Pharmacological evidence suggests that the lysozyme/PACAP receptor of Tetrahymena thermophila is a polycation receptor

Acta Protozoologica

Volumn 42, Issue 1, 2003, Pages 11-17

  Keedy, Michael ^a   Yorgey, Nathan ^a   Hilty, Jeremy ^a   Price, Angela ^a   Hassenzahl, David ^a   Kuruvilla, Heather ^a  

^a CEDARVILLE UNIVERSITY   (United States)

Author keywords

Chemorepellent; G protein; PACAP 38; PKA; PKC; Polycation receptor; Tetrahymena

Indexed keywords

TETRAHYMENA; TETRAHYMENA THERMOPHILA;

EID: 0037298380     PISSN: 00651583     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Cantor J. M., Mace S. R., Kooy C. M., Caldwell B. D., Kuruvilla H. G. (1999) Adaptation to lysozyme does not occur via receptor-mediated endocytosis in Tetrahymena thermophila. WWW J Biol. 4. Available online at http://www.epress.com/w3jbio/vol4/cantor/paper.htm
2. Delporte C., Poloczek P., de Neef P., Vertongen P., Ciccarelli E., Svoboda M., Herchuelz A., Winand J., Robberecht P. (1995) Pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide stimulate two signaling pathways in CHO cells stably transfected with the selective type PACAP receptor. Mol. Cell Endocrinol. 107: 71-76
3. Dentler W. L. (1988) Fractionation of Tetrahymena ciliary membranes with Triton X-114 and the identification of a ciliary membrane ATPase. J. Cell Biol. 107: 2679-2688
4. Gustin M., Hennessey T. M. (1988) Neomycin inhibits the calcium current of Paramecium. Biochim. Biophys. Acta 940: 99-104
5. Hahm S. H., Hsu C., Eiden L. E. (1998) PACAP activates calcium influx-dependent and -independent pathways to couple metenkephalin secretion and biosynthesis in chromaffin cells. J. Mol. Neurosci. 11: 43-56
6. Harmar A. J., Arimura A., Gozes I., Journot L., Laburthe M., Pisegna J. R., Rawlings S. R., Robberecht P., Said S. I., Sreedharan S. P., Wank S. A., Waschek J. A. (1998). International union of pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide. Pharmacol. Rev. 50: 265-270
7. Hassenzahl D. L., Yorgey N. K., Keedy M. D., Price A. R., Hall J. A., Myzcka C. C., Kuruvilla H. G. (2001) Chemorepellent signaling through the PACAP/lysozyme receptor occurs through both cAMP and PKC in Tetrahymena thermophila. J. Comp. Physiol. A 187: 171-176
8. Kuruvilla H. G., Hennessey T. M. (1998) Purification and characterization of a novel chemorepellent receptor from Tetrahymena thermophila. J. Memb. Biol. 162: 51-57
9. Kuruvilla H. G., Hennessey T. M. (1999) Chemosensory responses of Tetrahymena thermophila to CB, a 24-amino acid fragment of lysozyme. J. Comp. Physiol. A. 184: 529-534
10. Kuruvilla H. G., Kim M. Y., Hennessey T. M. (1997) Chemosensory adaptation to lysozyme and GTP involves independently regulated receptors in Tetrahymena thermophila. J. Euk. Microbiol. 44: 263-268
11. Mace S. R., Dean J. G., Murphy J. R., Rhodes J. L., Kuruvilla H. G. (2000) PACAP-38 is a chemorepellent and and agonist for the lysozyme receptor in Tetrahymena thermophila. J. Comp. Physiol. A 186: 39-43
12. Miyata A., Arimura A., Dahl R. R., Minamino N., Uehara A., Jiang L., Culler, M. D., Coy, D.H. (1989) Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells. Biochem. Biophys. Res. Commun. 164: 567-574
13. Miyata A., Jiang L., Dahl R. D., Kitada C., Kubo K., Fujino M., Minamino N., Arimura A. (1990) Isolation of a neuropeptide corresponding to the N-terminal 27 residues of the pituitary adenylate cyclase activating polypeptide with 38 residues (PACAP38). Biochem. Biophys. Res. Commun. 170: 643-648
14. Robberecht P., Woussen-Colle M. C., De Neef P., Gourlet P., Buscail L., Vandermeers A., Vandermeers-Piret M. C., Christophe J. (1991) The two forms of the pituitary adenylate cyclase activating polypeptide [PACAP (1-27) and PACAP (1-38)] interact with distinct receptors on rat pancreatic AR 4-2J cell membranes. FEBS Lett. 286: 133-136
15. Seebeck J., Kruse M. L., Schmidt-Choudbury A., Schmidt W. E. (1998) Pituitary adenylate cyclase activating polypeptide induces degranulation of rat peritoneal mast cells via high-affinity PACAP-receptor-independent activation of G-proteins. Ann. NY Acad. Sci. 865: 141-146
16. Vaudry D., Gonzales B. J., Basille M., Yon L., Fournier A., Vaudry H. (2000). Pituitary adenylate cyclase-activating polypeptide and its receptors: From structure to function. Pharm. Rev. 52: 269-324