Increased serum nIgM in voluntarily physically active rats: A potential role for B-1 cells

Journal of Applied Physiology

Volumn 94, Issue 2, 2003, Pages 660-667

  Elphick, Gwendolyn F ^a   Greenwood, Benjamin N ^a   Campisi, Jay ^a   Fleshner, Monika ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Exercise; Immunologlobulin A; Keyhole limpet hemocyanin; Nonantigen driven B 1 natural immunologlobulin M

Indexed keywords

ANTIGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; KEYHOLE LIMPET HEMOCYANIN; NATURAL IMMUNOGLOBULIN M; PLASMA PROTEIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; B1 LYMPHOCYTE; B2 LYMPHOCYTE; CONTROLLED STUDY; CYTOTOXICITY; EXERCISE; HEALTH; IMMUNE RESPONSE; IMMUNITY; IMMUNOGLOBULIN BLOOD LEVEL; LYMPHOCYTE PROLIFERATION; MACROPHAGE FUNCTION; MALE; NATURAL KILLER CELL; NONHUMAN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RAT; T LYMPHOCYTE;

EID: 0037310102     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00547.2002     Document Type: Article

References (36)

1. Bacuau RF, Belmonte MA, Seelaender MC, and Costa Rosa LF. Effect of a moderate intensity exercise training protocol on the metabolism of macrophages and lymphocytes of tumour-bearing rats. Cell Biochem Funct 18: 249-258, 2000.
2. Baldwin DR, Wilcos ZC, and Zheng G. The effects of voluntary exercise and immoblization on humoral immunity and endocrine responses in rats. Physiology of Behavior 61: 447-453, 1997.
3. Berland R and Wortis HH. A model for autoantigen induction of natural antibody producing B-1a cells. Curr Top Microbiol Immunol 252: 49-56, 2000.
4. Berland R and Wortis HH. Origins and functions of B-1 cells with notes on the rle of CD5. Ann Rev Immunol 20: 253-300, 2002.
5. Boes M, Esau C, Fishcer MB, Shmidt T, Carroll M, and Chen J. Enhanced B-1 development, but impaired IgG antibody responses in mice deficient in secreted IgM. J Immunol 60: 4776-4787, 1998.
6. Bratthall D and Widerstrom L. Ups and downs for salivary IgA. Scand J Dent Res 93: 128-134, 1985.
7. Bravenboer N, Engelbregt MJ, Visser NA, Popp-Snijder C, and Lips P. The effect of exercise on systemic and bone concentrations of growth factors in rats. Ortho Res 19: 945-949, 2001.
8. Carroll M and Produes AP. Lineages of innate and adaptive immunity. Curr Op Immunol 10: 36-40, 1998.
9. Chow DA and Yuan XY. Polyclonal natural antitumor antibody binding dynamics: preferential release of surface membrane molecules and increased metastasis. Invasion Metastasis 12: 218-232, 1995.
10. Coleman KJ and Rager DR. Effects of voluntary exercise on immune function in rats. Physiol Behav 54: 89-92, 1993.
11. David K, Ollert MW, Juhl H, Vollmert C, Erttmann R, Vogel CW, and Bredehorst R. Growth arrest of solid human neuroblastoma xenografts in nude rats by natural IgM from healthy humans. Nat Med 2: 686-689, 1996.
12. De Waard R, Dammers PM, Tung JW, Kantor AB, Wilshire JA, Bos NA, Herzenberg LA, and Kroese FG. Presence of germline and full-length IgA RNA transcripts among peritoneal B-1 cells. Dev Immunol 6: 81-87, 1998.
13. Fagarasan S and Honjo T. T-independent immune response: new aspects of B cell biology. Science 290: 89-92, 2000.
14. Fleshner M, Nguyen KT, Cotter CS, Watkins LR, and Maier SF. Acute stressor exposure both suppresses acquired immunity and potentiates innate immunity. Am J Physiol Regul Integr Comp Physiol 275: R870-R878, 1998.
15. Gagnerault MC, Postel-Vinay MC, and Dardenne M. Expression of growth hormone receptors in murine lymphoid cells analyzed by flow cytofluorometry. Endocrinology 137: 1719-1726, 1996.
16. Gardby E, Lane P, and Lycke NY. Requirements for B7-CD28 costimulation in mucosal IgA responses: paradoxes observed in CTLA4-H gamma 1 transgenic mice. J Immunol 161: 49-59, 1998.
17. Gleeson M. Special feature for the Olympics: effects of exercise on the immune system. Overview: exercise immunology. Immunol Cell Biol 78: 483-484, 2000.
18. Hayakawa K, Shinton SA, Asano M, and Hardy RR. B1 cell definition. Curr Top Microbiol Immunol 252: 15-22, 2000.
19. Hiroi T, Yanagita M, Ohta N, Sakaue G, and Kiyono H. IL-15 and IL-15 receptor selectively regulate differentiation of common mucosal immune system-independent B-1 cells for IgA responses. J Immunol 165: 4329-4337, 2000.
20. Jonsdottir IH, Asea A, Hoffmann P, Dahlgren UI, Andersson B, Hellstrand K, and Thoren P. Voluntary chronic exercise augments in vivo natural immunity in rats. J Appl Physiol 80: 1799-1803, 1996.
21. Jonsdottir IH, Hellstrand K, Thoren P, and Hoffmann P. Enhancement of natural immunity seen after voluntary exercise in rats. Role of central opioid receptors. Life Sci 66: 1231-1239, 2000.
22. Kiyono H, Kweon MN, Hiroi T, and Takahashi I. The mucosal immune system: from specialized immune defense to inflammation and allergy. Acta Odontol Scand 59: 145-153, 2001.
23. Kodama S, Suzuki M, Arita M, and Mogi G. Increase in tonsillar germinal centre B-1 cell numbers in IgA nephropathy (IgAN) patients and reduced susceptibility to Fas-mediated apoptosis. Clin Exp Immunol 123: 301-308, 2001.
24. Lu Q, Ceddia MA, Price EA, Ye SM, and Woods JA. Chronic exercise increases macrophage-mediated tumor cytolysis in young and old mice. Am J Physiol Regul Integr Comp Physiol 276: R482-R489, 1999.
25. Miletic ID, Schiffman SS, Miletic VD, and Sattely-Miller EA. Salivary IgA secretion rate in young and elderly persons. Physiol Behav 60: 243-248, 1996.
26. Moraska A, Deak T, Spencer RL, Roth D, and Fleshner M. Treadmill running produces both positive and negative physiological adaptations in Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol 279: R1321-R1329, 2000.
27. Moraska A and Fleshner M. Voluntary physical activity prevents stress-induced behavioral depression and anti-KLH antibody suppression. Am J Physiol Regul Integr Comp Physiol 281: R484-R489, 2001.
28. Moriguchi S, Kato M, Sakai K, Yamamoto S, and Shimizu E. Exercise training restores decreased cellular immune functions in obese Zucker rats. J Appl Physiol 84: 311-317, 1998.
29. Nieman DC. Exercise immunology: practical applications. Int J Sports Med 18, Suppl 1: S91-S100, 1997.
30. O'Garra A, Chang R, Go N, Hastings R, Haughton G, and Howard M. Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10. Eur J Immunol 22: 711-717, 1992.
31. Pedersen BK. Special feature for the Olympics: effects of exercise on the immune system: exercise and cytokines. Immunol Cell Biol 78: 532-535, 2000.
32. Schuler PB, Lloyd LK, Leblanc PA, Clapp TA, Abadie BR, and Collins RK. The effect of physical activity and fitness on specific antibody production in college students. J Sports Med Phys Fitness 39: 233-239, 1999.
33. Sugiura H, Nishida H, Inaba R, Mirbod SM, and Iwata H. Immunomodulation by 8-week voluntary exercise in mice. Acta Physiol Scand 168: 413-420, 2000.
34. Van Praag H, Kempermann G, and Gage FH. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci 2: 266-270, 1999.
35. Vogel LA, Lester TL, Van Cleave VH, and Metzger DW. Inhibition of murine B1 lymphocytes by interleukin-12. Eur J Immunol 26: 219-223, 1996.
36. Woods JA, Davis JM, Mayer EP, Ghaffar A, and Pate RR. Exercise increases inflammatory macrophage antitumor cytotoxicity. J Appl Physiol 75: 879-886, 1993.