Pituitary adenylate cyclase activating polypeptide induces degranulation of rat peritoneal mast cells via high-affinity PACAP receptor-independent activation of G proteins

Annals of the New York Academy of Sciences

Volumn 865, Issue , 1998, Pages 141-146

  Seebeck, Jörg ^a   Kruse, Marie Luise ^a   Schmidt Choudhury, Anjona ^a   Schmidt, Wolfgang E ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE RECEPTOR; PHOSPHOLIPASE C INHIBITOR; SEROTONIN; TRITIUM;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; CELL SECRETION; CONFERENCE PAPER; CONTROLLED STUDY; DEGRANULATION; NONHUMAN; PERITONEUM MAST CELL; RAT; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION;

ANIMALIA; TRITIUM;

EID: 0032430768     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb11172.x     Document Type: Conference Paper

References (11)

1. Mori,T. et al. 1994. Histamine release induced by pituitary adenylate cyclase activating polypeptide from rat peritoneal mast cells. Arzneim.-Forsch./Drug Res. 44 (II): 1044-1046.
2. Buscail., L. et al. 1990. Presence of highly selective receptors for PACAP (pituitary adenylate cyclase activating peptide) in membranes from the rat pancreatic acinar cell line AR 4-2J. FEBS Lett. 262: 77-81.
3. Schmidt, W. E. et al. 1993. PACAP and vip stimulate enzyme secretion in rat pancreatic acini via interaction with VIP/PACAP-2 receptors: Additive augmentation of CCK/carbachol- induced enzyme release. Pancreas 8: 476-487.
4. Spengler, D. et al. 1993. Different signal transduction by five splice variants of the PACAP receptor. Nature 365: 170-175.
5. Pisegna, J. R. & S. A. Wank. 1993. Molecular cloning and functional expression of the pituitary adenylate cyclase activating polypeptide type 1 receptor. Proc. Natl. Acad. Sci. USA 90: 6345-6349.
6. Chahl, L. A. 1991. Role of histamine in the action of neuropeptides and local hormones. Handb. Pharmacol. 97:521-540.
7. Aridor, M. et al. 1993. Activation of exocytosis by the heterotrimeric G protein Gi3. Science 262: 1569-1573.
8. Mousli, M. et al. 1989. Activation of rat peritoneal mast cells by substance P and mastoparan. J. Pharmacol. Exp. Ther. 250: 329-335.
9. Nakamura, T. & M. Ui 1985. Simultaneous inhibitions of inositol phospholipid breakdown, arachidonic acid release, and histamine secretion in mast cells by islet-activating protein, pertussis toxin. J. Biol. Chem. 260: 3584-3593.
10. Penner, R. 1988. Multiple signalling pathways control stimulus-secretion coupling in rat peritoneal mast cells. Proc. Natl. Acad. Sci. USA 85: 9856-9860.
11. Smith, R. J. 1990. Receptor-coupled signal transduction in human polymorphonuclear neutrophils: Effects of a novel inhibitor of phospholipase c-dependent processes on cell responsiveness. J. Pharmacol. Exp. Ther. 253: 688-697.