Compounded brain volume deficits in schizophrenia-alcoholism comorbidity

Archives of General Psychiatry

Volumn 60, Issue 3, 2003, Pages 245-252

  Mathalon, Daniel H ^a,e   Pfefferbaum, Adolf ^b,c   Lim, Kelvin O ^d   Rosenbloom, Margaret J ^c   Sullivan, Edith V ^c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SRI INTERNATIONAL   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^e VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALCOHOL ABUSE; ALCOHOLISM; ANALYSIS OF VARIANCE; ARTICLE; BRAIN SIZE; COMORBIDITY; CONTROLLED STUDY; CORRELATION ANALYSIS; DEMOGRAPHY; DIAGNOSTIC IMAGING; DISEASE SEVERITY; GRAY MATTER; HUMAN; IMAGE PROCESSING; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PREFRONTAL CORTEX; QUANTITATIVE ANALYSIS; RETROSPECTIVE STUDY; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SCORING SYSTEM; STATISTICAL ANALYSIS; SUBSTANCE ABUSE; TEMPORAL LOBE;

ADULT; ALCOHOL DRINKING; ALCOHOLISM; BRAIN; BRIEF PSYCHIATRIC RATING SCALE; COMORBIDITY; DIAGNOSIS, DUAL (PSYCHIATRY); HUMANS; MAGNETIC RESONANCE IMAGING; MALE; PREFRONTAL CORTEX; SCHIZOPHRENIA; SUBSTANCE-RELATED DISORDERS; TEMPORAL LOBE;

EID: 0037336950     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.60.3.245     Document Type: Article

References (75)

1. Cuffel BJ. Prevalence estimates of substance abuse in schizophrenia and their correlates. J Nerv Ment Dis. 1992;180:589-592.
2. Duke PJ, Pantelis C, Barnes TR. South Westminster schizophrenia survey: alcohol use and its relationship to symptoms, tardive dyskinesia and illness onset. Br J Psychiatry. 1994;164:630-636.
3. Fowler IL, Carr VJ, Carter NT, Lewin TJ. Patterns of current and lifetime substance use in schizophrenia. Schizophr Bull. 1998;24:443-455.
4. Mueser KT, Yarnold PR, Levinson DF, Singh H, Bellack AS, Kee K, Morrison RL, Yadalam KG. Prevalence of substance abuse in schizophrenia: demographic and clinical correlates. Schizophr Bull. 1990;16:31-56.
5. Galanter M, Castaneda R, Ferman J. Substance abuse among general psychiatric patients: place of presentation, diagnosis, and treatment. Am J Drug Alcohol Abuse. 1988;14:211-235.
6. Dixon L. Dual diagnosis of substance abuse in schizophrenia: prevalence and impact on outcomes. Schizophr Res. 1999;35(suppl):S93-S100.
7. Regier DA, Farmer ME, Rae DS, Locke BZ, Keith SJ, Judd LL, Goodwin FK. Comorbidity of mental disorders with alcohol and other drug abuse: results from the Epidemiologic Catchment Area (ECA) Study. JAMA. 1990;264:2511-2518.
8. Dixon L, Haas G, Weiden P, Sweeney J, Frances A. Acute effects of drug abuse on schizophrenic patients. Schizophr Bull. 1990;16:69-79.
9. Mueser KT, Drake RE, Wallach MA. Dual diagnosis: a review of etiological theories. Addict Behav. 1998;23:717-734.
10. Buckley PF. Substance abuse in schizophrenia. J Clin Psychiatry. 1998;59(suppl): 26-30.
11. Drake RE, Osher FC, Wallach MA. Alcohol use and abuse in schizophrenia: a prospective community study. J Nerv Ment Dis. 1989;177:408-414.
12. Soyka M, Albus M, Kathmann N, Finelli A, Hofstetter S, Holzbach R, Immler B, Sand P. Prevalence of alcohol and drug abuse in schizophrenic inpatients. Eur Arch Psychiatry Clin Neurosci. 1993;242:362-372.
13. Dixon L, Haas G, Weiden PJ, Sweeney J, Frances AJ. Drug abuse in schizophrenic patients. Am J Psychiatry. 1991;148:224-230.
14. Bartels SJ, Teague GB, Drake RE, Clark RE, Bush PW, Noordsy DL. Substance abuse in schizophrenia: service utilization and costs. J Nerv Ment Dis. 1993;181: 227-232.
15. Drake RE, Osher FC, Wallach MA. Homelessness and dual diagnosis. Am Psychol. 1991;46:1149-1158.
16. Bartels SJ, Drake RE, McHugo GJ. Alcohol abuse, depression, and suicidal behavior in schizophrenia. Am J Psychiatry. 1992;149:394-395.
17. Sullivan EV, Deshmukh A, Desmond JE, Mathalon DH, Rosenbloom MJ, Lim KO, Pfefferbaum A. Contribution of alcohol abuse to cerebellar volume deficits in men with schizophrenia. Arch Gen Psychiatry. 2000;57:894-902.
18. Scheller-Gilkey G, Lewine RRJ, Caudle J, Brown FW. Schizophrenia, substance use, and brain morphology. Schizophr Res. 1999;35:113-120.
19. Jernigan TL, Butters N, DiTraglia G, Schafer K, Smith T, Irwin M, Grant I, Schuckit M, Cermak L. Reduced cerebral grey matter observed in alcoholics using magnetic resonance imaging. Alcohol Clin Exp Res. 1991;15:418-427.
20. Pfefferbaum A, Lim KO, Zipursky RB, Mathalon DH, Lane B, Ha CN, Rosenbloom MJ, Sullivan EV. Brain gray and white matter volume loss accelerates with aging in chronic alcoholics. Alcohol Clin Exp Res. 1992;16:1078-1089.
21. Sullivan E, Lim K, Mathalon D, Marsh L, Beal D, Harris D, Hoff A, Faustman W, Pfefferbaum A. A profile of cortical gray matter volume deficits characteristic of schizophrenia. Cereb Cortex. 1998;8:117-124.
22. McCarley RW, Wible CG, Frumin M, Hirayasu Y, Levitt JJ, Fischer IA, Shenton ME. MRI anatomy of schizophrenia. Biol Psychiatry. 1999;45:1099-1119.
23. Pearlson GD, Petty RG, Ross CA, Tien AY. Schizophrenia: a disease of heteromodal association cortex? Neuropsychopharmacology. 1996;14:1-17.
24. Sullivan EV, Mathalon DH, Lim KO, Marsh L, Pfefferbaum A. Patterns of regional cortical dysmorphology distinguishing schizophrenia and chronic alcoholism. Biol Psychiatry. 1998;43:118-131.
25. Goldman-Rakic P. Working memory dysfunction in schizophrenia. J Neuropsychiatry Clin Neurosci. 1994;6:348-357.
26. Knable MB, Weinberger DR. Dopamine, the prefrontal cortex and schizophrenia. J Psychopharmacol. 1997;11:123-131.
27. Morice R, Delahunty A. Frontal/executive impairments in schizophrenia. Schizophr Bull. 1996;22:125-137.
28. Breier A, Buchanan RW, Elkashef A, Munson RC, Kirkpatrick B, Gellad F. Brain morphology and schizophrenia. Arch Gen Psychiatry. 1992;49:921-926.
29. Buchanan RW, Vladar K, Barta PE, Pearlson GD. Structural evaluation of the prefrontal cortex in schizophrenia. Am J Psychiatry. 1998;155:1049-1055.
30. Gur RE, Cowell PE, Latshaw A, Turetsky BI, Grossman RI, Arnold SE, Bilker WB, Gur RC. Reduced dorsal and orbital prefrontal gray matter volumes in schizophrenia. Arch Gen Psychiatry. 2000;57:761-768.
31. Schlaepfer TE, Harris GJ, Tien AY, Peng LW, Lee S, Federman EB, Chase GA, Barta PE, Pearlson GD. Decreased regional cortical gray matter volume in schizophrenia. Am J Psychiatry. 1994;151:842-848.
32. Wible CG, Shenton ME, Hokama H, Kikinis R, Jolesz FA, Metcalf D, Mccarley RW. Prefrontal cortex and schizophrenia. Arch Gen Psychiatry. 1995;52:279-288.
33. Bertolino A, Nawroz S, Mattay VS, Barnett AS, Duyn JH, Moonen CTW, Frank JA, Tedeschi G, Weinberger DR. Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging. Am J Psychiatry. 1996;153:1554-1563.
34. Cecil KM, Lenkinski RE, Gur RE, Gur RC. Proton magnetic resonance spectroscopy in the frontal and temporal lobes of neuroleptic naive patients with schizophrenia. Neuropsychopharmacology. 1999;20:131-140.
35. Deicken RF, Zhou L, Corwin F, Vinogradov S, Weiner MW. Decreased left frontal lobe N-acetylaspartate in schizophrenia. Am J Psychiatry. 1997;154:688-690.
36. Gold JM, Blaxton TA, Hermann BP, Randolph C, Fedio P, Goldberg TE, Theodore WH, Weinberger DR. Memory and intelligence in lateralized temporal lobe epilepsy and schizophrenia. Schizophr Res. 1995;17:59-65.
37. Kolb B, Whishaw IQ. Performance of schizophrenic patients on tests sensitive to left or right frontal, temporal, or parietal function in neurological patients. J Nerv Ment Dis. 1983;171:435-443.
38. Sullivan EV, Mathalon DH, Zipursky RB, Kersteen-Tucker Z, Knight RT, Pfefferbaum A. Factors of the Wisconsin Card Sorting Test as a test of dorsolateral prefrontal cortical function in schizophrenia and alcoholism. Psychiatry Res. 1993; 46:175-199.
39. Berman KF, Zec RF, Weinberger DR. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia, II. Arch Gen Psychiatry. 1986;43:126-135.
40. 2O PET study during single-trial Stroop task performance. Am J Psychiatry. 1997;154:1670-1675.
41. Callicott J, Ramsey N, Tallent K, Bertolino A, Knable M, Coppola R, Goldberg T, van Gelderen P, Mattay V, Frank J, Moonen C, Weinberger D. Functional magnetic resonance imaging brain mapping in psychiatry. Neuropsychopharmacology. 1998;18:186-196.
42. Courville CB. Effects of Alcohol on the Nervous System of Man. Los Angeles, Calif: San Lucas Press; 1955.
43. Harper CG, Kril JJ. Neuropathology of alcoholism. Alcohol Alcohol 1990;25: 207-216.
44. Freund G, Ballinger Jr WE. Decrease of benzodiazepine receptors in frontal cortex of alcoholics. Alcohol. 1988;5:275-282.
45. Freund G, Ballinger Jr WE. Loss of cholinergic muscarinic receptors in the frontal cortex of alcohol abusers. Alcohol. 1988;5:630-638.
46. Lewohl J, Wang L, Miles M, Zhang L, Dodd P, Harris R. Gene expression in human alcoholism. Alcohol Clin Exp Res. 2000;24:1873-1882.
47. Pfefferbaum A, Sullivan EV, Mathalon DH, Lim KO. Frontal lobe volume loss observed with magnetic resonance imaging in older chronic alcoholics. Alcohol Clin Exp Res. 1997;21:521-529.
48. Oscar-Berman M, Hutner N. Frontal lobe changes after chronic alcohol ingestion. In: Hunt WA, Nixon SJ, eds. Alcohol-Induced Brain Damage, NIAAA Research Monographs #22. Rockville, Md: National Institutes of Health; 1993:121-156.
49. Nixon SJ, Tivis R, Parsons OA. Behavioral dysfunction and cognitive efficiency in male and female alcoholics. Alcohol Clin Exp Res. 1995;19:577-581.
50. Parsons OA, Stevens L. Previous alcohol intake and residual cognitive deficits in detoxified alcoholics and animals. Alcohol Alcohol. 1986;21:137-157.
51. Pfefferbaum A, Desmond JE, Galloway C, Menon V, Glover GH, Sullivan EV. Reorganization of frontal systems used by alcoholics for spatial working memory: an fMRI study. Neuroimage. 2001;14:7-20.
52. Tapert SF, Brown GG, Kindermann SS, Cheung E, Frank LR, Brown SA. fMRI measurement of brain dysfunction in alcohol dependent young women. Alcohol Clin Exp Res. 2001;25:236-245.
53. Pfefferbaum A, Mathalon DH, Sullivan EV, Rawles JM, Zipursky RB, Lim KO. A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Arch Neurol. 1994;51:874-887.
54. Pfefferbaum A, Sullivan EV, Mathalon DH, Shear PK, Rosenbloom MJ, Lim KO. Longitudinal changes in magnetic resonance imaging brain volumes in abstinent and relapsed alcoholics. Alcohol Clin Exp Res. 1995;19:1177-1191.
55. Spitzer RL, Endicott J, Robins E. Research Diagnostic Criteria (RDC). New York: Biometrics Research, New York State Psychiatric Institute; 1975.
56. Spitzer RL, Gibbon M, Skodol AE, Williams JBW, First MB. DSM-III-R Case-book. Washington, DC: American Psychiatric Press; 1989.
57. Overall JE, Gorham DR. The Brief Psychiatric Rating Scale (BPRS): recent developments in ascertainment and scaling. Psychopharmacol Bull. 1988;24:97-99.
58. Hedlund JL, Vieweg BW. The Brief Psychiatric Rating Scale (BPRS): a comprehensive review. J Operational Psychiatry. 1980;11:48-64.
59. Folstein MF, Folstein SE, McHugh PR. Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12:189-198.
60. Skinner HA. Development and Validation of a Lifetime Alcohol Consumption Assessment Procedure. Toronto, Ontario: Addiction Research Foundation; 1982.
61. Skinner HA, Sheu WJ. Reliability of alcohol use indices: the lifetime drinking history and the MAST. J Stud Alcohol. 1982;43:1157-1170.
62. Pfefferbaum A, Rosenbloom MJ, Crusan K, Jernigan TL. Brain CT changes in alcoholics. Alcohol Clin Exp Res. 1988;12:81-87.
63. Lim KO, Pfefferbaum A. Segmentation of MR brain images into cerebrospinal fluid spaces, white and gray matter. J Comput Assist Tomogr. 1989;13:588-593.
64. Zipursky RB, Lim KO, Sullivan EV, Brown BW, Pfefferbaum A. Widespread cerebral gray matter volume deficits in schizophrenia. Arch Gen Psychiatry. 1992; 49:195-205.
65. Sullivan EV, Marsh L, Mathalon DH, Lim KO, Pfefferbaum A. Anterior hippocampal volume deficits in nonamnesic, aging chronic alcoholics. Alcohol Clin Exp Res. 1995;19:110-122.
66. Zipursky RB, Marsh L, Lim KO, DeMent S, Shear PK, Sullivan EV, Murphy GM, Csernansky JG, Pfefferbaum A. Volumetric MRI assessment of temporal lobe structures in schizophrenia. Biol Psychiatry. 1994;35:501-516.
67. Mathalon DH, Sullivan EV, Rawles JM, Pfefferbaum A. Correction for head size in brain-imaging measurements. Psychiatry Res. 1993;50:121-139.
68. Morrison DF. Multivariate Statistical Methods, 2nd Edition. New York, NY: McGraw-Hill Co; 1976.
69. Keppel G. Design and Analysis: A Researcher's Handbook. Englewood Cliffs, NJ: Prentice-Hall International Inc; 1991.
70. Siegel S, Castellan NJ. Nonparametric Statistics for the Behavioral Sciences. 2nd ed. New York, NY: McGraw-Hill Co; 1988.
71. Nelson HE. The National Adult Reading Test (NART). Windsor, Ontario: Nelson Publishing Co; 1982.
72. Crovitz HF, Zener KA. Group test for assessing hand and eye dominance. Am J Psychol. 1962;75:271-276.
73. Selemon LD, Goldman-Rakic PS. Common cortical and subcortical targets of the dorsolateral prefrontal and posterior parietal cortices in the rhesus monkey. J Neurosci. 1988;8:4049-4068.
74. Lim KO, Hedehus M, Moseley M, De Crespigny A, Sullivan EV, Pfefferbaum A. Compromised white matter tract integrity in schizophrenia inferred from diffusion tensor imaging. Arch Gen Psychiatry. 1999;56:367-374.
75. Lim KO, Adalsteinson A, Spielman D, Rosenbloom MJ, Sullivan EV, Pfefferbaum A. Proton magnetic resonance spectroscopic imaging of cortical gray and white matter in schizophrenia. Arch Gen Psychiatry. 1998;55:346-352.