Amphetamine concentrations in human urine following single-dose administration of the calcium antagonist prenylamine - Studies using fluorescence polarization immunoassay (FPIA) and GC-MS

Journal of Analytical Toxicology

Volumn 27, Issue 2, 2003, Pages 68-73

  Kraemer, Thomas ^a   Roditis, Susanne K ^a   Peters, Frank T ^a   Maurer, Hans H ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACID ANHYDRIDE; AMPHETAMINE; CALCIUM ANTAGONIST; CYTOCHROME P450; DRUG METABOLITE; ILLICIT DRUG; PERFLUOROBUTYRIC ANHYDRIDE; PRENYLAMINE; UNCLASSIFIED DRUG;

CONFERENCE PAPER; CONTROLLED STUDY; DEALKYLATION; DRUG EXCRETION; DRUG METABOLISM; DRUG URINE LEVEL; ENANTIOMER; FLUORESCENCE POLARIZATION IMMUNOASSAY; FORENSIC PATHOLOGY; GAS CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MASS SPECTROMETRY; NORMAL HUMAN; QUANTITATIVE ANALYSIS; SOLID PHASE EXTRACTION;

EID: 0037334368     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/27.2.68     Document Type: Conference Paper

References (31)

1. A. Fleckenstein. History of calcium antagonists. Circ. Res. 52: 13-16 (1983).
2. L.C. Slegers, A. Vermeulen, and C.A. Sumajow. Double-blind comparison of prenylamine and penbutolol in patients with angina pectoris. J. Int. Med. Res. 13: 229-235 (1985).
3. R. Bayer, J. Schwarzmaier, and R. Pernice. Basic mechanisms underlying prenylamine-induced 'torsade de pointes': differences between prenylamine and fendiline due to basic actions of the isomers. Curr. Med. Res. Opin. 11: 254-272 (1988).
4. R.R. Makkar, B.S. Fromm, R.T. Steinman, M.D. Meissner, and M.H. Lehmann. Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs. J. Am. Med. Assoc. 270: 2590-2597 (1993).
5. 14C]prenylamine in man. Biomed. Mass Spectrom. 4: 297-304 (1977).
6. H.H. Maurer. Systematic toxicological analysis of drugs and their metabolites by gas chromatography-mass spectrometry. J. Chromatogr. 580: 3-41 (1992).
7. H.H. Maurer. Toxicological analysis of drugs and poisons by GC-MS. Spectroscopy Europe 6: 21-23 (1994).
8. H.H. Maurer. Methods for GC-MS. In Mass Spectral and GC Data of Drugs, Poisons, Pesticides, Pollutants and their Metabolites, K. Pfleger, H.H. Maurer, and A. Weber, Eds. Wiley-VCH, Weinheim, Germany, 2000, pp 3-241.
9. J. Bickeboeller-Friedrich and H.H. Maurer. Screening for detection of new antidepressants, neuroleptics, hypnotics, and their metabolites in urine by GC-MS developed using rat liver microsomes. Ther. Drug Monit. 23: 61-70 (2001).
10. H.H. Maurer and J. Bickeboeller-Friedrich. Screening procedure for detection of antidepressants of the selective serotonin reuptake inhibitor type and their metabolites in urine as part of a modified systematic toxicological analysis procedure using gas chromatography-mass spectrometry. J. Anal. Toxicol. 24: 340-347 (2000).
11. T. Kraemer, A.A. Weber, and H.H. Maurer. Improvement of sample preparation for the STA - Acceleration of acid hydrolysis and derivatization procedures by microwave irradiation. In Proceedings of the Xth GTFCh Symposium in Mosbach, F. Pragst, Ed. HelmVerlag, Heppenheim, Germany, 1997, pp 200-204.
12. K. Pfleger, H.H. Maurer, and A. Weber. Mass Spectral Library of Drugs, Poisons, Pesticides, Pollutants and their Metabolites, 3rd ed. Agilent Technologies, Palo Alto, CA, 2000.
13. K. Pfleger, H.H. Maurer, and A. Weber. Mass Spectral and GC Data of Drugs, Poisons, Pesticides, Pollutants and their Metabolites, part 4, 2nd ed. Wiley-VCH, Weinheim, Germany, 2000.
14. H.H. Maurer. On the metabolism and the toxicological analysis of methylenedioxyphenylalkylamine designer drugs by gas chromatography-mass spectrometry. Ther. Drug Monit. 18: 465-470 (1996).
15. H.H. Maurer, J.W. Arlt, T. Kraemer, C.J. Schmitt, and A.A. Weber. Analytical development for low molecular weight xenobiotic compounds. Arch. Toxicol. 19 Suppl.: 189-197 (1997).
16. T. Kraemer, I. Vernaleken, and H.H. Maurer. Studies on the metabolism and toxicological detection of the amphetamine-like anorectic mefenorex in human urine by gas chromatography-mass spectrometry and fluorescence polarization immunoassay. J. Chromatogr. B 702: 93-102 (1997).
17. T. Kraemer, G.A. Theis, A.A. Weber, and H.H. Maurer. Studies on the metabolism and toxicological detection of the amphetamine- like anorectic fenproporex in human urine by gas chromatography-mass spectrometry and fluorescence polarization immunoassay (FPIA). J. Chromatogr. B 738: 107-118 (2000).
18. T. Kraemer, R. Wennig, and H.H. Maurer. The antispasmodic mebeverine leads to positive amphetamine results with the fluorescence polarization immunoassay (FPIA) - studies on the toxicological detection in urine by FPIA and GC-MS. J. Anal. Toxicol. 25: 333-338 (2001).
19. H.H. Maurer, T. Kraemer, O. Ledvinka, C.J. Schmitt, and A.A. Weber. Gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) in toxicological analysis. Studies on the detection of clobenzorex and its metabolites within a systematic toxicological analysis procedure by GC-MS and by immunoassay and studies on the detection of alpha- and beta-amanitin in urine by atmospheric pressure ionization electrospray LC-MS. J. Chromatogr. B 689: 81-89 (1997).
20. H.H. Maurer. Screening procedures for simultaneous detection of several drug classes used for high throughput toxicological analysis and doping control. A review. Comb. Chem. High Throughput Screen. 3: 467-480 (2000).
21. H.K. Ensslin, K.A. Kovar, and H.H. Maurer. Toxicological detection of the designer drug 3,4-methylenedioxyethylamphetamine (MDE, "Eve") and its metabolites in urine by gas chromatography-mass spectrometry and fluorescence polarization immunoassay. J. Chromatogr. B 683: 189-197 (1996).
22. R.F. Staack, G. Fritschi, and H.H. Maurer. GC-MS studies on the metabolism and on the toxicological analysis of the new piperazine-like designer drugs BZP, MDBP, TFMPP, mCPP, MeOPP. In Proceedings of the 39th International TIAFT Meeting in Prague, M.Balikova and E.Navakova, Eds. Prague, Czech Republic, 2002, in press.
23. H. Maurer and K. Pfleger. Screening procedure for the detection of opioids, other potent analgesics and their metabolites in urine using a computerized gas chromatographic-mass spectrometric technique. Fresenius' Z. Anal. Chem. 317: 42-52 (1984).
24. H.H. Maurer and C.F. Fritz. Toxicological detection of pholcodine and its metabolites in urine and hair using radio immunoassay, fluorescence polarisation immunoassay, enzyme immunoassay and gas chromatography-mass spectrometry. Int. J. Legal Med. 104: 43-46 (1990).
25. H. Maurer and K. Pfleger. Identification and differentiation of benzodiazepines and their metabolites in urine by computerized gas chromatography-mass spectrometry. J. Chromatogr. 422: 85-101 (1987).
26. H.H. Maurer. Identification and differentiation of barbiturates, other sedative-hypnotics and their metabolites in urine integrated in a general screening procedure using computerized gas chromatography-mass spectrometry. J. Chromatogr. 530: 307-326 (1990).
27. V.P. Shah, K.K. Midha, S. Dighe, I.J. McGilveray, J.P. Skelly, A. Yacobi, T. Layloff, C.T. Viswanathan, C.E. Cook, R.D. Mc- Dowall, K.A. Pittman, and S. Spector. Analytical methods validation: bioavailability, bioequivalence and pharmacokinetic studies. Conference report. Pharm. Res. 9: 588-592 (1992).
28. V.P. Shah, K.K. Midha, J.W. Findlay, H.M. Hill, J.D. Hulse, I.J. McGilveray, G. McKay, K.J. Miller, R.N. Patnaik, M.L. Powell, A. Tonelli, C.T. Viswanathan, and A. Yacobi. Bioanalytical method validation - a revisit with a decade of progress. Pharm. Res. 17: 1551-1557 (2000).
29. W.D. Paar, D. Brockmeier, M. Hirzebruch, E.K. Schmidt, G.E. von Unruh, and H.J. Dengler. Pharmacokinetics of prenylamine racemate and enantiomers in man. Arzneimittelforschung 40: 657-661 (1990).
30. Y. Gietl, H. Spahn, H.Knauf, and E.Mutschler. Single- and multiple-dose pharmacokinetics of R-(-)-and S-(+)-prenylamine in man. Eur. J. Clin. Pharmacol. 38: 587-593 (1990).
31. T. Kraemer and H.H. Maurer. Determination of amphetamine, methamphetamine and amphetamine-derived designer drugs or medicaments in blood and urine. J. Chromatogr. B 713: 163-187 (1998).