Synthesis of 21,21-difluoro-3β-hydroxy-20-methylpregna-5,20-diene and 5,16,20-triene as potential inhibitors of steroid C17(20) lyase

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 3, 2003, Pages 427-431

  Weintraub, Philip M ^a   Holland, Amy K ^b   Gates, Cynthia A ^c   Moore, William R ^d   Resvick, Robert J ^a   Bey, Philippe ^e   Peet, Norton P ^f  

^a SANOFI   (France)

^b Vankel   (United States)

^c VERTEX PHARMACEUTICALS   (United States)

^d Locus Pharmaceuticals   (United States)

^e ARQULE INC   (United States)

^f Aurigene Discovery Technologies   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

21,21 DIFLUORO 20 METHYLPREGNA 5,16,20 TRIEN 3BETA OL; 21,21 DIFLUORO 20 METHYLPREGNA 5,20 DIEN 3BETA OL; ALKENE DERIVATIVE; LYASE INHIBITOR; PREGNENOLONE; REAGENT; STEROID; STEROID 17,20 LYASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; TIME; WITTIG REACTION;

ANIMALS; ENZYME INHIBITORS; MACACA FASCICULARIS; MALE; PREGNENOLONE; STEROID 17-ALPHA-HYDROXYLASE; STEROIDS, FLUORINATED; STRUCTURE-ACTIVITY RELATIONSHIP; TESTIS; TIME FACTORS;

EID: 0037294123     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00434-0     Document Type: Article

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