Caffeine enhances myocardial uptake of idarubicin but reverses its negative inotropic effect

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 367, Issue 2, 2003, Pages 151-155

  Kang, Wonku ^a   Weiss, Michael ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Caffeine; Cardiotoxicity; Heart; Idarubicin (IDA); Inotropism; Saturable uptake; Theophylline

Indexed keywords

CAFFEINE; IDARUBICIN; METHYLXANTHINE DERIVATIVE; THEOPHYLLINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATTENUATION; CARDIOTOXICITY; DRUG UPTAKE; HEART LEFT VENTRICLE PRESSURE; INOTROPISM; ISOLATED HEART; LEUKEMIA CELL; MALE; NONHUMAN; RAT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CAFFEINE; DRUG INTERACTIONS; HEART RATE; IDARUBICIN; MALE; MYOCARDIAL CONTRACTION; RATS; RATS, SPRAGUE-DAWLEY; THEOPHYLLINE; VASCULAR RESISTANCE; VASODILATOR AGENTS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 0037291073     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-002-0683-2     Document Type: Article

References (18)

1. Daly JW (1993) Mechanism of action of caffeine. In: Garattini S (ed) Caffeine, coffee, and health. Raven, New York, pp 97-150
2. D'Argenio DZ, Schumitzky A (1997) ADAPT II user's guide: pharmacokinetic/pharmacodynamic systems analysis software. Biomedical Simulations Resource, Los Angeles
3. Hosenpud JD, Wright J, Simpson L, Abramson JJ (1995) Caffeine enhances doxorubicin cardiac toxicity in an animal model. J Card Fail 1:155-160
4. Huet S, Bouvier A, Gruet M-A, Jolivet E (1996) Statistical tools for nonlinear regression. Springer, New York Berlin Heidelberg, pp 69-70
5. Jacquez JA, Perry T (1990) Parameter estimation: local identifiability of parameters. Am J Physiol 258:E727-E736
6. Kakkar T, Pak, Mayersohn M (2000) Evaluation of a minimal experimental design for determination of enzyme kinetic parameters and inhibition mechanism. J Pharmacol Exp Ther 293:861-869
7. Kang W, Weiss M (2001) Influence of P-glycoprotein modulators on cardiac uptake, metabolism, and effects of idarubicin. Pharm Res 18:1535-1541
8. Kuhlmann O, Hofmann S, Weiss M (1999) Determination of idarubicin and idarubicinol in rat plasma using reversed-phase high-performance liquid chromatography and fluorescence detection, J Chromatogr B Biomed Sci Appl 728:279-282
9. Looby M, Linke R, Weiss M (1997) Pharmacokinetics and tissue distribution of idarubicin and its active metabolite idarubicinol in the rabbit. Cancer Chemother Pharmacol 39:554-556
10. Matsushita T, Okamato M, Toyama J, Kodama I, Ito S, Fukutomi T, Suzuki S, Itoh M (2000) Adriamycin causes dual inotropic effects through complex modulation of myocardial Ca2+ handling. Jpn Circ J 64:65-71
11. Nagasawa K, Ohnishi N, Yokoyama T (1997) Transport mechanisms of idarubicin, an anthracycline derivative, in human leukemia HL60 cells and mononuclear cells, and comparison with those of its analogs. Jpn J Cancer Res 88:750-759
12. Olson RD, Li X, Palade P, Shadle SE, Mushlin PS, Gambliel HA, Fill M, Boucek RJ Jr, Cusack BJ (2000) Sarcoplasmic reticulum calcium release is stimulated and inhibited by daunorubicin and daunorubicinol. Toxicol Appl Pharmacol 169:168-176
13. Pessah IN, Durie EL, Schiedt MJ, Zimanyi I (1990) Anthraquinone-sensitized Ca2+ release channel from rat cardiac sarcoplasmic reticulum: possible receptor-mediated mechanism of doxorubicin cardiomyopathy. Mol Pharmacol 37:503-514
14. Sadzuka Y, Mochizuki E, Takino Y (1995) Mechanism of caffeine modulation of the antitumor activity of adriamycin. Toxicol Lett 75:39-49
15. Sadzuka Y, Egawa Y, Sugiyama T, Sawanishi H, Miyamoto K, Sonobe T (2000) Effects of 1-methyl-3-propyl-7-butylxanthine (MPBX) on idarubicin-induced antitumor activity and bone marrow suppression. Jpn J Cancer Res 91:651-657
16. Temma K, Chugun A, Akera T, Hara Y, Sasaki T, Kondo H (1997) Ca2+ overloading causes the negative inotropic effect of doxorubicin in myocytes isolated from guinea-pig hearts. Eur J Pharmacol 322:235-242
17. Tsuchiya H, Yamamoto N, Asada N, Terasaki T, Kanazawa Y, Takanaka T, Nishijima H, Tomita K (2000) Caffeine-potentiated radiochemotherapy and function-saving surgery for high-grade soft tissue sarcoma. Anticancer Res 20:2137-2143
18. Weiss M, Kang W (2002) P-glycoprotein inhibitors enhance saturable uptake of idarubicin in rat heart: pharmacokinetic/pharmacodynamic modeling. J Pharmacol Exp Ther 300:688-694