Effects of bupivacaine used with sevoflurane on the rhythm and contractility in the isolated rat heart

European Journal of Anaesthesiology

Volumn 20, Issue 3, 2003, Pages 199-204

  Bozkurt, P ^a,c   Suzer O ^a   Ekici, E ^a   Demirci, O ^b   Kaya, G ^a   Hacibekiroglu M ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b FLORENCE NIGHTINGALE HOSPITAL   (Turkey)

^c Fikret Biyal Laboratory ^*  (Turkey)

Author keywords

Anaesthetics, inhalation, sevoflurane; Anaesthetics, local, bupivacaine; Cardiovascular system, heart, heart conduction system; Heart diseases, arrhythmia

Indexed keywords

BUPIVACAINE; SEVOFLURANE;

ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; DOSE RESPONSE; DRUG EFFECT; HEART ARRHYTHMIA; HEART LEFT VENTRICLE CONTRACTION; HEART LEFT VENTRICLE DP-DT; HEART MUSCLE CONTRACTILITY; HEART RATE; HEART RHYTHM; ISOLATED HEART; NONHUMAN; PR INTERVAL; QRS COMPLEX; RAT;

ANESTHETICS, INHALATION; ANESTHETICS, LOCAL; ANIMALS; ARRHYTHMIA; ATRIOVENTRICULAR NODE; BLOOD PRESSURE; BUPIVACAINE; CREATINE KINASE; ELECTROCARDIOGRAPHY; HEART RATE; L-LACTATE DEHYDROGENASE; MALE; METHYL ETHERS; MYOCARDIAL CONTRACTION; MYOCARDIUM; PERFUSION; RATS; RATS, WISTAR; VENTRICULAR FUNCTION, LEFT;

EID: 0037337624     PISSN: 02650215     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0265021503000346     Document Type: Article

References (21)

1. Albright GA. Cardiac arrest following regional anesthesia with etidocaine or bupivacaine. Anesthesiology 1979; 51: 285-287.
2. Singh P, Lee JS. Cardiovascular and central nervous system toxicity of local anesthetics. Seminars in Anesthesia, Perioperative Medicine and Pain 1998; 17: 18-23.
3. Heavner JE, Badgwell JM, Dreyden SF, Flinders C. Bupivacaine toxicity in lightly anesthetized pigs with respiratory imbalances plus or minus halothane. Reg Anesth 1995; 20: 20-26.
4. Umuroǧlu T, Eti Z, Göǧü ş FY, Ay B, Yayci A. The effects of sevoflurane and halothane anesthesia on bupivacaine cardiotoxicity in rabbits. J Turk Soc Algology 1998; 10: 29-34.
5. Badgwell JM, Heavner JE, Kytta J, Bupivacaine toxicity in young pigs is age dependent and is affected by volatile anesthetics. Anesthesiology 1990; 73: 297-303.
6. Fukuda H, Hirabayashi YY, Shimizu R, Saitoh K, Mitsuhata H. Sevoflurane is equivalent to isoflurane for attenuating bupivacaine induced arrhythmias and seizures in rats. Anesth Analg 1996; 83: 570-573.
7. Ohmuro S, Ohta T, Yamamoto K, Kobayashi T. A comparison of the effects of propofol and sevoflurane on the systemic toxicity of intravenous bupivacaine in rats. Anesth Analg 1999; 88: 155-159.
8. Clarkson CW, Hondeghem LM. Mechanism for bupivacaine depression of cardiac conduction. Fast block of sodium channels during the action potential with slow recovery from block during diastole. Anesthesiology 1985; 62: 396-405.
9. Hanouz JL, Vivien B, Guegniaud PY, Lecarpentier Y, Coriat P, Riou B. Comparison of the effects of isoflurane and halothane on rat myocardium. Br J Anaesth 1998; 80: 621-627.
10. Bozkurt AK, Süzer Ö, Kaynar M. Benefits of supplementing St. Thomas' Hospital cardioplegic solution with tetraethylammonium on functional and metabolic recovery of isolated rat hearts. Cardiovasc Surg 1997; 5: 117-124.
11. Walker MJ, Curtis MJ, Hearse DJ, et al. The Lambeth Conventions: guidelines for the study of arrhythmias in ischaemia infarction, and reperfusion. Cardiovasc Res 1988; 22: 447-455.
12. Thomas RD, Behbehani MM, Coyle DE, Denson DD. Cardiovascular toxicity of local anesthetics an alternative hypothesis. Anesth Analg 1986; 65: 444-450.
13. Nishikawa K, Terai T, Morimotu O, Yukioka H, Asada A. Bupivacaine does not suppress cardiac sympathetic nerve activity during halothane anesthesia in the cat. Acta Anaesthesiol Scand 1997; 40: 595-601.
14. Graf BM, Martin E, Nosnkaj ZJ, Stowe DE Stereospecific effect of bupivacaine isomers on atrioventricular conduction in the isolated perfused guinea pig heart. Anesthesiology 1997; 86: 410-419.
15. Eledjam JJ, de la Coussaya JE, Bassoul B, Brugeda J. Mechanisms of cardiac toxicity of bupivacaine. Ann Fr Reanim 1988; 3: 204-210.
16. Freysz M, Timour Q, Bertrix L, Loufoua-Moundanga J, Omar S, Faucon G. Enhancement by ischemia of the risk of cardiac disorders, especially fibrillation, in regional anesthesia with bupivacaine. Acta Anaesthesiol Scand 1993; 37: 350-356.
17. Timour Q, Gaillard P, Bui-Xuan B, Vial T, Evreux JC, Freysz M. Cardiac accidents of locoregional anesthesia: experimental study of risk factors with bupivacaine. Bull Acad Natl Med 1998; 182: 217-232.
18. Park WP, Pancrazio J, Suh CK, Lynch C. Myocardial depressant effects of sevoflurane. Anesthesiology 1996; 84: 1166-1176.
19. Harkin CP, Pagel PS, Kersten JR, Hetitrick D, Waltier D. Direct negative inotropic and lusitropic effects of sevoflurane. Anesthesiology 1994; 81: 156-157.
20. Bosnjak ZJ, Stowe DF, Kampine JP. Comparison of lidocaine and bupivacaine depression of sinoatrial nodal activity during hypoxia and acidosis in adult and neonatal guinea pigs. Anesth Analg 1986; 65: 911-917.
21. Knudsen K, Beckman S, Blomberg S, Sjovall J, Edvardsson N. Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers. Br J Anaesth 1997; 78: 507-514.