Site-specific protein modification to identify the MutL interface of MutH

Nucleic Acids Research

Volumn 31, Issue 3, 2003, Pages 819-825

  Toedt, Grischa H ^a   Krishnan, Ravi ^a   Friedhoff, Peter ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; DNA; ESCHERICHIA COLI PROTEIN; PROTEIN MUTH; PROTEIN MUTL; THIOL; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; BINDING SITE; CONTROLLED STUDY; DNA CLEAVAGE; ESCHERICHIA COLI; IN VITRO STUDY; IN VIVO STUDY; MISMATCH REPAIR; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; REVIEW;

ADENOSINE TRIPHOSPHATASES; BINDING SITES; CYSTEINE; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; ENDODEOXYRIBONUCLEASES; ESCHERICHIA COLI PROTEINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN INTERACTION MAPPING; STRUCTURE-ACTIVITY RELATIONSHIP;

ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0037330066     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkg191     Document Type: Review

References (38)

1. Modrich, P. and Lahue, R. (1996) Mismatch repair in replication fidelity, genetic recombination and cancer biology. Annu. Rev. Biochem., 65, 101-133.
2. Kolodner, R.D. and Marsischky, G.T. (1999) Eukaryotic DNA mismatch repair. Curr. Opin. Genet. Dev., 9, 89-96.
3. Kunkel, T.A. and Bebenek, K. (2000) DNA replication fidelity. Annu. Rev. Biochem., 69, 497-529.
4. Harfe, B.D. and Jinks-Robertson, S. (2000) DNA mismatch repair and genetic instability. Annu. Rev. Genet., 34, 359-399.
5. Hsieh, P. (2001) Molecular mechanisms of DNA mismatch repair. Mutat. Res., 486, 71-87.
6. Lahue, R.S., Au, K.G. and Modrich, P. (1989) DNA mismatch correction in a defined system. Science, 245, 160-164.
7. Welsh, K.M., Lu, A.L., Clark, S. and Modrich, P. (1987) Isolation and characterization of the Escherichia coli mutH gene product. J. Biol. Chem., 262, 15624-15629.
8. Burdett, V., Baitinger, C., Viswanathan, M., Lovett, S.T. and Modrich, P. (2001) In vivo requirement for RecJ, ExoVII, ExoI and ExoX in methyl-directed mismatch repair. Proc. Natl Acad. Sci. USA, 98, 6765-6770.
9. Ban, C. and Yang, W. (1998) Structural basis for MutH activation in E.coli mismatch repair and relationship of MutH to restriction endonucleases. EMBO J., 17, 1526-1534.
10. Ban, C., Junop, M. and Yang, W. (1999) Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair. Cell, 97, 85-97.
11. Ban, C. and Yang, W. (1998) Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesis. Cell, 95, 541-552.
12. Obmolova, G., Ban, C., Hsieh, P. and Yang, W. (2000) Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA. Nature, 407, 703-710.
13. Lamers, M.H., Perrakis, A., Enzlin, J.H., Winterwerp, H.H., de Wind, N. and Sixma, T.K. (2000) The crystal structure of DNA mismatch repair protein MutS binding to a G × T mismatch. Nature, 407, 711-717.
14. Au, K.G., Welsh, K. and Modrich, P. (1992) Initiation of methyl-directed mismatch repair. J. Biol. Chem., 267, 12142-12148.
15. Schofield, M.J., Nayak, S., Scott, T.H., Du, C. and Hsieh, P. (2001) Interaction of Escherichia coli MutS and MutL at a DNA mismatch. J. Biol. Chem., 276, 28291-28299.
16. Hall, M.C. and Matson, S.W. (1999) The Escherichia coli MutL protein physically interacts with MutH and stimulates the MutH-associated endonuclease activity. J. Biol. Chem., 274, 1306-1312.
17. Mansour, C.A., Doiron, K.M.J. and Cupples, C.G. (2001) Characterization of functional interactions among the Escherichia coli mismatch repair proteins using a bacterial two-hybrid assay. Mutat. Res., 485, 331-338.
18. Spampinato, C. and Modrich, P. (2000) The MutL ATPase is required for mismatch repair. J. Biol. Chem., 275, 9861-9869.
19. Wu, T.H., Loh, T. and Marinus, M.G. (2002) The function of Asp70, Glu77 and Lys79 in the Escherichia coli MutH protein. Nucleic Acids Res., 30, 818-822.
20. Yang, W. (2000) Structure and function of mismatch repair proteins. Mutat. Res., 460, 245-256.
21. Loh, T., Murphy, K.C. and Marinus, M.G. (2001) Mutational analysis of the MutH protein from Escherichia coli. J. Biol. Chem., 276, 12113-12119.
22. Friedhoff, P., Sheybani, B., Thomas, E., Merz, C. and Pingoud, A. (2002) Haemophilus influenzae and Vibrio cholerae genes for mutH are able to fully complement a mutH defect in Escherichia coli. FEMS Microbiol. Lett., 208, 121-126.
23. Latham, G.J., Bacheller, D.J., Pietroni, P. and von Hippel, P.H. (1997) Structural analyses of gp45 sliding clamp interactions during assembly of the bacteriophage T4 DNA polymerase holoenzyme. II. The Gp44/62 clamp loader interacts with a single defined face of the sliding clamp ring. J. Biol. Chem., 272, 31677-31684.
24. Pepinsky, R.B., Rayhorn, P., Day, E.S., Dergay, A., Williams, K.P., Galdes, A., Taylor, F.R., Boriack-Sjodin, P.A. and Garber, E.A. (2000) Mapping sonic hedgehog-receptor interactions by steric interference. J. Biol. Chem., 275, 10995-11001.
25. DeLano, W.L. (2002) Unraveling hot spots in binding interfaces: progress and challenges. Curr. Opin. Struct. Biol., 12, 14-20.
26. Cupples, C.G. and Miller, J.H. (1989) A set of lacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutions. Proc. Natl Acad. Sci. USA, 86, 5345-5349.
27. 6-MutS repair proteins of Escherichia coli K-12. Biotechniques, 19, 956-965.
28. Yanisch-Perron, C., Vieira, J. and Messing, J. (1985) Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene, 33, 103-119.
29. Vieira, J. and Messing, J. (1982) The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. Gene, 19, 259-268.
30. Kirsch, R.D. and Joly, E. (1998) An improved PCR-mutagenesis strategy for two-site mutagenesis or sequence swapping between related genes. Nucleic Acids Res., 26, 1848-1850.
31. Friedhoff, P., Thomas, E. and Pingoud, A. (2003) Tyr-212: A key residue involved in strand discrimination by the DNA mismatch repair endonuclease MutH. J. Mol. Biol., 325, 285-297.
32. Pace, C.N., Vajdos, F., Fee, L., Grimsley, G. and Gray, T. (1995) How to measure and predict the molar absorption coefficient of a protein. Protein Sci., 4, 2411-2423.
33. Creighton, T.E. (1993) Proteins - Structures and Molecular Properties, 2nd Edn. W.H. Freeman and Company, New York, pp. 333-334.
34. Bogan, A.A. and Thorn, K.S. (1998) Anatomy of hot spots in protein interfaces. J. Mol. Biol., 280, 1-9.
35. Pingoud, A. and Jeltsch, A. (1997) Recognition and cleavage of DNA by type-II restriction endonucleases. Eur. J. Biochem., 246, 1-22.
36. Allen, D.J., Makhov, A., Grilley, M., Taylor, J., Thresher, R., Modrich, P. and Griffith, J.D. (1997) MutS mediates heteroduplex loop formation by a translocation mechanism. EMBO J., 16, 4467-4476.
37. Drotschmann, K., Aronshtam, A., Fritz, H.J. and Marinus, M.G. (1998) The Escherichia coli MutL protein stimulates binding of Vsr and MutS to heteroduplex DNA. Nucleic Acids Res., 26, 948-953.
38. Lea, D.E. and Coulson, C.A. (1949) The distribution of mutants in bacterial populations. J. Genet., 49, 264-285.