In-vitro evaluation of bioadhesion in particulate systems and possible improvement using interactive mixtures

Journal of Pharmacy and Pharmacology

Volumn 55, Issue 2, 2003, Pages 169-177

  Bredenberg, Sussanne ^a   Nyström, Christer ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALGINIC ACID; CALCIUM PHOSPHATE DIBASIC; CARBOXYMETHYLCELLULOSE; EXCIPIENT; KOLLIDON CLM; MANNITOL; POVIDONE; WATER;

ADHESION; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CROSS LINKING; DISPERSIBLE TABLET; DRUG ABSORPTION; DRUG COATING; DRUG FORMULATION; DRUG MIXTURE; DRUG SOLUBILITY; IN VITRO STUDY; INTESTINE; MUCOSA; NONHUMAN; PARTICLE SIZE; POWDER; SWINE; TABLET COMPRESSION; TABLET POROSITY; TABLET PROPERTY; TENSILE STRENGTH;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; EXCIPIENTS; INTESTINAL MUCOSA; TABLETS;

EID: 0037331968     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/002235702423     Document Type: Article

References (28)

1. Alderborn, G., Pasanen, K., Nyström, C. (1985) Studies on direct compression of tablets. XI. Characterization of particle fragmentation during compaction by permeametry measurements of tablets. Int. J. Pharmaceutics 23: 79-86
2. Chickering, D. E., Mathiowitz, E. (1995) Bioadhesive microspheres: I. A novel electrobalance-based method to study adhesive interactions between individual microspheres and intestinal mucosa. J. Control. Release 34: 251-262
3. Chickering, C. D., Mathiowitz, E. (1999) Definitions, mechanisms and theories of bioadhesion. In: Mathiowitz, E., Chickering, D. E., Lehr, C. M. (eds) Bioadhesive Drug Delivery Systems: Fundamentals, Novel Approaches and Development. Marcel Dekker Inc, New York, pp 1-10
4. Corne, S. J., Morrisey, S. M., Woods, R. J. (1974) A method for the quantitative estimation of gastric barrier mucus. J. Physiol. 242: 116-117
5. Duchêne, D., Ponchel, G. (1989) Bioadhesion a new pharmaco-technical method for improving therapeutic efficiency. S.T.P. Pharma 5: 830-838
6. Duchêne, D., Touchard, F., Peppas, N. A. (1988) Pharmaceutical and medical aspects of bioadhesive systems for drug administration. Drug Dev. Ind. Pharm. 14: 283-318
7. Eriksson, M., Nyström, C., Alderborn, G. (1990) Evaluation of a permeametry technique for surface area measurements of coarse particulate materials. Int. J. Pharmaceutics 63: 189-199
8. Gåserød, O., Jolliffe, I. G., Hampson, F. C., Dettmar, P. W., Skåk-Bræk., G. (1998) The enhancement of the bioadhesive properties of calcium alginate gel beads by coating with chitosan. Int. J. Pharmaceutics 175: 237-246
9. Gissinger, D., Stamm, A. (1980) A comparative evaluation of the properties of some tablet disintegrants. Drug Dev. Ind. Pharm. 6: 511-536
10. Hägerström, H., Edsman, K. (2001) Interpretation of mucoadhesive properties of polymer gel preparations using a tensile strength method. J. Pharm. Pharmacol. 53: 1589-1599
11. Hersey, J. A. (1975) Ordered mixing: A new concept in powder mixing practice. Powder Technol. 11: 41-44
12. Mahrag Tur, K., Ch'ng, H.-S. (1998) Evaluation of possible mechanism(s) of bioadhesion. Int. J. Pharmaceutics 160: 61-74
13. Mattsson, S., Nyström, C. (2000) Evaluation of strength-enhancing factors of a ductile binder in direct compression of sodium bicarbonate and calcium carbonate powders. Eur. J. Pharm. Sci. 10: 53-66
14. Mikos, A. G., Peppas, N. A. (1989) Measurement of the surface tension of mucin solutions. Int. J. Pharmaceutics 53: 1-5
15. Mortazavi, S. A., Smart, J. D. (1993) An investigation into the role of water movement and mucus gel dehydration in mucoadhesion. J. Control. Release 25: 197-203
16. Nyström, C., Mazur, J., Sjögren, J. (1982) Studies on direct compression of tablets II. The influence of the particle size of a dry binder on the mechanical strength of tablets. Int. J. Pharmaceutics 10: 209-218
17. Olsson, H., Nyström, C. (2001) Assessing tablet bond types from structural features that affect tablet tensile strength. Pharm. Res. 18: 203-210
18. Ponchel, G., Touchard, F., Duchêne, D., Peppas, N. A. (1987) Bioadhesive analysis of controlled-release systems. I. Fracture and interpenetration analysis in poly(acrylic acid)-containing systems. J. Control. Release 5: 129-141
19. Ranga Rao, K. V., Buri, P. (1989) A novel in situ method to test polymers and coated microparticles for bioadhesion. Int. J. Pharmaceutics 52: 265-270
20. Reich, S., Levy, M., Meshorer, A., Blumental, M., Yalon, M., Sheets, J. W., Goldberg, E. P. (1984) Intraocular-lens-endothelial interface: Adhesive force measurements. J. Biomed. Mater. Res. 18: 737-744
21. Robert, C., Buri, P., Peppas, N. A. (1988) Experimental method for bioadhesive testing of various polymers. Acta Pharm. Technol. 34: 95-98
22. Smart, J. D. (1999) The role of water movement and polymer hydration in mucoadhesion. In: Mathiovitz, E., Chickering, D. E., Lehr, C. M. (eds) Bioadhesive Drug Delivery Systems: Fundamentals, Novel Approaches and Development. Marcel Dekker, New York, pp 11-23
23. Smart, J. D., Kellaway, I. W., Worthington, H. E. C. (1984) An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery. J. Pharm. Pharmacol. 36: 295-299
24. Sundell-Bredenberg, S., Nyström, C. (2001) The possibility of achieving an interactive mixture with high dose homogeneity containing an extremely low proportion of a micronised drug. Eur. J. Pharm. Sci. 12: 285-295
25. Tobyn, M. J., Johnson, J. R., Dettmar, P. W. (1995) Factors affecting in vitro gastric mucoadhesion I. Test conditions and instrumental parameters. Eur. J. Pharm. Biopharm. 41: 235-241
26. Tobyn, M. J., Johnson, J. R., Dettmar, P. W. (1997) Factors affecting in vitro gastric mucoadhesion IV. Influence of tablet excipients, surfactants and salts on the observed mucoadhesion of polymers. Eur. J. Pharm. Biopharm. 43: 65-71
27. Wade, A., Weller, P. J. 1994 Handbook of Pharmaceutical Excipients. American Pharmaceutical Association and the Pharmaceutical Press, Washington DC and London
28. Westerberg, M. (1992) Studies on ordered mixture for fast release and dissolution of drugs with low aqueous solubility. Ph.D. Thesis, Uppsala University, Reprocentralen, HSC, Uppsala, Sweden