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Volumn 18, Issue 4, 1996, Pages 465-470

On the metabolism and the toxicological analysis of methylenedioxyphenylalkylamine designer drugs by gas chromatography-mass spectrometry

Author keywords

Analysis; Designer drugs; Gas chromatography mass spectrometry; Metabolism; Methylenedioxyphenylalkylamines

Indexed keywords

1,3 BENZODIOXOLE DERIVATIVE; 3,4 METHYLENEDIOXYAMPHETAMINE; BENZODIOXAZOLYLBUTANAMINE; DESIGNER DRUG; UNCLASSIFIED DRUG;

EID: 0029789280     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-199608000-00027     Document Type: Conference Paper
Times cited : (99)

References (43)
  • 1
    • 0027098207 scopus 로고
    • Sleep EEG effects of 3,4-methylenedioxyethylamphetamine (MDE, "Eve") in healthy volunteers
    • Gouzoulis E, Steiger A, Ensslin HK, Kovar K-A, Hermle L. Sleep EEG effects of 3,4-methylenedioxyethylamphetamine (MDE, "Eve") in healthy volunteers. Biol Psychiatry 1992;32:1108-17.
    • (1992) Biol Psychiatry , vol.32 , pp. 1108-1117
    • Gouzoulis, E.1    Steiger, A.2    Ensslin, H.K.3    Kovar, K.-A.4    Hermle, L.5
  • 2
    • 0022874762 scopus 로고
    • Derivatives of 1-(1,3-benzodioxol-5-yl)-2-butanamines: Representatives of a novel therapeutic class
    • Nichols DE, Hoffman AJ, Oberlender RA, Jacob P, Shulgin AT. Derivatives of 1-(1,3-benzodioxol-5-yl)-2-butanamines: representatives of a novel therapeutic class. J Med Chem 1986;29:2009-15.
    • (1986) J Med Chem , vol.29 , pp. 2009-2015
    • Nichols, D.E.1    Hoffman, A.J.2    Oberlender, R.A.3    Jacob, P.4    Shulgin, A.T.5
  • 3
    • 0022838197 scopus 로고
    • Differences between the mechanism of action of MDMA, MBDB, and the classic hallucinogens. Identification of a new therapeutic class: Entactogens
    • Nichols DE. Differences between the mechanism of action of MDMA, MBDB, and the classic hallucinogens. Identification of a new therapeutic class: entactogens. J Psychoactive Drugs 1986;18:305-13.
    • (1986) J Psychoactive Drugs , vol.18 , pp. 305-313
    • Nichols, D.E.1
  • 4
    • 0023154112 scopus 로고
    • A comparison of the neurotoxic potential of methylenedioxyamphetamine (MDA) and its N-methylated and N-ethylated derivatives
    • Stone DM, Johnson M, Hanson GR, Gibb JW. A comparison of the neurotoxic potential of methylenedioxyamphetamine (MDA) and its N-methylated and N-ethylated derivatives. Eur J Pharmacol 1987;134:245-8.
    • (1987) Eur J Pharmacol , vol.134 , pp. 245-248
    • Stone, D.M.1    Johnson, M.2    Hanson, G.R.3    Gibb, J.W.4
  • 6
    • 0343954082 scopus 로고
    • Flashbacks following MDMA
    • McGuire P, Fahy T. Flashbacks following MDMA. J Psychiatry 1992;160:276-85.
    • (1992) J Psychiatry , vol.160 , pp. 276-285
    • McGuire, P.1    Fahy, T.2
  • 7
    • 0026680529 scopus 로고
    • Toxicity and deaths from 3,4-methylenedioxymethamphetamine
    • Henry JA, Jeffreys KJ, Dawling S. Toxicity and deaths from 3,4-methylenedioxymethamphetamine. Lancet 1992; 340:384-7.
    • (1992) Lancet , vol.340 , pp. 384-387
    • Henry, J.A.1    Jeffreys, K.J.2    Dawling, S.3
  • 8
    • 85047691384 scopus 로고
    • "Eve" and "Ecstasy." a report of five deaths associated with the use of MDEA and MDMA
    • Dowling GP, McDonough ET, Bost RO. "Eve" and "Ecstasy." A report of five deaths associated with the use of MDEA and MDMA. JAMA 1987;257:1615-7.
    • (1987) JAMA , vol.257 , pp. 1615-1617
    • Dowling, G.P.1    McDonough, E.T.2    Bost, R.O.3
  • 9
    • 0027529852 scopus 로고
    • A case of toxic psychosis induced by "Eve" (3,4-methylenedioxyethylamphetamine)
    • Gouzoulis E, Borchardt D, Hermle L. A case of toxic psychosis induced by "Eve" (3,4-methylenedioxyethylamphetamine). Arch Gen Psychiatry 1993;50:75.
    • (1993) Arch Gen Psychiatry , vol.50 , pp. 75
    • Gouzoulis, E.1    Borchardt, D.2    Hermle, L.3
  • 10
    • 0027631397 scopus 로고
    • Ecstasy abuse in Ireland
    • Cregg MT, Tracey JA. Ecstasy abuse in Ireland. Ir Med J 1993;86:118-20.
    • (1993) Ir Med J , vol.86 , pp. 118-120
    • Cregg, M.T.1    Tracey, J.A.2
  • 11
    • 0027425757 scopus 로고
    • Cerebral infarction in association with ecstasy abuse
    • Manchada S, Connolly MJ. Cerebral infarction in association with ecstasy abuse. Postgrad Med J 1993;69:874-5.
    • (1993) Postgrad Med J , vol.69 , pp. 874-875
    • Manchada, S.1    Connolly, M.J.2
  • 12
    • 0017830238 scopus 로고
    • Metabolism of 3,4-methylenedioxyamphetamine in the rat
    • Marquardt GM, DiStefano V, Ling JJ. Metabolism of 3,4-methylenedioxyamphetamine in the rat. Biochem Pharmacol 1978;27:1503-5.
    • (1978) Biochem Pharmacol , vol.27 , pp. 1503-1505
    • Marquardt, G.M.1    DiStefano, V.2    Ling, J.J.3
  • 13
    • 0026731379 scopus 로고
    • Enzymatic and chemical demethylenation of (methylenedioxy)amphetamine and (methylenedioxy)methamphetamine by rat brain microsomes
    • Lin LY, Kumagai Y, Cho AK. Enzymatic and chemical demethylenation of (methylenedioxy)amphetamine and (methylenedioxy)methamphetamine by rat brain microsomes. Chem Res Toxicol 1992;5:401-6.
    • (1992) Chem Res Toxicol , vol.5 , pp. 401-406
    • Lin, L.Y.1    Kumagai, Y.2    Cho, A.K.3
  • 14
    • 0016295364 scopus 로고
    • The hepatic microsomal metabolism of 3,4-methylenedioxyamphetamine (MDA)
    • Marquardt GM, DiStefano V. The hepatic microsomal metabolism of 3,4-methylenedioxyamphetamine (MDA). Life Sci 1974;15:1603-10.
    • (1974) Life Sci , vol.15 , pp. 1603-1610
    • Marquardt, G.M.1    DiStefano, V.2
  • 15
    • 0024214871 scopus 로고
    • In vivo and in vitro metabolism of 3,4-(methylenedioxy)methamphetamine in the rat: Identification of metabolites using an ion trap detector
    • Lim HK, Foltz RL. In vivo and in vitro metabolism of 3,4-(methylenedioxy)methamphetamine in the rat: identification of metabolites using an ion trap detector. Chem Res Toxicol 1988;1:370-8.
    • (1988) Chem Res Toxicol , vol.1 , pp. 370-378
    • Lim, H.K.1    Foltz, R.L.2
  • 17
    • 0024906350 scopus 로고
    • Influence of inducers and inhibitors on the metabolism in vitro and neurochemical effects in vivo of MDMA
    • Gollamudi R, Ali SF, Lipe G, et al. Influence of inducers and inhibitors on the metabolism in vitro and neurochemical effects in vivo of MDMA. Neurotoxicology 1989;10:455-66.
    • (1989) Neurotoxicology , vol.10 , pp. 455-466
    • Gollamudi, R.1    Ali, S.F.2    Lipe, G.3
  • 18
    • 0000808392 scopus 로고
    • On the metabolism of designer drugs. Part I: Studies on methylenedioxyetilamfetamine (MDE) in rats
    • Maurer HH, Ensslin H, Kovar K-A. On the metabolism of designer drugs. Part I: studies on methylenedioxyetilamfetamine (MDE) in rats. Bull Soc Sci Med Grand Duche Lux 1990;127:467-71.
    • (1990) Bull Soc Sci Med Grand Duche Lux , vol.127 , pp. 467-471
    • Maurer, H.H.1    Ensslin, H.2    Kovar, K.-A.3
  • 19
    • 0024372072 scopus 로고
    • Identification of metabolites of 3,4-(methylenedioxy)methamphetamine in human urine
    • Lim HK, Foltz RL. Identification of metabolites of 3,4-(methylenedioxy)methamphetamine in human urine. Chem Res Toxicol 1989;2:142-3.
    • (1989) Chem Res Toxicol , vol.2 , pp. 142-143
    • Lim, H.K.1    Foltz, R.L.2
  • 20
    • 0025109540 scopus 로고
    • Detection of D,L-amphetamine, D,L-methamphetamine and illicit amphetamine analogues using Diagnostic Products Corporation's Amphetamine and Methamphetamine Radioimmunoassay
    • Cody JT. Detection of D,L-amphetamine, D,L-methamphetamine and illicit amphetamine analogues using Diagnostic Products Corporation's Amphetamine and Methamphetamine Radioimmunoassay. J Anal Toxicol 1990;14:321-4.
    • (1990) J Anal Toxicol , vol.14 , pp. 321-324
    • Cody, J.T.1
  • 21
    • 0025294315 scopus 로고
    • Application of the Syva EMIT and Abbott TDx amphetamine immunoassay to the detection of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyethamphetamine (MDE) in urine
    • Kunsman GW, Manno JE, Cockerham KR, Manno BR. Application of the Syva EMIT and Abbott TDx amphetamine immunoassay to the detection of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyethamphetamine (MDE) in urine. J Anal Toxicol 1990;14:149-53.
    • (1990) J Anal Toxicol , vol.14 , pp. 149-153
    • Kunsman, G.W.1    Manno, J.E.2    Cockerham, K.R.3    Manno, B.R.4
  • 22
    • 0027255666 scopus 로고
    • EMIT-d.a.u. monoclonal amphetamine/methamphetamine assay. II. Detection of methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA)
    • Poklis A, Fitzgerald RL, Hall KV, Saady JJ. EMIT-d.a.u. monoclonal amphetamine/methamphetamine assay. II. Detection of methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA). Forensic Sci Int 1993;59:63-70.
    • (1993) Forensic Sci Int , vol.59 , pp. 63-70
    • Poklis, A.1    Fitzgerald, R.L.2    Hall, K.V.3    Saady, J.J.4
  • 23
    • 0027396905 scopus 로고
    • Fluorescence polarization immunoassay detection of amphetamine, methamphetamine, and illicit amphetamine analogues
    • Cody JT, Schwarzhoff R. Fluorescence polarization immunoassay detection of amphetamine, methamphetamine, and illicit amphetamine analogues. J Anal Toxicol 1993;17:26-30.
    • (1993) J Anal Toxicol , vol.17 , pp. 26-30
    • Cody, J.T.1    Schwarzhoff, R.2
  • 24
    • 0026746212 scopus 로고
    • Toxicological detection of selegiline and its metabolites in urine using fluorescence polarisation immunoassay (FPIA) and gas chromatography-mass spectrometry (GC-MS) and differentiation by enantioselective GC-MS of the intake of selegiline from an abuse of methamphetamine or amphetamine
    • Maurer HH, Kraemer T. Toxicological detection of selegiline and its metabolites in urine using fluorescence polarisation immunoassay (FPIA) and gas chromatography-mass spectrometry (GC-MS) and differentiation by enantioselective GC-MS of the intake of selegiline from an abuse of methamphetamine or amphetamine. Arch Toxicol 1992;66:675-8.
    • (1992) Arch Toxicol , vol.66 , pp. 675-678
    • Maurer, H.H.1    Kraemer, T.2
  • 25
    • 0027471368 scopus 로고
    • Simultaneous identification of amphetamine and its derivatives in urine using HPLC-UV
    • Tedeschi L, Frison G, Castagna F, Giorgetti R, Ferrara SD. Simultaneous identification of amphetamine and its derivatives in urine using HPLC-UV. Int J Legal Med 1993;105: 265-9.
    • (1993) Int J Legal Med , vol.105 , pp. 265-269
    • Tedeschi, L.1    Frison, G.2    Castagna, F.3    Giorgetti, R.4    Ferrara, S.D.5
  • 26
    • 0026500419 scopus 로고
    • Determination of psychotropic phenylalkylamine derivatives in biological matrices by high performance liquid chromatography with photodiode-array detection
    • Helmlin HJ, Brenneisen R. Determination of psychotropic phenylalkylamine derivatives in biological matrices by high performance liquid chromatography with photodiode-array detection. J Chromatogr 1992;593:87-94.
    • (1992) J Chromatogr , vol.593 , pp. 87-94
    • Helmlin, H.J.1    Brenneisen, R.2
  • 27
    • 0027486112 scopus 로고
    • High-pressure liquid chromatography/electrochemical detection method for monitoring MDA and MDMA in whole blood and other biological tissues
    • Michel RE, Rege AB, George WJ. High-pressure liquid chromatography/electrochemical detection method for monitoring MDA and MDMA in whole blood and other biological tissues. J Neurosci Methods 1993;50:61-6.
    • (1993) J Neurosci Methods , vol.50 , pp. 61-66
    • Michel, R.E.1    Rege, A.B.2    George, W.J.3
  • 28
    • 0026133554 scopus 로고
    • Methods for the analysis of 1-(3,4-methylenedioxyphenyl)-2-butanamine and N-methyl-1-(3,4-methylenedioxyphenyl)-2-propanamine (MDMA)
    • Noggle FT Jr, Clark CR, Andurkar S, DeRuiter J. Methods for the analysis of 1-(3,4-methylenedioxyphenyl)-2-butanamine and N-methyl-1-(3,4-methylenedioxyphenyl)-2-propanamine (MDMA). J Chromatogr Sci 1991;29:103-6.
    • (1991) J Chromatogr Sci , vol.29 , pp. 103-106
    • Noggle Jr., F.T.1    Clark, C.R.2    Andurkar, S.3    DeRuiter, J.4
  • 29
    • 0025992875 scopus 로고
    • Simultaneous analysis of amphetamine, methamphetamine, and 3,4-methylenedioxymethamphetamine (MDMA) in urine samples by solid-phase extraction, derivatization, and gas chromatography/mass spectrometry
    • Can BK, Baugh D, Liu RH, Walia AS. Simultaneous analysis of amphetamine, methamphetamine, and 3,4-methylenedioxymethamphetamine (MDMA) in urine samples by solid-phase extraction, derivatization, and gas chromatography/mass spectrometry. J Forensic Sci 1991;36:1331-41.
    • (1991) J Forensic Sci , vol.36 , pp. 1331-1341
    • Can, B.K.1    Baugh, D.2    Liu, R.H.3    Walia, A.S.4
  • 30
    • 0028100673 scopus 로고
    • Microwave-induced rapid preparation of fluoro derivatives of amphetamine, methamphetamine, and 3,4-methylenedioxymethamphetamine for GC-MS confirmation assays
    • Thompson WC, Dasgupta A. Microwave-induced rapid preparation of fluoro derivatives of amphetamine, methamphetamine, and 3,4-methylenedioxymethamphetamine for GC-MS confirmation assays. Clin Chem 1994;40:1703-6.
    • (1994) Clin Chem , vol.40 , pp. 1703-1706
    • Thompson, W.C.1    Dasgupta, A.2
  • 34
    • 9444251290 scopus 로고    scopus 로고
    • On the metabolism and the toxicological analysis of 3,4-methylenedioxymethamphetamine by GC-MS
    • in preparation
    • Maurer HH, Moeller MR, Kovar K-A, Kraemer T. On the metabolism and the toxicological analysis of 3,4-methylenedioxymethamphetamine by GC-MS. J Chromatogr [B] (in preparation).
    • J Chromatogr [B]
    • Maurer, H.H.1    Moeller, M.R.2    Kovar, K.-A.3    Kraemer, T.4
  • 36
    • 0025186934 scopus 로고
    • Basic profiles of organic acids in urine
    • Liebich HM, Foerst C. Basic profiles of organic acids in urine. J Chromatogr 1990;525:1-14.
    • (1990) J Chromatogr , vol.525 , pp. 1-14
    • Liebich, H.M.1    Foerst, C.2
  • 37
    • 0017040122 scopus 로고
    • The metabolism of amphetamines in mammals
    • Caldwell J. The metabolism of amphetamines in mammals. Drug Metab Rev 1976;5:219-80.
    • (1976) Drug Metab Rev , vol.5 , pp. 219-280
    • Caldwell, J.1
  • 38
    • 9444250067 scopus 로고    scopus 로고
    • On the phase II metabolism of the methylenedioxyphenylalkylamine designer drugs MDA, MDMA, MDE, BDB and MBDM in humans
    • in preparation
    • Kraemer T, Kovar K-A, Maurer HH. On the phase II metabolism of the methylenedioxyphenylalkylamine designer drugs MDA, MDMA, MDE, BDB and MBDM in humans. J Chromatogr [B] (in preparation).
    • J Chromatogr [B]
    • Kraemer, T.1    Kovar, K.-A.2    Maurer, H.H.3
  • 39
    • 0026733756 scopus 로고
    • Systematic toxicological analysis of drugs and their metabolites by gas chromatography-mass spectrometry
    • Maurer HH. Systematic toxicological analysis of drugs and their metabolites by gas chromatography-mass spectrometry. J Chromatogr 1992;580:3-41.
    • (1992) J Chromatogr , vol.580 , pp. 3-41
    • Maurer, H.H.1
  • 40
    • 0002246368 scopus 로고
    • Toxicological analysis of drugs and poisons by GC-MS
    • Maurer HH. Toxicological analysis of drugs and poisons by GC-MS. Spectrosc Eur 1994;6:21-3.
    • (1994) Spectrosc Eur , vol.6 , pp. 21-23
    • Maurer, H.H.1
  • 41
    • 9444291483 scopus 로고    scopus 로고
    • Toxicological detection of the designer drug 3,4-methylenedioxyethylamphetamine (MDE, "Eve") and its metabolites in urine by fluorescence polarization immunoassay (FPIA) and gas chromatography-mass spectrometry (GC-MS)
    • in press
    • Ensslin HK, Kovar K-A, Maurer HH. Toxicological detection of the designer drug 3,4-methylenedioxyethylamphetamine (MDE, "Eve") and its metabolites in urine by fluorescence polarization immunoassay (FPIA) and gas chromatography-mass spectrometry (GC-MS). J Chromatogr [B] (in press).
    • J Chromatogr [B]
    • Ensslin, H.K.1    Kovar, K.-A.2    Maurer, H.H.3


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