Cyclosporins: Lack of correlation between antischistosomal properties and inhibition of cyclophilin isomerase activity

Experimental Parasitology

Volumn 90, Issue 1, 1998, Pages 103-109

  Khattab, A ^a   Pica Mattoccia, L ^a   Klinkert, Mo Quen ^a   Wenger, R ^b,c   Cioli, D ^a  

^a CNR   (Italy)

^b NOVARTIS PHARMA AG   (Switzerland)

^c Wenger Chemtech   (Switzerland)

Author keywords

Cyclosporins; FK506; PPIase; Schistosoma mansoni

Indexed keywords

CYCLOPHILIN; CYCLOSPORIN A; CYCLOSPORIN DERIVATIVE; FK 506 BINDING PROTEIN; ISOMERASE; SDZ 204 718; SDZ 205 549; SDZ 205549; SDZ 207 256; SDZ 208 032; SDZ 209313; SDZ 210 039; SDZ 211 810; SDZ 214 013; SDZ 214 103; SDZ 215 918; SDZ 220 384; SDZ 27 400; SDZ 33 804; SDZ 34 271; SDZ 37 325; SDZ 37 839; SDZ 90 004; TACROLIMUS; UNCLASSIFIED DRUG; VALSPODAR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTHELMINTIC ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALIA; SCHISTOSOMA; SCHISTOSOMA MANSONI; TREMATODA;

EID: 0031754226     PISSN: 00144894     EISSN: None     Source Type: Journal    
DOI: 10.1006/expr.1998.4307     Document Type: Article

References (33)

1. Argaet, V. P., and Mitchell, G. F. 1992. Cyclophilin of Schistosoma japonicum. Journal of Parasitology 78, 660-664.
2. Basch, P. F. 1981. Cultivation of Schistosoma mansoni in vitro. Establishment of cultures from cercariae and development until pairing. Journal of Parasitology 67, 179-185.
3. Bell, A., Wernli, B., and Franklin, R. 1994. Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin. Biochemical Pharmacology 48, 495-503.
4. Bell, A., Roberts, H. C. and Chappell, L. H. 1996. The antiparasitic effects of cyclosporin A: Possible drug targets and clinical applications. General Pharmacology 27, 963-971.
5. Bergsma, D. J., Eder, C., Gross, M., Kersten, H., Sylvester, D., Appelbaum, E., Cusimano, D., Livi, G. P., McLaughlin, M. M., Kasyan, K., Porter, T. G., Silverman, C., Dunnington, D., Hand, A., Prichett, W. P., Bossard, M. J., Brandt, M. and Levy, M. A. 1991. The cyclophilin multigene family of peptidyl-prolyl isomerases. Journal of Biological Chemistry, 266, 23204-23214.
6. Borel, J. F., Baumann, G., Chapman, L., Donatsch, P., Fahr, A., Mueller, E. A., and Vigouret, J.-M. 1996. In vivo pharmacological effects of ciclosporin and some analogues. Advances in Pharmacology 35, 115-245.
7. Bram, R. J., Hung, D. T., Martin, P. K., Schreiber, S. L., and Crabtree, G. R. 1993. Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: Roles of calcineurin binding and cellular location. Molecular and Cellular Biology 13, 4760-4769.
8. Brannan, L. R., Chappell, L. H., Woo, J., and Thomson, A. W. 1989. Antischistosomal activity of cyclosporin A: Studies on murine spleen cells and the influence of a cyclosporin antagonist on resistance to infection. Immunology 67, 382-387.
9. Bueding, E., Hawkins, J., and Cha, Y. N. 1981. Antischistosomal effects of cyclosporin A. Agents and Actions 11, 380-383.
10. Bugli, F., Khattab, A., Vigneti, E., Butler, R., Cioli, D., and Klinkert, M. Q. 1998. Expression cloning and biochemical characterizations of recombinant cyclophilin proteins from Schistosoma mansoni. Protein Expression and Purification 12, 340-346.
11. Chappell, L. H., Thomson, A. W., Barker, G. C., and Smith, S. W. G. 1987. Dosage, timing, route and administration of cyclosporin A and non-immunosuppressive derivatives of dihydrocyclosporin A and cyclosporin C against Schistosoma mansoni in vivo and in vitro. Antimicrobial Agents for Chemotherapy 31, 1567-1571.
12. Chappell, L. H., and Thomson, A. W. 1988. Studies on the action of cyclosporin A against Schistosoma mansoni and other parasitic infections. Transplantation Proceedings 20, 291-297.
13. Clipstone, N. A., and Crabtree, G. R. 1992. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 357, 695-697.
14. Fischer, G., Wietmann-Liebold, B., Lang, K., Kiefhaber, T., and Schmid, F. X. 1989. Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins. Nature 337, 476-478.
15. Fruman, D. A., Klee, C. B., Bierer, B., and Burakoff, S. J. 1992. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A. Proceedings of the National Academy of Science U.S.A. 89, 3686-3690.
16. Gething, M.-J., and Sambrook, J. 1992. Protein folding in the cell. Nature 355, 33-45.
17. Harding, M. W., Galat, A., Uehling, D. E., and Schreiber, S. L. 1989. A receptor for the immunosuppressant FK506 is a cis-trans peptidyl prolyl isomerase. Nature 341, 758-760.
18. Kay, J. E. 1996. Structure-function relationships in the FK506-binding protein (FKBP) family of peptidylprolyl cis-trans isomerases. Biochemical Journal 314, 361-386.
19. Kiang, D., El Ghazalie, N. E., Medhat, A. M., Abdel-Fattah, M., Karim, A. M., and LoVerde, P. T. 1996. Identification and characterization of Schistosoma mansoni p17.7, a cyclophilin. Molecular and Biochemical Parasitology 76, 73-82.
20. Klinkert, M. Q., Bugli, F., Engels, B., Carasquillo, E., Valle, C., and Cioli, D. 1995. Characterization of a Schistosoma mansoni cDNA encoding a B-like cyclophilin and its expression in Escherichia coli. Molecular and Biochemical Parasitology 75, 99-111.
21. Klinkert, M. Q., Bugli, F., Cruz, J., Engels, B., and Cioli, D. 1996. Sequence conservation of schistosome cyclophilins. Molecular and Biochemical Parasitology 81, 239-242.
22. Kofron, J. L., Kuzmic, P., Kishore, V., Colon-Bonilla, E., and Rich, D. H. 1991. Determination of kinetic constants for peptidyl prolyl cis-trans isomerases by an improved spectrophotometric assay. Biochemistry, 6127-6134.
23. Liu, J. F., Farmer, J. D., Lane, W. S., Friedmann, J., Weissman, I., and Schreiber, S. 1991. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66, 807-815.
24. Liu, J. F., and Chappell, L. H. 1992. In vivo and in vitro activity of cyclosporin A against Schistosoma mansoni. In "Sixth European Multicolloquium of Parasitology." p. 99, The Hague.
25. Liu, J. F. 1993. FK506 and cyclosporin, molecular probes for studying intracellular signal transduction. Immunology Today 14, 290-295.
26. Osman, A., Kiang, D., Loverde, P. T., and Karim, A. M. 1995. Schistosoma mansoni: Characterization of p50, an immunophilin. Experimental Parasitology 80, 550-559.
27. Pica-Mattoccia, L., Archer, S., and Cioli, D. 1992. Hycanthone resistance in schistosomes correlates with the lack of an enzymatic activity which produces the covalent binding of hycanthone to parasite macromolecules. Molecular and Biochemical Parasitology 55, 167-176.
28. Price, E. R., Zydowsky, L. D., Jin, M., Baker, C. H., Mckeon, F. D., and Walsh, C. T. 1991. Human cyclophilin B: A second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence. Proceedings of the National Academy Science U.S.A. 88, 1903-1907.
29. Schreiber, S. L., and Crabtree, G. R. 1992. The mechanism of action of cyclosporin A and FK506. Immunology Today 13, 136-142.
30. Standaert, R. E., Galat, A., Verdine, G. L., and Schreiber, S. L. 1990. Molecular cloning and overexpression of the human FK506-binding protein FKBP. Nature 346, 671-674.
31. Tradinh, C. C., Pao, G. M., and Saier, M. H., Jr. 1992. Structural and evolutionary relationships among the immunophilins: two ubiquitous families of peptidyl-prolyl cis-trans isomerases. FASEB Journal 6, 3410-3420.
32. Walsh, C. T., Zydowsky L. D., and Mckeon, F. D. 1992. Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction. Journal of Biological Chemistry 267, 13115-13118.
33. Wenger, R. 1986. Cyclosporine and analogues: structural requirements for immunosuppressive activity. Transplantation Proceedings 18, 213-218.