Smallest LDL particles are most strongly related to coronary disease progression in men

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 23, Issue 2, 2003, Pages 314-321

  Williams, Paul T ^a   Superko, H Robert ^b   Haskell, William L ^c   Alderman, Edwin L ^c   Blanche, Patricia J ^a   Holl, Laura Glines ^a   Krauss, Ronald M ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Berkeley HeartLab Inc   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

Coronary disease; HDL; LDL; Lipoproteins; Risk factors

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN; POLYACRYLAMIDE GEL; VERY LOW DENSITY LIPOPROTEIN;

ADULT; ARTICLE; CORONARY ARTERY DISEASE; CORONARY ARTERY OBSTRUCTION; DISEASE COURSE; DISEASE MARKER; GEL ELECTROPHORESIS; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR;

ADULT; AGED; BLOOD GLUCOSE; CORONARY ANGIOGRAPHY; CORONARY DISEASE; CORONARY STENOSIS; DISEASE PROGRESSION; HUMANS; INSULIN; LIPIDS; LIPOPROTEINS, HDL; LIPOPROTEINS, VLDL; MALE; MIDDLE AGED;

EID: 0037329268     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000053385.64132.2D     Document Type: Article

References (62)

1. Nichols AV, Krauss RM, Musliner TA. Nondenaturing polyacrylamide gradient gel electrophoresis. Methods Enzymol. 1986;128:417-431.
2. Krauss RM, Burke DJ. Identification of multiple subclasses of plasma low density lipoproteins in normal humans. J Lipid Res. 1982;23:97-104.
3. Crouse JR, Parks JS, Schey HM, Kahl FR. Studies of low density lipoprotein molecular weight in human beings with coronary artery disease. J Lipid Res. 1985;26:566-574.
4. Austin MA, Breslow JL, Hennekens CH, Buring JE, Willett WC, Krauss RM. Low-density lipoprotein subclass patterns and risk of myocardial infarction. JAMA. 1988;260:1917-1921.
5. Hokanson JE, Austin MA, Brunzell JD. Measurement and clinical significance of low density lipoprotein subclasses, n: Rifai N, Warnick GR. Dominiczak MH, eds. Handbook of Lipoprotein Testing. Washington, DC: AACC Press' 1997;14:267-282.
6. Gardner CD, Fortmann SP, Krauss RM. Association of small low-density lipoprotein particles with the incidence of coronary artery disease in men and women. JAMA. 1996;276:875-881.
7. Blake GJ, Otvos JD. Rifai N, Ridker PM. Low-density lipoprotein particle concentration, and size as determined by nuclear magnetic resonance spectroscopy as predictors of cardiovascular disease in women. Circulation. 2002;106:1930-1939.
8. St-Pierre AC, Ruel IL, Cantin B, Dagenais GR, Bernard PM, Despres JP, Lamarche B. Comparison of various electrophoretic characteristics of LDL particles and their relationship to the risk of ischemic heart disease. Circulation. 2001;104:2295-2299.
9. Kuller L, Arnold A, Tracy R, Otvos J, Burke G, Psaty B, Siscovick D, Freedman DS, Kronmal R. Nuclear magnetic resonance spectroscopy of lipoproteins and risk of coronary heart disease in the Cardiovascular Health Study. Arterioscler Thromb Vasc Biol. 2002;22:1175-1180.
10. Rosenson RS, Otvos JD, Freedman DS. Relations of lipoprotein subclass levels and low-density lipoprotein size to progression of coronary artery disease in the Pravastatin Limitation of Atherosclerosis in the Coronary Arteries (PLAC-I) trial. Am J Cardiol. 2002;90:89-94.
11. Blanche PJ, Gong EL, Forte TM, Nichols AV. Characterization of human high-density lipoproteins by gradient gel electrophoresis. Biochim Biophys Acta. 1981;665:408-419.
12. Wilson HM, Patel JC, Skinner ER. The distribution of high-dehsity lipoprotein subfractions in coronary survivors. Biochem Soc Trans. 1990;18:1175-1176.
13. Johansson J, Carlson LA, Landou C, Hamsten A. High density lipoproteins and coronary atherosclerosis. Arterioscler Thromb Vasc Biol. 1991;11:174-182.
14. Cheung MC, Brown BG, Wolf AC, Albers JJ. Altered particle size distribution of apolipoprotein A-I-containing lipoproteins in subjects with coronary artery disease. J Lipid Res. 1991;32:383-394.
15. Azen SP, Mack WJ, Cashin-Hemphill L, LaBree L, Shircore AM, Selzer RH, Blankenhorn DH, Hodis HN. Progression of coronary artery disease predicts clinical coronary events: long-term follow-up from the Cholesterol Lowering Atherosclerosis Study. Circulation. 1996;93:34-41.
16. Mack WJ, Xiang M, Selzer RH, Hodis HN. Serial quantitative coronary angiography and coronary events. Am Heart J. 2000;139:993-999.
17. Mack WJ, LaBree L, Liu C, Selzer RH, Hodis HN. Correlations between measures of atherosclerosis change using carotid ultrasonography and coronary angiography. Atherosclerosis. 2000;150:371-379.
18. Watts GF, Mandalia S, Slavin BM, Brunt JN, Coltart DJ, Lewis B. Metabolic determinants of the course of coronary artery disease in men. Clin Chem. 1994;40:2240-2246.
19. Thompson GR, Hollyer J, Waters DD. Percentage change rather than plasma level of LDL-cholesterol determines therapeutic response in coronary heart disease. Curr Opin Lipidol. 1995;6:386-388.
20. Johansson J, Olsson AG, Bergstrand L, Elinder LS, Nilsson S, Erikson U, Molgaard J, Holme I, Walldius G. Lowering of HDL2b by probucol partly explains the failure of the drug to affect femoral atherosclerosis in subjects with hypercholesterolemia: a Probucol Quantitative Regression Swedish Trial (PQRST) Report. Arterioscler Thromb Vasc Biol. 1995;15:1049-1056.
21. Phillips NR, Waters D, Havel RJ. Plasma lipoproteins and progression of coronary artery disease evaluated by angiography and clinical events. Circulation. 1993;88:2762-2770.
22. Mack WJ, Krauss RM, Hodis HN. Lipoprotein subclasses in the monitored atherosclerosis regression study (MARS): treatment effects and relation to coronary angiographic progression. Arterioscler Thromb Vasc Biol. 1996;16:697-704.
23. Zhao XQ, Kosinski AS, Malinow MR, Superko HR, King SB. Association of LDL heterogeneity and native coronary disease progression at 3 years following PTCA or CABG in East. Circulation. 2000;18(suppl II):II-699. Abstract.
24. Zambon A, Hokanson JE, Brown BG, Brunzell JD. Evidence for a new pathophysiological mechanism for coronary artery disease regression: hepatic lipase-mediated changes in LDL density. Circulation. 1999;99:1959-1964.
25. Cobbaert C, Jukema JW, Zwinderman AH, Withagen AJ, Lindemans J, Bruschke AV. Modulation of lipoprotein(a) atherogenicity by high density lipoprotein cholesterol levels in middle-aged men with symptomatic coronary artery disease and normal to moderately elevated serum cholesterol: Regression Growth Evaluation Statin Study. J Am Coll Cardiol. 1997;30:1491-1499.
26. Haskell WL, Alderman EL, Fair JM, Maron DJ, Mackey SF, Superko HR, Williams PT, Johnstone IM, Champagne MA, Krauss RM. Effects of intensive multiple risk factor reduction on coronary atherosclerosis and clinical cardiac events in men and women with coronary artery disease: the Stanford Coronary Risk Intervention Project (SCRIP). Circulation. 1994;89:975-990.
27. Hodis HN, Mack WJ, Azen SP, Alaupovic P, Pogoda JM, LaBree L, Hemphill LC, Kramsch DM, Blankenhorn DH. Triglyceride- and cholesterol-rich lipoproteins have a differenfial effect on mild/moderate and severe lesion progression as assessed by quantitative coronary angiography in a controlled trial of lovastafin. Circulation. 1994;90:42-49.
28. Williams PT, Vranizan KM, Krauss RM. Correlations of plasma lipoproteins with LDL subfractions by particle size in men and women. J Lipid Res. 1992;33:765-774.
29. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem. 1974;20:470-475.
30. Hainline A Jr, Karon J, Lippel K, eds. Manual of Laboratory Operations: Lipid and Lipoprotein Analysis. 2nd ed. Washington DC: US Government Printing Office, National Heart Lung and Blood Institute, Lipid Research Clinics Program; 1982. DHEW publication No. NIH 75-628 (revised).
31. 2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. Clin Chem. 1982;28:1379-1388.
32. Lindgren FT. Serum lipoproteins: isolation and analysis with the preparative and analytic ultracentrifuge. In: Burton RM, Guerra FC, eds. Fundamentals of Lipid Chemistry. 2nd ed. Webster Grove, Mo: BI-Science Publications Division; 1974:475-510.
33. Corsetti JP, Sterry JA, Sparks JD, Sparks CE, Weintraub M. Effect of weight loss on serum lipoprotein(a) concentrations in an obese population. Clin Chem. 1991;37:1191-1195.
34. Tijssen P. Practice and theory of enzyme immunoassays. In: Burton RH, van Knippenberg PH, eds. Laboratory Techniques in Biochemistry and Molecular Biology. Vol 15. Amsterdam: Elsevier Science Publishers BV; 1985:345-347.
35. Trinder P. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann Clin Biochem. 1969;6:24-27.
36. Hales CN, Ralldle PJ. Immunoassay of insulin with insulin antibody precipitate. Biochem J. 1963;88:137-146.
37. Lindgren FT, Jensen LC, Hatch FT. The isolation and quantitative analysis of serum lipoproteins. In: Nelson GJ, ed. Blood Lipids and Lipoproteins: Quantitation, Composition, and Metabolism. New York: John Wiley and Sons; 1972:181-274.
38. Williams PT, Krauss RM. Associations of age, adiposity, menopause, and alcohol intake with low-density lipoprotein subclasses. Arterioscler Thromb Vasc Biol. 1997;17:1082-1090.
39. Gardner CD, Fortmann SP, Krauss RM. Association of small low-density lipoprotein particles with the incidence of coronary artery disease in men and women. JAMA. 1996;276:875-881.
40. Stampfer MJ, Krauss RM, Ma J, Blanche PJ, Holl LG, Sacks FM, Hennekens CH. A prospective study of triglyceride level, low-density lipoprotein particle diameter, and risk of myocardial infarction. JAMA. 1996;276:882-888.
41. Austin MA, Breslow JL, Hennekens CH, Buring JE, Willett WC, Krauss RM. Low-density lipoprotein subclass patterns and risk of myocardial infarction. JAMA. 1988;260:1917-1721.
42. Sniderman AD, Scantlebury T, Cianflone K. Hypertriglyceridemic hyperapoB: the unappreciated atherogenic dyslipoproteinemia in type 2 diabetes mellitus. Ann Intern Med. 2001;135:447-459.
43. Campos H, Roederer GO, Lussier-Cacan S, Davignon J, Krauss RM. Predominance of large LDL and reduced HDL2 cholesterol in normolipidemic men with coronary artery disease. Arterioscler Thromb Vasc Biol. 1995;15:1043-1048.
44. Gray RS, Robbins DC, Wang W, Yeh JL, Fabsitz RR, Cowan LD, Welty TK, Lee ET, Krauss RM, Howard BV. Relation of LDL size to the insulin resistance syndrome and coronary heart disease in American Indians: the Strong Heart Study. Arterioscler Thromb Vasc Biol. 1997;17:2713-2720.
45. Wahi S, Gatzka CD, Sherrard B, Simpson H, Collins V, Dowse G, Zimmet P, Jennings G, Dart AM. Risk factors for coronary heart disease in a population with a high prevalence of obesity and diabetes: a case-control study of the Polynesian population of Western Samoa. J Cardiovasc Risk. 1997;4:173-178.
46. Ruotolo G, Tettamanti C, Garancini MP, Ragogna F, Derosa G, Nardecchia L, Parlato F, Pozza G. Smaller, denser LDL particles are not a risk factor for cardioascular disease in healthy nonagenarian women of the Cremona Population Study. Atherosclerosis. 1998;140:65-70.
47. Campos H, Moye LA, Glasser SP, Stampfer MJ, Sacks FM. Low-density lipoprotein size, pravastatin treatment, and coronary events. JAMA. 2001; 286:1468-1474.
48. Tribble DL, Rizzo M, Chait A, Lewis DM, Blanche PJ, Krauss RM. Enhanced oxidative susceptibility and reduced antioxidant content of metabolic precursors of small, dense low-density lipoproteins. Am J Med. 2001;110:103-110.
49. Chancharme L, Thérond P, Nigon F, Lepage S, Couturier M, Chapman MJ. Cholesteryl ester hydroperoxide lability is a key feature of the oxidative susceptibility of small, dense LDL. Arterioscler Thromb Vasc Biol. 1999;19:810-820.
50. Kontush A. Hübner C, Finckh B. Kohlschütter A, Beisiegel U. How different corisfituents of low density lipoprotein determine its oxidizability by copper: a correlational approach. Free Radic Res. 1995;24:135-147.
51. Bjornheden T, Babyi A, Bondjers G, Wiklund O. Accumulation of lipoprotein fractions and subfractions in the arterial wall, determined in an in vitro perfusion system. Atherosclerosis. 1996;123:43-45.
52. Anber V, Griffin BA, McConnell M, Packard CJ, Shepherd J. Influence of plasma lipid and LDL-subfraction profile on the interaction between low density lipoprotein with human arterial wall proteoglycans. Atherosclerosis. 1996;124:261-271.
53. Superko HR, Krauss RM. Garlic powder, effect on plasma lipids, postprandial lipemia, low-density lipoprotein particle size, high-density lipoprotein subclass distribution and lipoprotein(a). J Am Coll Cardiol. 2000;35:321-326.
54. Reaven GM, Chen YD, Jeppesen J, Maheux P, Krauss RM. Insulin resistance and hyperinsulinemia in individuals with small, dense low density lipoprotein particles. J Clin Invest. 1993;92:141-146.
55. Albers JJ, Chen CH, Aladjem F. Human serum lipoproteins: evidence for three classes of lipoproteins in Sf 0-2. Biochemistry. 1972;11:57-63.
56. International Collaborative Group. Asymptomatic hyperglycemia and coronary heart disease: a series of papers by the International Collaborative Group based on studies in fifteen populations. J Chronic Dis. 1979;32:829-837.
57. Donahue RP, Orchard TJ. Diabetes mellitus and macrovascular complicafions: an epidemiological perspective. Diabetes Care. 1992;15:1141-1155.
58. Jarrett RJ. The cardiovascular risk associated with impaired glucose tolerance. Diabet Med. 1996;13:S15-S19.
59. Balkau B, Shipley M, Jarrett RJ, Pyorala K, Pyorala M, Forhan A, Eschwege E. High blood glucose concentration is a risk factor for mortality in middle-aged nondiabetic men: 20-year follow-up in the Whitehall Study, the Paris Prospective Study, and the Helsinki Policemen Study. Diabetes Care. 1998;2:360-367.
60. Balkau B, Bertrais S, Ducimetiere P, Eschwege E. Is there a glycemic threshold for mortality risk? Diabetes Care. 1999;22:696-699.
61. Scheidt-Nave C, Barrett-Connor E, Wingard DL, Cohn BA, Edelstein SL. Sex differences in fasting glycemia as a risk factor for ischemic heart disease death. Am J Epidemiol. 1991;133:565-576.
62. Grundy SN. Small LDL, atherogenic dyslipidemia and the metabolic syndrome. Circulation. 1997;95:1-4.