration. Aliment. Pharmacol. Ther. 10:(Suppl. 1):1996;57-64.
    • (1996) Aliment. Pharmacol. Ther. , vol.10 , Issue.SUPPL. 1 , pp. 57-64
    • Mobley, H.L.1
  • 8
    • 0034695684 scopus 로고    scopus 로고
    • +-gated urea channel: The link between Helicobacter pylori urease and gastric colonization
    • +-gated urea channel: the link between Helicobacter pylori urease and gastric colonization. Science. 287:2001;482-485.
    • (2001) Science , vol.287 , pp. 482-485
    • Weeks, D.L.1
  • 9
    • 0034747001 scopus 로고    scopus 로고
    • The Helicobacter pylori UreI protein: Role in adaptation to acidity and identification of residues essential for its activity and for acid activation
    • Bury-Mone S., et al. The Helicobacter pylori UreI protein: role in adaptation to acidity and identification of residues essential for its activity and for acid activation. Mol. Microbiol. 42:2001;1021-1034.
    • (2001) Mol. Microbiol. , vol.42 , pp. 1021-1034
    • Bury-Mone, S.1
  • 10
    • 0035062020 scopus 로고    scopus 로고
    • The design of vaccines against Helicobacter pylori and their development
    • Del Giudice G., et al. The design of vaccines against Helicobacter pylori and their development. Annu. Rev. Immunol. 19:2001;523-563.
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 523-563
    • Del Giudice, G.1
  • 11
    • 0033000163 scopus 로고    scopus 로고
    • Oral immunization with urease and Escherichia coli heat-labile enterotoxin is safe and immunogenic in Helicobacter pylori-infected adults
    • Michetti P., et al. Oral immunization with urease and Escherichia coli heat-labile enterotoxin is safe and immunogenic in Helicobacter pylori-infected adults. Gastroenterology. 116:1999;804-812.
    • (1999) Gastroenterology , vol.116 , pp. 804-812
    • Michetti, P.1
  • 12
    • 0032444909 scopus 로고    scopus 로고
    • Immunization of mice with urease vaccine affords protection against Helicobacter pylori infection in the absence of antibodies and is mediated by MHC class II-restricted responses
    • Ermak T.H., et al. Immunization of mice with urease vaccine affords protection against Helicobacter pylori infection in the absence of antibodies and is mediated by MHC class II-restricted responses. J. Exp. Med. 188:1998;2277-2288.
    • (1998) J. Exp. Med. , vol.188 , pp. 2277-2288
    • Ermak, T.H.1
  • 13
    • 0034661646 scopus 로고    scopus 로고
    • Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-γ, gene-deficient mice
    • Smythies L.E., et al. Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-γ, gene-deficient mice. J. Immunol. 165:2000;1022-1029.
    • (2000) J. Immunol. , vol.165 , pp. 1022-1029
    • Smythies, L.E.1
  • 14
    • 0033744274 scopus 로고    scopus 로고
    • Structural overview of the Helicobacter cytotoxin
    • Reyrat J.M., et al. Structural overview of the Helicobacter cytotoxin. Int. J. Med. Microbiol. 290:2000;375-379.
    • (2000) Int. J. Med. Microbiol. , vol.290 , pp. 375-379
    • Reyrat, J.M.1
  • 15
    • 0027173990 scopus 로고
    • Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer
    • Covacci A., et al. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc. Natl. Acad. Sci. U. S. A. 90:1993;5791-5795.
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 5791-5795
    • Covacci, A.1
  • 16
    • 0029963677 scopus 로고    scopus 로고
    • Cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors
    • Censini S., et al. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc. Natl. Acad. Sci. U. S. A. 93:1996;14648-14653.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 14648-14653
    • Censini, S.1
  • 17
    • 0031032033 scopus 로고    scopus 로고
    • Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori
    • Atherton J.C., et al. Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology. 112:1997;92-99.
    • (1997) Gastroenterology , vol.112 , pp. 92-99
    • Atherton, J.C.1
  • 18
    • 0033607258 scopus 로고    scopus 로고
    • Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin
    • Gerhard M., et al. Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin. Proc. Natl. Acad. Sci. U. S. A. 96:1999;12778-12783.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 12778-12783
    • Gerhard, M.1
  • 19
    • 15144347037 scopus 로고    scopus 로고
    • Differential stimulation of interleukin-12 (IL-12) and IL-10 by live and killed Helicobacter pylori in vitro and association of IL-12 production with gamma interferon-producing T cells in the human gastric mucosa
    • Haeberle H.A., et al. Differential stimulation of interleukin-12 (IL-12) and IL-10 by live and killed Helicobacter pylori in vitro and association of IL-12 production with gamma interferon-producing T cells in the human gastric mucosa. Infect. Immun. 65:1997;4229-4235.
    • (1997) Infect. Immun. , vol.65 , pp. 4229-4235
    • Haeberle, H.A.1
  • 20
    • 15444357984 scopus 로고    scopus 로고
    • Helicobacter pylori adhesin binding fucosylated histo-blood group antigen revealed by retagging
    • Ilver D., et al. Helicobacter pylori adhesin binding fucosylated histo-blood group antigen revealed by retagging. Science. 279:1998;373-377.
    • (1998) Science , vol.279 , pp. 373-377
    • Ilver, D.1
  • 21
    • 0035266309 scopus 로고    scopus 로고
    • Key importance of the Helicobacter pylori adherence factor blood group antigen binding adhesin during chronic gastric inflammation
    • Prinz C., et al. Key importance of the Helicobacter pylori adherence factor blood group antigen binding adhesin during chronic gastric inflammation. Cancer Res. 61:2001;1903-1909.
    • (2001) Cancer Res. , vol.61 , pp. 1903-1909
    • Prinz, C.1
  • 22
    • 0037087337 scopus 로고    scopus 로고
    • The Helicobacter pylori blood group antigen-binding adhesin facilitates bacterial colonization and augments a nonspecific immune response
    • Rad R., et al. The Helicobacter pylori blood group antigen-binding adhesin facilitates bacterial colonization and augments a nonspecific immune response. J. Immunol. 168:2002;3033-3041.
    • (2002) J. Immunol. , vol.168 , pp. 3033-3041
    • Rad, R.1
  • 23
    • 0033918170 scopus 로고    scopus 로고
    • Comparative genomics of Helicobacter pylori: Analysis of the outer membrane protein families
    • Alm R.A., et al. Comparative genomics of Helicobacter pylori: analysis of the outer membrane protein families. Infect. Immun. 68:2000;4155-4168.
    • (2000) Infect. Immun. , vol.68 , pp. 4155-4168
    • Alm, R.A.1
  • 24
    • 0033989808 scopus 로고    scopus 로고
    • A role for the bacterial outer membrane in the pathogenesis of Helicobacter pylori infection
    • Keenan J., et al. A role for the bacterial outer membrane in the pathogenesis of Helicobacter pylori infection. FEMS Microbiol. Lett. 182:2000;259-264.
    • (2000) FEMS Microbiol. Lett. , vol.182 , pp. 259-264
    • Keenan, J.1
  • 25
    • 0033789578 scopus 로고    scopus 로고
    • Modulation of innate cytokine responses by products of Helicobacter pylori
    • Meyer F., et al. Modulation of innate cytokine responses by products of Helicobacter pylori. Infect. Immun. 68:2000;6265-6272.
    • (2000) Infect. Immun. , vol.68 , pp. 6265-6272
    • Meyer, F.1
  • 26
    • 0032906393 scopus 로고    scopus 로고
    • Host response and vaccine development to Helicobacter pylori infection
    • Blanchard T.G., et al. Host response and vaccine development to Helicobacter pylori infection. Curr. Top. Microbiol. Immunol. 241:1999;181-213.
    • (1999) Curr. Top. Microbiol. Immunol. , vol.241 , pp. 181-213
    • Blanchard, T.G.1
  • 27
    • 0027441698 scopus 로고
    • Helicobacter pylori: Microbiology of a 'slow' bacterial infection
    • Blaser M.J. Helicobacter pylori: microbiology of a 'slow' bacterial infection. Trends Microbiol. 1:1993;255-260.
    • (1993) Trends Microbiol. , vol.1 , pp. 255-260
    • Blaser, M.J.1
  • 28
    • 0028898495 scopus 로고
    • Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype
    • Crabtree J.E., et al. Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype. J. Clin. Pathol. 48:1995;41-45.
    • (1995) J. Clin. Pathol. , vol.48 , pp. 41-45
    • Crabtree, J.E.1
  • 29
    • 0029880538 scopus 로고    scopus 로고
    • Immune and inflammatory responses to Helicobacter pylori infection
    • Crabtree J.E. Immune and inflammatory responses to Helicobacter pylori infection. Scand. J. Gastroenterol. (Suppl.). 215:1996;3-10.
    • (1996) Scand. J. Gastroenterol. (Suppl.) , vol.215 , pp. 3-10
    • Crabtree, J.E.1
  • 30
    • 0035077518 scopus 로고    scopus 로고
    • Helicobacter pylori resists phagocytosis by macrophages: Quantitative assessment by confocal microscopy and fluorescence-activated cell sorting
    • Ramarao N., Meyer T.F. Helicobacter pylori resists phagocytosis by macrophages: quantitative assessment by confocal microscopy and fluorescence-activated cell sorting. Infect. Immun. 69:2001;2604-2611.
    • (2001) Infect. Immun. , vol.69 , pp. 2604-2611
    • Ramarao, N.1    Meyer, T.F.2
  • 31
    • 0031567981 scopus 로고    scopus 로고
    • T helper effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease
    • D'Elios M.M., et al. T helper effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease. J. Immunol. 158:1997;962-967.
    • (1997) J. Immunol. , vol.158 , pp. 962-967
    • D'Elios, M.M.1
  • 32
    • 0032412104 scopus 로고    scopus 로고
    • + lymphocytes in Helicobacter gastritis display a Th1 phenotype
    • + lymphocytes in Helicobacter gastritis display a Th1 phenotype. Infect. Immun. 66:1998;5543-5546.
    • (1998) Infect. Immun. , vol.66 , pp. 5543-5546
    • Sommer, F.1
  • 33
    • 0029882267 scopus 로고    scopus 로고
    • Helicobacter-specific cell-mediated immune responses display a predominant Th1 phenotype and promote a delayed-type hypersensitivity response in the stomachs of mice
    • Mohammadi M., et al. Helicobacter-specific cell-mediated immune responses display a predominant Th1 phenotype and promote a delayed-type hypersensitivity response in the stomachs of mice. J. Immunol. 156:1996;4729-4738.
    • (1996) J. Immunol. , vol.156 , pp. 4729-4738
    • Mohammadi, M.1
  • 34
    • 0035879357 scopus 로고    scopus 로고
    • Negative selection of T cells by Helicobacter pylori as a model for bacterial strain selection by immune evasion
    • Wang J., et al. Negative selection of T cells by Helicobacter pylori as a model for bacterial strain selection by immune evasion. J. Immunol. 167:2001;926-934.
    • (2001) J. Immunol. , vol.167 , pp. 926-934
    • Wang, J.1
  • 35
    • 0035003538 scopus 로고    scopus 로고
    • Toll meets bacterial CpG-DNA
    • Wagner H. Toll meets bacterial CpG-DNA. Immunity. 14:2001;499-502.
    • (2001) Immunity , vol.14 , pp. 499-502
    • Wagner, H.1
  • 36
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg A.M. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20:2002;709-760.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 37
    • 0035501012 scopus 로고    scopus 로고
    • Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs
    • Ballas Z.K., et al. Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs. J. Immunol. 167:2001;4878-4886.
    • (2001) J. Immunol. , vol.167 , pp. 4878-4886
    • Ballas, Z.K.1
  • 38
    • 0037124332 scopus 로고    scopus 로고
    • + T cell responses and protection against Leishmania major infection
    • + T cell responses and protection against Leishmania major infection. J. Exp. Med. 195:2002;1565-1573.
    • (2002) J. Exp. Med. , vol.195 , pp. 1565-1573
    • Rhee, E.G.1
  • 39
    • 0035010023 scopus 로고    scopus 로고
    • Safety and immunogenicity of oral inactivated whole-cell Helicobacter pylori vaccine with adjuvant among volunteers with or without subclinical infection
    • Kotloff K.L., et al. Safety and immunogenicity of oral inactivated whole-cell Helicobacter pylori vaccine with adjuvant among volunteers with or without subclinical infection. Infect. Immun. 69:2001;3581-3590.
    • (2001) Infect. Immun. , vol.69 , pp. 3581-3590
    • Kotloff, K.L.1
  • 40
    • 0032873474 scopus 로고    scopus 로고
    • Safety and immunogenicity of phoP/phoQ-deleted Salmonella typhi expressing Helicobacter pylori urease in adult volunteers
    • DiPetrillo M.D., et al. Safety and immunogenicity of phoP/phoQ-deleted Salmonella typhi expressing Helicobacter pylori urease in adult volunteers. Vaccine. 18:1999;449-459.
    • (1999) Vaccine , vol.18 , pp. 449-459
    • DiPetrillo, M.D.1
  • 41
    • 0034116071 scopus 로고    scopus 로고
    • Pilot study of phoP/phoQ-deleted Salmonella enterica serovar Typhimurium expressing Helicobacter pylori urease in adult volunteers
    • Angelakopoulos H., Hohmann E.L. Pilot study of phoP/phoQ-deleted Salmonella enterica serovar Typhimurium expressing Helicobacter pylori urease in adult volunteers. Infect. Immun. 68:2000;2135-2141.
    • (2000) Infect. Immun. , vol.68 , pp. 2135-2141
    • Angelakopoulos, H.1    Hohmann, E.L.2
  • 42
    • 0035852273 scopus 로고    scopus 로고
    • Safety and immunogenicity of live recombinant Salmonella enterica serovar Typhi Ty21a expressing urease A and B from Helicobacter pylori in human volunteers
    • Bumann D., et al. Safety and immunogenicity of live recombinant Salmonella enterica serovar Typhi Ty21a expressing urease A and B from Helicobacter pylori in human volunteers. Vaccine. 20:2001;845-852.
    • (2001) Vaccine , vol.20 , pp. 845-852
    • Bumann, D.1
  • 43
    • 0028902758 scopus 로고
    • Development of a mouse model of Helicobacter pylori infection that mimics human disease
    • Marchetti M., et al. Development of a mouse model of Helicobacter pylori infection that mimics human disease. Science. 267:1995;1655-1658.
    • (1995) Science , vol.267 , pp. 1655-1658
    • Marchetti, M.1
  • 44
    • 0033529607 scopus 로고    scopus 로고
    • Immunization of rhesus monkeys with a mucosal prime, parenteral boost strategy protects against infection with Helicobacter pylori
    • Lee C.K., et al. Immunization of rhesus monkeys with a mucosal prime, parenteral boost strategy protects against infection with Helicobacter pylori. Vaccine. 17:1999;3072-3082.
    • (1999) Vaccine , vol.17 , pp. 3072-3082
    • Lee, C.K.1
  • 45
    • 0031661881 scopus 로고    scopus 로고
    • Immunization against natural Helicobacter pylori infection in nonhuman primates
    • Dubois A., et al. Immunization against natural Helicobacter pylori infection in nonhuman primates. Infect. Immun. 66:1998;4340-4346.
    • (1998) Infect. Immun. , vol.66 , pp. 4340-4346
    • Dubois, A.1
  • 46
    • 0031986493 scopus 로고    scopus 로고
    • Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant
    • Marchetti M., et al. Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant. Vaccine. 16:1998;33-37.
    • (1998) Vaccine , vol.16 , pp. 33-37
    • Marchetti, M.1
  • 47
    • 0033577342 scopus 로고    scopus 로고
    • Immunization with recombinant Helicobacter pylori urease decreases colonization levels following experimental infection of rhesus monkeys
    • Lee C.K., et al. Immunization with recombinant Helicobacter pylori urease decreases colonization levels following experimental infection of rhesus monkeys. Vaccine. 17:1999;1493-1505.
    • (1999) Vaccine , vol.17 , pp. 1493-1505
    • Lee, C.K.1
  • 48
    • 0033525781 scopus 로고    scopus 로고
    • Comparison between targeted and untargeted systemic immunizations with adjuvanted urease to cure Helicobacter pylori infection in mice
    • Guy B., et al. Comparison between targeted and untargeted systemic immunizations with adjuvanted urease to cure Helicobacter pylori infection in mice. Vaccine. 17:1999;1130-1135.
    • (1999) Vaccine , vol.17 , pp. 1130-1135
    • Guy, B.1
  • 49
    • 0030728943 scopus 로고    scopus 로고
    • Therapeutic intragastric vaccination against Helicobacter pylori in mice eradicates an otherwise chronic infection and confers protection against reinfection
    • Ghiara P., et al. Therapeutic intragastric vaccination against Helicobacter pylori in mice eradicates an otherwise chronic infection and confers protection against reinfection. Infect. Immun. 65:1997;4996-5002.
    • (1997) Infect. Immun. , vol.65 , pp. 4996-5002
    • Ghiara, P.1


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