Identification of a novel class of human adherent CD34- stem cells that give rise to SCID-repopulating cells

Blood

Volumn 101, Issue 3, 2003, Pages 869-876

  Kuçi, Selim ^a,b,c   Wessels, Johannes T ^a,b,c   Bühring, Hans Jörg ^a,b,c   Schilbach, Karin ^a,b,c   Schumm, Michael ^a,b,c   Seitz, Gabriele ^a,b,c   Löffler, Jürgen ^a,b,c   Bader, Peter ^a,b,c   Schlegel, Paul G ^a,b,c   Niethammer, Dietrich ^a,b,c   Handgretinger, Rupert ^a,b,c  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; CD34 ANTIGEN; FLT3 LIGAND; HERMES ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LIGAND; PROTEIN FLK2; REGULATOR PROTEIN; SIGNAL REGULATORY PROTEIN ALPHA; STEM CELL FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CELL ADHESION; CELL FRACTIONATION; CELL LINEAGE; CELL POPULATION; CELL TYPE; COMBINED IMMUNODEFICIENCY; DENDRITIC CELL; ENDOTHELIUM CELL; FIBROBLAST; HUMAN; HUMAN CELL; LYMPHOCYTE COUNT; MESENCHYME CELL; MOBILIZATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PERIPHERAL CIRCULATION; PHENOTYPE; PRIORITY JOURNAL; SCID MOUSE; STEM CELL; STEM CELL TRANSPLANTATION; STROMA CELL; T LYMPHOCYTE;

EID: 0037305235     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-03-0711     Document Type: Article

References (33)

1. Ogawa M. Differentiation and proliferation of hematopoietic stem cells. Blood. 1993;81:2844-2853.
2. Williams DA. Ex vivo expansion of hematopoietic stem and progenitor cells - robbing Peter to pay Paul? [editorial]. Blood. 1993;81:3169-3172.
3. Moore MA. Expansion of myeloid stem cells in culture. Semin Hematol. 1995;32:183-200.
4. Spangrude GJ, Heimfeld S, Weissman IL. Purification and characterization of mouse hematopoietic stem cells [published erratum appears in Science. 1989;244:1030]. Science. 1988;241:58-62.
5. Jones RJ, Wagner JE, Celano P, Zicha MS, Sharkis SJ. Separation of pluripotent haematopoietic stem cells from spleen colony-forming cells [see comments]. Nature. 1990;347:188-189.
6. Berardi AC, Wang A, Levine JD, Lopez P, Scadden DT. Functional isolation and characterization of human hematopoietic stem cells. Science. 1995;267:104-108.
7. Kawashima I, Zanjani ED, Almaida PG, Flake AW, Zeng H, Ogawa M. CD34+ human marrow cells that express low levels of Kit protein are enriched for long-term marrow-engrafting cells. Blood. 1996;87:4136-4142.
8. Huang S, Terstappen LW. Lymphoid and myeloid differentiation of single human CD34+, HLADR+, CD38- hematopoietic stem cells. Blood. 1994;83:1515-1526.
9. Krause DS, Fackler MJ, Civin CI, May WS. CD34: structure, biology, and clinical utility [see comments]. Blood. 1996;87:1-13.
10. Osawa M, Hanada K, Hamada H, Nakauchi H. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science. 1996;273:242-245.
11. Goodell MA, Brose K, Paradis G, Conner AS, Mulligan RC. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med. 1996;183:1797-1806.
12. Morel F, Galy A, Chen B, Szilvassy SJ. Equal distribution of competitive long-term repopulating stem cells in the CD34+ and CD34- fractions of Thy-1lowLin-/lowSca-1+ bone marrow cells. Exp Hematol. 1998;26:440-448.
13. Bhatia M, Bonnet D, Murdoch B, Gan OI, Dick JE. A newly discovered class of human hematopoietic cells with SCID-repopulating activity [see comments]. Nat Med. 1998;4:1038-1045.
14. Zanjani ED, Almeida PG, Livingston AG, Flake AW, Ogawa M. Human bone marrow CD34-cells engraft in vivo and undergo multilineage expression that includes giving rise to CD34+ cells. Exp Hematol. 1998;26:353-360.
15. Sato T, Laver HJ, Ogawa M. Reversible expression of CD34 by murine hematopoietic stem cells. Blood. 1999;94:2548-2554.
16. Nakamura Y, Ando K, Chargui J, et al. Ex vivo generation of CD34+ cells from CD34- hematopoietic cells. Blood. 1999;94:4053-4059.
17. Yin AH, Miraglia S, Zanjani ED, et al. AC133, a novel marker for human hematopoietic stem and progenitor cells. Blood. 1997;90:5002-5012.
18. Miraglia S, Godfrey W, Yin AH, et al. A novel five-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning. Blood. 1997;90:5013-5021.
19. Gallacher L, Murdoch B, Wu DM, Karanu FN, Keeney M, Bhatia M. Isolation and characterization of human CD34(-)Lin(-) and CD34(+) Lin(-) hematopoietic stem cells using cell surface markers AC133 and CD7. Blood. 2000;95:2813-2820.
20. Watt SM, Buhring HJ, Rappold I, et al. CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21. Blood. 1998;92:849-866.
21. - hematopoietic cells. Blood. 2001;97:2741-2749.
22. Giesert C, Almeida PG, Scheffold A, Kanz L, Zanjani DE, Bühring HJ. The monoclonal antibody W7C5 defines a novel surface antigen on hematopoietic stem cells. In: Orlic D, Brümmendorf TH, Sharkis SJ, Kanz L, eds. Hematopoietic Stem Cells 2000: Basic and Clinical Sciences. Vol 938. New York, NY: Ann New York Acad Sci; 2001:175-183.
23. Ploemacher RE, van der Sluijs JP, Voerman JS, Brons NH. An in vitro limiting-dilution assay of long-term repopulating hematopoietic stem cells in the mouse. Blood. 1989;74:2755-2763.
24. Holtke HJ, Kessler C. Non-radioactive labeling of RNA transcripts in vitro with the hapten digoxigenin (DIG); hybridization and ELISA-based detection. Nucleic Acids Res. 1990;18:5843-5851.
25. Zanjani ED, Almeida PG, Ascensao JL, MacKintosh FR, Flake AW. Transplantation of hematopoietic stem cells in utero. Stem Cells. 1997;15(suppl 1):79-92.
26. Dick JE, Bhatia M, Gan O, Kapp U, Wang JC. Assay of human stem cells by repopulation of NOD/SCID mice. Stem Cells. 1997;15(suppl 1):199-203.
27. Bhatia M, Wang JCY, Kapp U, Bonnet D, Dick JE. Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. Proc Natl Acad Sci U S A. 1997;94:5320-5325.
28. Conneally E, Cashman J, Petzer A, Eaves C. Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice. Proc Natl Acad Sci U S A. 1997;94:9836-9841.
29. Wang JC, Doedens M, Dick JE. Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay. Blood. 1997;89:3919-3924.
30. Tourino C, Pflumio F, Novault S, et al. Efficient ex vivo expansion of NOD/SCID-repopulating cells with lympho-myeloid potential in hematopoietic grafts of children with solid tumors. Hematol J. 2001;2:108-116.
31. Gallacher L, Murdoch B, Wu D, Karanu F, Fellows F, Bhatia M. Identification of novel circulating human embryonic blood stem cells. Blood. 2000;96:1740-1747.
32. Suzuki A, Andrew DP, Gonzalo JA, et al. CD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein. Blood. 1996;87:3550-3562.
33. Cheng J, Baumhueter S, Cacalano G, et al. Hematopoietic defects in mice lacking the sialomucin CD34. Blood. 1996;87:479-490.