Suppressive effect of a traditional Japanese medicine, Hachimi-jio-gan (Ba-Wei-Di-Huang-Wan), on the hyperresponsiveness to IL-18 in autoimmune MRL/MPJ-lpr/lpr mice

International Immunopharmacology

Volumn 3, Issue 3, 2003, Pages 365-373

  Furuya, Yuriko ^a   Kawakita, Takuya ^a   Nomoto, Kikuo ^b  

^a KANEBO LTD   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

HMG (Hachimi jio gan); IL 18; MRL lpr mice; V 14NKT

Indexed keywords

CD45 ANTIGEN; GAMMA INTERFERON; HACHIMIJIOGAN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 18 RECEPTOR; INTERLEUKIN 4; MESSENGER RNA; STAT4 PROTEIN; STAT6 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HYPERSENSITIVITY; IMMUNOSUPPRESSIVE TREATMENT; LYMPH NODE CELL; MESENTERY LYMPH NODE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SYMPTOM; T LYMPHOCYTE; TRADITIONAL MEDICINE; UPREGULATION;

EID: 0037333335     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-5769(02)00257-6     Document Type: Article

References (31)

1. Andrew B.S., Eisenberg R.A., Theofilopoulos A.N., Izui S., Wilson C.B.et al. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J. Exp. Med. 148:1978;1198-1215.
2. Watanabe-Fukunaga R., Brannan C.I., Copeland N.G., Jenkins N.A., Nagata S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature (Lond.). 356:1992;314-317.
3. Radvanyi L.G., Raju K., Spaner D., Mills G.B., Miller R.G. Interleukin-2 reverses the defect in activation-induced apoptosis in T cells from autoimmune lpr mice. Cell. Immunol. 183:1998;1-12.
4. Koh D.R., Ho A., Rahemtulla A., Fung-Leung W., Griesser H., Mak T. Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cell. Eur. J. Immunol. 25:1995;2558-2562.
5. Takahashi S., Fossati L., Iwamoto M., Merino R., Motta R.et al. Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice. J. Clin. Invest. 97:1996;1597-1604.
6. Balomenos D., Rumold R., Theofilopoulos N.A. IFN-γ is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J. Clin. Invest. 101:1997;364-371.
7. lpr mice. J. Immunol. 163:1999;6884-6891.
8. Okamura H., Tsutsui H., Komatsu T., Yutsudo M., Hakura A.et al. Cloning of new cytokine that induces IFN-γ production by T cells. Nature. 378:1995;88-91.
9. Ushio S., Namba K., Hattori K., Nukada Y., Akita K.et al. Cloning of cDNA for human IFN-γ inducing factor, expression in Escherichia coli, and studies on the biological activities of the protein. J. Immunol. 156:1996;4274-4279.
10. + T lymphocytes. J. Immunol. 160:1998;3642-3647.
11. - cells. J. Immunol. 160:1998;4738-4746.
12. Parnet P., Garka K.E., Bonnert T.P., Dower S.K., Sims J.E.et al. IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. J. Biol. Chem. 271:1996;3967-3970.
13. Born T.L., Thomassen E., Bird T.A., Sims J.E. Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling. J. Biol. Chem. 273:1998;29445-29450.
14. Lawless V.A., Zhang S., Ozes O.N., Bruns H.A., Oldman I.et al. Stat4 regulates multiple components of IFN-γ-inducing signaling pathway. J. Immunol. 165:2000;6803-6808.
15. - T cell subsets to express IL-18 receptor and produce IFN-γ in response to IL-18. J. Immunol. 160:1998;3759-3765.
16. Yoshimoto T., Takeda K., Tanaka T., Ohkusu K., Kashiwamura S.et al. IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-γ production. J. Immunol. 161:1998;3400-3407.
17. Nakahira M., Tomura M., Iwasaki M., Ahn H.J., Bian Y.et al. An absolute requirement for STAT4 and a role for IFN-γ as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex. J. Immunol. 167:2001;1306-1312.
18. Kim S.H., Reznikov L.L., Stuyt R.J.L., Selzman C.H., Fantuzzi G.et al. Functional reconstitution and regulation of IL-18 activity by the IL-18Rβ chain. J. Immunol. 166:2001;148-154.
19. Esfandiari E., McInnes I.B., Lindop G., Huang F.P., Field M.et al. A proinflammatory role of IL-18 in the development of spontaneous autoimmune disease. J. Immunol. 167:2001;5338-5347.
20. Neumann D., Giudice E.D., Ciaramella A., Boraschi D., Bossu P. Lymphocytes from autoimmune MRL lpr/lpr mice are hyperresponsive to IL-18 and overexpress the IL-18 receptor accessory chain. J. Immunol. 166:2001;3757-3762.
21. Furuya Y., Kawakita T., Nomoto K. Immunomodulating effect of a traditional Japanese medicine Hachimi-jio-gan (Ba-Wei-Di-Huang-Wan), on Th1 predominance in autoimmune MRL/Mp-lpr/lpr mice. Int. Immunopharmacol. 1:2001;551-559.
22. Furuya Y., Kawakita T., Nomoto K. Participation of contrasting changes in IL-10 and IL-12 production in the reduction of TH1-predominance by Hachimi-jio-gan in autoimmune MRL/MP-lpr/lpr mice. Immunopharmacol. Immunotoxicol. 24:2001;17-29.
23. + T cells during T helper (Th)1/Th2 differentiation: critical downregulatory role of IL-4. J. Exp. Med. 194:2001;143-153.
24. + T cell populations. Int. Immunol. 7(7):1995;1157-1161.
25. + NKT cells associated with disease development in autoimmune-prone mice. J. Immunol. 156:1996;4035-4040.
26. Yoshimoto T., Paul W.E. CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179:1996;1285-1295.
27. Murray L.J., Lee R., Martens C. In vivo cytokine gene expression in T cell subsets of the autoimmune MRL/Mp-lpr/lpr mouse. Eur. J. Immunol. 20:1990;163-170.
28. Mori K., Kobayashi S., Inobe M., Jia W.Y., Tamakoshi M.et al. In vivo cytokine gene expression in various cell subsets of the autoimmune MRL/Mp-lpr/lpr mouse. Autoimmunity. 17:1994;49-57.
29. + NK T cells. J. Immunol. 158:1997;2076-2082.
30. Laloux V., Beaudoin L., Jeske D., Carnaud C., Lehuen A. NK T cell-induced protection against diabetes in Vα14-Jα281 transgenic nonobese diabetic mice is associated with a Th2 shift circumscribed regionally to the islets and functionally to islet autoantigen. J. Immunol. 166:2001;3749-3756.
31. Cui J., Shin T., Kawano T., Sato H., Kondo E.et al. Requirement for Vα14 NKT cells in IL-12-mediated rejection of tumors. Science. 278:1997;1623-1626.