Influences of naturally occurring and experimentally induced porcine pneumonia on blood parameters

Research in Veterinary Science

Volumn 74, Issue 1, 2003, Pages 23-30

  Muller G ^a   Kohler H ^a   Rassbach A ^a   Berndt, A ^a   Schimmel, D ^a  

^a Federal Institute for Health Protection of Consumers and Veterinary Medicine (BgVV)   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; CYTOKINE; FREE RADICAL; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

BLOOD CELL; BLOOD LEVEL; BODY GROWTH; CELL COMPOSITION; CELL FUNCTION; CHRONIC DISEASE; CONTROLLED STUDY; EXPERIMENTAL INFECTION; FOOD QUALITY; HAEMOPHILUS PARASUIS; HEMATOLOGICAL PARAMETERS; LEUKOCYTE DIFFERENTIAL COUNT; LUNG FLUID; LUNG LAVAGE; MEAT; NONHUMAN; PASTEURELLA MULTOCIDA; PHAGOCYTOSIS; PNEUMONIA; REACTION TIME; REVIEW; SWINE;

ACUTE DISEASE; ANIMALS; BLOOD CELL COUNT; BRONCHOALVEOLAR LAVAGE FLUID; CHRONIC DISEASE; FREE RADICALS; HAEMOPHILUS; INTERLEUKIN-6; LUNG; MEAT; PASTEURELLA MULTOCIDA; PHAGOCYTOSIS; PNEUMONIA; RECEPTORS, INTERLEUKIN-2; SWINE; SWINE DISEASES; TUMOR NECROSIS FACTOR-ALPHA;

HAEMOPHILUS; HAEMOPHILUS PARASUIS; PASTEURELLA; PASTEURELLA MULTOCIDA; SUIDAE; SUS SCROFA;

EID: 0037314110     PISSN: 00345288     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0034-5288(02)00148-0     Document Type: Article

References (59)

1. Amano, H., Shibata, M., Takahashi, K., Sasaki, Y., 1997. Effects on endotoxin pathogenicity in pigs with acute septicemia of Haemophilus-parasuis infection. J. Vet. Med. Sci. 59, 451-455.
2. Arbeitskreis für veterinärmedizinische infektionsdiagnostik (AVID), 1992. Methoden der veterinärmedizinischen Infektionsdiagnostik-Bordetella bronchiseptica, Haemophilus parasuis, Acholeplasma pleuropneumonia, Pasteurella multocida, und Mykoplasmen. AVID. I, III, und VIII, pp. 1-9.
3. Asai, T., Okada, M., Ono, M., Irisawa, T., Mori, Y., Yokomizo, Y., Sato, S., 1993. Increased levels of tumor necrosis factor and interleukin-1 in bronchoalveolar lavage fluids from pigs infected with Mycoplasma hyopneumoniae. Vet. Immunol. Immunopathol. 38, 253-260.
4. Baarsch, M.J., Scamurra, R.W., Burger, K., Foss, D.L., Maheswaran, S.K., Murtaugh, M.P., 1995. Inflammatory cytokine expression in swine experimentally infected with Actinobacillus pleuropneumoniae. Infect. Immun. 63, 3587-3594.
5. Bailey, M., Stevens, K., Bland, P.W., Stokes, C.R., 1992. A monoclonal antibody recognising an epitope associated with pig interleukin-2 receptors. J. Immunol. Methods 153, 85-91.
6. Bauer, T.T., Monton, C., Torres, A., Cabello, H., Fillela, X., Maldonado, A., Nicolas, J.M., Zavala, E., 2000. Comparison of systemic cytokine levels in patients with acute respiratory distress syndrome, severe pneumonia, and controls. Thorax 55, 46-52.
7. Bednarek, D., Zdzisinska, B., Kondracki, M., Rzeski, W., Lokaj, I., Kandefer-Szerszen, M., 1998. Alterations in peripheral blood leukocytes functions during enzootic bronchopneumonia of calves. Effect of treatment with antibiotics and immunomodulators. Dtsch. tieärztl. Wschr. 105, 173-208.
8. Bednarek, D., Szuster-Ciesielska, A., Zdzisinska, B., Kondracki, M., Paduch, R., Kandefer-Szerszen, M., 1999. The effect of steroidal and non-steroidal anti-inflammatory drugs on the cellular immunity of calves with experimentally induced local lung inflammation. Vet. Immunol. Immunopathol. 71, 1-15.
9. Berndt, A., Müller, G., 1997. Heterogeneity of porcine alveolar macrophages in experimental pneumonia. Vet. Immunol. Immunopathol. 57, 279-287.
10. Berndt, A., Müller, G., 1995. Occurrence of T lymphocytes in perivascular regions of the lung after intratracheal infection of swine with Pasteurella multocida. Vet. Immunol. Immunopathol. 49, 143-159.
11. Bertoni, G., Kuhnert, P., Peterhans, E., Pauli, U., 1993. Improved bioassay for the detection of porcine tumor necrosis factor using a homologous cell line-PK(15). J. Immunol. Methods 160, 267-271.
12. Blaha, T.H., Große Beilage, E., Harms, J., 1994. Erfassung pathologisch-anatomischer Organbefunde am Schlachthof. Fleischwirtschaft 74, 427-429.
13. Bont, L., Heijnen, C.J., Kavelaars, A., Van Aalderen, W.M., Brus, F., Draaisma, J.T, Geelen, S.M., Vanvught, H.J., Kimpen, J.L., 1999. Peripheral blood cytokine responses and disease severity in respiratory syncytial virus bronchiolitis. Eur. Resp. J. 14, 144-149.
14. Bühling, J., Ittenson, A., Kaiser, D., Thölert, G., Hoffmann, B., Reinhold, D., Ansorge, S., Welte, T., 2000. MRP8/MRP14, CD11b and HLA-DR expression of alveolar macrophages in pneumonia. Immunol. Lett. 71, 185-190.
15. Carstens, J., Andersen, P.L., 1994. Changes in serum neopterin and serum β(2)-microglobulin in subjects with lung infections. Eur. Resp. J. 7, 1233-1238.
16. Chabot, F., Mitchell, J.A, Gutteridge, J.M., Evans, T.W., 1998. Reactive oxygen species in acute lung injury. Eur. Resp. J. 11, 745-757.
17. Cholletmartin, S., Montravers, P., Gibert, C., Elbim, C., Desmonts, J.M., Fagon, J.Y., Gougerotpocidalo, M.A., 1993. High levels of interleukin-8 in the blood and alveolar spaces of patients with pneumonia and adult respiratory distress syndrome. Infect. Immun. 61, 4553-4559.
18. Doerschuk, C.M., Mizgerd, J.P., Kubo, H., Qin, L., Kumasaka, T., 1999. Adhesion molecules and cellular biomechanical changes in acute lung injury. Chest 116, 37S-43S.
19. Drazen, M.J., Austen, F., 1987. Leukotrienes and airway responses. Am. Rev. Respir. Dis. 136, 985-998.
20. Erler, W., Schönherr, W., Heilmann, P., Kielstein, P., Müller, G., Feist, H., Floß Mann, K.-D., 1983. Zur immunogenen Wirkung von Extrakten aus Pasteurella multocida im Kalb gegen die Pasteurella-Infektion. Mh. Vet.-Med. 38, 87-92.
21. Fehlhaber, K., Stryczek, E., Schüppel, H., 1992. Untersuchungen zur lebensmittelhygienischen Bedeutung von Lungenveränderungen bei Schlachttieren. Beitrag zum Problem der Entstehung primärer bakterieller Kontamination des Fleisches. Fleischwirtschaft 72, 778-784.
22. Fireman, E., Ben- Efraim, S., Spinrad, S., Topilsky, M., Greif, J., 1993. Suppressive mechanisms of alveolar macrophages in interstitial lung diseases: role of soluble factors and cell-to-cell contact. Eur. Respir. J. 6, 956-964.
23. Fuchs, D., Gruber, A., Uberall, F., Wachter, H., 1994. Oxidative stress and apoptosis. Immun. Today 15, 496.
24. Hammel, von M.L., Blaha, T., 1993. Erfassung pathologisch-anatomischer Organbefunde am Schlachthof 3. Zusammenhänge zwischen der Tiergesundheit und der Schlachtkörperqualität beim Schwein. Fleischwirtschaft 73, 1427-1430.
25. Henderson, B., Wilson, M., Wren, B., 1997. Are bacterial exotoxins cytokine network regulators? Trends Microbiol. 5, 454-458.
26. Hill, R.J., Warren, M.K., Levin, J., Gauldie, J., 1992. Evidence that interleukin-6 does not play a role in the stimulation of platelet production after induction of acute thrombocytopenia. Blood 80, 346-351.
27. Johnson, R.W., 1997. Inhibition of growth by pro-inflammatory cytokines - an integrated view. J. Anim. Sci. 75, 1244-1255.
28. Jones, R.D., Webster, F.J., 1984. Relationships between counts of nasopharyngeal bacteria, temperature, humidity and lung lesions in veal calves. Res. Vet. Sci. 37, 132-137.
29. Jörres, R.A., Magnussen, H., 1997. Oxidative stress in COPD. Eur. Respir. Rev. 7, 131-135.
30. Khair, O.A., Davies, R.J., Devalia, J.L., 1996. Bacterial-induced release of inflammatory mediators by bronchial epithelial cells. Eur. Resp. J. 9, 1913-1922.
31. Klein, C., 1999. Sonographie der Lunge und Analyse der Atmungsmechanik mittels Impuls-Oszilloresistometrie beim lungengesunden and pneumoniekranken Ferkel und Läuferschwein. Inaug.-Diss., Veterinärmedizinische Fakultät Uni. Leipzig. 219 S.
32. Köhler, W., Schachtel, G., Voleske, P., 1995. Biostatistik. Springer, Berlin, Heidelberg, New York, 2. Auflage.
33. Krüger, G., Hoy, S., Dorn, W., Mehlhorn, G., 1988. Untersuchungen zur Fleischqualität bei Mastschweinen mit unterschiedlichen entzündlichen Lungenveränderungen. Fleisch 42, 195-197.
34. Larrick, J.W., Kunkel, S.L., 1988. The role of tumor necrosis factor and interleukin 1 in the immunoinflammatory response. Pharmaceut. Res. 5, 129-139.
35. Martin, T.R., 1999. Lung cytokines and ARDS. Chest 116, 2S-8.
36. Mcinnes, E., Collins, R.A., Taylor, G., 1998. Cytokine expression in pulmonary and peripheral-blood mononuclear-cells from calves infected with bovine respiratory syncytial virus. Res. Vet. Sci. 64, 163-166.
37. Mehrad, B., Standiford, T.J., 1999. Role of cytokines in pulmonary antimicrobial host defense. Immunol. Res. 20, 15-27.
38. Mehta, C.R., Patel, N.R., 1995. SPSS Exact Tests 6.1 for Windows. Handbuch SPSS Inc.
39. Müller, G., Heilmann, P., 1990. Der Einfluβ lokaler und systemischer Immunisierungen von Läuferschweinen auf die bronchoalveoläre Clearance und auf intrabronchiale Infektionen mit Pasteurella multocida. Arch. Exper. Vet. Med. 44, 301-310.
40. Müller, G., Kielstein, P., Rosner, H., Berndt, A., Heller, M., Köhler, H., 1999. Studies of the influence of ochratoxin A on immune and defence reactions in weaners. Mycoses 42, 495-505.
41. Müller, G., Köhler, H., Stache, B., Heilmann, P., Kludas, K.-H., 1993. Aerogene Immunstimulationen von Läuferschweinen gegen experimentell induzierte respiratorische Infektionen mit Pasteurella multocida. J. Vet. Med. B. 40, 423-429.
42. Murtaugh, M.P., Baarsch, M.J., Zhou, Y.L., Scamurra, R.W., Lin, G.F., 1996. Inflammatory cytokines in animal health and disease. Vet. Immunol. Immunopathol. 54, 45-55.
43. Paisley, L.G., Vraaandersen, L., Dybkjaer, L., Moller, K., Christensen, G., Mousing, J., Agger, J.F., 1993. An epidemiologic and economic study of respiratory diseases in 2 conventional danish swine herds. 1. Prevalence of respiratory lesions at slaughter and their effects on growth. Acta Vet. Scand. 34, 319-329.
44. Predoiu, J., Blaha, T.H., 1993. Erfassung pathologisch-anatomischer Organbefunde am Schlachthof 2. Beitrag integrierter Qualitätssicherungssysteme zur Verbesserung des Verbraucherschutzes, der Tiergesundheit und des Tierschutzes. Fleischwirtschaft 73, 1183-1186.
45. Saalmüller, A., Jonjic, S., Bühring, H.-J., Reddehase, M.J., Koszinowski, U.H., 1987. Monoclonal antibodies reactive with swine lymphocytes II. Detection of an antigen on resting cells down-regulated after activation. J. Immunol. 138, 1852-1857.
46. Sanderud, J., Bjoro, K., Saugstad, O.D., 1993. Oxygen radicals stimulate thromboxane and prostacyclin synthesis and induce vasoconstriction in pig lungs. Scand. J. Clin. Lab. Invest. 53, 447-455.
47. Sankaran, R.T., Mattana, J., Pollack, S., Bhat, P., Ahuja, T., Patel, A., Singhal, P.C., 1997. Laboratory abnormalities in patients with bacterial pneumonia. Chest 111, 595-600.
48. Schultek, T.H., Braun, J., Wießman, K.J., Wood, G.W., 1987. IgA concentration in serum, sputum and bronchoalveolar lavage in patients with chronic bronchitis. Dtsch. Med. Wschr. 112, 1811-1814.
49. Schüppel, H., Fehlhaber, K., Stryczek, E., 1994. Endogene Kontamination bei Schlachttieren. (Literaturübersicht). Berl. münch Tieärztl. Wschr. 107, 23-29.
50. Spurlock, M.E., 1997. Regulation of metabolism and growth during immune challenge-an overview of cytokine function. J. Anim. Sci. 75, 1773-1783.
51. Strieter, R.M., Kunkel, S.L., Keane, M.P., Standiford, T.J., 1999. Chemokines in lung injury-Thomas A. Neff lecture. Chest 116, 103S-110S.
52. Stryczek, E., 1991. Einfluβ von Lungenveränderungen bei Schlachtschweinen auf die Entstehung von Bakteriämien vor der Schlachtung. Diss. A, Vet. Med. Fak. Uni Leipzig. 84 S.
53. Thompson, A.B., Robbins, R.A., Romberger, D.J., Sisson, J.H., Spurzem, J.R., Teschler, H., Rennard, S.I., 1995. Immunological functions of the pulmonary epithelium. Eur. Resp. J. 8, 127-149.
54. Van Eeden, S.F., Kitagawa, Y., Sato, Y., Hogg, J.C., 1999. Polymorphonuclear leukocytes released from the bone marrow and acute lung injury. Chest 116, 43S-46S.
55. Van Snick, J., Cayphas, S., Vink, A., Uyttenhove, C., Coulie, P.G., Rubria, M.R., Simpson, R.J., 1986. Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas. Proc. Natl. Acad. Sci. USA 83, 9679-9683.
56. Verordnung über gesetzliche Handelsklassen für Schweinehälften. 1990, Bundesgesetzblatt, Bundesrepublik Deutschland., 1990. Jahrgang 1990, Teil I, vom 16.08. 1810-1812.
57. Wallgren, P., Beskow, P., Fellström, C., Renström, L.H., 1994. Porcine lung lesions at slaughter and their correlation to the incidence of infections by Mycoplasma hyopneumoniae and Actinobacillus pleuropneumoniae during the rearing period. J. Vet. Med. B. 41, 441-452.
58. Ward, A.P., 1986. Host-defense mechanisms responsible for lung injury. J. Allerg. Clin. Immunol. 78, 373-378.
59. Ziegler-Heitbrock, H.W.L., Ströbel, M., Kieper, D., Fingerle, G., Schlunk, T., Petersman, I., Ellwart, J., Blumenstein, M., Haas, J.G., 1992. Differential expression of cytokines in human blood monocyte subpopulations. Blood 79, 503-511.