Identification of amino acid residues, essential for maintaining the tetrameric structure of sheep liver cytosolic serine hydroxymethyltransferase, by targeted mutagenesis

Biochemical Journal

Volumn 369, Issue 3, 2003, Pages 469-476

  Jala, Venkatakrishna Rao ^a,b   Appaji Rao, Naropantul ^a   Savithri, Handanahal Subbarao ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

Oligomeric structure; Pyridoxal 5 phosphate; Sequence comparison; Site directed mutagenesis; Subunit interaction

Indexed keywords

CATALYST ACTIVITY; HYDROPHOBICITY; MUTAGENESIS; OLIGOMERS;

HYDROPHOBIC RESIDUES;

AMINO ACIDS;

ALANINE; ARGININE; ASPARTIC ACID; GLYCINE; GLYCINE HYDROXYMETHYLTRANSFERASE; LYSINE; METHYLENETETRAHYDROFOLIC ACID; OLIGOMER; PHENYLALANINE; PYRIDOXAL 5 PHOSPHATE; RECOMBINANT ENZYME; TETRAHYDROFOLIC ACID; TETRAMER; TRYPTOPHAN; TYROSINE;

AMINO ACID ANALYSIS; ARTICLE; BINDING SITE; CATALYSIS; ENZYME ASSAY; ENZYME KINETICS; HUMAN; LIVER CYTOSOL; MUTATION; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN FOLDING; SEQUENCE ANALYSIS; SHEEP; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CONSERVED SEQUENCE; CYTOSOL; GLYCINE HYDROXYMETHYLTRANSFERASE; LIVER; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PYRIDOXAL PHOSPHATE; SHEEP;

OVIS ARIES;

EID: 0037330665     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20021160     Document Type: Article

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