Development of a physiologically based pharmacokinetic model for methyl tertiary-butyl ether and tertiary-butanol in male fischer-344 rats'

Fundamental and Applied Toxicology

Volumn 30, Issue 2, 1996, Pages 264-275

  Borghoff, S J ^a   Murphy, J E ^a   Medinsky, M A ^a  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TERT BUTYL ALCOHOL; TERT BUTYL METHYL ETHER;

ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; MALE; METABOLITE; MODEL; NONHUMAN; PHARMACOKINETICS; RAT; TOXICOKINETICS; XENOBIOTIC METABOLISM;

EID: 26844518554     PISSN: 02720590     EISSN: None     Source Type: Journal    
DOI: 10.1006/faat.1996.0064     Document Type: Article

References (40)

1. Andersen, M. E., Clewell, H. J., III, Gargas, M. L., Smith, F. A., and Reitz, R. H. (1987). Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. Toxicol. Appl. Pharmacol. 87, 185-205.
2. Arms, A. D., and Travis, C. C. (1988). Reference physiological parameters in pharmacokinetic modeling. U.S. EPA/600/6-88/004, Final Report, NTIS, Springfield, VA.
3. Baker, R. C., Sorensen, S. M., and Deitrich, R. A. (1982). The in vivo metabolism of tertiary butanol by adult rats. Alchohol Clin. Exper. Res. 6(2), 247-251.
4. 14C-MTBE. Report No. 38843, Senneville, Quebec Canada.
5. 14C-MTBE. Report No. 38845, Senneville, Quebec, Canada.
6. Bio-Research Laboratories (1990c). Pharmacokinetics of methyl tert-butyl ether (MTBE) and tert-butyl alcohol (TBA) in male and female Fischer-344 rats after administration of MTBE by intravenous, oral and dermal routes. Report No. 38842, Senneville, Quebec, Canada.
7. Bio-Research Laboratories (1990d). Pharmacokinetics of methyl tert-butyl ether (MTBE) and tert-butyl alcohol (TBA) in male and female Fischer-344 rats after single and repeat inhalation nose-only exposure to MTBE. Report No. 38844, Senneville, Quebec, Canada.
8. Borghoff, S. J., Short, B. G., and Swenberg, J. A. (1990). Biochemical mechanisms and pathobiology of α2u-globulin nephropathy. Annu. Rev. Pharmacol. Toxicol. 30, 349-367.
9. Brady, J. F., Lee, M. J., Li, M., Ishizaki, H., and Yang, C. S. (1988). Diethyl ether as a substrate for acetone/ethanol-inducible cytochrome P450 and as an inducer for cytochromes(s) P450. Mol. Pharmacol. 33, 148-154.
10. Brady, J. F., Xiano, F., Ning, S. M., and Yang, C. S. (1990). Metabolism of methyl tertiary-butyl ether by rat hepatic microsomes. Arch. Toxicol. 64, 157-160.
11. Burleigh-Flayer, H. D., Chun, J. S., and Kintigh, W. J. (1992). Methyl tertiary butyl ether: Vapor inhalation oncogenicity study in CD-1 mice. Union Carbide, Bushy Run Research Center, BRRC, Report 91N0013A. Export, PA.
12. Cain, W. S., Leaderer, B. P., Ginsberg, G. L., Andrews, L. S., Cometto-Muniz, J. E., Gent, J. F., Buck, M., Berglund, L. G., Mohsenin, V., Monahan, E., and Kjaergaard, S. (1996). Acute exposure to low-level methyl tertiary-butyl ether (MTBE): Human reactions and pharmacokinetic response. Inhalation Toxicol. 8, 21-48.
13. Cederbaum, A. I., and Cohen, G. (1980). Oxidative demethylation of t-butyl alcohol by rat liver microsomes. Biochem. Biophys. Res. Commun. 97(2), 730-736.
14. Centers of Disease Control and Prevention (CDC). (1993). An Investigation of Exposure to MTBE and Gasoline among Motorists and Exposed Workers in Albany, New York. Centers for Disease Control and Prevention, Atlanta, GA.
15. Chemical Market Reporter (1990). MTBE: Stage Two? Oil, Paint and Drug Reporter, March 19, 1990. pp. 7, 32, Schnell, New York.
16. Chengelis, C. P., and Neal, R. A. (1980). Microsomal metabolism of diethyl ether. Biochem. Pharmacol. 29, 247-248.
17. Chun, J. S., Burleigh-Flayer, H. D., and Kintigh, W. J. (1992). Methyl tertiary butyl ether: Vapor inhalation oncogenicity study in Fischer 344 rats. Union Carbide, Bushy Run Research Center, BRRC, Report 91N0013B. Export, PA.
18. Corley, R. A., Mendrala, A. L., Smith, F. A., Staats, D. A., Gargas, M. L., Conolly, R. B., and Andersen, M. E. (1990). Development of a PBPK model for chloroform. Toxicol. Appl. Pharmacol. 103, 512-527.
19. Costantini, M. S. (1993). Health effects of oxygenated fuels. Environ. Health Perspect. 101(Suppl. 6), 151-160.
20. Faulkner, T. P., and Hussain, A. S. (1989). The pharmacokinetics of tertiary butanol in C57B1/6J mice. Res. Commun. Chem. Pathol. Pharmacol. 64(1), 31-39.
21. Gargas, M. L., Andersen, M. E., and Clewell, H. J. (1986). A physiologically based simulation approach for determining metabolic constants from gas uptake data. Toxicol. Appl. Pharmacol. 86, 341-352.
22. Gargas, M. L., Burgess, R. J., Voisard, D. E., Carson, G. H., and Andersen, M. E. (1989). Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues. Toxicol. Appl. Pharmacol. 98, 87-99.
23. Gargas, M. L., Clewell, H. J., III, and Andersen, M. E. (1990). Gas uptake techniques and the rates of metabolism of chloromethanes, chloroethanes, and chloroethylenes in the rat. Inhalation Toxicol. 2, 295-319.
24. Horton, V. L., Higuchi, M. A., and Rickert, D. R. (1992). Physiologically based pharmacokinetic model for methanol in rats, monkeys, and humans. Toxicol. Appl. Pharmacol. 117, 26-36.
25. McGregor, D. B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W. J. (1988). Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. II. 18 coded chemicals. Environ. Mol. Mutagen. 11, 91-118.
26. Mohr, S. N., Fiedler, N., Weisel, C., and Kelly-McNeil, K. (1994). Health effects of MTBE among New Jersey garage workers. Inhalation Toxicol. 6, 553-562.
27. Moolenaar, R. L., Hefflin, B. J., Ashley, D. L., Middaugh, J. P., and Etzel, R. A. (1994). Methyl tertiary butyl ether in human blood after exposure to oxygenated fuel in Fairbanks, Alaska. Arch. Environ. Health 49, 402-409.
28. National Institutes of Health (1985). Guide for the Care and Use of Laboratory Animals, U.S. Department of Health and Human Services, Public Health Service, NIH Publication No. 86-23.
29. National Research Council (NRC) (1986). Drinking Water and Health, Vol. 6. National Academy Press, Washington DC.
30. National Toxicology Program (NTP). (1995). Technical Report on the Toxicology and carcinogenesis studies of t-butyl alcohol in F344/N rats and B6C3F1 mice. NTP TR 436, NIH Publication No. 95-3167 (May, 1995).
31. Nihlen, A., Walindi, R., Lof, A., and Johanson, G. (1994). Toxicokinetics and irritative effects of methyl tertiary butyl ether in man. Poster Presentation, ISEE Conference, Research Triangle Park, NC.
32. Prah, J. D., Goldstein, G. M., Devlin, R., and Otto, D. (1994). Sensory, symptomatic, inflammatory, and ocular responses to and the metabolism of methyl tertiary butyl ether in a controlled human exposure experiment. Inhal. Toxicol. 6, 521-538.
33. Ramsey, J. C., and Andersen, M. E. (1984). A physiological based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol. Appl. Pharmacol. 73, 159-175.
34. Robinson, M., Bruner, R. H., and Olson, G. R. (1990). Fourteen and ninety-day oral toxicity studies of methyl tertiary-butyl ether in Sprague-Dawley rats. J. Am. Coll. Toxicol. 9, 525-540.
35. Swenberg, J. A., and Dietrich, D. R. (1991). Immunohistochemical localization of alpha-2u-globulin in kidneys of treated and control rats of a 13-week vapor inhalation study undertaken with methyl tertiary butyl ether (MTBE). Report to John Kniess (Manager, MTBE Task Force), July 26, 1991.
36. Thurman, R. G., Winn, K., and Urquhart, B. (1980). Rat brain cyclic AMP levels and withdrawal behavior following treatment with t-butanol. Adv. Exp. Med. Biol. 126, 271-281.
37. U.S. Environmental Protection Agency (U.S. EPA) (1993). Assessment of potential health risks of gasoline oxygenated with methyl tertiary butyl ether (MTBE). EPA/600/R-93/206, Office of Research and Development, U.S. Environmental Protection Agency, Washington DC.
38. U.S. Environmental Protection Agency (U.S. EPA) (1988). Guidance on estimating motor vehicle emission reductions from the use of alternative fuels and fuel blends. Report No. EPA-AA-TSS-PA-87-4, Ann Arbor, MI.
39. White, M. C., Johnson, C. A., Ashley, D. L., Buchta, T. M., and Pelletier, D. J. (1995). Exposure to Methyl tertiary-butyl ether from oxygenated gasoline in Stamford, Connecticut. Arch. Environ. Health 50, 183-189.
40. Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. (1987). Salmonella mutagenicity tests. III. Results from the testing of 255 chemicals. Environ. Mutagen. 9(Suppl. 9), 1-110.