Evidence for the primary role for 4-aminopyridine-sensitive Kv channels in β3-adrenoceptor-mediated, cyclic AMP-independent relaxations of guinea-pig gastrointestinal smooth muscles

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 367, Issue 2, 2003, Pages 193-203

  Horinouchi, Takahiro ^a   Tanaka, Yoshio ^a   Koike, Katsuo ^a  

^a TOHO UNIVERSITY   (Japan)

Author keywords

3 adrenoceptors; 4 aminopyridine; Cyclic AMP independent relaxation; Duodenum; Gastric fundus; Large conductance, Ca2+ sensitive and voltage gated K+ (BKCa) channel; SQ 22,536

Indexed keywords

4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; 4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID METHYL ESTER; 4 AMINOPYRIDINE; 9 (TETRAHYDRO 2 FURYL)ADENINE; ADRENALIN; ATENOLOL; BETA 3 ADRENERGIC RECEPTOR; BUTOXAMINE; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; IBERIOTOXIN; ISOPRENALINE; NORADRENALIN; POTASSIUM CHLORIDE; PROPRANOLOL; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DUODENUM; GASTROINTESTINAL TRACT; GUINEA PIG; MALE; MUSCLE TONE; NONHUMAN; POTASSIUM CONDUCTANCE; SMOOTH MUSCLE RELAXATION; STOMACH FUNDUS;

4-AMINOPYRIDINE; ADRENERGIC AGONISTS; ANIMALS; CATECHOLAMINES; CYCLIC AMP; EPINEPHRINE; ETHANOLAMINES; GUINEA PIGS; ION CHANNEL GATING; ISOPROTERENOL; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH; NOREPINEPHRINE; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; PROPANOLAMINES; RECEPTORS, ADRENERGIC, BETA-3;

EID: 0037291722     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-002-0658-3     Document Type: Article

References (29)

1. 3- and atypical β-adrenoceptors. Med Res Rev 13:663-729
2. i in rat adipocytes. Cell Signal 6:457-465
3. i through a membrane-delimited pathway. Pflugers Arch 437:508-510
4. Deng C, Moinat M, Curtis L, Nadakal A, Preitner F, Boss O, Assimacopoulos-Jeannet F, Seydoux J, Giacobino JP (1997) Effects of β-adrenoceptor subtype stimulation on obese gene messenger ribonucleic acid and on leptin secretion in mouse brown adipocytes differentiated in culture. Endocrinology 138:548-552
5. 4-adrenoceptors. Pharmacol Res 39:345-348
6. Farrugia G (1999) Ionic conductances in gastrointestinal smooth muscles and interstitial cells of Cajal. Annu Rev Physiol 61:45-84
7. Galvez A, Gimenez-Gallego G, Reuben JP, Roy-Contancin L, Feigenbaum P, Kaczorowski J, Garcia ML (1990) Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. J Biol Chem 265:11083-11090
8. 3-adrenergic receptor. Mol Pharmacol 48:492-498
9. v1.1) in interstitial cells of Cajal. J Physiol 533:315-327
10. 3-adrenoceptor antagonist bupranolol. Pharmacology 59:290-297
11. Horinouchi T, Koike K (1999b) Characterization of atypical β-adrenoceptors in the guinea pig duodenum. Eur J Pharmacol 376:61-66
12. 3-adrenoceptors on guinea pig gastrointestine. Eur J Pharmacol 442:137-146
13. Horowitz B, Ward SM, Sanders KM (1999) Cellular and molecular basis for electrical rhythmicity in gastrointestinal muscles. Annu Rev Physiol 61:19-43
14. Ida K, Hashimoto K, Kamiya M, Muto S, Nakamura Y, Kato K, Mizota M (1996) Stereoselective action of (R*,R*)-(+/-)-methyl-4-[2-[2-hydroxy-2-(3-chlorophenyl) ethylamino]propyl]-phenoxyacetic acid (BRL37344) on β-adrenoceptors and metabolic chiral inversion. Biochem Pharmacol 52:1521-1527
15. + channels by protein kinase A. Pflugers Arch 432:401-412
16. 3-adrenoceptor mechanisms in guinea-pig taenia caecum. Life Sci 62:1503-1507
17. Ca channels in airway smooth muscle by cAMP-dependent and -independent mechanisms. J Clin Invest 93:371-379
18. 3-adrenoceptors and intestinal motility. Fund Clin Pharmacol 9:332-342
19. Mathie A, Wooltorton JR, Watkins CS (1998) Voltage-activated potassium channels in mammalian neurons and their block by novel pharmacological agents. Gen Pharmacol 30:13-24
20. McLaughlin DP, MacDonald A (1991) Characterization of catecholamine-mediated relaxations in rat isolated gastric fundus: evidence for an atypical β-adrenoceptor. Br J Pharmacol 103:1351-1356
21. Rasmussen H (1986) The calcium messenger system. N Engl J Med 314:1094-1101
22. 2 receptors and β-adrenoceptor subtypes in guinea-pig isolated ileum. Br J Pharmacol 114:49-56
23. sα independent of phosphorylation by protein kinase A. Am J Physiol 265:H1460-H1465
24. Turcato S, Clapp LH (1999) Effects of the adenylyl cyclase inhibitor SQ22536 on iloprost-induced vasorelaxation and cyclic AMP elevation in isolated guinea-pig aorta. Br J Pharmacol 126:845-847
25. Van der Vliet A, Rademaker B, Bast A (1990) A beta adrenoceptor with atypical characteristics is involved in the relaxation of the rat small intestine. J Pharmacol Exp Ther 255:218-226
26. Vogalis F (2000) Potassium channels in gastrointestinal smooth muscle. J Auton Pharmacol 20:207-219
27. Ca channel cloned from myometrium. Receptors Channels 3:185-199
28. + channel openers on relaxations to nitric oxide and endothelium-derived hyperpolarizing factor in rat mesenteric artery. Eur J Pharmacol 357:41-51
29. Yamaki F, Kaga M, Horinouchi T, Tanaka H, Koike K, Shigenobu K, Toro L, Tanaka Y (2001) MaxiK channel-mediated relaxation of guinea-pig aorta following stimulation of IP receptor with beraprost via cyclic AMP-dependent and -independent mechanisms. Naunyn-Schmiedebergs Arch Pharmacol 364:538-550