Overexpression of the human inducible nitric oxide synthase gene enhances radiation-induced apoptosis in colorectal cancer cells via a caspase-dependent mechanism

Nitric Oxide - Biology and Chemistry

Volumn 8, Issue 2, 2003, Pages 119-126

  Chung, Peter ^a   Cook, Tracy ^a   Liu, Kaihong ^a   Vodovotz, Yoram ^a   Zamora, Ruben ^a   Finkelstein, Sydney ^a   Billiar, Timothy ^a   Blumberg, David ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer; Gene therapy; Inducible nitric oxide synthase (iNOS); Nitric oxide; Radiation

Indexed keywords

CASPASE; NITRIC OXIDE SYNTHASE; NITRITE;

APOPTOSIS; ARTICLE; CANCER CELL; COLORECTAL CARCINOMA; CONTROLLED STUDY; GENE OVEREXPRESSION; GENE TRANSFER; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RADIATION RESPONSE;

EID: 0037334280     PISSN: 10898603     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1089-8603(02)00147-7     Document Type: Article

References (34)

1. Blumberg D., Ramanathan R.K. Treatment of colon and rectal cancer. J. Clin. Gastroenterol. 34:2002;15-26.
2. Hyams D.M., Eleftherios M., Petrelli N., Howard R., Jones J.et al. A clinical trial to evaluate the worth of preoperative multimodality therapy in patients with operable carcinoma of the rectum: a progress report of National Surgical Adjuvant Breast and Bowel Project Protocol R-03. Dis. Colon Rectum. 40:1997;131-139.
3. Mehta V.K., Poen J., Ford J., Edelstein P.S., Vierra M.et al. Radiotherapy, concomitant protracted-venous-infusion 5-fluorouracil, and surgery for ultrasound-staged T3 or T4 rectal cancer. Dis. Colon Rectum. 44:2001;52-58.
4. Read T.E., McNevin M.S., Gross E.K.M., Whiteford H.M., Lewis J.L.et al. Neoadjuvant therapy for adenocarcinoma of the rectum: tumor response and acute toxicity. Dis. Colon Rectum. 44:2001;513-522.
5. Meade P.G., Blatchford G.J., Thorson A.G., Christensen M.A., Terment C.A. Preoperative chemoradiation downstages locally advanced ultrasound-staged rectal cancer. Am. J. Surg. 170:1995;609-613.
6. Bouzourene H., Bosman F.T., Seelentag W., Matter M., Coucke P. Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy. Cancer. 94:2002;1121-1130.
7. Myerson R.J., Valenti V., Bimbaum E.H., Cellini N., Coco C.et al. A phase I/II trial of three-dimensionally planned concurrent boost radiotherapy and protracted venous infusion of 5-FU chemotherapy for locally advanced rectal carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 50:2001;1299-1308.
8. Rosen E.M., Fan S., Goldberg Y.D., Rockwell S. Biologic basis of radiation sensitivity. Cellular and molecular determinants of radiosensitivity. Oncology. 14:2000;741-748.
9. Mitchell J.B., Wink D.A., DeGraff W., Gamson J., Keefer L.K., Krishna M.C. Hypoxic mammalian cell radiosensitization by nitric oxide. Cancer Res. 53:1993;5845-5848.
10. Griffin R.J., Makepeace C.M., Hur W.J., Song C.W. Radiosensitization of hypoxic tumor cells in vitro by nitric oxide. Int. J. Radiat. Oncol. Biol. Phys. 36:1996;377-383.
11. Kurimoto M., Endo S., Hirashima H., Ogiichi T., Takaku A. Growth inhibition and radiosensitization of cultured glioma cells by nitric oxide generating agents. J. Neurooncol. 42:1999;35.
12. Chung H.T., Pae H.O., Choi B.M., Billiar T.R., Kim Y.M. Nitric oxide as a bioregulator of apoptosis. Biochem. Biophys. Res. Commun. 282:2001;1075-1079.
13. Van de Casteele M., Hosli M., Sagesser H., Reichen J. Intraportal administration of glyceryl trinitrate or nitroprusside exerts more systemic than intrahepatic effects in anaesthetised cirrhotic rats. J. Hepatol. 31:1999;300-305.
14. Geller D.A., Lowenstein C.J., Shapiro R.A., Nussler A.K., Di Silvio M., Wang S.C., Nakayama D.K., Simmons R.L., Snyder S.H., Billiar T.R. Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc. Natl. Acad. Sci. USA. 90:1993;349-355.
15. Kibbe M.R., Nie S., Yoneyama T., Hatakeyama K., Lizonova A., Kovesdi I., Billiar T.R., Tzeng E. Optimization of ex-vivo inducible nitric oxide synthase gene transfer to vein grafts. Surgery. 126:1999;323-329.
16. Oh J.H., Ku J.L., Yoon K.A., Kwon H.J., Kim W.H., Park H.S., Yeo K.S., Song S.Y., Chung J.K., Park J.G. Establishment and characterization of 12 human colorectal-carcinoma cell lines. Int. J. Cancer. 81:1999;902-910.
17. 1 arrest in human cancer cells Cancer Res. 55:1995;5187-5190.
18. Miranda K.M., Espey M.G., Wink D.A. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide. 5:2001;62-71.
19. Aldridge D.R., Radford I.R. Explaining differences in sensitivity to killing by ionizing radiation between human lymphoid cell lines. Cancer Res. 51:1991;6304-6311.
20. Brown J.M., Wouters B.G. Apoptosis, p53, and tumor cell sensitivity to anticancer agents. Cancer Res. 59:1999;1391-1399.
21. Aldridge D.R., Arends M.J., Radford I.R. Increasing the susceptibility of the rat 208F fibroblast cell line to radiation-induced apoptosis does not alter its clonogenic survival dose-response. Br. J. Cancer. 71:1995;343-349.
22. Han J.W., Dionne C.A., Kedersha N.L., Goldmacher V.S. p53 status affects the rate of the onset but not the overall extent of doxorubicin-induced cell death in rat-1 fibroblasts constitutively expressing c-Myc. Cancer Res. 57:1997;176-182.
23. Lock R.B., Stribinskiene L. Dual modes of death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival. Cancer Res. 56:1996;4006-4012.
24. Kyprianou N., King E.D., Bradbury D., Rhee J.G. Bcl-2 overexpression delays radiation-induced apoptosis without affecting the clonogenic survival of human prostate cancer cells. Int. J. Cancer. 70:1997;341-348.
25. ′ -deoxycytidine (Gemcitabine)-mediated radiosensitization Clin. Cancer Res. 7:2001;314-319.
26. waf/cip1 antisense therapy radio sensitizes human colon cancer by converting growth arrest to apoptosis Cancer Res. 60:2000;679-684.
27. Kuninaka S., Ichinose Y., Koja K., Toh Y. Suppression of manganese superoxide dismutase augments sensitivity to radiation, hyperthermia and doxorubicin in colon cancer cell lines by inducing apoptosis. Br. J. Cancer. 83:2000;928-934.
28. Hughes F.M. Jr., Evans-Storms R.B., Cidlowski J.A. Evidence that non-caspase proteases are required for chromatin degradation during apoptosis. Cell Death Differ. 5(12):1998;1017-1027.
29. Spitz F.R., Nguyen D.et al. Adenoviral-mediated wild-type p53 gene expression sensitizes colorectal cancer cells to ionizing radiation. Clin. Cancer Res. 2:1996;1665-1671.
30. Nakaya N., Lowe S.W.et al. Specific pattern of p53 phosphorylation during nitric oxide-induced cell cycle arrest. Oncogene. 19:2000;6369-6375.
31. Soler M.N.et al. Gene therapy of rat medullary thyroid cancer by naked nitric oxide synthase II DNA injection. J. Gene Med. 2:2000;344-352.
32. Khare P.D.et al. Specifically targeted killing of carcinoembryonic antigen (CEA)-expressing cells by a retroviral vector displaying single-chain variable fragmented antibody to CEA and carrying the gene for inducible nitric oxide synthase. Cancer Res. 61:2001;370-375.
33. Worthington J., Robson T., O'Keefe M., Hirst D.G. Tumor cell radiosensitization using constitutive (CMV) and radiation inducible (WAF1) promoters to drive the iNOS gene: a novel suicide gene therapy. Gene Ther. 9:2002;263-269.
34. Xie K.et al. Destruction of bystander cells by tumor cells transfected with inducible nitric oxide (NO) synthase gene. J. Natl. Cancer Inst. 89:1997;421-477.