Cyclosporin A-mediated killing of Leishmania major by macrophages is independent of reactive nitrogen and endogenous TNF-α and is not inhibited by IL-10 and 13

Parasitology Research

Volumn 89, Issue 3, 2003, Pages 221-227

  Meißner, Udo ^a   Jüttner, Stefan ^b   Röllinghoff, Martin ^a   Gessner, André ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; NITRIC OXIDE SYNTHASE; NITROGEN; PROTEIN P55; REACTIVE NITROGEN SPECIES; TACROLIMUS; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ARTICLE; AUTOCRINE EFFECT; CONTROLLED STUDY; DOSE RESPONSE; DRUG SELECTIVITY; FEMALE; IMMUNOSUPPRESSIVE TREATMENT; KNOCKOUT MOUSE; LEISHMANIA MAJOR; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REDUCTION; REGULATORY MECHANISM;

LEISHMANIA MAJOR; MURINAE; PROTOZOA;

EID: 0037323174     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-002-0743-z     Document Type: Article

References (35)

1. Adinolfi LE, Bonventre PF (1990) Cyclosporin A treatment converts Leishmania donovani-infected C57BL/10 (curing) mice to a noncuring phenotype. Infect Immun 58:3151-3153
2. Allain F, Vanpouille C, Carpentier M, Slomianny MC, Durieux S, Spik G (2002) Interaction with glycosaminoglycans is required for cyclophilin B to trigger integrin-mediated adhesion of peripheral blood T lymphocytes to extracellular matrix. Proc Natl Acad Sci U S A 99:2714-2719
3. Al-Zamel F, Al-Shammary FJ, El-Shewemi S, Soliman R (1996) Enhancement of leishmanicidal activity of human macrophages against Leishmania major and Leishmania donovani infection using recombinant human granulocyte macrophage colony stimulating factor. Zentralbl Bakteriol 285:92-105.
4. Bell A, Wernli B, Franklin RM (1994) Roles of peptidyl-prolyl cistrans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin. Biochem Pharmacol 48:495-503
5. Bell A, Roberts HC, Chappell LH (1996) The antiparasite effects of cyclosporin A: possible drug targets and clinical applications. Gen Pharmacol 27:963-971
6. Berriman M, Fairlamb AH (1998) Detailed characterization of a cyclophilin from the human malaria parasite Plasmodium falciparum. Biochem J 334:437-445
7. Bogdan C, Nathan C (1993) Modulation of macrophage function by transforming growth factor beta, interleukin-4, and interleukin-10. Ann N Y Acad Sci 685:713-739
8. Bogdan C, Röllinghoff M (1998) The immune response to Leishmania: mechanisms of parasite control and evasion. Int J Parasitol 28:121-134
9. Bogdan C, Streck H, Röllinghoff M, Solbach W (1989) Cyclosporin A enhances elimination of intracellular L. major parasites by murine macrophages. Clin Exp Immunol 75:141-146
10. Bout D, Deslee D, Capron A (1986) Antischistosomal effect of cyclosporin A: cure and prevention of mouse and rat schistosomiasis mansoni. Infect Immun 52:823-827
11. Ciancio G, Burke GW, Miller J (2000) Current treatment practice in immunosuppression. Expert Opin Pharmacother 1:1307-1330
12. Gessner A, Vieth M, Will, Schröppel K, Röllinghoff M (1993) Interleukin-7 enhances antimicrobial activity against Leishmania major in murine macrophages. Infect Immun 61:4008-4012
13. Hoerauf A, Rascher C, Bang R, Pahl A, Solbach W, Brune K, Röllinghoff M, Bang H (1997) Host-cell cyclophilin is important for the intracellular replication of Leishmania major. Mol Microbiol 24:421-429
14. Ivery MT (2000) Immunophilins: switched on protein binding domains? Med Res Rev 20:452-484
15. Jones TC (1996) The effect of granulocyte-macrophage colony stimulating factor (rGM- CSF) on macrophage function in microbial disease. Med Oncol 13:141-147
16. Khattab A, Pica-Mattoccia L, Klinkert MQ, Wenger R, Cioli D (1998) Cyclosporins: lack of correlation between antischistosomal properties and inhibition of cyclophilin isomerase activity. Exp Parasitol 90:103-109
17. Maruyama T, Furutani M (2000) Archaeal peptidyl prolylcis-trans isomerases (PPIases). Front Biosci 5:D821-836
18. McCabe RE, Remington JS, Araujo FG (1985) In vivo and in vitro effects of cyclosporin A on Trypanosoma cruzi. Am J Trop Med Hyg 34:861-865
19. McCabe RE, Luft BJ, Remington JS (1986) The effects of cyclosporine on Toxoplasma gondii in vivo and in vitro, Transplantation 41:611-615
20. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A (2001) Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19:683-765
21. Moro A, Ruiz-Cabello F, Fernandez-Cano A, Stock RP, Gonzalez A (1995) Secretion by Trypanosoma cruzi of a peptidyl-prolyl cis-trans isomerase involved in cell infection. EMBO J 14:2483-2490
22. Murphy JR, Baqar S, Baker RH, Roberts E, Nickell SP, Cole GA (1988) Stage-selective inhibition of rodent malaria by cyclosporine. Antimicrob Agents Chemother 32:462-466
23. Olivier M, Tanner CE (1989) The effect of cyclosporin A in murine visceral leishmaniasis. Trop Med Parasitol 40:32-38
24. Perkins ME, Wu TW, Le Blancq SM (1998) Cyclosporin analogs inhibit in vitro growth of Cryptosporidium parvum. Antimicrob Agents Chemother 42:843-848
25. Pfeffer K, Matsuyama T, Kundig TM, Wakeham A, Kishihara K, Shahinian A, Wiegmann K, Ohashi PS, Kronke M, Mak TW (1993) Mice deficient for the 55 kD tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73:457-467
26. Rascher C, Pahl A, Pecht A, Brune K, Solbach W, Bang H (1998) Leishmania major parasites express cyclophilin isoforms with an unusual interaction with calcineurin. Biochem J 334:659-667
27. Sherry B, Yarlett N, Strupp A, Cerami A (1992) Identification of cyclophilin as a proinflammatory secretory product of lipopolysaccharide-activated macrophages. Proc Natl Acad Sci U S A 89:3511-3515
28. Shirahata T, Katsuda K, Ohta C, Goto H (1990). Effects of cyclosporin A on susceptibility and interferon-generating capacity in mice infected with Toxoplasma gondii. Nippon Juigaku Zasshi 52:387-393
29. Solbach W, Forberg K, Kammerer E, Bogdan C, Röllinghoff M (1986a) Suppressive effect of cyclosporin A on the development of Leishmania tropica-induced lesions in genetically susceptible BALB/c mice. J Immunol 137:702-707
30. Solbach W, Forberg K, Röllinghoff M (1986b) Effect of T-lymphocyte suppression on the parasite burden in Leishmania major-infected, genetically susceptible BALB/c mice. Infect Immun 54:909-912
31. Stenger S, Thuring H, Röllinghoff M, Manning P, Bogdan C (1995) L-N6-(1-iminoethyl)-lysine potently inhibits inducible nitric oxide synthase and is superior to NG-monomethyl-arginine in vitro and in vivo. Eur J Pharmacol 294:703-712
32. Vieth M, Will A, Schröppel K, Röllinghoff M, Gessner A (1994) Interleukin-10 inhibits antimicrobial activity against Leishmania major in murine macrophages. Scand J Immunol 40:403-409
33. Walsh CT, Zydowsky LD, McKeon FD (1992) Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction. J Biol Chem 267:13115-13118
34. Wiederrecht G, Lam E, Hung S, Martin M, Sigal N (1993) The mechanism of action of FK-506 and cyclosporin A. Ann N Y Acad Sci 696:9-19
35. Xu Q, Leiva MC, Fischkoff SA, Handschumacher RE, Lyttle CR (1992) Leukocyte chemotactic activity of cyclophilin. J Biol Chem 267:11968-11971