Synthesis and structure-activity relationships of 5,6,7,8-tetrahydropyrido[3,4-b]pyrazine-based hydroxamic acids as HB-EGF shedding inhibitors

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 3, 2003, Pages 433-450

  Yoshiizumi, Kazuya ^a,b   Yamamoto, Minoru ^a   Miyasaka, Tomohiro ^a   Ito, Yasuko ^a   Kumihara, Hiroshi ^a   Sawa, Masaaki ^a   Kiyoi, Takao ^a   Yamamoto, Takeshi ^a   Nakajima, Fumio ^a   Hirayama, Ryoichi ^a   Kondo, Hirosato ^a   Ishibushi, Etsuko ^a   Ohmoto, Hiroshi ^a   Inoue, Yoshimasa ^a   Yoshino, Kohichiro ^a  

^a Nippon Organon KK   (Japan)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (N BENZYL 4 METHOXYBENZENESULFONAMIDO) N HYDROXY 3 METHYLBUTANAMIDE; CARBON; CGS 27023A; COLLAGENASE INHIBITOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; HYDROXAMIC ACID DERIVATIVE; INTERSTITIAL COLLAGENASE; N HYDROXY 6 [4 (2 ETHOXYETHOXY)BENZENESULFONYL] 5,6,7,8 TETRAHYDROPYRIDO[3,4 B]PYRAZINE 7 CARBOXAMIDE; N HYDROXY 6 [4 (3 METHOXYPROPOXY)BENZENESULFONYL] 5,6,7,8 TETRAHYDROPYRIDO[3,4 B]PYRAZINE 7 CARBOXAMIDE; PHENYL GROUP; PYRAZINE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; INHIBITION KINETICS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

EPIDERMAL GROWTH FACTOR; HUMANS; HYDROXAMIC ACIDS; PROTEASE INHIBITORS; PYRAZINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TUMOR CELLS, CULTURED;

EID: 0037293521     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00426-1     Document Type: Article

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