Ca2+ overloading causes the negative inotropic effect of doxorubicin in myocytes isolated from guinea-pig hearts

European Journal of Pharmacology

Volumn 322, Issue 2-3, 1997, Pages 235-242

  Temma, Kyosuke ^a   Chugun, Akihito ^a   Akera, Tai ^b   Hara, Yukio ^a   Sasaki, Takushi ^a   Kondo, Hiroshi ^a  

^a KITASATO UNIVERSITY   (Japan)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Ca2+ concentration, intracellular; Cardiotoxicity; Cell contraction; Doxorubicin; Myocardial cell, single

Indexed keywords

DOXORUBICIN; CALCIUM; VERAPAMIL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CARDIOTOXICITY; DRUG EFFECT; GUINEA PIG; HEART MUSCLE CELL; INOTROPISM; MUSCLE TWITCH; NONHUMAN; PRIORITY JOURNAL; ANIMAL; HEART CONTRACTION; IN VITRO STUDY; MALE; METABOLISM;

ANIMALS; CALCIUM; DOXORUBICIN; GUINEA PIGS; MALE; MYOCARDIAL CONTRACTION; VERAPAMIL;

EID: 0030612062     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00994-6     Document Type: Article

References (1)

1. Azuma, J., N. Sperelakis, H. Hasegawa, Y. Tanimoto, S. Vogel, K. Ogura, N. Awata, A. Sawamura, H. Harada, T. Ishiyama, Y. Morita and Y. Yamamura, 1981, Adriamycin cardiotoxicity: possible pathogenic mechanisms, J. Mol. Cell. Cardiol.