GeneChip microarrays facilitate identification of protease nexin-1 as a target gene of the Prx2 (S8) homeoprotein

DNA and Cell Biology

Volumn 22, Issue 2, 2003, Pages 95-105

  Scott, Karen K ^a   Norris, Russell A ^a   Potter, S Steven ^b   Norrington, David W ^a   Baybo, Mary Ann ^a   Hicklin, David M ^a   Kern, Michael J ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOMEODOMAIN PROTEIN; PROTEASE NEXIN I;

ANIMAL CELL; ARTICLE; CELL CLONE; CONTROLLED STUDY; DNA MICROARRAY; GENE IDENTIFICATION; GENE SEQUENCE; GENE TARGETING; GENETIC SCREENING; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

3T3 CELLS; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BLOTTING, NORTHERN; CARRIER PROTEINS; GENE EXPRESSION PROFILING; HOMEODOMAIN PROTEINS; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS (GENETICS); RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANS-ACTIVATION (GENETICS); TRANSFECTION;

ANIMALIA;

EID: 0037306558     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/104454903321515904     Document Type: Article

References (53)

1. ALLAN, E.H., and MARTIN, T.J. (1995). Prostaglandin E2 regulates production of plasminogen activator isoenzymes, urokinase receptor, and plasminogen activator inhibitor-1 in primary cultures of rat calvarial osteoblasts. J. Cell Physiol. 165, 521-529.
2. BAKER, J.B., LOW, D.A., SIMMER, R.L., and CUNNINGHAM, D.D. (1980). Protease-nexin: A cellular component that links thrombin and plasminogen activator and mediates their binding to cells. Cell 21, 37-45.
3. BERGWERFF, M., GITTENBERGER-DE GROOT, A.C., WISSE, L.J., DERUITER, M.C., WESSELS, A., MARTIN, J.F., OLSON, E.N., and KERN, M.J. (2000). Loss of function of the Prx1 and Prx2 homeobox genes alters architecture of the great elastic arteries and ductus arteriosus. Virchows Arch. 436, 12-19.
4. CHANG, Y.E., and LAIMINS, L.A. (2000). Microarray analysis identifies interferon-inducible genes and Stat-1 as major transcriptional targets of human papillomavirus type 31. J. Virol. 74, 4174-4182.
5. CHESTERMAN, E.S., and KERN, M.J. (2002). Comparative analysis of Prx1 and Prx2 expression in mice provides evidence for incomplete compensation. Anat. Rec. 266, 1-4.
6. CHESTERMAN, E.S., GAINEY, G.D., VARN, A.C., PETERSON, R.E., JR., and KERN, M.J. (2001). Investigation of Prx1 protein expression provides evidence for conservation of cardiac-specific post-transcriptional regulation in vertebrates. Dev. Dyn. 222, 459-470.
7. CSERJESI, P., LILLY, B., BRYSON, L., WANG, Y., SASSOON, D.A., and OLSON, E.N. (1992). MHox: A mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer. Development 115, 1087-1101.
8. DEJONG, R., and MEIJLINK, R. (1993). The homeobox gene S8: Mesoderm-specific expression in presomite embryos and in cells cultured in vivo and modulation in differentiating pluripotent cells. Dev. Biol. 157, 133-146.
9. DEJONG, R., VAN DER HEIJDEN, J., and MEIJLINK, F. (1993). DNA-binding specificity of the S8 homeodomain. Nucleic Acids Res. 21, 4711-4720.
10. ERNO, H., and MONARD, D. (1993). Molecular organization of the rat glia-derived nexin/protease nexin-1 promoter. Gene Exp. 3, 163-174.
11. ERNO, H., KURY, P., BOTTERI, F.M., and MONARD, D. (1996). A krox binding site regulates protease nexin-1 promoter activity in embryonic heart, cartilage and parts of the nervous system. Mech. Dev. 60, 139-150.
12. GALLIOT, B., DE VARGAS, C., and MILLER, D. (1999). Evolution of homeobox genes: Q(50) paired-like genes founded the paired class. Dev. Genes Evol. 209, 186-197.
13. GATES, A.T., JONES, F.S., OAKEY, R.J., RABINOVITCH, M., and JONES, P.L. (1999). Regulation of tenascin-C by paired-related homeobox genes, Prx1 and Prx2. Mol. Biol. Cell 10, 2002.
14. GEHRING, W.J., AFFOLTER, M., and BURGLIN, T. (1994). Homeodomain proteins. Ann. Rev. Biochem. 63, 487-526.
15. HARKIN, D.P., BEAN, J.M., MIKLOS, D., SONG, Y.H., TRUONG, V.B., ENGLERT, C., CHRISTIANS, F.C., ELLISEN, L.W., MAHESWARAN, S., OLINER, J.D., et al. (1999). Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1. Cell 97, 575-586.
16. HAUTMANN, M.B., THOMPSON, M.M., SWARTZ, E.A., OLSON, E.N., and OWENS, G.K. (1997). Angiotensin II-induced stimulation of smooth muscle alpha-actin expression by serum response factor and the homeodomain transcription factor Mhox. Circ. Res. 81, 600-610.
17. HU, Y.S., FLANAGAN, J., BRENNAN, D.P., ZHOU, H., NG, K.W., EISMAN, J.A., and MORRISON, N.A. (1995). Rhox - A homeobox gene expressed in osteoblastic cells. J. Cell. Biochem. 59, 486-497.
18. HU, Y.S., ZHOU, H., KARTSOGIANNIS, V., EISMAN, J.A., MARTIN, T.J., and NG, K.W. (1998). Expression of rat homeobox gene, Rhox, in developing and adult tissues in mice and regulation of its Mrna expression in osteoblast by bone morphogenetic protein 2 and parathyroid hormone-related protein. Mol. Endocrinol. 12, 1721-1732.
19. ISHII, M., HASHIMOTO, S., TSUTSUMI, S., WADA, Y., MATSUSHIMA, K., KODAMA, T., and ABURATANI, H. (2000). Direct comparison of GeneChip and SAGE on the quantitative accuracy in transcript profiling analysis. Genomics 68, 136-143.
20. JONES, P.L., JONES, F.S., ZHOU, B., and RABINOVITCH, M. (1999). Induction of vascular smooth muscle cell tenascin-C gene expression by denatured type I collagen is dependent upon a beta3 integrin-mediated mitogen-activated protein kinase pathway and a 122-base pair promoter element. J. Cell Sci. 112, 435-445.
21. KERN, M.J., ARGAO, E.A., BIRKENMEIER, E.H., ROWE, L.B., and POTTER, S.S. (1994). Genomic organization and chromosome localization of the murine homeobox gene Pmx. Genomics 19, 334-340.
22. KERN, M.J., WITTE, D.P., VALERIUS, M.T., ARONOW, B.J., and POTTER, S.S. (1992). A novel murine homeobox gene isolated by a tissue specific PCR cloning strategy. Nucleic Acids Res. 20, 5189-5195.
23. KRUMLAUF, R. (1994). Hox genes in vertebrate development. Cell 78, 191-201.
24. KURATANI, S., MARTIN, J.F., WAWERSIK, S., LILLY, B., EICHELE, G., and OLSON, E.N. (1994). The expression pattern of the chick homeobox gene gMHox suggests a role in patterning of the limbs and face and in compartmentalization of somites. Dev. Biol. 161, 357-369.
25. KURY, P., SCHAERENWIEMERS, N., and MONARD, D. (1997). Protease nexin-1 is expressed at the mouse met-/mesencephalic junction and Fgf signaling regulates its promoter activity in primary met-/mesencephalic cells. Development 124, 1251-1262.
26. LEE, S.B., HUANG, K., PALMER, R., TRUONG, V.B., HERZLINGER, D., KOLQUIST, K.A., WONG, J., PAULDING, C., YOON, S.K., GERALD, W., et al. (1999). The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin. Cell 98, 663-673.
27. LEUSSINK, B., BROUWER, A., ELKHATTABI, M., POELMANN, R.E., GITTENBERGERDEGROOT, A.C., and MEIJLINK, F. (1995). Expression patterns of the paired-related homeobox genes Mhox/Prx1 and S8/Prx2 suggest roles in development of the heart and the forebrain. Mech. Dev. 52, 51-64.
28. LI, H., SCHRICK, J.J., FEWELL, G.D., MACFARLAND, K.L., WITTE, D.P., BODENMILLER, D.M., HSIEH-LI, H.M., SU, C.Y., and POTTER, S.S. (1999). Novel strategy yields candidate Gsh-1 homeobox gene targets using hypothalamus progenitor cell lines. Dev. Biol. 211, 64-76.
29. LIAO, J., XU, X., and WARGOVICH, M.J. (2000). Direct reprobing with anti-B-actin antibody as an internal control for western blotting analysis. BioTechniques 28, 216-218.
30. LIVESEY, F.J., FURUKAWA, T., STEFFEN, M.A., CHURCH, G.M., and CEPKO, C.L. (2000). Microarray analysis of the transcriptional network controlled by the photoreceptor homeobox gene Crx. Curr. Biol. 10, 301-310.
31. LU, M.F., CHENG, H.T., KERN, M.J., POTTER, S.S., TRAN, B., DIEKWISCH, T.G.H., and MARTIN, J.F. (1999a). prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme. Development 126, 495-504.
32. LU, M.E., CHENG, H.T., LACY, A.R., KERN, M.J., ARGAO, E.A., POTTER, S.S., OLSON, E.N., and MARTIN, J.F. (1999b). Paired-related homeobox genes cooperate in handplate and hindlimb zeugopod morphogenesis. Dev. Biol. 205, 145-157.
33. LYNCH, J., SUH, E.R., SILBERG, D.G., RULYAK, S., BLANCHARD, N., and TRABER, P.G. (2000). The caudal-related homeodomain protein Cdx1 inhibits proliferation of intestinal epithelial cells by down-regulation of D-type cyclins. J. Biol. Chem. 275, 4499-4506.
34. MANSUY, I.M., VAN DER PUTTGEN, H., SCHMID, P., MEINS, M., BOTTERI, F.M., and MONARD, D. (1993). Variable and multiple expression of Protease Nexin-1 during mouse organo-genesis and nervous system development. Development 119, 1119-1134.
35. MARTIN, T.J., ALLAN, E.H., and FUKUMOTO, S. (1993). The plasminogen activator and inhibitor system in bone remodelling. Growth Regul. 3, 209-214.
36. MEIER, R., SPREYER, P., ORTMANN, R., HAREL, A., and MONARD, D. (1989). Induction of glia-derived nexin after lesion of a peripheral nerve. Nature 342, 548-550.
37. MONARD, D., SOLOMON, F., RENTSCH, M., and GYSIN, R. (1973). Glia-induced morphological differentiation in neuroblastoma cells. Proc. Natl. Acad. Sci. USA 70, 1894-1897.
38. MULLIGAN, L.P., ROSENBLATT, D.E., TOMS, R., and JOHNSON, D. (1991). Protease nexin-1 activity in cultured Schwann cells. Neurosci. Lett. 128, 42-46.
39. NOHNO, T., KOYAMA, E., MYOKAI, F., TANIGUCHI, S., OHUCHI, H., SAITO, T., and NOJI, S. (1993). A chicken homeobox gene related to Drosophila paired is predominantly expressed in the developing limb. Dev. Biol. 158, 254-264.
40. NORRIS, R.A., and KERN, M.J. (2001a). Identification of domains mediating transcription activation, repression and inhibition in the paired related homeobox protein Prx2 (S8). DNA Cell Biol. 20, 89-99.
41. NORRIS, R.A., and KERN, M.J. (2001b). The identification of Prx1 transcription regulatory domains provides a mechanism for unequal compensation by the Prx1 and Prx2 loci. J. Biol. Chem. 276, 26829-26837.
42. NORRIS, R.A., SCOTT, K.K., MOORE, C.S., STETTEN, G., BROWN, C.R., JABS, E.W., WULFSBERG, E.A., YU, J., and KERN, M.J. (2000). Human PRRX1 and PRRX2 genes: Cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome. Mammal. Genome 11, 1000-1005.
43. OPSTELTEN, D.J.E., VOGELS, R., ROBERT, B., KALKHOVEN, E., SWARTKRUIS, F., DELAAF, L., DESTREE, O.H., DESCHAMPS, J., LAWSON, K.A., and MEIJLINK, F. (1991). The mouse homeobox gene, S8, is expressed during embryogenesis predominantly in mesenchyme. Mech. Dev. 34, 29-42.
44. POLLENZ, R.S. (1996). The aryl-hydrocarbon receptor, but not the aryl-hydrocarbon receptor nuclear translocator protein, is rapidly depleted in hepatic and nonhepatic culture cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Mol. Pharmacol. 49, 391-398.
45. QU, S.M., TUCKER, S.C., ZHAO, Q., DECROMBRUGGHE, B., and WISDOM, R. (1999). Physical and genetic interactions between Alx4 and Cart1. Development 126, 359-369.
46. SOUBEYRAN, P., ANDRE, F., LISSITZKY, J.C., MALLO, G.V., MOUCADEL, V., ROCCABIANCA, M., RECHRECHE, H., MARVALDI, J., DIKIC, I., DAGORN, J.C., et al. (1999). Cdx1 promotes differentiation in a rat intestinal epithelial cell line. Gastroenterology 117, 1326-1338.
47. STELNICKI, E.J., ARBEIT, J., CASS, D.L., SANER, C., HARRISON, M, and LARGMAN, C. (1998). Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds. J. Investig. Dermatol. 111, 57-63.
48. STRANDBERG, L., LAWRENCE, D., and NY, T. (1988). The organization of the human-plasminogen-activator-inhibitor-1 gene. Implications on the evolution of the serine-protease inhibitor family. Eur. J. Biochem. 176, 609-616.
49. TENBERGE, D., BROUWER, A., KORVING, J., MARTIN, J.F., and MEIJLINK, F. (1998). Prx1 and Prx2 in skeletogenesis - Roles in the craniofacial region, inner ear and limbs. Development 125, 3831-3842.
50. TREISMAN, J., HARRIS, E., WILSON, D., and DESPLAN, C. (1992). The homeodomain: A new face for the helix-turn-helix? BioEssays 14, 145-150.
51. WAGNER, S.L., VAN NOSTRAND, W.E., LAU, A.L., and CUNNINGHAM, D.D. (1988). Monoclonal antibodies to protease nexin 1 that differentially block its inhibition of target proteases. Biochemistry 27, 2173-2176.
52. YANG, J.N., ALLAN, E.H., ANDERSON, G.I., MARTIN, T.J., and MINKIN, C. (1997). Plasminogen activator system in osteoclasts. J. Bone Mineral Res. 12, 761-768.
53. ZIMMERMANN, J., ERDMANN, D., LALANDE, I., GROSSENBACHER, R., NOORANI, M., and FURST, P. (2000). Proteasome inhibitor induced gene expression profiles reveal overexpression of transcriptional regulators ATF3, GADD153 and MAD1. Oncogene 19, 2913-2920.