Semisynthesis of DB-67 and other silatecans from camptothecin by thiol-promoted addition of silyl radicals

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 3, 2003, Pages 451-458

  Du, Wu ^a   Kaskar, Bashir ^b   Blumbergs, Peter ^b   Subramanian, P K ^b   Curran, Dennis P ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b ASH STEVENS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

10 HYDROXYCAMPTOTHECIN; 7 TERT BUTYLDIMETHYLSILYL 10 HYDROXYCAMPTOTHECIN; CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; DB 67; RADICAL; SILATECAN DERIVATIVE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DRUG SYNTHESIS; HEATING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMER; PROTON NUCLEAR MAGNETIC RESONANCE; TEMPERATURE;

CAMPTOTHECIN; FREE RADICALS; HEAT; ISOMERISM; ORGANOSILICON COMPOUNDS; SULFHYDRYL COMPOUNDS;

EID: 0037293483     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00437-6     Document Type: Article

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