Studies on the metabolism and toxicological detection of the amphetamine-like anorectic mefenorex in human urine by gas chromatography- mass spectrometry and fluorescence polarization immunoassay

Journal of Chromatography B: Biomedical Applications

Volumn 702, Issue 1-2, 1997, Pages 93-102

  Kraemer, Thomas ^a   Vernaleken, Ingo ^a   Maurer, Hans H ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Amphetamine; Anorectics; Mefenorex

Indexed keywords

AMPHETAMINE; DRUG METABOLITE; MEFENOREX;

ARTICLE; DRUG EXCRETION; DRUG METABOLISM; EXTRACTION; FLUORESCENCE POLARIZATION IMMUNOASSAY; GAS CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HYDROLYSIS; MASS SPECTROMETRY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; URINE;

ADMINISTRATION, ORAL; AMPHETAMINES; APPETITE DEPRESSANTS; FLUORESCENCE POLARIZATION IMMUNOASSAY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; STEREOISOMERISM; TIME FACTORS;

EID: 0031582904     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(97)00357-5     Document Type: Article

References (25)

1. T. Kraemer, I. Vernaleken and H.H. Maurer, Proceedings of the GTFCh Symposium, Mosbach, Germany, April 18-19, 1997, in press.
2. Williams R.T., Caldwell J., Dring L.G. Front. Catecholamin. Res. XX:1973;927.
3. Caldwell J. Drug Metab. Rev. 5:1976;219.
4. Blum J.E. Drug Res. 19:1969;748.
5. Nazarali A.J., Baker G.B., Coutts R.T., Pasutto F.M. Prog. Neuropsychopharmacol. Biol. Psychiatry. 7:1983;813.
6. Rendic S. Acta Pharm. Jugosl. 39:1989;173.
7. Rendic S., Slavica M., Medi-Saric M. Eur. J. Drug. Metab. Pharmacokinet. 19:1994;107.
8. De-la-Torre R., Badia R., Gonzalez G., Garcia M., Pretel M.J., Farre M., Segura J. J. Anal. Toxicol. 20:1996;165.
9. Nakahara Y. Forensic. Sci. Int. 70:1995;135.
10. Maurer H.H. Spectrosc. Eur. 6:1994;21.
11. K. Pfleger, H.H. Maurer and A. Weber, Mass Spectral Library of Drugs, Poisons, Pesticides, Pollutants and Their Metabolites, Hewlett-Packard, Palo Alto, CA, 3rd ed., 1997, in preparation.
12. Maurer H.H. Ther. Drug Monit. 18:1996;465.
13. Ensslin H.K., Kovar K.-A., Maurer H.H. J. Chromatogr. B. 683:1996;189.
14. Ensslin H.K., Maurer H.H., Gouzoulis E., Hermle L., Kovar K.-A. Drug Metabol. Dispos. 24:1996;813.
15. Maurer H.H., Kraemer T., Ledvinka O., Schmitt C.J., Weber A.A. J. Chromatogr. B. 689:1997;81.
16. T. Kraemer, G. Theis and H.H. Maurer, Proceedings of the 34th Triennial Meeting of the TIAFT, Interlaken, August 11-15, 1996.
17. F.W. McLafferty and F. Turecek, Interpretation of Mass Spectra, University Science Books, Mill Valley, CA, 4th ed., 1993.
18. Moore R.G., Robertson A.V., Smyth M.P., Thomas J., Vine J. Xenobiotica. 5:1975;687.
19. Kovats E. Helv. Chim. Acta. 41:1958;1915.
20. Deutsche Forschungsgemeinschaft, Senatskommission für Klinisch-toxikologische Analytik, J. Clin. Chem. Clin. Biochem., 20 (1982) 699.
21. R.A. De Zeeuw, J.P. Franke, H.H. Maurer and K. Pfleger, Gas Chromatographic Retention Indices of Toxicologically Relevant Substances and their Metabolites (Report of the DFG Commission for Clinical Toxicological Analysis, Special Issue of the TIAFT Bulletin), VCH, Weinheim, New York, Basle, 3rd ed., 1992.
22. K. Pfleger, H.H. Maurer and A. Weber, Mass Spectral and GC Data of Drugs, Poisons, Pesticides, Pollutants and Their Metabolites, VCH, Weinheim, 3rd ed., 1997, in preparation.
23. Cody J.T., Valtier S. J. Anal. Toxicol. 20:1996;425.
24. Maurer H.H., Kraemer T. Arch. Toxicol. 66:1992;675.
25. Maurer H.H. J. Chromatogr. 580:1992;3.