Protective Effects of Medium-Chain Triglycerides on the Liver and Gut in Rats Administered Endotoxin

Annals of Surgery

Volumn 237, Issue 2, 2003, Pages 246-255

  Kono, Hiroshi ^a   Fujii, Hideki ^a   Asakawa, Masami ^a   Yamamoto, Masayuki ^b   Matsuda, Masanori ^a   Maki, Akira ^a   Matsumoto, Yoshiro ^c  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b Shinko Byoin Hospital   (Japan)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; COLLAGENASE; CORN OIL; ENDOTOXIN; LIPOPOLYSACCHARIDE; MEDIUM CHAIN TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; KETONE BODY; PROTECTIVE AGENT; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL ISOLATION; CENTRIFUGATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTOXEMIA; ENTERIC FEEDING; IMMUNOBLOTTING; INTESTINE; INTESTINE EPITHELIUM; INTESTINE FLORA; INTESTINE INJURY; INTESTINE MUCOSA PERMEABILITY; KUPFFER CELL; LIVER INJURY; LIVER PROTECTION; MALE; MORTALITY; NONHUMAN; ORGAN INJURY; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; ANIMAL; ANIMAL MODEL; BLOOD; DRUG EFFECT; ENERGY METABOLISM; ENTEROPATHY; EVALUATION; FECES; INFLAMMATION; INTESTINE MUCOSA; LIVER; LIVER CELL; LIVER DISEASE; METABOLISM; MICROBIOLOGY; NECROSIS; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIGENS, CD14; CORN OIL; ENDOTOXEMIA; ENERGY METABOLISM; ENTERAL NUTRITION; FECES; HEPATOCYTES; INFLAMMATION; INTESTINAL DISEASES; INTESTINAL MUCOSA; INTESTINES; KETONE BODIES; KUPFFER CELLS; LIPOPOLYSACCHARIDES; LIVER; LIVER DISEASES; MALE; MODELS, ANIMAL; NECROSIS; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037316048     PISSN: 00034932     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000658-200302000-00014     Document Type: Article

References (37)

1. Nolan JP. Endotoxin, reticuloendothelial function, and liver injury. Hepatology 1981; 1:458-465.
2. Kono H, Yamamoto M, Iimuro Y, et al. The role of splenic macrophages in plasma tumor necrosis factor levels in endotoxemia. Eur Surg Res 1997; 29:176-186.
3. Iimuro Y, Yamamoto M, Kono H. Blockade of liver macrophages by gadolinium chloride reduces lethality in endotoxemic rats; analysis of mechanisms of lethality in endotoxemia. J Leukoc Biol 1996; 55:723-728.
4. Seki S, Habu Y, Kawamura T, et al. The liver as a crucial organ in the first line of host defense: the roles of Kupffer cells, natural killer (NK) cells and NK1.1 + T cells in T helper immune responses. Immunol Rev 2000; 174:35-46.
5. Kohno H, Yamamoto M, Iimuro Y. Reduction of mortality in endotoxemic rats pretreatment with gadolinium chloride: relationship to suppression of superoxide production in liver macrophages. Yamanashi Med J 1993; 8:101-112.
6. Smith O. Animal models of human genetic disease. Trends Genet 1993; 9:112-116.
7. Woodcock NP, Zeigler D, Palmer MD, et al. Enteral versus parenteral nutrition: a pragmatic study. Nutrition 2001; 17:1-12.
8. Ikejima K, Iimuro Y, Forman DT, et al. A diet containing glycine improve survival in endotoxin shock in the rat. Am J Physiol 1996; 27:G97-G103.
9. Manhart N, Vierlinger K, Spittler A, et al. Oral feeding with glutamine prevents lymphocyte and glutathione depletion of Peyer's patches in endotoxemic mice. Ann Surg 2001; 234:92-97.
10. Kono H, Enomoto N, Connor HD, et al. Medium-chain triglycerides inhibit free radical formation and TNF-alpha production in rats given enteral ethanol. Am J Physiol 2000; 278:G467-G476.
11. Arai M. Effect of ethanol on the intestinal uptake of endotoxin. Nippon Shokakibyo Gakkai Zasshi 1986; 83:1060.
12. Ozawa K, Kamiyama Y, Kimura K. Relation of mitochondrial redox potential to hepatic energy charge in animals with hepatectomy, jaundice, hemorrhagic and sepsis as well as patients with multiple organ failure. Langenbeck Arch Chir 1982; 357:204-205.
13. Kono H, Fujii H, Matsuda M, et al. Gadolinium chloride prevents mortality in hepatectomized rats given endotoxin. J Surg Res 2001; 96:204-210.
14. Ukikusa M, Ozawa K, Shimahara Y. Changes in blood ketone body ratio. Their significance after major hepatic resection. Arch Surg 1981; 116:781-785.
15. Williamson DH, Mellanby J. D-(-)-3-Hydroxybuturate. In Bergmeyer HU, ed. Methods of enzymatic analysis. New York: Academic Press; 1974.
16. Mellanby J, Wiiliamson DH. Accetoacetate. In Bergmeyer HU, ed. Methods of enzymatic analysis. New York: Academic Press; 1974;
17. Ozawa K, Fujimoto T, Nakatani T. Changes in hepatic energy charge, blood ketone body ratio and indocyanine green clearance in relation to DNA synthesis after hepatectomy. Life Sci 1982; 31:481-490.
18. Bode JCH. Alcohol and the gastrointestinal tract. In: Advances in internal medicine and pediatrics. Heidelberg: Springer-Verlag; 1980.
19. Peters JM, Rusyn I, Rose ML, et al. Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis. Carcinogenesis 2000; 21:823-826.
20. Arii S, Imamura M. Physiological role of sinusoidal endothelial cells and Kupffer cells and their implication in the pathogenesis of liver injury. J Hepatobiliary Pancreat Surg 2000; 7:40-48.
21. French SW. Nutrition in the pathogenesis of alcoholic liver disease. Alcohol Alcoholism 1993; 28:97-109.
22. Yin M, Ikejima K, Arteel GE, et al. Glycine accelerates recovery from alcohol-induced liver injury. J Pharmacol Exp Ther 1998; 286:1014-1019.
23. Su GL, Rahemtulla A, Thomas P, et al. CD14 and lipopolysaccharide binding protein expression in a rat model of alcohol liver disease. Am J Physiol 1998; 152:841-849.
24. Kawada N, Mizoguchi Y, Kobyashi K, et al. Calcium-dependent prostaglandin biosynthesis by lipopolysaccharide-stimulated rat Kupffer cells. Prostaglandins Leukot Essent Fatty Acids 1992; 47:209-214.
25. Hijioka T, Rosenberg RL, Lemasters JJ, et al. Kupffer cells contains voltage-dependent calcium channels. Mol Pharmacol 1991; 41:435-440.
26. Alexander JW. Immunonutrition: the role of omega-3 fatty acids. Nutrition 1998; 14:627-633.
27. Rusyn I, Bradham CA, Cohn L, et al. Corn oil rapidly activates nuclear factor-κB in hepatic Kupffer cells by oxidant-dependent mechanisms. Carcinogenesis 1999; 20:2095-2100.
28. Iimuro Y, Gallucci RM, Luster MI, et al. Antibodies to tumor necrosis factor-α attenuate hepatic necrosis and inflammation due to chronic exposure to ethanol in the rat. Hepatology 1998; 26:1530-1537.
29. Nanji AA, Sadrzadeh SM, Yang EK, et al. Dietary saturated fatty acids: a novel treatment for alcoholic liver disease. Gastroenterology 1995; 109:547-554.
30. Wolfram G. Medium-chain triglycerides-useful energy carriers in parenteral nutrition. Wien Klin Wochenschr 1989; 101:300-303.
31. Lima LA. Neonatal parenteral nutrition with medium-chain triglycerides: rationale for research. J Parenter Enteral Nutr 1989; 13:312-317.
32. Famuralo G, De Simons C. A new era for carnitine. Immunol Today 1995; 16:211-213.
33. Ozaki N, Ringe B, Gubernatis G, et al. Changes in energy substrates in relation to arterial ketone ratio after human orthotopic liver transplantation. Surgery 1993; 113:403-409.
34. Nakatani T, Ozawa K, Asano M, et al. Changes in predominant energy substrate after hepatectomy. Life Sci 1981; 28:257-264.
35. Ohtoshi M, Jikko A, Asano M, et al. Ketogenesis during sepsis in relation to hepatic energy metabolism. Res Exp Med 1984; 184:209-219.
36. Alscher KT, Phang PT, McDonald TE, et al. Enteral feedings decrease gut apoptosis, permeability, and lung inflammation during murine endotoxemia. Am J Physiol 2001; 281:G569-G576.
37. Fukatsu K, Zarzaur B, Johnson CD, et al. Enteral nutrition prevents remote organ injury and death after a gut ischemic insult. Ann Surg 2001; 233:660-668.