Complement component C1q induces endothelial cell adhesion and spreading through a docking/signaling partnership of C1q receptors and integrins

International Immunopharmacology

Volumn 3, Issue 3, 2003, Pages 299-310

  Ghebrehiwet, Berhane ^a   Feng, Xiaodong ^b   Kumar, Rajeev ^a   Peerschke, Ellinor I B ^c  

^a STONY BROOK UNIVERSITY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

C1q; Endothelial cell; Kininogen

Indexed keywords

ALPHA5 INTEGRIN; BETA1 INTEGRIN; BINDING PROTEIN; COMPLEMENT COMPONENT C1Q; IMMUNOGLOBULIN G; KININOGEN; POLYCLONAL ANTIBODY; ZINC;

ANTIBODY PRODUCTION; ANTIGEN BINDING; BINDING SITE; BIOTINYLATION; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL ASSAY; CELL CULTURE; CELL SPREADING; CELL SURFACE; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; ENDOTHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROPHOBICITY; INCUBATION TIME; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

EID: 0037334390     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-5769(02)00270-9     Document Type: Conference Paper

References (30)

1. Silverstein R.L. The vascular endothelium. Gallin J.I., Snyderman R. Inflammation: Basic Principles and Clinical Correlates. 1999;207 Lippincott Williams and Wilkins, Philadelphia.
2. Andrews B.S., Shadforth M., Cunningham P., Davis J.S. IV Demonstration of a C1q receptor on the surface of human endothelial cells. J. Immunol. 127:1981;1075.
3. Peerschke E.I.B., Malhotra R., Ghebrehiwet B., Reid K.B.M., Willis A.C., Sim R.B. Isolation of a human endothelial cell C1q receptor (C1q-R). J. Leukoc. Biol. 53:1993;179.
4. Daha M.R., Dunn L., Van den Berg R.H., Muizert-de Lange Y., Gerritsen A.F., Van Eys L.A. Isolation of a human endothelial cell C1q receptor. Mediat. Inflamm. 2:1993;447.
5. Peerschke E.I.B., Smyth S.S., Teng E., Dalzell M., Ghebrehiwet B. Human umbilical vein endothelial cells possess binding sites for the globular domains of C1q. J. Immunol. 157:1996;4154.
6. Guo W.-X., Ghebrehiwet B., Weksler B., Schweizer K., Peerschke E.I.B. Upregulation of endothelial cell binding proteins/receptors for complement C1q by inflammatory cytokines. J. Lab. Clin. Med. 133:1999;541.
7. Lozada C., Levin R.I., Huie M., Hirschhorn R., Naime D., Whitlow M.et al. Identification of C1q as a heat-labile serum cofactor required for immune complexes to stimulate endothelial expression of the adhesion molecules E-selectin and intercellular and vascular cell adhesion molecules 1. Proc. Natl. Acad. Sci. U. S. A. 92:1995;8378.
8. van den Berg R.H., Faber-Krol M.C., Sim R.B., Daha M.R. The first subcomponent of complement, C1q, triggers the production of IL-8, IL-6 and monocyte chemoattractant peptide-1 by human umbilical vein endothelial cells. J. Immunol. 161:1998;6924.
9. Joseph K., Ghebrehiwet B., Peerschke E.I.B., Reid K.B.M., Kaplan A.P. Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: identity with the receptor which binds to the globular 'heads' of C1q (gC1q-R). Proc. Natl. Acad. Sci. U. S. A. 93:1996;8552.
10. Herwald H., Dedio J., Kellner R., Loos M., Muller-Esterl W. Isolation and characterization of the kininogen-binding protein p33 from endothelial cells. Identity with the gC1q receptor. J. Biol. Chem. 271:1996;13040.
11. Coleman R.W., Pixley R.A., Najamunnisa S., Yan W., Wang J., Mazer A.et al. Binding of high molecular kininogen to human endothelial cells is mediated via a site within domains 2 and 3 of the urokinase receptor. J. Clin. Invest. 100:1997;1481.
12. Hasan A.A.K., Zisman T., Schmaier A.H. Identification of cytokeratin 1 as a binding protein and presentation receptor for kininogens on endothelial cells. Proc. Natl. Acad. Sci. U. S. A. 95:1998;3615.
13. Joseph K., Ghebrehiwet B., Kaplan A.P. Activation of the kinin-forming cascade on the surface of endothelial cells. Biol. Chem. 382:2001;71.
14. Kolb W.P., Kolb L.M., Podack E.R. C1q: isolation from human serum in high yield by affinity chromatography and development of a highly sensitive hemolytic assay. J. Immunol. 122:1979;2103.
15. Silvestri L., Baker J.R., Roden L., Stroud R.M. The C1q inhibitor in serum is a chondroitin 4-sulfate proteoglycan. J. Biol. Chem. 256:1981;7383-7387.
16. Conradie J.D., Volanakis J.E., Stroud R.M. Evidence for a serum inhibitor of C1q. Immunochemistry. 12:1975;967-971.
17. Ghebrehiwet B., Lu P.D., Zhang W., Lim B.-L., Eggleton P., Leigh L.E.A.et al. Identification of functional domains on gC1q-R, a cell surface protein which binds to the globular "heads" of C1q, using monoclonal antibodies and synthetic peptides. Hybridoma. 15:1996;333.
18. Ghebrehiwet B., Lu P.D., Zhang W., Keilbaugh S.A., Leigh L.E.A., Eggleton P.et al. Evidence that the two C1q-binding membrane proteins gC1q-R and cC1q R associate to form a metal ion-independent complex. J. Immunol. 159:1997;1429.
19. Feng X., Clark R.A.F., Galanakis D., Tonnesen M.G. Fibrin and collagen differentially regulate human dermal microvascular endothelial cell integrins: stabilization of av/b3 mRNA by fibrin. J. Invest. Dermatol. 113:1999;913.
20. Feng X., Tonnesen M.G., Peerschke E.I.B., Ghebrehiwet B. Cooperation of C1q receptors and integrins in C1q-mediated endothelial cell adhesion and spreading. J. Immunol. 168:2002;2441-2448.
21. Gailit J., Clark R.A.F. Studies in vitro on the role of av and β1 integrins in the adhesion of human dermal fibroblasts to provisional matrix proteins fibronectin, vitronectin, and fibrinogen. J. Invest. Dermatol. 106:1996;102.
22. Bordin S., Ghebrehiwet B., Page R.C. Participation of C1q and its receptor in adherence of human diploid fibroblast. J. Immunol. 145:1990;2520.
23. Cardamone M., Puri N.K. Spectrofluorimetric assessment of the surface hydrophobicity of proteins. Biochem. J. 282:1992;589-593.
24. Sitrin R.G., Pan P.M., Harper H.A., Blackwood R.A., Todd R.F. III Urokinase receptor (CD87) aggregation triggers phosphoinositide and intracellular calcium mobilization in mononuclear phagocytes. J. Immunol. 163:1999;6193.
25. Sitrin R.G., Todd R.F. III, Petty H.R., Brock T.G., Shollenberger S.B., Abrecht E.et al. The urokinase receptor (CD87) facilitates CD11b/CD18-mediated adhesion of human monocytes. J. Clin. Invest. 97:1996;1942.
26. Sitrin R.G., Pan P.M., Blackwood R.A., Huang J., Petty H.R. Evidence for signaling partnership between urokinase receptors (CD87) and L-selectin (CD62L) in human polymorphonuclear neutrophils. J. Immunol. 166:2001;4822.
27. Sim R.B., Moestrup S.K., Stuart G.R., Lynch N.J., Lu J., Schwaeble W.J.et al. Interaction of C1q and the collectins with the potential receptors calreticulin (cC1qR/collectin receptor) and megalin. Immunobiology. 199:1998;208.
28. Malhotra R., Lu J., Thiel S., Jensenius J.-C., Willis A.C., Sim R.B. C1q receptor (collectin receptor): primary structure, homology, and interaction with ligands. Immunobiology. 184:1992;1437.
29. Jiang J., Zhang Y., Krainer A.R., Xu R.M. Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein. Proc. Natl. Acad. Sci. U. S. A. 96:1999;3572-3577.
30. Ghebrehiwet B., Jesty J., Peerschke E.I.B. gC1q-R/p33: structure-function predictions from the crystal structure. Immunobiology. 205:2002;421.