-
1
-
-
78651127719
-
Chemoaffinity in the orderly growth of nerve fiber patterns and connections
-
Sperry R. Chemoaffinity in the orderly growth of nerve fiber patterns and connections. Proc. Natl. Acad. Sci. U.S.A. 50:1963;703-710.
-
(1963)
Proc. Natl. Acad. Sci. U.S.A.
, vol.50
, pp. 703-710
-
-
Sperry, R.1
-
2
-
-
0029086140
-
Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map
-
Cheng H.J., Nakamoto M., Bergemann A.D., Flanagan J.G. Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map. Cell. 82:1995;371-381.
-
(1995)
Cell
, vol.82
, pp. 371-381
-
-
Cheng, H.J.1
Nakamoto, M.2
Bergemann, A.D.3
Flanagan, J.G.4
-
3
-
-
0029082312
-
In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases
-
Drescher U., Kremoser C., Handwerker C., Loschinger J., Noda M., Bonhoeffer F. In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases. Cell. 82:1995;359-370.
-
(1995)
Cell
, vol.82
, pp. 359-370
-
-
Drescher, U.1
Kremoser, C.2
Handwerker, C.3
Loschinger, J.4
Noda, M.5
Bonhoeffer, F.6
-
4
-
-
0035287473
-
Multiple roles of EPH receptors and ephrins in neural development
-
Wilkinson D.G. Multiple roles of EPH receptors and ephrins in neural development. Nat. Rev. Neurosci. 2:2001;155-164.
-
(2001)
Nat. Rev. Neurosci.
, vol.2
, pp. 155-164
-
-
Wilkinson, D.G.1
-
5
-
-
0024306214
-
Inaccuracies in initial growth and arborization of chick retinotectal axons followed by course corrections and axon remodeling to develop topographic order
-
Nakamura H., O'Leary D.D.M. Inaccuracies in initial growth and arborization of chick retinotectal axons followed by course corrections and axon remodeling to develop topographic order. J. Neurosci. 9:1989;3776-3795.
-
(1989)
J. Neurosci.
, vol.9
, pp. 3776-3795
-
-
Nakamura, H.1
O'Leary, D.D.M.2
-
6
-
-
0026598442
-
Development of topographic order in the mammalian retinocollicular projection
-
Simon D.K., O'Leary D.D.M. Development of topographic order in the mammalian retinocollicular projection. J. Neurosci. 12:1992;1212-1232.
-
(1992)
J. Neurosci.
, vol.12
, pp. 1212-1232
-
-
Simon, D.K.1
O'Leary, D.D.M.2
-
7
-
-
0026474853
-
Responses of retinal axons in vivo and in vitro to position-encoding molecules in the embryonic superior colliculus
-
Simon D.K., O'Leary D.D.M. Responses of retinal axons in vivo and in vitro to position-encoding molecules in the embryonic superior colliculus. Neuron. 9:1992;977-989.
-
(1992)
Neuron
, vol.9
, pp. 977-989
-
-
Simon, D.K.1
O'Leary, D.D.M.2
-
8
-
-
0026726861
-
Influence of position along the medial-lateral axis of the superior colliculus on the topographic targeting and survival of retinal axons
-
Simon D.K., O'Leary D.D.M. Influence of position along the medial-lateral axis of the superior colliculus on the topographic targeting and survival of retinal axons. Brain. Res. Dev. Brain. Res. 69:1992;167-172.
-
(1992)
Brain. Res. Dev. Brain. Res.
, vol.69
, pp. 167-172
-
-
Simon, D.K.1
O'Leary, D.D.M.2
-
9
-
-
0035503703
-
Topographic-specific axon branching controlled by ephrin-As is the critical event in retinotectal map development
-
The authors show the time course of development of the chick retinotectal map by injecting small amounts of DiI into the retina and describing in quantitative detail the initial posterior RGC axon overshoot of the TZ. In addition, the authors show that interstitial branches form most often in the A-P location of their future TZ, and arbors in the TZ are exclusively elaborated by interstitial branches. In vitro experiments show that branch formation is inhibited by ephrin-As. Modeling indicates that the repellent action of ephrin-As on growth cones and interstitial branches cannot be the only activity that controls A-P retinotectal mapping. Ephrin-As are likely to cooperate with an attractant that is expressed in a similar pattern to that of ephrin-As or with a repellent that is expressed in a gradient opposite to that of ephrin-As in the tectum.
-
Yates P.A., Roskies A.L., McLaughlin T., O'Leary D.D.M. Topographic-specific axon branching controlled by ephrin-As is the critical event in retinotectal map development. J. Neurosci. 21:2001;8548-8563 The authors show the time course of development of the chick retinotectal map by injecting small amounts of DiI into the retina and describing in quantitative detail the initial posterior RGC axon overshoot of the TZ. In addition, the authors show that interstitial branches form most often in the A-P location of their future TZ, and arbors in the TZ are exclusively elaborated by interstitial branches. In vitro experiments show that branch formation is inhibited by ephrin-As. Modeling indicates that the repellent action of ephrin-As on growth cones and interstitial branches cannot be the only activity that controls A-P retinotectal mapping. Ephrin-As are likely to cooperate with an attractant that is expressed in a similar pattern to that of ephrin-As or with a repellent that is expressed in a gradient opposite to that of ephrin-As in the tectum.
-
(2001)
J. Neurosci.
, vol.21
, pp. 8548-8563
-
-
Yates, P.A.1
Roskies, A.L.2
McLaughlin, T.3
O'Leary, D.D.M.4
-
10
-
-
0036685537
-
EphB forward signaling controls directional branch extension and arborization required for dorsal-ventral retinotopic mapping
-
Hindges R., McLaughlin T., Genoud N., Henkemeyer M., O'Leary D.D.M. EphB forward signaling controls directional branch extension and arborization required for dorsal-ventral retinotopic mapping. Neuron. 35:2002;475-487.
-
(2002)
Neuron
, vol.35
, pp. 475-487
-
-
Hindges, R.1
McLaughlin, T.2
Genoud, N.3
Henkemeyer, M.4
O'Leary, D.D.M.5
-
11
-
-
0023618902
-
Retinal axons with and without their somata, growing to and arborizing in the tectum of Xenopus embryos: A time-lapse video study of single fibres in vivo
-
Harris W.A., Holt C.E., Bonhoeffer F. Retinal axons with and without their somata, growing to and arborizing in the tectum of Xenopus embryos: a time-lapse video study of single fibres in vivo. Development. 101:1987;123-133.
-
(1987)
Development
, vol.101
, pp. 123-133
-
-
Harris, W.A.1
Holt, C.E.2
Bonhoeffer, F.3
-
12
-
-
0026687394
-
Dynamics of terminal arbor formation and target approach of retinotectal axons in living zebrafish embryos: A time-lapse study of single axons
-
Kaethner R.J., Stuermer C.A. Dynamics of terminal arbor formation and target approach of retinotectal axons in living zebrafish embryos: a time-lapse study of single axons. J. Neurosci. 12:1992;3257-3271.
-
(1992)
J. Neurosci.
, vol.12
, pp. 3257-3271
-
-
Kaethner, R.J.1
Stuermer, C.A.2
-
13
-
-
0028204466
-
Rapid remodeling of retinal arbors in the tectum with and without blockade of synaptic transmission
-
O'Rourke N.A., Cline H.T., Fraser S.E. Rapid remodeling of retinal arbors in the tectum with and without blockade of synaptic transmission. Neuron. 12:1994;921-934.
-
(1994)
Neuron
, vol.12
, pp. 921-934
-
-
O'Rourke, N.A.1
Cline, H.T.2
Fraser, S.E.3
-
14
-
-
0035503546
-
Semaphorin 3A elicits stage-dependent collapse, turning, and branching in Xenopus retinal growth cones
-
The authors examine the role of Sema3a in the guidance of Xenopus RGC axons. The response to Sema3a is stage-dependent and results in the collapse or turning of the growth cone. Sema3a-mediated growth cone collapse results in terminal branching that is highly reminiscent of backbranching, a process normally observed in retinotopic map formation. The stage-dependent actions of Sema3a, and the elicited branching, suggest multiple roles for this guidance molecule in topographic map development. Sema3a may contribute to the guidance of axons posteriorly from the contralateral telencephalon, the collapse of their growth cones in the tectum, and the induction of backbranching.
-
Campbell D.S., Regan A.G., Lopez J.S., Tannahill D., Harris W.A., Holt C.E. Semaphorin 3A elicits stage-dependent collapse, turning, and branching in Xenopus retinal growth cones. J. Neurosci. 21:2001;8538-8547 The authors examine the role of Sema3a in the guidance of Xenopus RGC axons. The response to Sema3a is stage-dependent and results in the collapse or turning of the growth cone. Sema3a-mediated growth cone collapse results in terminal branching that is highly reminiscent of backbranching, a process normally observed in retinotopic map formation. The stage-dependent actions of Sema3a, and the elicited branching, suggest multiple roles for this guidance molecule in topographic map development. Sema3a may contribute to the guidance of axons posteriorly from the contralateral telencephalon, the collapse of their growth cones in the tectum, and the induction of backbranching.
-
(2001)
J. Neurosci.
, vol.21
, pp. 8538-8547
-
-
Campbell, D.S.1
Regan, A.G.2
Lopez, J.S.3
Tannahill, D.4
Harris, W.A.5
Holt, C.E.6
-
15
-
-
0036471970
-
Activity-dependent mapping in the retinotectal projection
-
Debski E.A., Cline H.T. Activity-dependent mapping in the retinotectal projection. Curr. Opin. Neurobiol. 12:2002;93-99.
-
(2002)
Curr. Opin. Neurobiol.
, vol.12
, pp. 93-99
-
-
Debski, E.A.1
Cline, H.T.2
-
16
-
-
0030572695
-
Topographically specific effects of ELF-1 on retinal axon guidance in vitro and retinal axon mapping in vivo
-
Nakamoto M., Cheng H.J., Friedman G.C., McLaughlin T., Hansen M.J., Yoon C.H., O'Leary D.D.M., Flanagan J.G. Topographically specific effects of ELF-1 on retinal axon guidance in vitro and retinal axon mapping in vivo. Cell. 86:1996;755-766.
-
(1996)
Cell
, vol.86
, pp. 755-766
-
-
Nakamoto, M.1
Cheng, H.J.2
Friedman, G.C.3
McLaughlin, T.4
Hansen, M.J.5
Yoon, C.H.6
O'Leary, D.D.M.7
Flanagan, J.G.8
-
17
-
-
0031003116
-
Shared and distinct functions of RAGS and ELF-1 in guiding retinal axons
-
Monschau B., Kremoser C., Ohta K., Tanaka H., Kaneko T., Yamada T., Handwerker C., Hornberger M.R., Loschinger J., Pasquale E.B.et al. Shared and distinct functions of RAGS and ELF-1 in guiding retinal axons. EMBO J. 16:1997;1258-1267.
-
(1997)
EMBO J.
, vol.16
, pp. 1258-1267
-
-
Monschau, B.1
Kremoser, C.2
Ohta, K.3
Tanaka, H.4
Kaneko, T.5
Yamada, T.6
Handwerker, C.7
Hornberger, M.R.8
Loschinger, J.9
Pasquale, E.B.10
-
18
-
-
0032425305
-
Topographic guidance labels in a sensory projection to the forebrain
-
Feldheim D.A., Vanderhaeghen P., Hansen M.J., Frisen J., Lu Q., Barbacid M., Flanagan J.G. Topographic guidance labels in a sensory projection to the forebrain. Neuron. 21:1998;1303-1313.
-
(1998)
Neuron
, vol.21
, pp. 1303-1313
-
-
Feldheim, D.A.1
Vanderhaeghen, P.2
Hansen, M.J.3
Frisen, J.4
Lu, Q.5
Barbacid, M.6
Flanagan, J.G.7
-
19
-
-
0036679141
-
Ephrin-A5 restricts topographically specific arborization in the chick retinotectal projection in vivo
-
Sakurai T., Wong E., Drescher U., Tanaka H., Jay D.G. Ephrin-A5 restricts topographically specific arborization in the chick retinotectal projection in vivo. Proc. Natl. Acad. Sci. U.S.A. 99:2002;10795-10800.
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 10795-10800
-
-
Sakurai, T.1
Wong, E.2
Drescher, U.3
Tanaka, H.4
Jay, D.G.5
-
20
-
-
0030221467
-
Rostral optic tectum acquires caudal characteristics following ectopic engrailed expression
-
Logan C., Wizenmann A., Drescher U., Monschau B., Bonhoeffer F., Lumsden A. Rostral optic tectum acquires caudal characteristics following ectopic engrailed expression. Curr. Biol. 6:1996;1006-1014.
-
(1996)
Curr. Biol.
, vol.6
, pp. 1006-1014
-
-
Logan, C.1
Wizenmann, A.2
Drescher, U.3
Monschau, B.4
Bonhoeffer, F.5
Lumsden, A.6
-
21
-
-
0030937599
-
En-2 regulates the expression of the ligands for Eph type tyrosine kinases in chick embryonic tectum
-
Shigetani Y., Funahashi J.I., Nakamura H. En-2 regulates the expression of the ligands for Eph type tyrosine kinases in chick embryonic tectum. Neurosci. Res. 27:1997;211-217.
-
(1997)
Neurosci. Res.
, vol.27
, pp. 211-217
-
-
Shigetani, Y.1
Funahashi, J.I.2
Nakamura, H.3
-
22
-
-
0029800030
-
Retroviral misexpression of engrailed genes in the chick optic tectum perturbs the topographic targeting of retinal axons
-
Friedman G.C., O'Leary D.D.M. Retroviral misexpression of engrailed genes in the chick optic tectum perturbs the topographic targeting of retinal axons. J. Neurosci. 16:1996;5498-5509.
-
(1996)
J. Neurosci.
, vol.16
, pp. 5498-5509
-
-
Friedman, G.C.1
O'Leary, D.D.M.2
-
23
-
-
0030067618
-
A role for gradient en expression in positional specification on the optic tectum
-
Itasaki N., Nakamura H. A role for gradient en expression in positional specification on the optic tectum. Neuron. 16:1996;55-62.
-
(1996)
Neuron
, vol.16
, pp. 55-62
-
-
Itasaki, N.1
Nakamura, H.2
-
24
-
-
0032006223
-
Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system
-
Frisen J., Yates P.A., McLaughlin T., Friedman G.C., O'Leary D.D.M., Barbacid M. Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system. Neuron. 20:1998;235-243.
-
(1998)
Neuron
, vol.20
, pp. 235-243
-
-
Frisen, J.1
Yates, P.A.2
McLaughlin, T.3
Friedman, G.C.4
O'Leary, D.D.M.5
Barbacid, M.6
-
26
-
-
18544379947
-
RGM is a repulsive guidance molecule for retinal axons
-
The authors report the long-anticipated cloning of chick RGM. Initially, RGM activity was the first to differentially affect nasal and temporal RGC axons. The authors describe the sequence of RGM, which has no homology to any known guidance molecule. RGM is expressed in a low-to-high A-P gradient in the tectum. The authors also confirm that RGM is a topographic guidance molecule that preferentially causes the growth cones of temporal but not nasal RGC axons to collapse. Furthermore, RGC specifically repels temporal RGC axons in the stripe assay.
-
Monnier P.P., Sierra A., Macchi P., Deitinghoff L., Andersen J.S., Mann M., Flad M., Hornberger M.R., Stahl B., Bonhoeffer F., Mueller B.K. RGM is a repulsive guidance molecule for retinal axons. Nature. 419:2002;392-395 The authors report the long-anticipated cloning of chick RGM. Initially, RGM activity was the first to differentially affect nasal and temporal RGC axons. The authors describe the sequence of RGM, which has no homology to any known guidance molecule. RGM is expressed in a low-to-high A-P gradient in the tectum. The authors also confirm that RGM is a topographic guidance molecule that preferentially causes the growth cones of temporal but not nasal RGC axons to collapse. Furthermore, RGC specifically repels temporal RGC axons in the stripe assay.
-
(2002)
Nature
, vol.419
, pp. 392-395
-
-
Monnier, P.P.1
Sierra, A.2
Macchi, P.3
Deitinghoff, L.4
Andersen, J.S.5
Mann, M.6
Flad, M.7
Hornberger, M.R.8
Stahl, B.9
Bonhoeffer, F.10
Mueller, B.K.11
-
27
-
-
0025201860
-
Biochemical characterization of a putative axonal guidance molecule of the chick visual system
-
Stahl B., Muller B., von Boxberg Y., Cox E.C., Bonhoeffer F. Biochemical characterization of a putative axonal guidance molecule of the chick visual system. Neuron. 5:1990;735-743.
-
(1990)
Neuron
, vol.5
, pp. 735-743
-
-
Stahl, B.1
Muller, B.2
Von Boxberg, Y.3
Cox, E.C.4
Bonhoeffer, F.5
-
28
-
-
0030294867
-
Chromophore-assisted laser inactivation of a repulsive axonal guidance molecule
-
Muller B.K., Jay D.G., Bonhoeffer F. Chromophore-assisted laser inactivation of a repulsive axonal guidance molecule. Curr. Biol. 6:1996;1497-1502.
-
(1996)
Curr. Biol.
, vol.6
, pp. 1497-1502
-
-
Muller, B.K.1
Jay, D.G.2
Bonhoeffer, F.3
-
29
-
-
0033119320
-
Modulation of EphA receptor function by coexpressed ephrin-A ligands on retinal ganglion cell axons
-
Hornberger M.R., Dutting D., Ciossek T., Yamada T., Handwerker C., Lang S., Weth F., Huf J., Wessel R., Logan C.et al. Modulation of EphA receptor function by coexpressed ephrin-A ligands on retinal ganglion cell axons. Neuron. 22:1999;731-742.
-
(1999)
Neuron
, vol.22
, pp. 731-742
-
-
Hornberger, M.R.1
Dutting, D.2
Ciossek, T.3
Yamada, T.4
Handwerker, C.5
Lang, S.6
Weth, F.7
Huf, J.8
Wessel, R.9
Logan, C.10
-
30
-
-
0029851690
-
Bidirectional signaling through the Eph-family receptor Nuk and its transmembrane ligands
-
Holland S.J., Gale N.W., Mbamalu G., Yancopoulos G.D., Henkemeyer M., Pawson T. Bidirectional signaling through the Eph-family receptor Nuk and its transmembrane ligands. Nature. 383:1996;722-725.
-
(1996)
Nature
, vol.383
, pp. 722-725
-
-
Holland, S.J.1
Gale, N.W.2
Mbamalu, G.3
Yancopoulos, G.D.4
Henkemeyer, M.5
Pawson, T.6
-
31
-
-
0035794136
-
An ephrin-A-dependent signaling pathway controls integrin function and is linked to the tyrosine phosphorylation of a 120-kDa protein
-
Huai J., Drescher U. An ephrin-A-dependent signaling pathway controls integrin function and is linked to the tyrosine phosphorylation of a 120-kDa protein. J. Biol. Chem. 276:2001;6689-6694.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 6689-6694
-
-
Huai, J.1
Drescher, U.2
-
32
-
-
0034616944
-
Topographic mapping from the retina to the midbrain is controlled by relative but not absolute levels of EphA receptor signaling
-
Brown A., Yates P.A., Burrola P., Ortuno D., Vaidya A., Jessell T.M., Pfaff S.L., O'Leary D.D.M., Lemke G. Topographic mapping from the retina to the midbrain is controlled by relative but not absolute levels of EphA receptor signaling. Cell. 102:2000;77-88.
-
(2000)
Cell
, vol.102
, pp. 77-88
-
-
Brown, A.1
Yates, P.A.2
Burrola, P.3
Ortuno, D.4
Vaidya, A.5
Jessell, T.M.6
Pfaff, S.L.7
O'Leary, D.D.M.8
Lemke, G.9
-
33
-
-
0036685610
-
Topographic mapping in dorsoventral axis of the Xenopus retinotectal system depends on signaling through ephrin-B ligands
-
Mann F., Ray S., Harris W., Holt C. Topographic mapping in dorsoventral axis of the Xenopus retinotectal system depends on signaling through ephrin-B ligands. Neuron. 35:2002;461-473.
-
(2002)
Neuron
, vol.35
, pp. 461-473
-
-
Mann, F.1
Ray, S.2
Harris, W.3
Holt, C.4
-
34
-
-
0344816258
-
Nuk controls pathfinding of commissural axons in the mammalian central nervous system
-
Henkemeyer M., Orioli D., Henderson J.T., Saxton T.M., Roder J., Pawson T., Klein R. Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell. 86:1996;35-46.
-
(1996)
Cell
, vol.86
, pp. 35-46
-
-
Henkemeyer, M.1
Orioli, D.2
Henderson, J.T.3
Saxton, T.M.4
Roder, J.5
Pawson, T.6
Klein, R.7
-
35
-
-
0034034802
-
Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina
-
Birgbauer E., Cowan C.A., Sretavan D.W., Henkemeyer M. Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina. Development. 127:2000;1231-1241.
-
(2000)
Development
, vol.127
, pp. 1231-1241
-
-
Birgbauer, E.1
Cowan, C.A.2
Sretavan, D.W.3
Henkemeyer, M.4
-
36
-
-
0030890656
-
Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth
-
Wang H.U., Anderson D.J. Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth. Neuron. 18:1997;383-396.
-
(1997)
Neuron
, vol.18
, pp. 383-396
-
-
Wang, H.U.1
Anderson, D.J.2
-
37
-
-
0029561805
-
Polarized expression of the receptor protein tyrosine kinase Cek5 in the developing avian visual system
-
Holash J.A., Pasquale E.B. Polarized expression of the receptor protein tyrosine kinase Cek5 in the developing avian visual system. Dev. Biol. 175:1995;683-693.
-
(1995)
Dev. Biol.
, vol.175
, pp. 683-693
-
-
Holash, J.A.1
Pasquale, E.B.2
-
38
-
-
0031281317
-
Graded and lamina-specific distributions of ligands of EphB receptor tyrosine kinases in the developing retinotectal system
-
Braisted J.E., McLaughlin T., Wang H.U., Friedman G.C., Anderson D.J., O'Leary D.D.M. Graded and lamina-specific distributions of ligands of EphB receptor tyrosine kinases in the developing retinotectal system. Dev. Biol. 191:1997;14-28.
-
(1997)
Dev. Biol.
, vol.191
, pp. 14-28
-
-
Braisted, J.E.1
McLaughlin, T.2
Wang, H.U.3
Friedman, G.C.4
Anderson, D.J.5
O'Leary, D.D.M.6
-
39
-
-
0031883834
-
Expression and tyrosine phosphorylation of Eph receptors suggest multiple mechanisms in patterning of the visual system
-
Connor R.J., Menzel P., Pasquale E.B. Expression and tyrosine phosphorylation of Eph receptors suggest multiple mechanisms in patterning of the visual system. Dev. Biol. 193:1998;21-35.
-
(1998)
Dev. Biol.
, vol.193
, pp. 21-35
-
-
Connor, R.J.1
Menzel, P.2
Pasquale, E.B.3
-
41
-
-
0036471295
-
Patterning the neural retina
-
Peters M.A. Patterning the neural retina. Curr. Opin. Neurobiol. 12:2002;43-48.
-
(2002)
Curr. Opin. Neurobiol.
, vol.12
, pp. 43-48
-
-
Peters, M.A.1
-
42
-
-
0033738874
-
Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6
-
Schwarz M., Cecconi F., Bernier G., Andrejewski N., Kammandel B., Wagner M., Gruss P. Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6. Development. 127:2000;4325-4334.
-
(2000)
Development
, vol.127
, pp. 4325-4334
-
-
Schwarz, M.1
Cecconi, F.2
Bernier, G.3
Andrejewski, N.4
Kammandel, B.5
Wagner, M.6
Gruss, P.7
-
43
-
-
0033386714
-
The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain
-
Bertuzzi S., Hindges R., Mui S.H., O'Leary D.D.M., Lemke G. The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain. Genes. Dev. 13:1999;3092-3105.
-
(1999)
Genes. Dev.
, vol.13
, pp. 3092-3105
-
-
Bertuzzi, S.1
Hindges, R.2
Mui, S.H.3
O'Leary, D.D.M.4
Lemke, G.5
-
44
-
-
0033386715
-
Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system
-
Hallonet M., Hollemann T., Pieler T., Gruss P. Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system. Genes. Dev. 13:1999;3106-3114.
-
(1999)
Genes. Dev.
, vol.13
, pp. 3106-3114
-
-
Hallonet, M.1
Hollemann, T.2
Pieler, T.3
Gruss, P.4
-
45
-
-
0036337504
-
Vax2 inactivation in mouse determines alteration of the eye dorsal-ventral axis, misrouting of the optic fibres and eye coloboma
-
••]. Both groups used similar knock out strategies and mouse strains, and report many similar phenotypes. However, there are significant differences in some phenotypes that suggest further analysis needs to be done.
-
••]. Both groups used similar knock out strategies and mouse strains, and report many similar phenotypes. However, there are significant differences in some phenotypes that suggest further analysis needs to be done.
-
(2002)
Development
, vol.129
, pp. 805-813
-
-
Barbieri, A.M.1
Broccoli, V.2
Bovolenta, P.3
Alfano, G.4
Marchitiello, A.5
Mocchetti, C.6
Crippa, L.7
Bulfone, A.8
Marigo, V.9
Ballabio, A.10
Banfi, S.11
-
46
-
-
0036333371
-
The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye
-
Mui S.H., Hindges R., O'Leary D.D.M., Lemke G., Bertuzzi S. The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye. Development. 129:2002;797-804.
-
(2002)
Development
, vol.129
, pp. 797-804
-
-
Mui, S.H.1
Hindges, R.2
O'Leary, D.D.M.3
Lemke, G.4
Bertuzzi, S.5
-
47
-
-
0031827413
-
Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain
-
Hallonet M., Hollemann T., Wehr R., Jenkins N.A., Copeland N.G., Pieler T., Gruss P. Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain. Development. 125:1998;2599-2610.
-
(1998)
Development
, vol.125
, pp. 2599-2610
-
-
Hallonet, M.1
Hollemann, T.2
Wehr, R.3
Jenkins, N.A.4
Copeland, N.G.5
Pieler, T.6
Gruss, P.7
-
48
-
-
0036796862
-
Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle
-
-/- mice have altered retinal expression patterns for genes that are expressed along both retinal axes. In Pax6 knockout mice, the expression pattern of Vax2 is expanded and the expression of Tbx5 is reduced. Furthermore, both the onset and maintenance of expression of BF1 and BF2 requires Pax6.
-
-/- mice have altered retinal expression patterns for genes that are expressed along both retinal axes. In Pax6 knockout mice, the expression pattern of Vax2 is expanded and the expression of Tbx5 is reduced. Furthermore, both the onset and maintenance of expression of BF1 and BF2 requires Pax6.
-
(2002)
Development
, vol.129
, pp. 4535-4545
-
-
Baumer, N.1
Marquardt, T.2
Stoykova, A.3
Ashery-Padan, R.4
Chowdhury, K.5
Gruss, P.6
-
49
-
-
0036155692
-
Generating neuronal diversity in the retina: One for nearly all
-
Marquardt T., Gruss P. Generating neuronal diversity in the retina: one for nearly all. Trends Neurosci. 25:2002;32-38.
-
(2002)
Trends Neurosci.
, vol.25
, pp. 32-38
-
-
Marquardt, T.1
Gruss, P.2
-
50
-
-
0029741423
-
Visual projection map specified by topographic expression of transcription factors in the retina
-
Yuasa J., Hirano S., Yamagata M., Noda M. Visual projection map specified by topographic expression of transcription factors in the retina. Nature. 382:1996;632-635.
-
(1996)
Nature
, vol.382
, pp. 632-635
-
-
Yuasa, J.1
Hirano, S.2
Yamagata, M.3
Noda, M.4
-
51
-
-
0034532411
-
Two homeobox genes define the domain of EphA3 expression in the developing chick retina
-
The authors examine the functions of two homeobox genes, SOHo1 and GH6, expressed in a low to high T-N gradient in the retina. Retroviral misexpression of these genes reveals that the expression of EphA3 is specifically repressed in domains of ectopic expression in the retina. Surprisingly, the expression of EphA3 is not affected in ectopic domains of SOHo1 or GH6 in the brain. The expression of many other Eph receptors and ephrins is not affected by misexpression of SOHo1 or GH6. In addition, BF1 and BF2 do not appear to genetically interact with SOHo1 or GH6, indicating that key players in the establishment of T-N retinal polarity are unknown. Misexpression of SOHo1 or GH6 results in topographic map defects consistent with a reduction in EphA3 expression.
-
Schulte D., Cepko C.L. Two homeobox genes define the domain of EphA3 expression in the developing chick retina. Development. 127:2000;5033-5045 The authors examine the functions of two homeobox genes, SOHo1 and GH6, expressed in a low to high T-N gradient in the retina. Retroviral misexpression of these genes reveals that the expression of EphA3 is specifically repressed in domains of ectopic expression in the retina. Surprisingly, the expression of EphA3 is not affected in ectopic domains of SOHo1 or GH6 in the brain. The expression of many other Eph receptors and ephrins is not affected by misexpression of SOHo1 or GH6. In addition, BF1 and BF2 do not appear to genetically interact with SOHo1 or GH6, indicating that key players in the establishment of T-N retinal polarity are unknown. Misexpression of SOHo1 or GH6 results in topographic map defects consistent with a reduction in EphA3 expression.
-
(2000)
Development
, vol.127
, pp. 5033-5045
-
-
Schulte, D.1
Cepko, C.L.2
-
52
-
-
0035253399
-
Ephrin-A6, a new ligand for EphA receptors in the developing visual system
-
Menzel P., Valencia F., Godement P., Dodelet V.C., Pasquale E.B. Ephrin-A6, a new ligand for EphA receptors in the developing visual system. Dev. Biol. 230:2001;74-88.
-
(2001)
Dev. Biol.
, vol.230
, pp. 74-88
-
-
Menzel, P.1
Valencia, F.2
Godement, P.3
Dodelet, V.C.4
Pasquale, E.B.5
-
53
-
-
0035816588
-
Ventroptin: A BMP-4 antagonist expressed in a double-gradient pattern in the retina
-
The authors report the cloning of a BMP antagonist expressed in a high-to-low N-V to D-T gradient. They show, with retroviral overexpression, that ventroptin can repress the expression of the dorsal genes BMP4 and Tbx5 and enhance the expression of the ventral gene cVax. Retroviral overexpression of ventroptin also results in retinotectal mapping defects. The ventral retina of chicks that have been electroporated with ventroptin shows defects in mapping along the A-P and L-M tectal axes. In each case, a normal appearing TZ is evident in addition to posterior arborizations and possibly aberrantly lateral RGC axonal pathways. The expression of the nasal marker ephrin-A2 is enhanced in temporal retina by ventroptin overexpression.
-
Sakuta H., Suzuki R., Takahashi H., Kato A., Shintani T., Lemura S., Yamamoto T.S., Ueno N., Noda M. Ventroptin: a BMP-4 antagonist expressed in a double-gradient pattern in the retina. Science. 293:2001;111-115 The authors report the cloning of a BMP antagonist expressed in a high-to-low N-V to D-T gradient. They show, with retroviral overexpression, that ventroptin can repress the expression of the dorsal genes BMP4 and Tbx5 and enhance the expression of the ventral gene cVax. Retroviral overexpression of ventroptin also results in retinotectal mapping defects. The ventral retina of chicks that have been electroporated with ventroptin shows defects in mapping along the A-P and L-M tectal axes. In each case, a normal appearing TZ is evident in addition to posterior arborizations and possibly aberrantly lateral RGC axonal pathways. The expression of the nasal marker ephrin-A2 is enhanced in temporal retina by ventroptin overexpression.
-
(2001)
Science
, vol.293
, pp. 111-115
-
-
Sakuta, H.1
Suzuki, R.2
Takahashi, H.3
Kato, A.4
Shintani, T.5
Lemura, S.6
Yamamoto, T.S.7
Ueno, N.8
Noda, M.9
-
54
-
-
0034614689
-
Tbx5 and the retinotectum projection
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The authors use retroviral misexpression studies to analyze the Tbx5 gene in chick retinal development. Tbx5 is expressed in dorsal retina, and when misexpressed throughout retina it represses ventral markers such as cVax, Pax2, EphB2 and EphB3. In addition, misexpression induces the expression of the dorsal markers ephrin-B1 and ephrin-B2. Tbx5 misexpression also results in retinotectal mapping defects consistent with a dorsalization of retina. Furthermore, misexpression of BMP4 also dorsalizes the expression of several genes, perhaps by enhancing Tbx5 expression.
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Koshiba-Takeuchi K., Takeuchi J.K., Matsumoto K., Momose T., Uno K., Hoepker V., Ogura K., Takahashi N., Nakamura H., Yasuda K., Ogura T. Tbx5 and the retinotectum projection. Science. 287:2000;134-137 The authors use retroviral misexpression studies to analyze the Tbx5 gene in chick retinal development. Tbx5 is expressed in dorsal retina, and when misexpressed throughout retina it represses ventral markers such as cVax, Pax2, EphB2 and EphB3. In addition, misexpression induces the expression of the dorsal markers ephrin-B1 and ephrin-B2. Tbx5 misexpression also results in retinotectal mapping defects consistent with a dorsalization of retina. Furthermore, misexpression of BMP4 also dorsalizes the expression of several genes, perhaps by enhancing Tbx5 expression.
-
(2000)
Science
, vol.287
, pp. 134-137
-
-
Koshiba-Takeuchi, K.1
Takeuchi, J.K.2
Matsumoto, K.3
Momose, T.4
Uno, K.5
Hoepker, V.6
Ogura, K.7
Takahashi, N.8
Nakamura, H.9
Yasuda, K.10
Ogura, T.11
-
55
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-
0036429166
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The dorsal-ventral axis of the neural retina is divided into multiple domains of restricted gene expression which exhibit features of lineage compartments
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The authors show the precise distributions, and the relationships between the distributions, of multiple genes expressed along the D-V retinal axis. Using very high quality double in situs on flat-mounted chick retina, the authors demonstrate the relationships among known D-V markers, such as cVax, BMP4, Tbx5, EphB2, EphB3, ephrin-B1, and ephrin-B2. Importantly, the authors demonstrate a gap between the ventral expression of cVax and the dorsal expression of Tbx5, which would strongly suggest that these genes do not directly co-regulate each other. These markers can be divided into at least four zones along the D-V axis. In addition, the authors perform a clonal analysis of retinal cells that uses a replication incompetent retrovirus that expresses alkaline phosphatase to show that retinal cells rarely cross the expression boundaries of these markers. The authors suggest that EphBs and ephrin-Bs may mediate these affects.
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Peters M.A., Cepko C.L. The dorsal-ventral axis of the neural retina is divided into multiple domains of restricted gene expression which exhibit features of lineage compartments. Dev. Biol. 251:2002;59-73 The authors show the precise distributions, and the relationships between the distributions, of multiple genes expressed along the D-V retinal axis. Using very high quality double in situs on flat-mounted chick retina, the authors demonstrate the relationships among known D-V markers, such as cVax, BMP4, Tbx5, EphB2, EphB3, ephrin-B1, and ephrin-B2. Importantly, the authors demonstrate a gap between the ventral expression of cVax and the dorsal expression of Tbx5, which would strongly suggest that these genes do not directly co-regulate each other. These markers can be divided into at least four zones along the D-V axis. In addition, the authors perform a clonal analysis of retinal cells that uses a replication incompetent retrovirus that expresses alkaline phosphatase to show that retinal cells rarely cross the expression boundaries of these markers. The authors suggest that EphBs and ephrin-Bs may mediate these affects.
-
(2002)
Dev. Biol.
, vol.251
, pp. 59-73
-
-
Peters, M.A.1
Cepko, C.L.2
-
56
-
-
0033231291
-
Misexpression of the Emx-related homeobox genes cVax and mVax2 ventralizes the retina and perturbs the retinotectal map
-
Schulte D., Furukawa T., Peters M.A., Kozak C.A., Cepko C.L. Misexpression of the Emx-related homeobox genes cVax and mVax2 ventralizes the retina and perturbs the retinotectal map. Neuron. 24:1999;541-553.
-
(1999)
Neuron
, vol.24
, pp. 541-553
-
-
Schulte, D.1
Furukawa, T.2
Peters, M.A.3
Kozak, C.A.4
Cepko, C.L.5
-
57
-
-
0242707647
-
Topographic targeting and pathfinding errors of retinal axons following overexpression of ephrinA ligands on retinal ganglion cell axons
-
Dutting D., Handwerker C., Drescher U. Topographic targeting and pathfinding errors of retinal axons following overexpression of ephrinA ligands on retinal ganglion cell axons. Dev. Biol. 16:1999;297-311.
-
(1999)
Dev. Biol.
, vol.16
, pp. 297-311
-
-
Dutting, D.1
Handwerker, C.2
Drescher, U.3
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