Insights into the genetic organization of the Corynebacterium diphtheriae erythromycin resistance plasmid pNG2 deduced from its complete nucleotide sequence

Plasmid

Volumn 49, Issue 1, 2003, Pages 63-74

  Tauch, Andreas ^a   Bischoff, Nicole ^a   Brune, Iris ^a   Kalinowski, Jörn ^a  

^a BIELEFELD UNIVERSITY   (Germany)

Author keywords

Corynebacterium diphtheriae; Erythromycin resistance; Natural resistance associated macrophage protein; Nudix hydrolase; Plasmid genome; Plasmid replication; Resistance plasmid

Indexed keywords

BACTERIAL ENZYME; ERYTHROMYCIN; HYDROLASE; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN; REPLICATION PROTEIN A;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL GENETICS; BACTERIAL STRAIN; COMPARATIVE STUDY; CORYNEBACTERIUM DIPHTHERIAE; DNA FLANKING REGION; ESCHERICHIA COLI; GENE DELETION; GENE EXPRESSION; GENE INSERTION; GENE STRUCTURE; GENETIC CODE; GENETIC MARKER; GENETIC ORGANIZATION; GENOME ANALYSIS; HORIZONTAL GENE TRANSFER; INVERTED REPEAT; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PROTEIN MOTIF; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BASE SEQUENCE; CONSERVED SEQUENCE; CORYNEBACTERIUM DIPHTHERIAE; DNA HELICASES; DNA NUCLEOTIDYLTRANSFERASES; DNA TRANSPOSABLE ELEMENTS; DNA, INTERGENIC; DNA-BINDING PROTEINS; DRUG RESISTANCE, BACTERIAL; ERYTHROMYCIN; ESCHERICHIA COLI; GENE ORDER; MOLECULAR SEQUENCE DATA; PLASMIDS; PROTEINS; PYROPHOSPHATASES; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; TRANS-ACTIVATORS;

CORYNEBACTERIUM; CORYNEBACTERIUM DIPHTHERIAE; ESCHERICHIA COLI; INSERTION SEQUENCES; UNIDENTIFIED INSERTION SEQUENCE;

EID: 0037288201     PISSN: 0147619X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0147-619X(02)00115-4     Document Type: Article

References (28)

1. Agranoff D.D., Krishna S. Metal ion homeostasis and intracellular parasitism. Mol. Microbiol. 28:1998;403-412.
2. Bessman M.J., Frick D.N., O'Handley S.F. The MutT proteins or "Nudix" hydrolases, a family of versatile, widely distributed, "housecleaning" enzymes. J. Biol. Chem. 271:1996;25059-25062.
3. Delcher A.L., Harmon D., Kasif S., White O., Salzberg S.L. Improved microbial gene identification with GLIMMER. Nucleic Acids Res. 27:1999;4636-4641.
4. Dodd I.B., Egan J.B. Improved detection of helix-turn-helix DNA-binding motifs in protein sequences. Nucleic Acids Res. 18:1990;5019-5026.
5. Funke G., von Graevenitz A., Clarridge III J.E., Bernard K.A. Clinical microbiology of coryneform bacteria. Clin. Microbiol. Rev. 10:1997;125-159.
6. Gerdes K., Moller-Jensen J., Jensen R.B. Plasmid and chromosome partitioning: surprises from phylogeny. Mol. Microbiol. 37:2000;455-466.
7. Grant S.G.N., Jessee J., Bloom F.R., Hanahan D. Differential plasmid rescue from transgenic mouse DNAs into Escherichia coli methylation-restriction mutants. Proc. Natl. Acad. Sci. USA. 87:1990;4645-4649.
8. Ilyina T.V., Koonin E.V. Conserved sequence motifs in the initiator proteins for rolling circle DNA replication encoded by diverse replicons from eubacteria, eukaryotes and archaebacteria. Nucleic Acids Res. 20:1992;3279-3285.
9. Jost H.B., Billington S.J., Songer J.G. Electroporation-mediated transformation of Arcanobacterium (Actinomyces) pyogenes. Plasmid. 38:1997;135-140.
10. Llosa M., Bolland S., de la Cruz F. Genetic organization of the conjugal DNA processing region of the IncW plasmid R388. J. Mol. Biol. 235:1994;448-464.
11. Radford A.J., Hodgson A.L.M. Construction and characterization of a Mycobacterium-Escherichia coli shuttle vector. Plasmid. 25:1991;149-153.
12. Roberts M.C., Sutcliffe J., Courvalin P., Jensen L.B., Rood J., Seppala H. Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants. Antimicrob. Agents Chemother. 43:1999;2823-2830.
13. Rosato A.E., Lee B.S., Nash K.A. Inducible macrolide resistance in Corynebacterium jeikeium. Antimicrob. Agents Chemother. 45:2001;1982-1989.
14. B ) resistance in cutaneous propionibacteria from six European cities J. Antimicrob. Chemother. 49:2002;165-168.
15. Rost B., Casadio R., Fariselli P., Sander C. Prediction of helical transmembrane segments at 95% accuracy. Protein Sci. 4:1995;521-533.
16. Schiller J., Groman N., Coyle M. Plasmids in Corynebacterium diphtheriae and diphtheroids mediating erythromycin resistance. Antimicrob. Agents Chemother. 18:1980;814-821.
17. Serwold-Davis T.M., Groman N.B. Identification of a methylase gene for erythromycin resistance within the sequence of a spontaneously deleting fragment of Corynebacterium diphtheriae plasmid pNG2. FEMS Microbiol. Lett. 56:1988;7-14.
18. Serwold-Davis T.M., Groman N., Rabin M. Transformation of Corynebacterium diphtheriae, Corynebacterium ulcerans, Corynebacterium glutamicum, and Escherichia coli with the C. diphtheriae plasmid pNG2. Proc. Natl. Acad. Sci. USA. 84:1987;4964-4968.
19. Staden R. The Staden sequence analysis package. Mol. Biotechnol. 5:1996;233-241.
20. Tauch A., Kassing F., Kalinowski J., Pühler A. The Corynebacterium xerosis composite transposon Tn5432 consists of two identical insertion sequences, designated IS1249, flanking the erythromycin resistance gene ermCX. Plasmid. 34:1995;119-131.
21. Tauch A., Krieft S., Kalinowski J., Pühler A. The 51,409-bp R-plasmid pTP10 from the multiresistant clinical isolate Corynebacterium striatum M82B is composed of DNA segments initially identified in soil bacteria and in plant, animal, and human pathogens. Mol. Gen. Genet. 263:2000;1-11.
22. Tauch A., Pühler A., Kalinowski J., Thierbach G. TetZ, a new tetracycline resistance determinant discovered in Gram-positive bacteria, shows high homology to Gram-negative regulated efflux systems. Plasmid. 44:2000;285-291. doi:10.1006/plas.2000.1489.
23. Tauch A., Götker S., Pühler A., Kalinowski J., Thierbach G. The 27.8-kb R-plasmid pTET3 from Corynebacterium glutamicum encodes the aminoglycoside adenyltransferase gene cassette aadA9 and the regulated tetracycline efflux system Tet 33 flanked by active copies of the widespread insertion sequence IS6100. Plasmid. 48:2002;117-129.
24. Thompson J.D., Higgins D.G., Gibson T.J. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:1994;4673-4680.
25. Thomson J.M., Parrot W.A. pMECA: a cloning plasmid with 44 unique restriction sites that allows selection of recombinants based on colony size. BioTechniques. 24:1998;922-927.
26. Trautwetter A., Blanco C. Structural organization of the Corynebacterium glutamicum plasmid pCG100. J. Gen. Microbiol. 137:1991;2093-2101.
27. Xu W.L., Shen J.Y., Dunn C.A., Desai S., Bessman M.J. The Nudix hydrolases of Deinococcus radiodurans. Mol. Microbiol. 39:2001;286-290.
28. Zhang Y., Praszkier J., Hodgson A., Pittard A.J. Molecular analysis and characterization of the broad-host-range plasmid, pEP2. J. Bacteriol. 176:1994;5718-5728.