Ionic conductances in gastrointestinal smooth muscles and interstitial cells of Cajal

Annual Review of Physiology

Volumn 61, Issue , 1999, Pages 45-84

  Farrugia, G ^a  

^a MAYO CLINIC   (United States)

Author keywords

Ion channels; Patch clamp; Review

Indexed keywords

ACETYLCHOLINE; ANION CHANNEL; CALCIUM CHANNEL; CALCIUM ION; CATION CHANNEL; CHLORIDE ION; CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPROTEIN; POTASSIUM CHANNEL; POTASSIUM ION; SODIUM CHANNEL; SODIUM ION;

CALCIUM CONDUCTANCE; CHANNEL GATING; CHLORIDE CONDUCTANCE; CONCENTRATION RESPONSE; INTESTINE CELL; INTESTINE MUSCLE; NONHUMAN; PATCH CLAMP; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; SODIUM CONDUCTANCE; STOMACH MUSCLE; TRANSPORT KINETICS;

ANIMALS; CALCIUM CHANNELS; CHLORIDE CHANNELS; DIGESTIVE PHYSIOLOGY; DIGESTIVE SYSTEM; ELECTRIC CONDUCTIVITY; HUMANS; ION CHANNELS; MUSCLE, SMOOTH;

EID: 0033064339     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.61.1.45     Document Type: Review

References (131)

1. 1. McDonald TF, Pelzer S, Trautwein W, Pelzer DJ. 1994. Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells. Physiol. Rev. 74:365-507
2. 2. Singer D, Biel M, Lotan I, Flockerzi V, Hofmann F, Dascal N. 1991. The roles of the subunits in the function of the calcium channel. Science 253:1553-57
3. 3. Yoshino M, Yabu H. 1985. Single Ca channel currents in mammalian visceral smooth muscle cells. Pflügers Arch. 404: 285-86
4. 4. Yoshino M, Someya T, Nishio A, Yabu H. 1988. Whole-cell and unitary Ca channel currents in mammalian intestinal smooth muscle cells: evidence for the existence of two types of Ca channels. Pflügers Arch. 411:229-31
5. 5. Inoue Y, Xiong ZL, Kitamura K, Kuriyama H. 1989. Modulation produced by nifedipine of the unitary Ba current of dispersed smooth muscle cells of the rabbit ileum. Pflügers Arch. 414:534-42
6. 6. Rich A, Kenyon JL, Hume JR, Overturf K, Horowitz B, Sanders KM. 1993. Dihydropyridine-sensitive calcium channels expressed in canine colonic smooth muscle cells. Am. J. Physiol. 264:C745-54
7. 7. Farrugia G, Rich A, Rae JL, Sarr MG, Szurszewski JH. 1995. Calcium currents in human and canine jejunal circular smooth muscle cells. Gastroenterology 109:707-17
8. 8. Cavalie A, McDonald TF, Pelzer D, Trautwein W. 1985. Temperature-induced transitory and steady-state changes in the calcium current of guinea pig ventricular myocytes. Pflügers Arch. 405:294-96
9. 9. Ganitkevich VYa, Shuba MF, Smirnov SV. 1987. Calcium-dependent inactivation of potential-dependent calcium inward current in an isolated guinea pig smooth muscle cell. J. Physiol. 392:431-49
10. 10. Rich A, Farrugia G, Rae JL, Szurszewski JH. 1994. Temperature dependence of a inward calcium current in canine jejunal circular smooth muscle cells. Gastroenterology 107(4):1219 (Abstr.)
11. 11. Farrugia G. 1997. G-protein regulation of an L-type calcium channel current in canine jejunal circular smooth muscle. J. Membr. Biol. 160:39-46
12. 12. Ohya Y, Kitamura K, Kuriyama H. 1987. Modulation of ionic currents in smooth muscle balls of the rabbit intestine by intracellularly perfused ATP and cyclic AMP. Pflügers Arch. 408:465-73
13. 13. Romanin C, Grosswagen P, Schindler H. 1991. Calpastatin and nucleotides stabilize cardiac calcium channel activity in excised patches. Pflügers Arch. 418(12):86-92
14. 14. Katzka DA, Morad M. 1989. Properties of calcium channels in guinea pig gastric myocytes. J. Physiol. 413:175-97
15. 15. McCarron JG, McGeown JG, Walsh JV Jr, Fay FS. 1997. Modulation of high-and low-voltage-activated calcium currents in smooth muscle by calcium. Am. J. Physiol. 273:C883-92
16. 2+-current by alpha-adrenoceptor agonists in smooth muscle cells. Eur. J. Pharmacol. 288:355-64
17. 2+ current in canine colonic myocytes by cyclic nucleotide-dependent mechanisms. Am. J. Physiol. 271:C794-803
18. 18. Yabu H, Yoshino M, Usuki T, Someya T, Obara K, et al. 1990. Modification by calyculin A of inward Ca currents in smooth muscle cells isolated from guinea pig taenia coli. Prog. Clin. Biol. Res. 327:623-26
19. 2+ currents of gastric and colonic smooth muscle by phosphatase inhibitors. Am. J. Physiol. 261:C64-70
20. 2+-channel currents recorded in single smooth muscle cells of the guinea pig taenia caeci. Br. J. Pharmacol. 104:331-36
21. 21. Obara K, Yabu H. 1993. Dual effect of phosphatase inhibitors on calcium channels in intestinal smooth muscle cells. Am. J. Physiol. 264:C296-301
22. 22. Sims SM, Singer JJ, Walsh JV Jr. 1985. Cholinergic agonists suppress a potassium current in freshly dissociated smooth muscle cells of the toad. J. Physiol. 367:503-29
23. 2+ current in guinea pig gastric and tracheal smooth muscle cells. J. Physiol. 491:307-19
24. 24. Lee HK, Bayguinov O, Sanders KM. 1993. Role of nonselective cation current in muscarinic responses of canine colonic muscle. Am. J. Physiol. 265:C1463-71
25. 25. Farrugia G, Macielag MJ, Peeters TL, Sarr MG, Galdes A, Szurszewski JH. 1997. Motilin and OHM-11526 activate a calcium current in human and canine jejunal circular smooth muscle. Am. J. Physiol. 273:G404-12
26. 26. Hagiwara N, Irisawa H, Kameyama M. 1988. Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells. J. Physiol. 395:233-53
27. 27. Peres-Reyes E, Cribbs LL, Daud A, Lacerda AE, Barclay J, et al. 1998. Molecular characterization of a neuronal low-voltage-activated T-type calcium channel. Nature 391:896-900
28. 28. Yoshino M, Someya T, Nishio A, Yabu H. 1988. Whole-cell and unitary Ca channel currents in mammalian intestinal smooth muscle cells: evidence for the existence of two types of Ca channels. Pflügers Arch.411(2):229-31
29. 29. Yabu H, Yoshino M, Someya T, Totsuka M. 1989. Two types of Ca channels in smooth muscle cells isolated from guinea pig taenia coli. Adv. Exp. Med. Biol. 255:129-34
30. 30. Yoshino M, Someya T, Nishio A, Yazawa K, Usuki T, Yabu H. 1989. Multiple types of voltage-dependent Ca channels in mammalian intestinal smooth muscle cells. Pflügers Arch. 414(4):401-9
31. 31. Yamamoto Y, Hu SL, Kao CY. 1989. Inward current in single smooth muscle cells of the guinea pig taenia coli. J. Gen. Physiol. 93(3):521-50
32. 32. Smirnov SV, Zholos AV, Shuba MF. 1992. Potential-dependent inward currents in single isolated smooth muscle cells of the rat ileum. J. Physiol. 454:549-71
33. 33. Xiong Z, Sperelakis N, Noffsinger A, Fenoglio-Preiser C. 1993. Changes in calcium channel current densities in rat colonic smooth muscle cells during development and aging. Am. J. Physiol. 265: C617-25
34. 34. Ward SM, Sanders KM. 1992. Upstroke component of electrical slow waves in canine colonic smooth muscle due to nifedipine-resistant calcium current. J. Physiol. 455:321-37
35. 35. Morel JL, Drobecq H, Sautiere P, Tartar A, Mironneau J, et al. 1997. Purification of a new dimeric protein from Cliona vastifica sponge, which specifically blocks a non-L-type calcium channel in mouse duodenal myocytes. Mol. Pharmacol. 51(6):1042-52
36. 36. Jentsch TJ, Gunther W. 1997. Chloride channels: an emerging molecular picture. BioEssays 19(2):117-26
37. i and Ca-sensitive ion channels in mammalian colonic muscle. Ann. NY Acad. Sci. 632:439-41
38. 38. Deleted in proof
39. 39. Byrne NG, Large WA. 1987. Action of noradrenaline on single smooth muscle cells freshly dispersed from the rat anococcygeus muscle. J. Physiol. 389:513-25
40. 40. Ito S, Ohta T, Nakazato Y. 1993. Inward current activated by carbachol in rat intestinal smooth muscle cells. J. Physiol. 470:395-409
41. 41. Ohta T, Ito S, Nakazato Y. 1993. Chloride currents activated by caffeine in rat intestinal smooth muscle cells. J. Physiol. 465:149-62
42. - currents in rabbit oesophageal smooth muscle. J. Physiol. 460:117-33
43. - and cation currents in single opossum esophageal circular muscle cells. Am. J. Physiol. 271:C1725-34
44. 44. Crist JR, He XD, Goyal RK. 1991. Chloride-mediated inhibitory junction potentials in opossum esophageal circular smooth muscle. Am. J. Physiol. 261: G752-62
45. 45. Farrugia G. 1997. Activation of a chloride current by volume in canine jejunal circular smooth muscle cells. Gastroenterology 112:A730 (Abstr.)
46. 46. Sun XP, Supplisson S, Torres R, Sachs G, Mayer E. 1992. Characterization of large-conductance chloride channels in rabbit colonic smooth muscle. J. Physiol. 448:355-82
47. 47. Sun XP, Supplisson S, Mayer E. 1993. Chloride channels in myocytes from rabbit colon are regulated by a pertussis toxin-sensitive G protein. Am. J. Physiol. 264:G774-85
48. 48. Nilius B, Eggermont J, Voet T, Buyse G, Manolopoulos V, Droogmans G. 1997. Properties of volume-regulatied anion channels in mammalian cells. Prog. Biophys. Mol. Biol. 68(1):69-119
49. 49. Xu WX, Kim SJ, So I, Kang TM, Rhee JC, Kim KW. 1997. Volume-sensitive chloride current activated by hyposmotic swelling in antral gastric myocytes of the guinea pig. Pflügers Arch. 435(1):9-19
50. 50. Duan D, Winter C, Cowley S, Hume JR, Horowitz B. 1997. Molecular identification of a volume-regulated chloride channel. Nature 390:417-21
51. 51. Farrugia G. 1998. Role of the cytoskeleton in volume activation of an anion current in canine jejunal circular smooth muscle cells. Gastroenterology 114(4):A751
52. 52. Farrugia G, Sarr MG. 1998. Properties of a volume-activated chloride current in human jejunal circular smooth muscle cells. Neurogastroenterol. Motil. 10(1):70
53. 53. Fatt P, Katz B. 1951. An analysis of the end plate potential recorded with an intracellular electrode. J. Physiol. 115:320-70
54. 54. Inoue R, Kitamura K, Kuriyama H. 1987. Acetylcholine activates single sodium channels in smooth muscle cells. Pflügers Arch. 410(12):69-74
55. 55. Vogalis F, Sanders KM. 1990. Cholinergic stimulation activates a non-selective cation current in canine pyloric circular muscle cells. J. Physiol. 429:223-36
56. +-sensitive cation channel modulated by angiotensin II in cultured intestinal myocytes. Am. J. Physiol. 266:C1538-43
57. 2+-permeable, nonselective cation channel in smooth muscle cells. J. Gen. Physiol. 104(2):375-94
58. 57. Nakazawa K, Inoue K, Fujimori K, Takanaka A. 1990. Difference between substance P-and acetylcholine-induced currents in mammalian smooth muscle cells. Eur. J. Pharmacol. 179(3):453-56
59. 58. Lee HK, Shuttleworth CW, Sanders KM. 1995. Tachykinins activate nonselective cation currents in canine colonic myocytes. Am. J. Physiol. 269:C1394-401
60. 59. Benham CD, Bolton TB, Lang RJ. 1985. Acetylcholine activates an inward current in single mammalian smooth muscle cells. Nature 316:345-47
61. 60. Inoue R, Isenberg G. 1990. Effect of membrane potential on acetylcholine-induced inward current in guinea pig ileum. J. Physiol. 424:57-71
62. + modulates acetylcholine-activated nonselective cation channels in guinea pig ileum Am. J. Physiol. 268: C162-70
63. 62. Chen S, Inoue R, Ito Y. 1993. Pharmacological characterization of muscarinic receptor-activated cation channels in guinea pig ileum. Br. J. Pharmacol. 109(3):793-801
64. 63. Kim SJ, Ahn SC, So I, Kim KW. 1995. Quinidine blockade of the carbachol-activated nonselective cationic current in guinea pig gastric myocytes. Br. J. Pharmacol. 115(8):1407-14
65. 64. Inoue R, Isenberg G. 1990. Acetylcholine activates nonselective cation channels in guinea pig ileum through a G protein. Am. J. Physiol. 258:C1173-78
66. 65. Inoue R, Isenberg G. 1990. Intracellular calcium ions modulate acetylcholine-induced inward current in guinea pig ileum. J. Physiol. 424:73-92
67. 66. Pacaud P, Bolton TB. 1991. Relation between muscarinic receptor cationic current and internal calcium in guinea pig jejunal smooth muscle cells. J. Physiol. 441:477-99
68. 67. Sims SM. 1992. Cholinergic activation of a non-selective cation current in canine gastric smooth muscle is associated with contraction. J. Physiol. 449:377-98
69. 68. Komori S, Kawai M, Takewaki T, Ohashi H. 1992. GTP-binding protein involvement in membrane currents evoked by carbachol and histamine in guinea pig ileal muscle. J. Physiol. 450:105-26
70. 69. Inoue R, Chen S. 1993. Physiology of muscarinic receptor-operated nonselective cation channels in guinea pig ileal smooth muscle. In Nonselective Cation Channels: Pharmacology, Physiology and Biophysics, ed. D Siemen, J Hescheler, pp. 261-68. Basle: Birkhause Verlag
71. 70. Rich A, Farrugia G, Szurszewski JH. 1998. Muscarinic stimulation of a nonselective cation current in circular smooth muscle cells from canine jejunum. Neurogastroenterol. Motil. 10(1):93 (Abstr.)
72. 71. Deleted in proof
73. 72. Wayman CP, McFadzean I, Gibson A, Tucker JF. 1996. Inhibition by sodium nitroprusside of a calcium store depletion-activated non-selective cation current in smooth muscle cells of the mouse anococcygeus. Br. J. Pharmacol. 118(8):2001-8
74. 73. Ahn SC, Kim SJ, So I, Kim KW. 1997. Inhibitory effect of phorbol 12, 13 dibutyrate on carbachol-activated nonselective cationic current in guinea pig gastric myocytes. Pflügers Arch. 434(4):505-7
75. + channel from canine colonic smooth muscle. Proc. Natl. Acad. Sci. USA 90(20):9659-63
76. + channel from vascular and visceral smooth muscles. Am. J. Physiol. 267:C1231-38
77. + channels cloned from smooth muscle. Am. J. Physiol. 267:C1729-33
78. 77. Wong BS. 1989. Quinidine blockade of calcium-activated potassium channels in dissociated gastric smooth muscle cells. Pflügers Arch. 414(4):416-22
79. + channel may be mediated by fatty acids. J. Physiol. 484:331-37
80. 79. Benham CD, Bolton TB. 1983. Patchclamp studies of slow potential-sensitive potassium channels in longitudinal smooth muscle cells of rabbit jejunum. J. Physiol. 340:469-86
81. + channels by protein kinase A. Pflügers Arch. 432(3):401-12
82. 81. Shuttleworth CW, Koh SD, Bayginov O, Sanders KM. 1996. Activation of delayed rectifier potassium channels in canine proximal colon by vasoactive intestinal peptide. J. Physiol. 493:651-63
83. 82. Koh SD, Campbell JD, Carl A, Sanders KM. 1995. Nitric oxide activates multiple potassium channels in canine colonic smooth muscle. J. Physiol. 489:735-43
84. 83. Farrugia G, Rae JL, Szurszewski JH. 1993. Characterization of an outward potassium current in canine jejunal circular smooth muscle and its activation by fenamates. J. Physiol. 468:297-310
85. 84. Farrugia G, Rae JL, Sarr M, Szurszewski JH. 1993. A potassium whole cell current in jejunal human circular smooth muscle. Am. J. Physiol. 265:G873-79
86. + current in canine colonic smooth muscle. J. Physiol. 484: 339-53
87. 86. Yabu H, Obara K, Usuki T. 1992. Calcium and potassium channel regulation by protein phosphorylation in smooth muscle cells of guinea pig taenia coli. In Advances in Experimental Medicine and Biology, ed. GB Frank, CP Bianchi, HEDJ ter Keurs, 311:41-52. New York: Plenum
88. 87. Farrugia G, Rae JL, Sarr M, Szurszewski JH. 1993. Activation of whole cell currents in isolated human jejunal circular smooth muscle by carbon monoxide. Am. J. Physiol. 264:G1184-89
89. 88. Farrugia G, Miller SM, Rich A, Liu X, Maines MD, et al. 1998. Distribution of heme oxygenase and effects of exogenous carbon monoxide in canine jejunum. Am. J. Physiol. 274:G350-58
90. 89. Miller SM, Farrugia G, Schmalz PF, Ermilov LG, Maines MD, Szurszewski JH. 1998. Heme oxygenase 2 is present in interstitial cell networks of the mouse small intestine. Gastroenterology 114(2):239-44
91. 90. Hagiwara S, Kusano K, Saito N. 1961. Membrane changes of Onchidium nerve cell in potassium-rich media. J. Physiol. 155:470-89
92. 91. Vogalis F, Lang RJ, Bywater RA, Taylor GS. 1993. Voltage-gated ionic currents in smooth muscle cells of guinea pig proximal colon. Am. J. Physiol. 264:C527-36
93. 92. Akbarali HI, Hatakeyama N, Wang Q, Goyal RK. 1995. Transient outward current in opossum esophageal circular muscle. Am. J. Physiol. 268:G979-87
94. + conduction and selectivity. Science 280:69-77
95. 94. Vogalis F, Lang RJ. 1994. Identification of single transiently opening ("A-type") K channels in guinea pig colonic myocytes. Pflügers Arch. 429(2):160-64
96. 95. Smirnov SV, Zholos AV, Shuba MF. 1992. A potential-dependent fast outward current in single smooth muscle cells isolated from the newborn rat ileum. J. Physiol. 454:573-89
97. + currents in rabbit esophageal muscularis mucosae Am. J. Physiol. 264:G1001-7
98. 97. Duridanova DB, Boev KK. 1995. Three components of potassium outward current in cells isolated from the circular layer of guinea pig ileum. Gen. Physiol. Biophys. 14(2):125-37
99. 98. Duridanova DB, Gagov HS, Damyanov D, Boev KK. 1997. Two components of potassium outward current in smooth muscle cells from the circular layer of human jejunum. Gen. Physiol. Biophys. 16(1):49-58
100. 99. Xiong Z, Sperelakis N, Noffsinger A, Fenoglio-Preiser C. 1995. Potassium currents in rat colonic smooth muscle cells and changes during development and aging. Pflügers Arch. 430(4):563-72
101. 100. Nagano N, Imaizumi Y, Watanabe M. 1997. Effects of arachidonic acid on A-type potassium currents in smooth muscle cells of the guinea pig. Am. J. Physiol. 272:C860-69
102. + channel. Am. J. Physiol. 272:G962-71
103. + channels by purinergic agonists in smooth muscle cells of the mouse ileum. J. Physiol. 502:497-508
104. + channels activated by ATP in murine colonic smooth muscle. Am. J. Physiol. 273:C2010-21
105. + channel from colonic smooth muscle. Am. J. Physiol. 271: G629-39
106. 105. Carl A, Lee HK, Sanders KM. 1996. Regulation of ion channels in smooth muscles by calcium. Am. J. Physiol. 271:C9-34
107. + channels in electrical activity of canine gastric smooth muscle. J. Physiol. 429:205-21
108. 2+-activated K channels of canine colonic myocytes. Am. J. Physiol. 257:C470-80
109. + channels by substance P. Am. J. Physiol. 257:G887-97
110. 109. Jury J, Boev KR, Daniel EE. 1996. Nitric oxide mediates outward potassium currents in opossum esophageal circular smooth muscle. Am. J. Physiol. 270: G932-38
111. 110. Quayle JM, Nelson MT, Standen NB. 1997. ATP-sensitive and inwardly rectifying potassium channels in smooth muscle. Physiol. Rev. 77(4):1165-232
112. 111. Zini S, Ben-Ari Y, Ashford ML. 1991. Characterization of sulfonylurea receptors and the action of potassium channel openers on cholinergic neurotransmission in guinea pig isolated small intestine. J. Pharmacol. Exp. Ther. 259(2):566-73
113. 112. Post JM, Stevens RJ, Sanders KM, Hume JR. 1991. Effect of cromakalim and lemakalim on slow waves and membrane currents in colonic smooth muscle. Am. J. Physiol. 260:C375-82
114. + channels in canine colon. Pflügers Arch. 421(1):67-76
115. + channel in rabbit esophageal smooth muscle. Am. J. Physiol. 268:C877-85
116. 115. Ohya Y, Terada K, Kitamura K, Kuriyama H. 1986. Membrane currents recorded from a fragment of rabbit intestinal smooth muscle cell. Am. J. Physiol. 251: C335-46
117. 116. Muraki K, Imaizumi Y, Watanabe M. 1991. Sodium currents in smooth muscle cells freshly isolated from stomach fundus of the rat and ureter of the guinea pig. J. Physiol. 442:351-75
118. 117. Yamamoto Y, Fukuta H, Suzuki H. 1993. Blockade of sodium channels by divalent cations in rat gastric smooth muscle. Jpn. J. Physiol. 43(6):785-96
119. + current in circular smooth muscle cells of the large intestine. Pflügers Arch. 423(56):485-91
120. 119. Morgan KG, Angel F, Schmalz PF, Szurszewski JH. 1985. Intracellular electrical activity of muscularis mucosae of the dog stomach. Am. J. Physiol. 249: G256-63
121. 120. Ward SM, Burns AJ, Torihashi S, Sanders KM. 1994. Mutation in the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine. J. Physiol. 480:91-97
122. 121. Huizinga JD, Thuneberg L, Kluppel M, Malysz J, Mikkelsen HB, Bernstein A. 1995. W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature 373:347-49
123. 122. Vanderwinden JM, Liu H, DeLaet MH, Vanderhaeghen JJ. 1996. Study of the interstitial cells of Cajal in infantile hypertrophic pyloric stenosis. Gastroenterology 111:279-88
124. 123. Vanderwinden JM, Rumessen JJ, Liu H, Descamps D, DeLaet MH, Vanderhaeghen JJ. 1996. Interstitial cells of Cajal in human colon and in Hirschsprung's disease. Gastroenterology 111(4):901-10
125. + cells in patients with a myopathic form of chronic idiopathic intestinal pseudo-obstruction. Am. J. Gastroenterol. 92(2):332-34
126. 125. Rumessen JJ. 1996. Ultrastructure of interstitial cells of Cajal at the colonic submuscular border in patients with ulcerative colitis. Gastroenterology 111(6): 1447-55
127. 126. Langton P, Ward SM, Carl A, Norell MA, Sanders KM. 1989. Spontaneous electrical activity of interstitial cells of Cajal isolated from canine proximal colon. Proc. Natl. Acad. Sci. USA 86(18):7280-84
128. - current and physiological roles of the intestinal c-kit-positive cells. Pflügers Arch. 431(2):169-77
129. 128. Thomsen L, Robinson T, Lee J, Farraway L, Huizenga JD. 1998. Characterization of spontaneous electrical activity in isolated interstitial cells of Cajal. Neurogastroenterol. Motil. 10(1):A104 (Abstr.)
130. 129. Farrugia G. 1996. Modulation of ionic currents in isolated canine and human jejunal circular smooth muscle cells by fluoxetine. Gastroenterology 110:1438-45
131. 130. Rich A, Farrugia G, Sarr MG, Szurszewski JH. 1998. Calcium currents in intestinal cells from human jejunum. Gastroenterology 114(4):A826