Effects of K+ channel openers on relaxations to nitric oxide and endothelium-derived hyperpolarizing factor in rat mesenteric artery

European Journal of Pharmacology

Volumn 357, Issue 1, 1998, Pages 41-51

  White, Richard ^a   Hiley, C Robin ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Ca2+ ionophore A23187; Carbachol; EDHF (endothelium derived hyperpolarizing factor); Endothelium; Levcromakalim; Mesenteric artery, rat; Nitric oxide (NO)

Indexed keywords

CALCIMYCIN; CARBACHOL; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; GLIBENCLAMIDE; LEMAKALIM; METHOXAMINE; NITRIC OXIDE; PINACIDIL;

ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTERY MUSCLE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; MALE; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION;

ANIMALS; BIOLOGICAL FACTORS; CALCIMYCIN; CROMAKALIM; DRUG INTERACTIONS; ELECTROPHYSIOLOGY; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; IONOPHORES; MALE; MEMBRANE POTENTIALS; MESENTERIC ARTERIES; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; POTASSIUM CHANNELS; RATS; RATS, WISTAR;

EID: 0032508740     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00538-X     Document Type: Article

References (29)

1. +: a functional approach to separating EDHF- and EDNO-related mechanisms in perfused rat mesenteric arterial bed. J. Cardiovasc. Pharmacol. 21:1993;423-429.
2. Bauersachs J., Popp R., Hecker M., Sauer E., Fleming I., Busse R. Nitric oxide attenuates the release of endothelium-derived hyperpolarizing factor. Circulation. 94:1996;3341-3347.
3. Bray K.M., Weston A.H., Duty S., Newgreen D.T., Longmore J., Edwards G., Brown T.J. Differences between the effects of cromakalim and nifedipine on agonist-induced responses in rabbit aorta. Br. J. Pharmacol. 102:1991;337-344.
4. Chen G., Cheung D.W. Characterization of acetylcholine-induced membrane hyperpolarization in endothelial cells. Circ. Res. 70:1992;257-263.
5. Cook N.S. The pharmacology of potassium channels and their therapeutic potential. Trends Pharmacol. Sci. 9:1988;21-28.
6. Dainty I.A., McGrath J.C., Spedding M., Templeton A.G.B. The influence of the initial stretch and the agonist-induced tone on the effect of basal and stimulated release of EDRF. Br. J. Pharmacol. 100:1990;767-773.
7. Drieu La Rochelle C., Richard V., Dubois-Rande J.L., Roupie E., Guidicelli J.F., Hittinger L., Berdeaux A. Potassium channel openers dilate large epicardial coronary arteries in conscious dogs by an indirect, endothelium-dependent mechanism. J. Pharmacol. Exp. Ther. 263:1992;1091-1096.
8. +-channel openers. Trends Pharmacol. Sci. 11:1990;417-422.
9. ω-nitro-L-arginine methyl ester-sensitive responses to cromakalim and diazoxide in the rat mesenteric bed. Eur. J. Pharmacol. 319:1997;229-238.
10. 2+ in relation to generation of acetylcholine-induced endothelium-dependent hyperpolarization in rat mesenteric artery. Br. J. Pharmacol. 120:1997;1328-1334.
11. 2+ entry in porcine aortic endothelial cells. Br. J. Pharmacol. 121:1997;1579-1588.
12. + channels mediate EDRF release to flow but not agonists in rabbit aorta. Am. J. Physiol. 266:1994;H590-H596.
13. 2+ concentration and mechanical activity induced by noradrenaline in the rabbit mesenteric artery. Br. J. Pharmacol. 104:1991;227-233.
14. + channels in rat aorta and brain microvascular endothelial cells. Am. J. Physiol. 265:1993;C812-C821.
15. Katnik C., Adams D.J. Characterization of ATP-sensitive potassium channels in freshly dissociated rabbit aortic endothelial cells. Am. J. Physiol. 272:1997;H2507-H2511.
16. Kühberger E., Kukovetz W.R., Groschner K. Cromakalim inhibits multiple mechanisms of smooth muscle activation with similar stereoselectivity. J. Cardiovasc. Pharmacol. 21:1993;947-954.
17. ATP in endothelium. Am. J. Physiol. 269:1995;H541-H549.
18. + channel openers in isolated coronary capillaries. Pflugers Archiv. Eur. J. Physiol. 435:1998;435-438.
19. Lückhoff A., Busse R. Activators of potassium channels enhance calcium influx into endothelial cells as a consequence of potassium currents. Naunyn Schmiedeberg's Arch. Pharmacol. 342:1990;94-99.
20. McCulloch A.I., Randall M.D. The effects of levcromakalim on nitric-oxide- and EDHF-mediated relaxations in the rat isolated mesenteric arterial bed. Br. J. Pharmacol. 120:1997;155P.
21. McCulloch A.I., Bottrill F.E., Randall M.D., Hiley C.R. Characterisation and modulation of EDHF-mediated relaxations in the rat isolated superior mesenteric bed. Br. J. Pharmacol. 120:1997;1431-1438.
22. Mulvany M.J., Halpern W. Contractile responses of small resistance vessels in spontaneously hypertensive and normotensive rats. Circ. Res. 41:1977;19-26.
23. Nagao T., Illiano S., Vanhoutte P.M. Calmodulin antagonists inhibit endothelium-dependent hyperpolarization in the canine coronary artery. Br. J. Pharmacol. 107:1992;382-386.
24. Nilius B., Viana F., Droogmans G. Ion channels in vascular endothelium. Annu. Rev. Physiol. 59:1997;145-170.
25. Parsaee H., McEwan J.R., Joseph S., MacDermot J. Differential sensitivities of the prostacyclin and nitric oxide biosynthetic pathway to cytosolic calcium in bovine aortic endothelial cells. Br. J. Pharmacol. 107:1992;1013-1019.
26. Plane F., Garland C.J. Influence of contractile agonists on the mechanism of endothelium-dependent relaxation in rat isolated mesenteric artery. Br. J. Pharmacol. 119:1996;191-193.
27. Reed P.W., Lardy H.A. A23187: a divalent cation ionophore. J. Biol. Chem. 247:1972;6970-6977.
28. White R., Hiley C.R. A comparison of EDHF-mediated and anandamide-induced relaxations in the rat isolated mesenteric artery. Br. J. Pharmacol. 122:1997;1573-1584.
29. White R., Hiley C.R. Endothelium and cannabinoid receptor involvement in levcromakalim relaxation. Eur. J. Pharmacol. 339:1997;157-160.